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The map label for this gene is coaBC [H]

Identifier: 188585957

GI number: 188585957

Start: 1403772

End: 1405001

Strand: Direct

Name: coaBC [H]

Synonym: Nther_1331

Alternate gene names: 188585957

Gene position: 1403772-1405001 (Clockwise)

Preceding gene: 188585956

Following gene: 188585958

Centisome position: 44.35

GC content: 39.11

Gene sequence:

>1230_bases
GTGTCTGACCAAAGACAAGGTAATATTTTAGTTGCAGTTACAGGTGGGATTGCAGCTTATAAAAGCGTGGAAATTTGCAG
CCGCTTGAGAAAAGCCGGTTTTAATGTAAAGGTTATGATGACTGAATCTGCAAAAGAATTCGTTACACCCCTTACTTTTG
AAACAGTAACCCAAAATCCCGTGGCTTCTGATATGTTTTCTAGAGAAGCAAATTGGGACGTAGAACACATTAGTTGGGCC
CAGTGGTGTGATTTAGTGTTAATCTGTCCTGCAACCGCAAATATTATTGGCAAGTTAGTTTCTGGAGTGTGTGATGATTT
TGTTTCCACTACTTTAATAGCTAGCAAAGCCCACTGTATGATTGCTCCAGCAATGAATACGGGTATGTATCAGCATCCCG
CTGTTCAAGATAATTTGTCTAAGTTGGAACAATACGGATACCAGATTATTGATCCGGATTCTGGTAAATTAGCTTGTGGT
GATGAAGGAAAAGGCCGTCTAGCTCCTGTAGAACAAATAGTTGATCAGGTGGCTAATTTTTTTGATAAAGAAGCAGCTGA
TCCAAGTCCAGGACAAATGTTAAGAGGATATACTGTTATGGTGACTGCGGGTGCCACGATGGAAAAACTAGACCCGGTCC
GATACTTAACTAATCCAAGTTCCGGGAAAATGGGTTACTCAATTGCCCAAGCTGCAGTAAATGACGGCGCTCATGTAATA
CTAATTTCTGCTTCCACTAGTTTAACACCACCAGAAGGGGTCGAATTGATCTCAGTTACATCAGCAAGGGATATGTATGA
ACAGGTTATGGCGAATTTGGATAGATCAGATGTGATTATAAAAACTGCAGCAGTCAGTGATTATCGCCCCCAGGAAACTT
ACCACAATAAATTAAAGAAAGAAAATCAGCAGGATGATCAATATCAGTTGACTCTAGTCCGTAATCCTGACATATTAAAG
GAAGTTGGCGAAAAAAAAGGTGATAAGCTTGTCATTGGCTTTGCTGCAGAAACTGACAATATTTACGAGCATGCGAGAGC
TAAATTAACTAAAAAGAACTTGGATATGATAGTTGTAAATGATATCAGTTCCGATAAAGCAGGTTTTGGAAAAGATATAA
ATACTGTAACTCTGTTTTTTGAGGATGGCTCCTGTAAAGAATTAGATACCATGTCAAAGTTAGAATTAGCCGAGCATCTT
CTAGCTGAAATTGAGAACTTATTAAATTGA

Upstream 100 bases:

>100_bases
AATCACCAAAAAGTGTTACTGTAGCCCTAAAAGAAATTGATGCGAATAAGCTAAATTATCATAAAAAGTAGAGCTGAACA
AGGAAAGAGGGGCGAGTATA

Downstream 100 bases:

>100_bases
CCGACCTGGGATAGGTCGGTCAATTTAATAGCTAGGTTGTATTAAAGTTGAATGTGGATAGTTGAATATTGATAACTGTA
AATATTACAGTATCAACAAC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSDQRQGNILVAVTGGIAAYKSVEICSRLRKAGFNVKVMMTESAKEFVTPLTFETVTQNPVASDMFSREANWDVEHISWA
QWCDLVLICPATANIIGKLVSGVCDDFVSTTLIASKAHCMIAPAMNTGMYQHPAVQDNLSKLEQYGYQIIDPDSGKLACG
DEGKGRLAPVEQIVDQVANFFDKEAADPSPGQMLRGYTVMVTAGATMEKLDPVRYLTNPSSGKMGYSIAQAAVNDGAHVI
LISASTSLTPPEGVELISVTSARDMYEQVMANLDRSDVIIKTAAVSDYRPQETYHNKLKKENQQDDQYQLTLVRNPDILK
EVGEKKGDKLVIGFAAETDNIYEHARAKLTKKNLDMIVVNDISSDKAGFGKDINTVTLFFEDGSCKELDTMSKLELAEHL
LAEIENLLN

Sequences:

>Translated_409_residues
MSDQRQGNILVAVTGGIAAYKSVEICSRLRKAGFNVKVMMTESAKEFVTPLTFETVTQNPVASDMFSREANWDVEHISWA
QWCDLVLICPATANIIGKLVSGVCDDFVSTTLIASKAHCMIAPAMNTGMYQHPAVQDNLSKLEQYGYQIIDPDSGKLACG
DEGKGRLAPVEQIVDQVANFFDKEAADPSPGQMLRGYTVMVTAGATMEKLDPVRYLTNPSSGKMGYSIAQAAVNDGAHVI
LISASTSLTPPEGVELISVTSARDMYEQVMANLDRSDVIIKTAAVSDYRPQETYHNKLKKENQQDDQYQLTLVRNPDILK
EVGEKKGDKLVIGFAAETDNIYEHARAKLTKKNLDMIVVNDISSDKAGFGKDINTVTLFFEDGSCKELDTMSKLELAEHL
LAEIENLLN
>Mature_408_residues
SDQRQGNILVAVTGGIAAYKSVEICSRLRKAGFNVKVMMTESAKEFVTPLTFETVTQNPVASDMFSREANWDVEHISWAQ
WCDLVLICPATANIIGKLVSGVCDDFVSTTLIASKAHCMIAPAMNTGMYQHPAVQDNLSKLEQYGYQIIDPDSGKLACGD
EGKGRLAPVEQIVDQVANFFDKEAADPSPGQMLRGYTVMVTAGATMEKLDPVRYLTNPSSGKMGYSIAQAAVNDGAHVIL
ISASTSLTPPEGVELISVTSARDMYEQVMANLDRSDVIIKTAAVSDYRPQETYHNKLKKENQQDDQYQLTLVRNPDILKE
VGEKKGDKLVIGFAAETDNIYEHARAKLTKKNLDMIVVNDISSDKAGFGKDINTVTLFFEDGSCKELDTMSKLELAEHLL
AEIENLLN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=35.1351351351351, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI87082301, Length=397, Percent_Identity=42.8211586901763, Blast_Score=298, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI17560194, Length=191, Percent_Identity=33.5078534031414, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=198, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=33.6842105263158, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44834; Mature: 44703

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQRQGNILVAVTGGIAAYKSVEICSRLRKAGFNVKVMMTESAKEFVTPLTFETVTQNP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCEEHHHCCCC
VASDMFSREANWDVEHISWAQWCDLVLICPATANIIGKLVSGVCDDFVSTTLIASKAHCM
HHHHHHHCCCCCCHHHCCHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IAPAMNTGMYQHPAVQDNLSKLEQYGYQIIDPDSGKLACGDEGKGRLAPVEQIVDQVANF
EEECCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHH
FDKEAADPSPGQMLRGYTVMVTAGATMEKLDPVRYLTNPSSGKMGYSIAQAAVNDGAHVI
HHHCCCCCCCCHHHCCEEEEEECCCCHHHCCCHHEECCCCCCCCCHHHHHHHHCCCCEEE
LISASTSLTPPEGVELISVTSARDMYEQVMANLDRSDVIIKTAAVSDYRPQETYHNKLKK
EEECCCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHH
ENQQDDQYQLTLVRNPDILKEVGEKKGDKLVIGFAAETDNIYEHARAKLTKKNLDMIVVN
CCCCCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEE
DISSDKAGFGKDINTVTLFFEDGSCKELDTMSKLELAEHLLAEIENLLN
CCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDQRQGNILVAVTGGIAAYKSVEICSRLRKAGFNVKVMMTESAKEFVTPLTFETVTQNP
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCEEHHHCCCC
VASDMFSREANWDVEHISWAQWCDLVLICPATANIIGKLVSGVCDDFVSTTLIASKAHCM
HHHHHHHCCCCCCHHHCCHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IAPAMNTGMYQHPAVQDNLSKLEQYGYQIIDPDSGKLACGDEGKGRLAPVEQIVDQVANF
EEECCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHH
FDKEAADPSPGQMLRGYTVMVTAGATMEKLDPVRYLTNPSSGKMGYSIAQAAVNDGAHVI
HHHCCCCCCCCHHHCCEEEEEECCCCHHHCCCHHEECCCCCCCCCHHHHHHHHCCCCEEE
LISASTSLTPPEGVELISVTSARDMYEQVMANLDRSDVIIKTAAVSDYRPQETYHNKLKK
EEECCCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHH
ENQQDDQYQLTLVRNPDILKEVGEKKGDKLVIGFAAETDNIYEHARAKLTKKNLDMIVVN
CCCCCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEE
DISSDKAGFGKDINTVTLFFEDGSCKELDTMSKLELAEHLLAEIENLLN
CCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]