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The map label for this gene is apt

Identifier: 188585574

GI number: 188585574

Start: 1003223

End: 1003738

Strand: Direct

Name: apt

Synonym: Nther_0946

Alternate gene names: 188585574

Gene position: 1003223-1003738 (Clockwise)

Preceding gene: 188585573

Following gene: 188585575

Centisome position: 31.69

GC content: 37.98

Gene sequence:

>516_bases
GTGTTGAAACTGAGAGACTATATTAGAGATATTCCGGATTTTCCTAAAAAAGGAGTTGTGTTTAAAGATATTACCACAGC
TTTGAAAGATCCCGAATTATTAGCGGAAATTATAATTAACTTATCCAGTCATTACGAAAAGGAAGTACCAGACAAAATTG
TAGGCATAGAGTCTAGGGGCTTTATACTGGGGCCAGCTATAGCCAAAGAACTAGGTGCTGGGTTTGTTCCTGCCCGAAAA
GGCGGAAAACTGCCATCTAAGACAGCGTCTCAAGAGTATAATACCGAATATTCCACAGATGTTTTAGAAATTCATGAAGA
TGCTATAGAAAAGAATGAAAGAGTTTTAATAGTTGACGATTTATTGGCCACAGGTGGAACTGCTCAAGCCACAGCAAAAA
TTGTAGAACAGCTGGAAGGACAAGTGGTGGGTTTTGCTTTTATGTTAGAGTTATCTTTTCTTAAGGGCCGTGAAAAGATA
GGCGATTATCCAATAAAAGTGTTAGAGCAATTTTAG

Upstream 100 bases:

>100_bases
CCTTGGGAGCTCAAAATGCCGGAATGACTTATTTTTTGTACAAGGGAGATAACTTTGGAGAATTACTGAAAAGACTTAAA
GCTTTTTGGAGGTGAAGTTT

Downstream 100 bases:

>100_bases
AGCTTATTAGGCAAGCAAATCAAAGGTGATGTATTACAAAGCCAATAAAAAAGTAGCAGATTAAAATACTGCTGCTTTTT
TATTAGCTTGTTTTATTAAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MLKLRDYIRDIPDFPKKGVVFKDITTALKDPELLAEIIINLSSHYEKEVPDKIVGIESRGFILGPAIAKELGAGFVPARK
GGKLPSKTASQEYNTEYSTDVLEIHEDAIEKNERVLIVDDLLATGGTAQATAKIVEQLEGQVVGFAFMLELSFLKGREKI
GDYPIKVLEQF

Sequences:

>Translated_171_residues
MLKLRDYIRDIPDFPKKGVVFKDITTALKDPELLAEIIINLSSHYEKEVPDKIVGIESRGFILGPAIAKELGAGFVPARK
GGKLPSKTASQEYNTEYSTDVLEIHEDAIEKNERVLIVDDLLATGGTAQATAKIVEQLEGQVVGFAFMLELSFLKGREKI
GDYPIKVLEQF
>Mature_171_residues
MLKLRDYIRDIPDFPKKGVVFKDITTALKDPELLAEIIINLSSHYEKEVPDKIVGIESRGFILGPAIAKELGAGFVPARK
GGKLPSKTASQEYNTEYSTDVLEIHEDAIEKNERVLIVDDLLATGGTAQATAKIVEQLEGQVVGFAFMLELSFLKGREKI
GDYPIKVLEQF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=45.5089820359281, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=49.5867768595041, Blast_Score=113, Evalue=8e-26,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=47.7707006369427, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17509087, Length=172, Percent_Identity=42.4418604651163, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=42.9447852760736, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=36.4197530864198, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136334, Length=161, Percent_Identity=39.7515527950311, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_NATTJ (B2A0H0)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917119.1
- ProteinModelPortal:   B2A0H0
- SMR:   B2A0H0
- GeneID:   6314923
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0946
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18935; Mature: 18935

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLRDYIRDIPDFPKKGVVFKDITTALKDPELLAEIIINLSSHYEKEVPDKIVGIESRG
CCCHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
FILGPAIAKELGAGFVPARKGGKLPSKTASQEYNTEYSTDVLEIHEDAIEKNERVLIVDD
EEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEH
LLATGGTAQATAKIVEQLEGQVVGFAFMLELSFLKGREKIGDYPIKVLEQF
HHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MLKLRDYIRDIPDFPKKGVVFKDITTALKDPELLAEIIINLSSHYEKEVPDKIVGIESRG
CCCHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
FILGPAIAKELGAGFVPARKGGKLPSKTASQEYNTEYSTDVLEIHEDAIEKNERVLIVDD
EEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEH
LLATGGTAQATAKIVEQLEGQVVGFAFMLELSFLKGREKIGDYPIKVLEQF
HHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA