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The map label for this gene is ndhS [H]

Identifier: 188585396

GI number: 188585396

Start: 794137

End: 794601

Strand: Direct

Name: ndhS [H]

Synonym: Nther_0766

Alternate gene names: 188585396

Gene position: 794137-794601 (Clockwise)

Preceding gene: 188585395

Following gene: 188585397

Centisome position: 25.09

GC content: 35.91

Gene sequence:

>465_bases
ATGAAGCTAAATTTTAAAGTAAATGGCAAAGATAGAACCTTAGAGGTGGATGGAAATAGACGTCTGATAGATATATTAAG
AGAAGACTTAGGATTAACAGGTACGAAAGAAGGTTGTTCTGAAGGTGAATGTGGAGCTTGTACAGTGATTGTTGATGGAA
AGGCCCTACATTCTTGTTTATTAGTAGCAACACAATTAGAGGGTAAAGAGGTTATCACTATTGAAGGCCTATCTGAAAAT
GGGGAATTAGACATTATCCAAAAAAACTTTGTTGAAGAAACTGCTATTCAGTGTGGTTACTGTACACCAGGCATGATAAT
GTCAACTAAAGCGTTATTATTAAGAAACAGTAACCCAACAGAAGAAGAGATTCGTATTGCTTTATCAGGAAATATTTGTC
GATGTTCTGGATACAGTCAGATTATTCGTGCTGTACAAAGAAGTGCACAAGAAATGGAGGGTTAA

Upstream 100 bases:

>100_bases
ACAATCGTTGGTGCAATAAATGATGCATTATCAACTGAAATTTGTGAAATTCCAATTAATCCAGATAAAATTGCTAAACT
TATGAGTGGGAGGGCTTAAC

Downstream 100 bases:

>100_bases
TAAAATGATGAGTTTTACACCAAAAACATTATCTGAATTACATGCTTCATTGGCACAATTAACACCACAAAGCAAAATAA
TTAGTGGAGGAACTGACCTT

Product: (2Fe-2S)-binding domain protein

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MKLNFKVNGKDRTLEVDGNRRLIDILREDLGLTGTKEGCSEGECGACTVIVDGKALHSCLLVATQLEGKEVITIEGLSEN
GELDIIQKNFVEETAIQCGYCTPGMIMSTKALLLRNSNPTEEEIRIALSGNICRCSGYSQIIRAVQRSAQEMEG

Sequences:

>Translated_154_residues
MKLNFKVNGKDRTLEVDGNRRLIDILREDLGLTGTKEGCSEGECGACTVIVDGKALHSCLLVATQLEGKEVITIEGLSEN
GELDIIQKNFVEETAIQCGYCTPGMIMSTKALLLRNSNPTEEEIRIALSGNICRCSGYSQIIRAVQRSAQEMEG
>Mature_154_residues
MKLNFKVNGKDRTLEVDGNRRLIDILREDLGLTGTKEGCSEGECGACTVIVDGKALHSCLLVATQLEGKEVITIEGLSEN
GELDIIQKNFVEETAIQCGYCTPGMIMSTKALLLRNSNPTEEEIRIALSGNICRCSGYSQIIRAVQRSAQEMEG

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=162, Percent_Identity=40.1234567901235, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI71773480, Length=91, Percent_Identity=39.5604395604396, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1786480, Length=168, Percent_Identity=44.047619047619, Blast_Score=141, Evalue=2e-35,
Organism=Escherichia coli, GI1789232, Length=141, Percent_Identity=46.8085106382979, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1789246, Length=147, Percent_Identity=29.9319727891156, Blast_Score=69, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540638, Length=163, Percent_Identity=41.1042944785276, Blast_Score=119, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17539860, Length=152, Percent_Identity=42.7631578947368, Blast_Score=118, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32566215, Length=161, Percent_Identity=39.1304347826087, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17737937, Length=161, Percent_Identity=39.1304347826087, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24647199, Length=158, Percent_Identity=35.4430379746835, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24647197, Length=164, Percent_Identity=32.9268292682927, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24647195, Length=164, Percent_Identity=32.9268292682927, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24647193, Length=136, Percent_Identity=38.2352941176471, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647201, Length=158, Percent_Identity=35.4430379746835, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 16782; Mature: 16782

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
5.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNFKVNGKDRTLEVDGNRRLIDILREDLGLTGTKEGCSEGECGACTVIVDGKALHSCL
CEEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHH
LVATQLEGKEVITIEGLSENGELDIIQKNFVEETAIQCGYCTPGMIMSTKALLLRNSNPT
HHHEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHEEEEEECCCCC
EEEIRIALSGNICRCSGYSQIIRAVQRSAQEMEG
HHHEEEEECCCEEEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLNFKVNGKDRTLEVDGNRRLIDILREDLGLTGTKEGCSEGECGACTVIVDGKALHSCL
CEEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHH
LVATQLEGKEVITIEGLSENGELDIIQKNFVEETAIQCGYCTPGMIMSTKALLLRNSNPT
HHHEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHEEEEEECCCCC
EEEIRIALSGNICRCSGYSQIIRAVQRSAQEMEG
HHHEEEEECCCEEEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA