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The map label for this gene is yhaU [H]

Identifier: 188585519

GI number: 188585519

Start: 938941

End: 940086

Strand: Reverse

Name: yhaU [H]

Synonym: Nther_0891

Alternate gene names: 188585519

Gene position: 940086-938941 (Counterclockwise)

Preceding gene: 188585522

Following gene: 188585518

Centisome position: 29.7

GC content: 32.98

Gene sequence:

>1146_bases
ATGCAATTTATATTACTTGCTGGTGGTCTCCTACTATTTTTATTATTCATTATCAGCCATTCCTTTAGCAAGTTACATAT
TCCTACTTTATTATCATATATTTTTTTGGGGTTATTACTTTCGGGATTTTTAGCTCACCCTGAAATCGCAGTAATTCATG
ATATTGCCCAGATTGGTATTGTTTTATTGTTTTTCCTCTTAGGTCTTAAATTTCCTTTGAATCATTTGATCAATATTTCT
AAACGAATATGGAAAGTAGGAACTTTAGATATTATTTTAAATTTTGGAGTCAGTTTCGGGATAACTTATGTATTGGGTTT
TGGAGTAATTGATGCGCTTATTATCGGAGGTGTTTGTTATGCTACGAGCTCTTCTATCACTATGAAAGCTCTGGAGGAAA
CCGATAGAGAACATACGCCTGAAGCTGAATTTAAGCTGGCTTTATTAATATTTGAAGATATAGCCGCACCTGTAATAGTT
TCCATCTTAACAGCTTTAACAGTTGAAGGCCAGGTTCAATTGGCCTCTGTTATTATTATTTTGGGTAAAGCCATATTAAT
GACGATAGTCTCTATATTTGTTGCTCGATATGTTTTTAAAAAACTTGAATTATTTTTCTACAGGTACTTAGAAACCGACT
ATATGCCGCTACTAATTATGTCTATCATATTTCTAGTTTCAGGTATAGCAGTTTATTTAGAGCTATCTAAATTATTAGGG
GCATTTTTGGCCGGTGTTATGATTTCTGAAACATTAACAGGAGAAGATATTGATAAAAATATTACTCCTATAAAAAATAT
TTTACTTCCTTTTTTCTTTTTCTGGTTTGGAACTTCTATTTCCTTTGAAGCAGGTCTTATACACCCTCTTGCTTTAGTAG
TCTTAATAATTTGGAGTTTAGTTGCAAAATTCATTATTGGACTATACGGAGGTAGGATATACGGATTATCGGCAAAGAGT
TCACTTAGAGCGGGTTTTTCCTTAACTCAAAGAGGAGAATTCAGCGTAATCATAGCTAGTCTAGCAGGTCCAGCAGTACT
CACCTTTTCAGGAGTTTACATTATCATAACAGCACTTATAGGATTAGTATTTTTTTATAAAGCAACAGAGCTTTCAGATT
ACTTTTACCGAATAACAACTAAGTGA

Upstream 100 bases:

>100_bases
ACACATTTTGTGCAGCTGTTGATACAGAATTATCGTATAATGAATTCCATCAATTAAAAAACTATAAAAGTAAACTACTT
CTTCAAGGAGATGGATAAAC

Downstream 100 bases:

>100_bases
AAATTGAGGTGTTTACAATGCTTGTAACAATAATTGGCGGAAGTCAAGTTGGTAAAAAACTAGCTAAAATGTTAATTAAA
AGAAAACATAAAGTCACTTT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MQFILLAGGLLLFLLFIISHSFSKLHIPTLLSYIFLGLLLSGFLAHPEIAVIHDIAQIGIVLLFFLLGLKFPLNHLINIS
KRIWKVGTLDIILNFGVSFGITYVLGFGVIDALIIGGVCYATSSSITMKALEETDREHTPEAEFKLALLIFEDIAAPVIV
SILTALTVEGQVQLASVIIILGKAILMTIVSIFVARYVFKKLELFFYRYLETDYMPLLIMSIIFLVSGIAVYLELSKLLG
AFLAGVMISETLTGEDIDKNITPIKNILLPFFFFWFGTSISFEAGLIHPLALVVLIIWSLVAKFIIGLYGGRIYGLSAKS
SLRAGFSLTQRGEFSVIIASLAGPAVLTFSGVYIIITALIGLVFFYKATELSDYFYRITTK

Sequences:

>Translated_381_residues
MQFILLAGGLLLFLLFIISHSFSKLHIPTLLSYIFLGLLLSGFLAHPEIAVIHDIAQIGIVLLFFLLGLKFPLNHLINIS
KRIWKVGTLDIILNFGVSFGITYVLGFGVIDALIIGGVCYATSSSITMKALEETDREHTPEAEFKLALLIFEDIAAPVIV
SILTALTVEGQVQLASVIIILGKAILMTIVSIFVARYVFKKLELFFYRYLETDYMPLLIMSIIFLVSGIAVYLELSKLLG
AFLAGVMISETLTGEDIDKNITPIKNILLPFFFFWFGTSISFEAGLIHPLALVVLIIWSLVAKFIIGLYGGRIYGLSAKS
SLRAGFSLTQRGEFSVIIASLAGPAVLTFSGVYIIITALIGLVFFYKATELSDYFYRITTK
>Mature_381_residues
MQFILLAGGLLLFLLFIISHSFSKLHIPTLLSYIFLGLLLSGFLAHPEIAVIHDIAQIGIVLLFFLLGLKFPLNHLINIS
KRIWKVGTLDIILNFGVSFGITYVLGFGVIDALIIGGVCYATSSSITMKALEETDREHTPEAEFKLALLIFEDIAAPVIV
SILTALTVEGQVQLASVIIILGKAILMTIVSIFVARYVFKKLELFFYRYLETDYMPLLIMSIIFLVSGIAVYLELSKLLG
AFLAGVMISETLTGEDIDKNITPIKNILLPFFFFWFGTSISFEAGLIHPLALVVLIIWSLVAKFIIGLYGGRIYGLSAKS
SLRAGFSLTQRGEFSVIIASLAGPAVLTFSGVYIIITALIGLVFFYKATELSDYFYRITTK

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=343, Percent_Identity=25.9475218658892, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786232, Length=292, Percent_Identity=28.0821917808219, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789749, Length=356, Percent_Identity=24.438202247191, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 42021; Mature: 42021

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFILLAGGLLLFLLFIISHSFSKLHIPTLLSYIFLGLLLSGFLAHPEIAVIHDIAQIGI
CEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VLLFFLLGLKFPLNHLINISKRIWKVGTLDIILNFGVSFGITYVLGFGVIDALIIGGVCY
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSSSITMKALEETDREHTPEAEFKLALLIFEDIAAPVIVSILTALTVEGQVQLASVIII
HCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGKAILMTIVSIFVARYVFKKLELFFYRYLETDYMPLLIMSIIFLVSGIAVYLELSKLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AFLAGVMISETLTGEDIDKNITPIKNILLPFFFFWFGTSISFEAGLIHPLALVVLIIWSL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
VAKFIIGLYGGRIYGLSAKSSLRAGFSLTQRGEFSVIIASLAGPAVLTFSGVYIIITALI
HHHHHHHHHCCEEEEECCHHHHHCCCCCCCCCCHHEEEEHHCCCHHHHHHHHHHHHHHHH
GLVFFYKATELSDYFYRITTK
HHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MQFILLAGGLLLFLLFIISHSFSKLHIPTLLSYIFLGLLLSGFLAHPEIAVIHDIAQIGI
CEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VLLFFLLGLKFPLNHLINISKRIWKVGTLDIILNFGVSFGITYVLGFGVIDALIIGGVCY
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSSSITMKALEETDREHTPEAEFKLALLIFEDIAAPVIVSILTALTVEGQVQLASVIII
HCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGKAILMTIVSIFVARYVFKKLELFFYRYLETDYMPLLIMSIIFLVSGIAVYLELSKLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AFLAGVMISETLTGEDIDKNITPIKNILLPFFFFWFGTSISFEAGLIHPLALVVLIIWSL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
VAKFIIGLYGGRIYGLSAKSSLRAGFSLTQRGEFSVIIASLAGPAVLTFSGVYIIITALI
HHHHHHHHHCCEEEEECCHHHHHCCCCCCCCCCHHEEEEHHCCCHHHHHHHHHHHHHHHH
GLVFFYKATELSDYFYRITTK
HHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]