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The map label for this gene is yfbG [C]

Identifier: 188586200

GI number: 188586200

Start: 1663379

End: 1664344

Strand: Direct

Name: yfbG [C]

Synonym: Nther_1582

Alternate gene names: 188586200

Gene position: 1663379-1664344 (Clockwise)

Preceding gene: 188586199

Following gene: 188586201

Centisome position: 52.55

GC content: 35.61

Gene sequence:

>966_bases
ATGAAATATTTAGTAACAGGTGCTGCTGGCTTTATAGGTTCCCATCTTTGTAAAGAGCTGGTCACTCGTGGAAACAAAGT
ATGGGGACTAGATAATCTTAGTCAGGGAAAAATAGAAAGATTACAGGAACTTGAGGACCACCCAGATTTTCAATTCATAG
ATAGCTGTATATCTGACGATGAAGTTTTGGAAGAACTTATTAATAAAGTTGATATTATATATCATATGGCTGCAGTTGTT
GGGGTAAAACGATATGTAGAAAAACCGGAGAGAGTAATTGACGTAAATGTACGCTTCACTTCACGGTTGTTTGAACTTGC
GTATCAATTGGATAAAAAGGTAATATTTGCTTCAACATCAGAAGTCTATGGAAAAAACAATAGTATTCCCTTTAGTGAAG
ATGATAATCGCATTTACGGCCCCTCCACTACAGATAGATGGTCTTATGCAATATCAAAGAGTGCAGCTGAACACCTTTGT
TTGGGTTATGTTAAAAAAGGACTTAAGGCTGTAATAATACGATATTTTAATGTTTATGGACCATATGCAGATACCTCGGC
ATATGGTGGTGTGGTTACTCGATTCGTAAATCAACTTTTAACTAATAAACCAATGACTGTTCACAATGACGGTAGTCAAA
CACGCTGCTTCACCTATATCGACGATATAATAAAAGGAACAATTGAAGCTGGTAGTCGGCCTGAGGCAGAAGGAAAAGTA
TTCAATCTTGGACATCATCGTGAAACTTCCATTCTTGAACTTGCTGAAACCATTTTAAAAGTTTCTGGAATAAATGGTGA
CATAGTTTTTCAACCATATAAAGAATTTTATGGTAATAGTTATGAGGACATTACTAGAAGAGTTCCAGATTTATCAGAAG
CAAGAAAAATCCTTGATTACGATCCTGAAATAACTCTTGAAGATGGGCTCAAAAAAACCTTAAATTGGTATAAAGACAGA
GTATGA

Upstream 100 bases:

>100_bases
TTTGTGCTGAAATGAAAAAACCACTAGTCGTAGACGGAAGAAACCTATTTAATCGTGAAGAAATGGAATCCCATGGCATT
GTTTATGTGGGGGTAGGTAT

Downstream 100 bases:

>100_bases
TTAGGAGTGAGTAATTTTGAACATTAAAAAAGCAATCATACCTGTCGCAGGCTTTGGTACTAGACTTTTACCTATTACCA
AAGCCATCCCTAAAACAATG

Product: NAD-dependent epimerase/dehydratase

Products: UDPgalactose

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKYLVTGAAGFIGSHLCKELVTRGNKVWGLDNLSQGKIERLQELEDHPDFQFIDSCISDDEVLEELINKVDIIYHMAAVV
GVKRYVEKPERVIDVNVRFTSRLFELAYQLDKKVIFASTSEVYGKNNSIPFSEDDNRIYGPSTTDRWSYAISKSAAEHLC
LGYVKKGLKAVIIRYFNVYGPYADTSAYGGVVTRFVNQLLTNKPMTVHNDGSQTRCFTYIDDIIKGTIEAGSRPEAEGKV
FNLGHHRETSILELAETILKVSGINGDIVFQPYKEFYGNSYEDITRRVPDLSEARKILDYDPEITLEDGLKKTLNWYKDR
V

Sequences:

