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The map label for this gene is ffh [H]

Identifier: 188585994

GI number: 188585994

Start: 1440694

End: 1442037

Strand: Direct

Name: ffh [H]

Synonym: Nther_1368

Alternate gene names: 188585994

Gene position: 1440694-1442037 (Clockwise)

Preceding gene: 188585993

Following gene: 188585995

Centisome position: 45.51

GC content: 37.65

Gene sequence:

>1344_bases
ATGCTTCAAAGACTATCAGAAAAATTACAGGATACCTTTGGCAAACTGACAGGAAAAGGTAAAGTCAACGAAAAAGACGT
TAAAGAAGCCATGAGAGAAGTTCGTCTGGCCCTTCTAGAAGCCGACGTTAACTATAAAGTAGTTAAAGAGTTTGTCAATA
ATGTTAAAGAAAGAGCTGTTGGGGAAGAAGTATTAGAAAGTTTAACTCCGGGTCAACAAGTGATCAAAATTGTCCGGGAT
GAATTAACACAATTAATGGGTGGAGAAGTTAGCGAAGTAAACTTTTCTGATCAACCTCCAACTGTTATTATGCTTTCTGG
TTTGCAAGGTACTGGAAAAACCACGGCATCTGCTAAGCTGGCTAAAAAATTTAAAAAAGATGGCAAAAATCCATTGATGG
TTGCCTGTGATACCCAACGTCCAGCTGCAATTAAACAGTTACAAGTTTTAGGAGAACAAACTGATATCCCTGTTTTCAGT
ATGGGAGATAAACAGCACCCAGCTGATATAGCTAAAGGTGCTGTGGAACATGCTAAAAAAAATCAGATGGATGTTGTTAT
TTTAGATACAGCTGGTAGATTGCATATTGATGAAGATCTAATGACAGAGTTGCGTGAGGTTGAGAGCAGTGTCGAGCCTC
ATGAAATCTTACTAGTTGTAGATGCTATGACAGGTCAGGATGCAGTCAATGTTGCCGAAAGATTTGATCAGGATTTAGAT
TTATCTGGAATAGTAATGACTAAGCTTGATGGAGATACCAGGGGCGGAGCAGCGCTCTCAGTCAAAAAAGTCACTGGAAA
ACCAATTAAATTTATTGGTACAGGGGAAAAAGTTGATGAATTAGAAGTTTTCCATCCTGATCGATTGGCTTCTAGAATTC
TGGGCATGGGAGATGTAATGTCTCTGATAGAAAAAGCTGAAACTAGTATGGACCAGAAAAAAGCCCAAGAACTGGAAAAG
AAAATTAAAAGCCAGTCTTTTACCTTCGAAGATTTTTTAGAGCAGCTACAACAATTGAAGAGCATGGGTCCTTTGGACCA
AATTATGGATATGATGCCTGGTATGGCAGGTAACAAAAAGATGAAAAATTTCTCTGTAGATGAACAAGAACTAGTTAAAA
TTGAAGCTATTATTCAATCAATGACTCAAGAAGAACGTGTTAAACCTGAAGTAATTAATAGCAGTAGAAAAAAACGTATA
GCCAAAGGAAGTGGAACCAGAGTCCAAGATGTCAACAAACTTCTGAAGCAATTTGAGCAAATGAAGAAAATGATGAAACA
AATGGGTAAAATGGGTAAAAAGAAAATGCCGGGAAAAATGGGGAACAATCTTCCCTTTATGTAA

Upstream 100 bases:

>100_bases
AAAAGATAAAAGAAATTTTGACAAGGGAAACTCACCTAGATAATAACACTAGAGAAAAGTGCCTTAAATTGTTGGATGAA
TTATTAAGGAGTGAGGCTTA

Downstream 100 bases:

>100_bases
TAATTTAATGGAATTTAGAAATCCATCTAATCAAACTAAGGAGGTGTAGAACTAATGGCTGTTAGAATGAGACTTAAAAG
AATGGGAGCTAAGAAACAAC

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLQRLSEKLQDTFGKLTGKGKVNEKDVKEAMREVRLALLEADVNYKVVKEFVNNVKERAVGEEVLESLTPGQQVIKIVRD
ELTQLMGGEVSEVNFSDQPPTVIMLSGLQGTGKTTASAKLAKKFKKDGKNPLMVACDTQRPAAIKQLQVLGEQTDIPVFS
MGDKQHPADIAKGAVEHAKKNQMDVVILDTAGRLHIDEDLMTELREVESSVEPHEILLVVDAMTGQDAVNVAERFDQDLD
LSGIVMTKLDGDTRGGAALSVKKVTGKPIKFIGTGEKVDELEVFHPDRLASRILGMGDVMSLIEKAETSMDQKKAQELEK
KIKSQSFTFEDFLEQLQQLKSMGPLDQIMDMMPGMAGNKKMKNFSVDEQELVKIEAIIQSMTQEERVKPEVINSSRKKRI
AKGSGTRVQDVNKLLKQFEQMKKMMKQMGKMGKKKMPGKMGNNLPFM

Sequences:

>Translated_447_residues
MLQRLSEKLQDTFGKLTGKGKVNEKDVKEAMREVRLALLEADVNYKVVKEFVNNVKERAVGEEVLESLTPGQQVIKIVRD
ELTQLMGGEVSEVNFSDQPPTVIMLSGLQGTGKTTASAKLAKKFKKDGKNPLMVACDTQRPAAIKQLQVLGEQTDIPVFS
MGDKQHPADIAKGAVEHAKKNQMDVVILDTAGRLHIDEDLMTELREVESSVEPHEILLVVDAMTGQDAVNVAERFDQDLD
LSGIVMTKLDGDTRGGAALSVKKVTGKPIKFIGTGEKVDELEVFHPDRLASRILGMGDVMSLIEKAETSMDQKKAQELEK
KIKSQSFTFEDFLEQLQQLKSMGPLDQIMDMMPGMAGNKKMKNFSVDEQELVKIEAIIQSMTQEERVKPEVINSSRKKRI
AKGSGTRVQDVNKLLKQFEQMKKMMKQMGKMGKKKMPGKMGNNLPFM
>Mature_447_residues
MLQRLSEKLQDTFGKLTGKGKVNEKDVKEAMREVRLALLEADVNYKVVKEFVNNVKERAVGEEVLESLTPGQQVIKIVRD
ELTQLMGGEVSEVNFSDQPPTVIMLSGLQGTGKTTASAKLAKKFKKDGKNPLMVACDTQRPAAIKQLQVLGEQTDIPVFS
MGDKQHPADIAKGAVEHAKKNQMDVVILDTAGRLHIDEDLMTELREVESSVEPHEILLVVDAMTGQDAVNVAERFDQDLD
LSGIVMTKLDGDTRGGAALSVKKVTGKPIKFIGTGEKVDELEVFHPDRLASRILGMGDVMSLIEKAETSMDQKKAQELEK
KIKSQSFTFEDFLEQLQQLKSMGPLDQIMDMMPGMAGNKKMKNFSVDEQELVKIEAIIQSMTQEERVKPEVINSSRKKRI
AKGSGTRVQDVNKLLKQFEQMKKMMKQMGKMGKKKMPGKMGNNLPFM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=439, Percent_Identity=35.0797266514806, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI226371618, Length=378, Percent_Identity=34.9206349206349, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI23308697, Length=284, Percent_Identity=30.2816901408451, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI295424842, Length=283, Percent_Identity=30.3886925795053, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI89061728, Length=150, Percent_Identity=38.6666666666667, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=52.4705882352941, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=35.2272727272727, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17539958, Length=454, Percent_Identity=32.15859030837, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI193206261, Length=256, Percent_Identity=32.03125, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=425, Percent_Identity=34.8235294117647, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6320498, Length=308, Percent_Identity=25.974025974026, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647949, Length=436, Percent_Identity=31.8807339449541, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24641198, Length=264, Percent_Identity=31.0606060606061, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49722; Mature: 49722

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQRLSEKLQDTFGKLTGKGKVNEKDVKEAMREVRLALLEADVNYKVVKEFVNNVKERAV
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVLESLTPGQQVIKIVRDELTQLMGGEVSEVNFSDQPPTVIMLSGLQGTGKTTASAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHH
AKKFKKDGKNPLMVACDTQRPAAIKQLQVLGEQTDIPVFSMGDKQHPADIAKGAVEHAKK
HHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHC
NQMDVVILDTAGRLHIDEDLMTELREVESSVEPHEILLVVDAMTGQDAVNVAERFDQDLD
CCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCCC
LSGIVMTKLDGDTRGGAALSVKKVTGKPIKFIGTGEKVDELEVFHPDRLASRILGMGDVM
CCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHCCCHHHHHHHHHCHHHHH
SLIEKAETSMDQKKAQELEKKIKSQSFTFEDFLEQLQQLKSMGPLDQIMDMMPGMAGNKK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC
MKNFSVDEQELVKIEAIIQSMTQEERVKPEVINSSRKKRIAKGSGTRVQDVNKLLKQFEQ
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHH
MKKMMKQMGKMGKKKMPGKMGNNLPFM
HHHHHHHHHHHCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLQRLSEKLQDTFGKLTGKGKVNEKDVKEAMREVRLALLEADVNYKVVKEFVNNVKERAV
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVLESLTPGQQVIKIVRDELTQLMGGEVSEVNFSDQPPTVIMLSGLQGTGKTTASAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHH
AKKFKKDGKNPLMVACDTQRPAAIKQLQVLGEQTDIPVFSMGDKQHPADIAKGAVEHAKK
HHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHC
NQMDVVILDTAGRLHIDEDLMTELREVESSVEPHEILLVVDAMTGQDAVNVAERFDQDLD
CCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCCC
LSGIVMTKLDGDTRGGAALSVKKVTGKPIKFIGTGEKVDELEVFHPDRLASRILGMGDVM
CCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHCCCHHHHHHHHHCHHHHH
SLIEKAETSMDQKKAQELEKKIKSQSFTFEDFLEQLQQLKSMGPLDQIMDMMPGMAGNKK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC
MKNFSVDEQELVKIEAIIQSMTQEERVKPEVINSSRKKRIAKGSGTRVQDVNKLLKQFEQ
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHH
MKKMMKQMGKMGKKKMPGKMGNNLPFM
HHHHHHHHHHHCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]