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The map label for this gene is accD [C]

Identifier: 188586115

GI number: 188586115

Start: 1560580

End: 1562136

Strand: Direct

Name: accD [C]

Synonym: Nther_1489

Alternate gene names: 188586115

Gene position: 1560580-1562136 (Clockwise)

Preceding gene: 188586114

Following gene: 188586116

Centisome position: 49.3

GC content: 40.21

Gene sequence:

>1557_bases
ATGGCAACTAATGATAAAGACAAATTGGAAATGTTACAGGAAGAAAAAGAAAAGATATCTAAAGGCGGAGGAGAAAAACG
GATCGCTAAACAGCATGAAAAAGGAAAATTAACAGCTCGAGAGCGCATAGAAAACTTTCTAGATAATGGAAGTTTTGTCG
AATTGAACGCCTTTGTCAAGCATCGACAAACCCAATTGGGAATGGACAAAAAAGAAGCTCCTGGTGAAGGAGTTGTTACT
GGATACGGAACTGTAGATGGGCGTTTAGTCTACGTTTTTGCTCAAGACTTTACAGTTCTTGGTGGAACTTTGGGTGAAAT
GCATGCGTATAAAATATGTGATGCCATGGATCGGGCTGCTAAAGTAGGTGCTCCTTTCATCGGTTTAAATGATTCTGGAG
GGGCCCGTATTCAAGAAGGGGTAGATGCGCTTAAAGGTTATGGCAATATTTTCTACCGAAACACTATTTATTCCGGAGTT
ATACCGCAAATTTCCGCAATTATGGGTCCTTGTGCTGGAGGGGCTGTATACTCACCAGCCTTGACAGACTTTGTGTTTAT
GGTAAGAGACACCAGTCAAATGTTTATTACAGGCCCCCAAGTAATTAAAACAGTTACTGGTGAAGAGGTGTCTTTTGAAG
AGCTAGGCGGTGCCGATACCCATAATTCAAAAAGCGGTGTGGGTCATTTTGCTGCTGATAATGATGAAGACTGTCTGGCA
CAAATCCGGGAATTGCTTAGCTTTATTCCATCAAATAATGCTGAAGATCCACCAGCTGTGGAGCCTAGTGATGATCCCAA
CCGCAAAGAAGAAGATTTAAAAGATATAATCCCGGAAAATCCTAATAAACCTTATGATGTACGAGACGTTATTACCAGAA
TTACAGATGATGGCTATTTCTTTGAAATTCAAGAAAGTTATGCCCAAAACATAATAATTGGATTTTCGCGTTTGAATGGC
CGGACGGTAGGTATTATAGCAAATCAACCTGCTCATCTGGCTGGTTGTTTGGATATTAATGCCTCGGACAAAGCATCCAG
ATTTATCCGTTTCTGTGACTCCTTTAATATCCCTATTGTAACTTTCCAAGATGTACCGGGTTATTTACCGGGAACGGATC
AAGAGCATGGTGGTATTATTCGCCATGGTGCCAAACTATTGTATGCCTATTCTGAAGCTACTGTTCCTAAGATTACTGTC
ATTCTTAGAAAATCCTATGGTGGCTCTTACTTAGCCATGTGTTCTAAATCATTACAGGCAGATGTAGTTTATGCCTATCC
CAGTGCCGAAATTGCTGTTATGGGACCTGAAGGGGCTGCAAATATAATTTTCAAAAAAGATATTGAAAACTCCGATGATC
CAGAAAATACTCGACAAGAAAAGATTTCCGAATATCGGGAACAGTTTGCTAATCCTTATGTAGCTGCATCAAGAGGTAGG
GTTGATGATATTATTGATCCAAAAGAAACCCGACCTAGATTAATCTATGCCCTAGAAACATTACAAACCAAGAGAGAGCA
ACGGCCATCTAAAAAACATGGAAATATCCCTGTTTAA

Upstream 100 bases:

>100_bases
GTGGGGCAAAGATTGCCTTTGTACATCCAAAAAGTACGGGTGGCACTTTAATAGAGCTTTGCGAGCGTGAAGAATAACCC
CAATTAAGGAGGTCATCCAT

Downstream 100 bases:

>100_bases
TTTTCAGTGGGCTTTGAAATACTGGGACAAAGGATGTGATGATTATGGATATGGATACTTTTGATCAAGGAATTCAAATC
ACTATTATAGGGTTTTCAGT

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MATNDKDKLEMLQEEKEKISKGGGEKRIAKQHEKGKLTARERIENFLDNGSFVELNAFVKHRQTQLGMDKKEAPGEGVVT
GYGTVDGRLVYVFAQDFTVLGGTLGEMHAYKICDAMDRAAKVGAPFIGLNDSGGARIQEGVDALKGYGNIFYRNTIYSGV
IPQISAIMGPCAGGAVYSPALTDFVFMVRDTSQMFITGPQVIKTVTGEEVSFEELGGADTHNSKSGVGHFAADNDEDCLA
QIRELLSFIPSNNAEDPPAVEPSDDPNRKEEDLKDIIPENPNKPYDVRDVITRITDDGYFFEIQESYAQNIIIGFSRLNG
RTVGIIANQPAHLAGCLDINASDKASRFIRFCDSFNIPIVTFQDVPGYLPGTDQEHGGIIRHGAKLLYAYSEATVPKITV
ILRKSYGGSYLAMCSKSLQADVVYAYPSAEIAVMGPEGAANIIFKKDIENSDDPENTRQEKISEYREQFANPYVAASRGR
VDDIIDPKETRPRLIYALETLQTKREQRPSKKHGNIPV

Sequences:

>Translated_518_residues
MATNDKDKLEMLQEEKEKISKGGGEKRIAKQHEKGKLTARERIENFLDNGSFVELNAFVKHRQTQLGMDKKEAPGEGVVT
GYGTVDGRLVYVFAQDFTVLGGTLGEMHAYKICDAMDRAAKVGAPFIGLNDSGGARIQEGVDALKGYGNIFYRNTIYSGV
IPQISAIMGPCAGGAVYSPALTDFVFMVRDTSQMFITGPQVIKTVTGEEVSFEELGGADTHNSKSGVGHFAADNDEDCLA
QIRELLSFIPSNNAEDPPAVEPSDDPNRKEEDLKDIIPENPNKPYDVRDVITRITDDGYFFEIQESYAQNIIIGFSRLNG
RTVGIIANQPAHLAGCLDINASDKASRFIRFCDSFNIPIVTFQDVPGYLPGTDQEHGGIIRHGAKLLYAYSEATVPKITV
ILRKSYGGSYLAMCSKSLQADVVYAYPSAEIAVMGPEGAANIIFKKDIENSDDPENTRQEKISEYREQFANPYVAASRGR
VDDIIDPKETRPRLIYALETLQTKREQRPSKKHGNIPV
>Mature_517_residues
ATNDKDKLEMLQEEKEKISKGGGEKRIAKQHEKGKLTARERIENFLDNGSFVELNAFVKHRQTQLGMDKKEAPGEGVVTG
YGTVDGRLVYVFAQDFTVLGGTLGEMHAYKICDAMDRAAKVGAPFIGLNDSGGARIQEGVDALKGYGNIFYRNTIYSGVI
PQISAIMGPCAGGAVYSPALTDFVFMVRDTSQMFITGPQVIKTVTGEEVSFEELGGADTHNSKSGVGHFAADNDEDCLAQ
IRELLSFIPSNNAEDPPAVEPSDDPNRKEEDLKDIIPENPNKPYDVRDVITRITDDGYFFEIQESYAQNIIIGFSRLNGR
TVGIIANQPAHLAGCLDINASDKASRFIRFCDSFNIPIVTFQDVPGYLPGTDQEHGGIIRHGAKLLYAYSEATVPKITVI
LRKSYGGSYLAMCSKSLQADVVYAYPSAEIAVMGPEGAANIIFKKDIENSDDPENTRQEKISEYREQFANPYVAASRGRV
DDIIDPKETRPRLIYALETLQTKREQRPSKKHGNIPV

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=57.9256360078278, Blast_Score=606, Evalue=1e-173,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=55.743879472693, Blast_Score=595, Evalue=1e-170,
Organism=Homo sapiens, GI11545863, Length=499, Percent_Identity=36.2725450901804, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI134142062, Length=394, Percent_Identity=24.8730964467005, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38679960, Length=395, Percent_Identity=23.5443037974684, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI38679974, Length=395, Percent_Identity=23.5443037974684, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI38679971, Length=395, Percent_Identity=23.5443037974684, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI38679977, Length=395, Percent_Identity=23.5443037974684, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679967, Length=395, Percent_Identity=23.5443037974684, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=28.042328042328, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=56.2130177514793, Blast_Score=594, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=56.2130177514793, Blast_Score=594, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17552936, Length=520, Percent_Identity=37.5, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI71997163, Length=390, Percent_Identity=23.0769230769231, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324343, Length=377, Percent_Identity=25.1989389920424, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323863, Length=351, Percent_Identity=23.9316239316239, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24586065, Length=516, Percent_Identity=35.6589147286822, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 57002; Mature: 56871

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNDKDKLEMLQEEKEKISKGGGEKRIAKQHEKGKLTARERIENFLDNGSFVELNAFVK
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEHHHHH
HRQTQLGMDKKEAPGEGVVTGYGTVDGRLVYVFAQDFTVLGGTLGEMHAYKICDAMDRAA
HHHHHCCCCCCCCCCCCEEEECCCCCCEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHH
KVGAPFIGLNDSGGARIQEGVDALKGYGNIFYRNTIYSGVIPQISAIMGPCAGGAVYSPA
HCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEECHHHHCHHHHHHHHHCCCCCCCCCCHH
LTDFVFMVRDTSQMFITGPQVIKTVTGEEVSFEELGGADTHNSKSGVGHFAADNDEDCLA
HHHHHHEEECCCCEEEECHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
QIRELLSFIPSNNAEDPPAVEPSDDPNRKEEDLKDIIPENPNKPYDVRDVITRITDDGYF
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEE
FEIQESYAQNIIIGFSRLNGRTVGIIANQPAHLAGCLDINASDKASRFIRFCDSFNIPIV
EEEEHHHHCEEEEEEEECCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEE
TFQDVPGYLPGTDQEHGGIIRHGAKLLYAYSEATVPKITVILRKSYGGSYLAMCSKSLQA
EECCCCCCCCCCCCCCCCHHHCCCEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHCCCC
DVVYAYPSAEIAVMGPEGAANIIFKKDIENSDDPENTRQEKISEYREQFANPYVAASRGR
CEEEEECCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCC
VDDIIDPKETRPRLIYALETLQTKREQRPSKKHGNIPV
CCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ATNDKDKLEMLQEEKEKISKGGGEKRIAKQHEKGKLTARERIENFLDNGSFVELNAFVK
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEHHHHH
HRQTQLGMDKKEAPGEGVVTGYGTVDGRLVYVFAQDFTVLGGTLGEMHAYKICDAMDRAA
HHHHHCCCCCCCCCCCCEEEECCCCCCEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHH
KVGAPFIGLNDSGGARIQEGVDALKGYGNIFYRNTIYSGVIPQISAIMGPCAGGAVYSPA
HCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEECHHHHCHHHHHHHHHCCCCCCCCCCHH
LTDFVFMVRDTSQMFITGPQVIKTVTGEEVSFEELGGADTHNSKSGVGHFAADNDEDCLA
HHHHHHEEECCCCEEEECHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
QIRELLSFIPSNNAEDPPAVEPSDDPNRKEEDLKDIIPENPNKPYDVRDVITRITDDGYF
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEE
FEIQESYAQNIIIGFSRLNGRTVGIIANQPAHLAGCLDINASDKASRFIRFCDSFNIPIV
EEEEHHHHCEEEEEEEECCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEE
TFQDVPGYLPGTDQEHGGIIRHGAKLLYAYSEATVPKITVILRKSYGGSYLAMCSKSLQA
EECCCCCCCCCCCCCCCCHHHCCCEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHCCCC
DVVYAYPSAEIAVMGPEGAANIIFKKDIENSDDPENTRQEKISEYREQFANPYVAASRGR
CEEEEECCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCC
VDDIIDPKETRPRLIYALETLQTKREQRPSKKHGNIPV
CCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]