>Translated_321_residues
MKYLVTGAAGFIGSHLCKELVTRGNKVWGLDNLSQGKIERLQELEDHPDFQFIDSCISDDEVLEELINKVDIIYHMAAVV
GVKRYVEKPERVIDVNVRFTSRLFELAYQLDKKVIFASTSEVYGKNNSIPFSEDDNRIYGPSTTDRWSYAISKSAAEHLC
LGYVKKGLKAVIIRYFNVYGPYADTSAYGGVVTRFVNQLLTNKPMTVHNDGSQTRCFTYIDDIIKGTIEAGSRPEAEGKV
FNLGHHRETSILELAETILKVSGINGDIVFQPYKEFYGNSYEDITRRVPDLSEARKILDYDPEITLEDGLKKTLNWYKDR
V
>Mature_321_residues
MKYLVTGAAGFIGSHLCKELVTRGNKVWGLDNLSQGKIERLQELEDHPDFQFIDSCISDDEVLEELINKVDIIYHMAAVV
GVKRYVEKPERVIDVNVRFTSRLFELAYQLDKKVIFASTSEVYGKNNSIPFSEDDNRIYGPSTTDRWSYAISKSAAEHLC
LGYVKKGLKAVIIRYFNVYGPYADTSAYGGVVTRFVNQLLTNKPMTVHNDGSQTRCFTYIDDIIKGTIEAGSRPEAEGKV
FNLGHHRETSILELAETILKVSGINGDIVFQPYKEFYGNSYEDITRRVPDLSEARKILDYDPEITLEDGLKKTLNWYKDR
V

Specific function: Unknown

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=318, Percent_Identity=33.0188679245283, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI7657641, Length=328, Percent_Identity=29.5731707317073, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI56237023, Length=292, Percent_Identity=27.0547945205479, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI56118217, Length=292, Percent_Identity=27.0547945205479, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI189083684, Length=292, Percent_Identity=27.0547945205479, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788589, Length=341, Percent_Identity=31.6715542521994, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI48994969, Length=337, Percent_Identity=27.5964391691395, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786974, Length=343, Percent_Identity=25.9475218658892, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788353, Length=347, Percent_Identity=27.0893371757925, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788365, Length=335, Percent_Identity=25.3731343283582, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539532, Length=325, Percent_Identity=31.3846153846154, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982035, Length=350, Percent_Identity=27.7142857142857, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71982038, Length=352, Percent_Identity=27.5568181818182, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17568069, Length=332, Percent_Identity=28.0120481927711, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115532424, Length=333, Percent_Identity=24.6246246246246, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=347, Percent_Identity=27.6657060518732, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21356223, Length=325, Percent_Identity=32.9230769230769, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19923002, Length=293, Percent_Identity=26.2798634812287, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.2

Molecular weight: Translated: 36482; Mature: 36482

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLVTGAAGFIGSHLCKELVTRGNKVWGLDNLSQGKIERLQELEDHPDFQFIDSCISDD
CCEEEECHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCH
EVLEELINKVDIIYHMAAVVGVKRYVEKPERVIDVNVRFTSRLFELAYQLDKKVIFASTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEECCH
EVYGKNNSIPFSEDDNRIYGPSTTDRWSYAISKSAAEHLCLGYVKKGLKAVIIRYFNVYG
HHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PYADTSAYGGVVTRFVNQLLTNKPMTVHNDGSQTRCFTYIDDIIKGTIEAGSRPEAEGKV
CCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCE
FNLGHHRETSILELAETILKVSGINGDIVFQPYKEFYGNSYEDITRRVPDLSEARKILDY
EECCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCHHHHHHHCCCHHHHHHHHCC
DPEITLEDGLKKTLNWYKDRV
CCCEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKYLVTGAAGFIGSHLCKELVTRGNKVWGLDNLSQGKIERLQELEDHPDFQFIDSCISDD
CCEEEECHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCH
EVLEELINKVDIIYHMAAVVGVKRYVEKPERVIDVNVRFTSRLFELAYQLDKKVIFASTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEECCH
EVYGKNNSIPFSEDDNRIYGPSTTDRWSYAISKSAAEHLCLGYVKKGLKAVIIRYFNVYG
HHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PYADTSAYGGVVTRFVNQLLTNKPMTVHNDGSQTRCFTYIDDIIKGTIEAGSRPEAEGKV
CCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCE
FNLGHHRETSILELAETILKVSGINGDIVFQPYKEFYGNSYEDITRRVPDLSEARKILDY
EECCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCHHHHHHHCCCHHHHHHHHCC
DPEITLEDGLKKTLNWYKDRV
CCCEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucose

Specific reaction: UDP-glucose = UDP-galactose

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]