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The map label for this gene is ndhF [H]

Identifier: 188585397

GI number: 188585397

Start: 794606

End: 795451

Strand: Direct

Name: ndhF [H]

Synonym: Nther_0767

Alternate gene names: 188585397

Gene position: 794606-795451 (Clockwise)

Preceding gene: 188585396

Following gene: 188585398

Centisome position: 25.1

GC content: 33.92

Gene sequence:

>846_bases
ATGATGAGTTTTACACCAAAAACATTATCTGAATTACATGCTTCATTGGCACAATTAACACCACAAAGCAAAATAATTAG
TGGAGGAACTGACCTTATTATTAATATGAATTCAGGAGAAATAACACCAGATGCTCTGCTTTATATGGGAAATGTTCCAG
AACTAAAAAAGATTGAGCAAGTAGGAGATACTGTAGAAATTGGTGCAGCTGTAACAATGACTGAATTAGAGAATAGTCCA
ATATTACAAGGGAAGCTACAAGCAATCGTTGATGGTGCAAAAGATGTAGGGTCTCAACAAATTCGCAACAACGGAACAAT
TGGAGGTAATATAGGGACTGCATCACCTGCTGGGGATTTTATACCTATACTATTCATGCTAGATGCAGTAATTGTCATTG
CTAATTCAGAAGGCACTTTCAAAGAATTACCAATTAAAGAAGTAATATTAGGTCCAGGAAAAACTTGTATTGACTATAAT
GAGGCAATTGTCAAAATCAAAATAAAAATTCCAGAGTCACCTAATTACAAAAGTGCATTTGTCAAACTAGGTTCTAGAAG
TAAAGTGACTATTTCAAGAATTGGTGTAACTATGGGGCTTGAAATAGAAGATCACAAAATAACAAAAGCCAAAGTTGTAA
TAGGAGCAATAACACCAACACCTGTAAATTTTGAAAAAGCTGAAAAGGCTATGATAGGAAGAGTAATAGATAAAGACTTA
AAAGATGAAATAGGACAAATGTTATCAGACTTAATCAAAGAGATATCAAAATCAAGGAGTCGTGAATACAAGGCTTGGGC
TGCAAAAGGAGTTATCGAAGATGTATTAGATAAATTTGTTGCCTAA

Upstream 100 bases:

>100_bases
ATTCGTATTGCTTTATCAGGAAATATTTGTCGATGTTCTGGATACAGTCAGATTATTCGTGCTGTACAAAGAAGTGCACA
AGAAATGGAGGGTTAATAAA

Downstream 100 bases:

>100_bases
TTATCAAATATAGGTGCTGCGTCTGCATGAAAAATCTCTGTTAGTAGACCAGTTGTACCAGTTGTTAATAAAACAATTCG
TGAAGGCGAGAACAAATAGG

Product: molybdopterin dehydrogenase FAD-binding

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase FAD-subunit; NAH [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MMSFTPKTLSELHASLAQLTPQSKIISGGTDLIINMNSGEITPDALLYMGNVPELKKIEQVGDTVEIGAAVTMTELENSP
ILQGKLQAIVDGAKDVGSQQIRNNGTIGGNIGTASPAGDFIPILFMLDAVIVIANSEGTFKELPIKEVILGPGKTCIDYN
EAIVKIKIKIPESPNYKSAFVKLGSRSKVTISRIGVTMGLEIEDHKITKAKVVIGAITPTPVNFEKAEKAMIGRVIDKDL
KDEIGQMLSDLIKEISKSRSREYKAWAAKGVIEDVLDKFVA

Sequences:

>Translated_281_residues
MMSFTPKTLSELHASLAQLTPQSKIISGGTDLIINMNSGEITPDALLYMGNVPELKKIEQVGDTVEIGAAVTMTELENSP
ILQGKLQAIVDGAKDVGSQQIRNNGTIGGNIGTASPAGDFIPILFMLDAVIVIANSEGTFKELPIKEVILGPGKTCIDYN
EAIVKIKIKIPESPNYKSAFVKLGSRSKVTISRIGVTMGLEIEDHKITKAKVVIGAITPTPVNFEKAEKAMIGRVIDKDL
KDEIGQMLSDLIKEISKSRSREYKAWAAKGVIEDVLDKFVA
>Mature_281_residues
MMSFTPKTLSELHASLAQLTPQSKIISGGTDLIINMNSGEITPDALLYMGNVPELKKIEQVGDTVEIGAAVTMTELENSP
ILQGKLQAIVDGAKDVGSQQIRNNGTIGGNIGTASPAGDFIPILFMLDAVIVIANSEGTFKELPIKEVILGPGKTCIDYN
EAIVKIKIKIPESPNYKSAFVKLGSRSKVTISRIGVTMGLEIEDHKITKAKVVIGAITPTPVNFEKAEKAMIGRVIDKDL
KDEIGQMLSDLIKEISKSRSREYKAWAAKGVIEDVLDKFVA

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789231, Length=263, Percent_Identity=26.615969581749, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17737937, Length=262, Percent_Identity=24.0458015267176, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 30250; Mature: 30250

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSFTPKTLSELHASLAQLTPQSKIISGGTDLIINMNSGEITPDALLYMGNVPELKKIEQ
CCCCCHHHHHHHHHHHHHCCCCHHEECCCCEEEEECCCCCCCHHHEEEECCCCHHHHHHH
VGDTVEIGAAVTMTELENSPILQGKLQAIVDGAKDVGSQQIRNNGTIGGNIGTASPAGDF
CCCEEECCCEEEEEECCCCCCHHHHHHHHHHCHHHHCHHHHHCCCCCCCCCCCCCCCCHH
IPILFMLDAVIVIANSEGTFKELPIKEVILGPGKTCIDYNEAIVKIKIKIPESPNYKSAF
HHHHHHHCEEEEEECCCCCHHHCCHHHHHCCCCCCEEECCCEEEEEEEECCCCCCHHHHH
VKLGSRSKVTISRIGVTMGLEIEDHKITKAKVVIGAITPTPVNFEKAEKAMIGRVIDKDL
HCCCCCCEEEEEEECEEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
KDEIGQMLSDLIKEISKSRSREYKAWAAKGVIEDVLDKFVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMSFTPKTLSELHASLAQLTPQSKIISGGTDLIINMNSGEITPDALLYMGNVPELKKIEQ
CCCCCHHHHHHHHHHHHHCCCCHHEECCCCEEEEECCCCCCCHHHEEEECCCCHHHHHHH
VGDTVEIGAAVTMTELENSPILQGKLQAIVDGAKDVGSQQIRNNGTIGGNIGTASPAGDF
CCCEEECCCEEEEEECCCCCCHHHHHHHHHHCHHHHCHHHHHCCCCCCCCCCCCCCCCHH
IPILFMLDAVIVIANSEGTFKELPIKEVILGPGKTCIDYNEAIVKIKIKIPESPNYKSAF
HHHHHHHCEEEEEECCCCCHHHCCHHHHHCCCCCCEEECCCEEEEEEEECCCCCCHHHHH
VKLGSRSKVTISRIGVTMGLEIEDHKITKAKVVIGAITPTPVNFEKAEKAMIGRVIDKDL
HCCCCCCEEEEEEECEEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
KDEIGQMLSDLIKEISKSRSREYKAWAAKGVIEDVLDKFVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA