Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 188585110

GI number: 188585110

Start: 499986

End: 500303

Strand: Direct

Name: trxA [H]

Synonym: Nther_0471

Alternate gene names: 188585110

Gene position: 499986-500303 (Clockwise)

Preceding gene: 188585109

Following gene: 188585111

Centisome position: 15.79

GC content: 31.76

Gene sequence:

>318_bases
ATGCAAGAAGTGGATAAAAATAATTTTGAAGAAGAAGTTTTACAAGCAGAAGGAGTGGTAATGGTAGACTTTTTCAGTCC
TAACTGTGAACCTTGTAATGAACTAAAACCAGAAATTGAAGACATGGCTGAGAAATACAAGGATAAGATGAAATTTTGTG
CCCTTGACATTAGTAAAAATAGAAGATTGGCAATTAATCAAAAAGTATTAAACCTACCAACAATTGTATTTTACAAAGAT
GGAGAAAAAATCTCTACTCTAACAGGAGAAGATTTAGAAGCTGAAGAGATTGAAGATGAGGTAAAGAAGCATATTTAG

Upstream 100 bases:

>100_bases
GATTTTTATCAAGATCTTGTCTAAAAATTTTGATGATTAATGGATAGTGGTAAGTTATAAGTATAAACTATGTTAATAAT
ATTAGGGAGGAGGTGGCATA

Downstream 100 bases:

>100_bases
TTGTTATGATTTTTGTGAAAAGTGAAGTTAATCAAGGAGGTGAATTGTGTGAGCCTGAGGCTTGAAAAGGTTAATGTTAA
AGACGTGAAGTTGGGTAGTG

Product: Thioredoxin domain

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 105; Mature: 105

Protein sequence:

>105_residues
MQEVDKNNFEEEVLQAEGVVMVDFFSPNCEPCNELKPEIEDMAEKYKDKMKFCALDISKNRRLAINQKVLNLPTIVFYKD
GEKISTLTGEDLEAEEIEDEVKKHI

Sequences:

>Translated_105_residues
MQEVDKNNFEEEVLQAEGVVMVDFFSPNCEPCNELKPEIEDMAEKYKDKMKFCALDISKNRRLAINQKVLNLPTIVFYKD
GEKISTLTGEDLEAEEIEDEVKKHI
>Mature_105_residues
MQEVDKNNFEEEVLQAEGVVMVDFFSPNCEPCNELKPEIEDMAEKYKDKMKFCALDISKNRRLAINQKVLNLPTIVFYKD
GEKISTLTGEDLEAEEIEDEVKKHI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI87082331, Length=83, Percent_Identity=31.3253012048193, Blast_Score=67, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=31.8181818181818, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12171; Mature: 12171

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEVDKNNFEEEVLQAEGVVMVDFFSPNCEPCNELKPEIEDMAEKYKDKMKFCALDISKN
CCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCHHCCCCHHHHHHHHHHHHHHHEEECCCC
RRLAINQKVLNLPTIVFYKDGEKISTLTGEDLEAEEIEDEVKKHI
CEEEECCEECCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQEVDKNNFEEEVLQAEGVVMVDFFSPNCEPCNELKPEIEDMAEKYKDKMKFCALDISKN
CCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCHHCCCCHHHHHHHHHHHHHHHEEECCCC
RRLAINQKVLNLPTIVFYKDGEKISTLTGEDLEAEEIEDEVKKHI
CEEEECCEECCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11271425; 9534247 [H]