Click here to switch to the map view.

The map label for this gene is lytC [H]

Identifier: 188585487

GI number: 188585487

Start: 903710

End: 904405

Strand: Direct

Name: lytC [H]

Synonym: Nther_0859

Alternate gene names: 188585487

Gene position: 903710-904405 (Clockwise)

Preceding gene: 188585486

Following gene: 188585490

Centisome position: 28.55

GC content: 37.64

Gene sequence:

>696_bases
ATGAAGATAATAAAATTATCAGTTTCACTACTGGTTTTTATAATGTTGTTTTCAGTAACTGGTCCTATTGTAGGGAATAA
TGTTAGCGCACAAGAACTAGAGGAGATAAGCTCAACTTATGCATCTACTGTAGATACTAATGAAAAACCTTTAGAGGGAG
TTACAATTCTACTGGATCCTGGTCATGGTGGATGGGATGCCGGTGCTGTTGGTCCCACAGGTCTAACGGAAAAAGAAGTT
GCTTTGGATGTATCTTTATTAACTGAGGACAAGCTCGAGTCCTTAGGGGCAGATGTGCATTTAACTAGATATTCTGATGT
GGATGTCTCTTTGTATAGACGAGCTGCCATGGCAAATGAAGTGGGTGCAGATTTATTTATCAGTGTCCATGCCAATGGGG
CGATAAACACTGCAGCTCAAGGAACGGAAACTTATTATTCTTCTTTTAGAAATCCTAATGACTACTACCTGGCTGAGAGC
TTACAAGAAGGAATGGTAAATAACATGGGTAGACCAGATAGAGGGGTTCTAAATCAAGACTTTTTAGTTTTGAGAGCATC
TAATGTACCATCAGCTGTTGTTGAATTAGCATTTCTTTCTAACTACGAAGAAGAACAGTTATTAAGAGATGATGATTTTA
AAGATAAAGCAGCTCAAGGAATTACAGAAGGAATATTAAATTATCTAGGTGAATAA

Upstream 100 bases:

>100_bases
AACTTTATAATATGCTTTGTGCTAGTTAGTTGACATAATCTCGTTCTCAAATCATTAATTAGCTTTGGACGAGAAATCAA
TTGATTTAGGAGGTATTACA

Downstream 100 bases:

>100_bases
TTAAACAATATTTAACAAAATATGAATCAATCATAAAAGTCAGTAGGGTTTTGAAAACTACCTACTGACTTTTAAATATA
CGACGTACAGCTTAAAATTT

Product: cell wall hydrolase/autolysin

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKIIKLSVSLLVFIMLFSVTGPIVGNNVSAQELEEISSTYASTVDTNEKPLEGVTILLDPGHGGWDAGAVGPTGLTEKEV
ALDVSLLTEDKLESLGADVHLTRYSDVDVSLYRRAAMANEVGADLFISVHANGAINTAAQGTETYYSSFRNPNDYYLAES
LQEGMVNNMGRPDRGVLNQDFLVLRASNVPSAVVELAFLSNYEEEQLLRDDDFKDKAAQGITEGILNYLGE

Sequences:

>Translated_231_residues
MKIIKLSVSLLVFIMLFSVTGPIVGNNVSAQELEEISSTYASTVDTNEKPLEGVTILLDPGHGGWDAGAVGPTGLTEKEV
ALDVSLLTEDKLESLGADVHLTRYSDVDVSLYRRAAMANEVGADLFISVHANGAINTAAQGTETYYSSFRNPNDYYLAES
LQEGMVNNMGRPDRGVLNQDFLVLRASNVPSAVVELAFLSNYEEEQLLRDDDFKDKAAQGITEGILNYLGE
>Mature_231_residues
MKIIKLSVSLLVFIMLFSVTGPIVGNNVSAQELEEISSTYASTVDTNEKPLEGVTILLDPGHGGWDAGAVGPTGLTEKEV
ALDVSLLTEDKLESLGADVHLTRYSDVDVSLYRRAAMANEVGADLFISVHANGAINTAAQGTETYYSSFRNPNDYYLAES
LQEGMVNNMGRPDRGVLNQDFLVLRASNVPSAVVELAFLSNYEEEQLLRDDDFKDKAAQGITEGILNYLGE

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=218, Percent_Identity=32.5688073394495, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082163, Length=226, Percent_Identity=31.858407079646, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790611, Length=245, Percent_Identity=28.9795918367347, Blast_Score=87, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 25027; Mature: 25027

Theoretical pI: Translated: 4.05; Mature: 4.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIKLSVSLLVFIMLFSVTGPIVGNNVSAQELEEISSTYASTVDTNEKPLEGVTILLDP
CEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
GHGGWDAGAVGPTGLTEKEVALDVSLLTEDKLESLGADVHLTRYSDVDVSLYRRAAMANE
CCCCCCCCCCCCCCCCCHHHHEEHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
VGADLFISVHANGAINTAAQGTETYYSSFRNPNDYYLAESLQEGMVNNMGRPDRGVLNQD
CCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
FLVLRASNVPSAVVELAFLSNYEEEQLLRDDDFKDKAAQGITEGILNYLGE
EEEEEECCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIIKLSVSLLVFIMLFSVTGPIVGNNVSAQELEEISSTYASTVDTNEKPLEGVTILLDP
CEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
GHGGWDAGAVGPTGLTEKEVALDVSLLTEDKLESLGADVHLTRYSDVDVSLYRRAAMANE
CCCCCCCCCCCCCCCCCHHHHEEHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
VGADLFISVHANGAINTAAQGTETYYSSFRNPNDYYLAESLQEGMVNNMGRPDRGVLNQD
CCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
FLVLRASNVPSAVVELAFLSNYEEEQLLRDDDFKDKAAQGITEGILNYLGE
EEEEEECCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]