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The map label for this gene is appC [H]

Identifier: 188585118

GI number: 188585118

Start: 510018

End: 510932

Strand: Direct

Name: appC [H]

Synonym: Nther_0479

Alternate gene names: 188585118

Gene position: 510018-510932 (Clockwise)

Preceding gene: 188585117

Following gene: 188585119

Centisome position: 16.11

GC content: 41.42

Gene sequence:

>915_bases
TTGGCTAAAAATGAACTGAATGAAAGTACAAGTCAAGAAGTTCAATCTCATGGCTTGTCTGAGGAAGTTGAAAGTCCTAT
TAAACTTATATGGAGACGCTTTAAGAGAAATAGATTAGCTTTGATCGGGCTGATTGTTTTATTAATACTGGTTTTTGGAG
CGGTTTTTGCTCCATTTTTGACGCCCCATGATAGGGATACTATTGACTATGCTAATGCCGATGCCGAGCCAGATAGTGAA
CACATTCTAGGGACCGACGACAGGGGCAGAGATATGTTTACCAGGCTTTTGTATGCAGGTAGAGTTTCCTTATCTGTGGG
TATTTTTGCTACTTTACTGCGGATTTTGATCGGTGTAACTTTGGGAGGTATCGCAGGTTACTACGGAGGAGCAGTTGATA
ATGTTATCATGCGGATAGCCGACGTCTTTATGTCCTTTCCATTTTTACCAATTGCCTTAACTTTCGTCGCCATACTGGGA
CCAAGTATTTACAATATCATGCTGGTAATAGCAATTATTGGTTGGCCGGGTATCTGCAGGATTGTAAGAGCGGAAATTCT
ATCCTTGAGAGAACAAGAATTTATTGAAGCTGCTAAAGCTCTAGGTCTTAGTGACCGTACCCAAATAATAAAACACTTGA
TTCCCAATACTATGGCTCCAATTATCGTTTCGGCTACTTTAGGTATAGCGGGTGCGATATTAACTGAATCATTTCTCAGC
TATTTGGGATTAGGGGTAAGTCCACCAACTCCCACCTGGGGCAATTTGCTATCTGCTGCCCAAGAATCCTATATTATTCG
AAATAGATGGTGGCAGTGGGTACCACCGGGTATTATGATTTTCTTGGCTGTTATGAGTCTAAACTTACTGGGAGATGGGC
TGAGAGATGCTCTTGATCCTAAACTTAAAGAGTAG

Upstream 100 bases:

>100_bases
CCTATGCCTTTGTAGATCCCAGAATCAGGTATGATTAATTTCTTTAAAAAATAATTTATTTATAATACTTGATATCTGTA
TGCCTAAAGGGGGGAATGAC

Downstream 100 bases:

>100_bases
GGGGTGCACTTTTTGTCCGACACACTTTTGGAAGTAAAGGGTTTACAGACCTATTTTTATACAGAAGATGGCACCGTTAA
AGCTGTGGACGGAGTAGACT

Product: binding-protein-dependent transport systems inner membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAKNELNESTSQEVQSHGLSEEVESPIKLIWRRFKRNRLALIGLIVLLILVFGAVFAPFLTPHDRDTIDYANADAEPDSE
HILGTDDRGRDMFTRLLYAGRVSLSVGIFATLLRILIGVTLGGIAGYYGGAVDNVIMRIADVFMSFPFLPIALTFVAILG
PSIYNIMLVIAIIGWPGICRIVRAEILSLREQEFIEAAKALGLSDRTQIIKHLIPNTMAPIIVSATLGIAGAILTESFLS
YLGLGVSPPTPTWGNLLSAAQESYIIRNRWWQWVPPGIMIFLAVMSLNLLGDGLRDALDPKLKE

Sequences:

>Translated_304_residues
MAKNELNESTSQEVQSHGLSEEVESPIKLIWRRFKRNRLALIGLIVLLILVFGAVFAPFLTPHDRDTIDYANADAEPDSE
HILGTDDRGRDMFTRLLYAGRVSLSVGIFATLLRILIGVTLGGIAGYYGGAVDNVIMRIADVFMSFPFLPIALTFVAILG
PSIYNIMLVIAIIGWPGICRIVRAEILSLREQEFIEAAKALGLSDRTQIIKHLIPNTMAPIIVSATLGIAGAILTESFLS
YLGLGVSPPTPTWGNLLSAAQESYIIRNRWWQWVPPGIMIFLAVMSLNLLGDGLRDALDPKLKE
>Mature_303_residues
AKNELNESTSQEVQSHGLSEEVESPIKLIWRRFKRNRLALIGLIVLLILVFGAVFAPFLTPHDRDTIDYANADAEPDSEH
ILGTDDRGRDMFTRLLYAGRVSLSVGIFATLLRILIGVTLGGIAGYYGGAVDNVIMRIADVFMSFPFLPIALTFVAILGP
SIYNIMLVIAIIGWPGICRIVRAEILSLREQEFIEAAKALGLSDRTQIIKHLIPNTMAPIIVSATLGIAGAILTESFLSY
LGLGVSPPTPTWGNLLSAAQESYIIRNRWWQWVPPGIMIFLAVMSLNLLGDGLRDALDPKLKE

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=284, Percent_Identity=41.5492957746479, Blast_Score=238, Evalue=3e-64,
Organism=Escherichia coli, GI1789964, Length=301, Percent_Identity=41.8604651162791, Blast_Score=200, Evalue=8e-53,
Organism=Escherichia coli, GI1787498, Length=302, Percent_Identity=38.7417218543046, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1787760, Length=274, Percent_Identity=36.4963503649635, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789889, Length=241, Percent_Identity=39.4190871369295, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1788505, Length=231, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787549, Length=280, Percent_Identity=30, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33413; Mature: 33282

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure 
AKNELNESTSQEVQSHGLSEEVESPIKLIWRRFKRNRLALIGLIVLLILVFGAVFAPFL
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHC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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]