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The map label for this gene is trxB [H]

Identifier: 188585109

GI number: 188585109

Start: 498680

End: 499909

Strand: Direct

Name: trxB [H]

Synonym: Nther_0470

Alternate gene names: 188585109

Gene position: 498680-499909 (Clockwise)

Preceding gene: 188585108

Following gene: 188585110

Centisome position: 15.75

GC content: 38.29

Gene sequence:

>1230_bases
ATGTCTGATGTATTTGATGTTTTAATAATTGGTGGTGGCCCTGCTGGATTAACTGCCGGAATATATGCTTCCAGATCTAA
GCTTAAAACAGCTATTTTAGAAAAGAAAAGGAAGCCCGGAGGACAAATGTCAACAACCTGGGAACTGGAGAATTACCCAG
GTTTTAAAGAGGCCACAGGCCCTGATATTGCAAAAAGCTTATCGGAGCATGCGGAAAAATTTGGATGTGAGTTTTTAAAA
GGAGAAGTAAAAGAAATTGACTTGCACTCTAATCCTAAGGTGGTAACTTCCAAAAAAGGCGAGGAATATCATGCTAAAAG
TGTGATCATGGCAACTGGGGCAGAGCCTAGAACCCTTGGTTTACCAGGAGAACATGAATTTAGAGGATTAGGAGTTGGCT
ACTGTGCCACTTGTGATGCGGATTTCTATACTGACCAAGAAGTTATCGTAATTGGAAGCGGAGATGCTGCTGTAGAAGAA
GCTATTTACTTGACTCGTTTTGCCAAAAAAGTAACTATTGTAGTGGTTCATGAGGAAGGGAAAATGGATGCTACAAAAGT
TATTCAGGAACGAGCCTTTGAAAATCCCAAAATAGATTATATTTGGAACTCGGTAGTTGAGGAAATTAAAGGAGATGAGC
TGGTAGATCGCGTAGTAGTCAAAAACATAAAGACCGGTGAAACCAGTGAAGTCAAAACTGATGGTGTATTTATTTTTGTA
GGGACAATACCAAAAACCGAGTTCATAGAAGGCCAGGTTGAGTTAACAGAACAAGGATATGTAAAAGTTAATGATCAGAT
GGAAACATCAGTACCAGGAGTTTACTCTGCAGGTGATGTTAATGATAAATTCCTGAGGCAAGTTGTAACAGCTTGTGCCG
ACGGAGCTATTGCAGCAACTGCTTGTGAAAGGTTTTTAGAGGAAAGGCAAGATATTGAAGAAAAAATAGAAGAGCCTTCC
CAAGAAAAATCAGTTATAGTGGTGTTTTGGAGTCCTACAGTAAAAGAAAGTATGGAAGCTATTTCTCAACTAGAGGAAGT
AGTTGGGAATGATAATCAAGTTAAGATTGTCAACATTGACACCTATAAGAGCACTGGAATAGCTGATAATTATCAAATTA
ATGAAATTCCATCAATTATTGCTGTCCGCAATAAAAAAGTGGTGGCTAGCTTAACAGGTAAAGAGGTTAATAAAGAAAAA
TTAGCCGATTTTTATCAAGATCTTGTCTAA

Upstream 100 bases:

>100_bases
TAATTATAGAGTATCATTGGCATTAATTGTCTGTGATGCTTTATTTTTCTGTTTTGGCTGTACAAGGCACGGTTTAAATT
TATTTAGGGGAGGGAAATAT

Downstream 100 bases:

>100_bases
AAATTTTGATGATTAATGGATAGTGGTAAGTTATAAGTATAAACTATGTTAATAATATTAGGGAGGAGGTGGCATAATGC
AAGAAGTGGATAAAAATAAT

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSDVFDVLIIGGGPAGLTAGIYASRSKLKTAILEKKRKPGGQMSTTWELENYPGFKEATGPDIAKSLSEHAEKFGCEFLK
GEVKEIDLHSNPKVVTSKKGEEYHAKSVIMATGAEPRTLGLPGEHEFRGLGVGYCATCDADFYTDQEVIVIGSGDAAVEE
AIYLTRFAKKVTIVVVHEEGKMDATKVIQERAFENPKIDYIWNSVVEEIKGDELVDRVVVKNIKTGETSEVKTDGVFIFV
GTIPKTEFIEGQVELTEQGYVKVNDQMETSVPGVYSAGDVNDKFLRQVVTACADGAIAATACERFLEERQDIEEKIEEPS
QEKSVIVVFWSPTVKESMEAISQLEEVVGNDNQVKIVNIDTYKSTGIADNYQINEIPSIIAVRNKKVVASLTGKEVNKEK
LADFYQDLV

Sequences:

>Translated_409_residues
MSDVFDVLIIGGGPAGLTAGIYASRSKLKTAILEKKRKPGGQMSTTWELENYPGFKEATGPDIAKSLSEHAEKFGCEFLK
GEVKEIDLHSNPKVVTSKKGEEYHAKSVIMATGAEPRTLGLPGEHEFRGLGVGYCATCDADFYTDQEVIVIGSGDAAVEE
AIYLTRFAKKVTIVVVHEEGKMDATKVIQERAFENPKIDYIWNSVVEEIKGDELVDRVVVKNIKTGETSEVKTDGVFIFV
GTIPKTEFIEGQVELTEQGYVKVNDQMETSVPGVYSAGDVNDKFLRQVVTACADGAIAATACERFLEERQDIEEKIEEPS
QEKSVIVVFWSPTVKESMEAISQLEEVVGNDNQVKIVNIDTYKSTGIADNYQINEIPSIIAVRNKKVVASLTGKEVNKEK
LADFYQDLV
>Mature_408_residues
SDVFDVLIIGGGPAGLTAGIYASRSKLKTAILEKKRKPGGQMSTTWELENYPGFKEATGPDIAKSLSEHAEKFGCEFLKG
EVKEIDLHSNPKVVTSKKGEEYHAKSVIMATGAEPRTLGLPGEHEFRGLGVGYCATCDADFYTDQEVIVIGSGDAAVEEA
IYLTRFAKKVTIVVVHEEGKMDATKVIQERAFENPKIDYIWNSVVEEIKGDELVDRVVVKNIKTGETSEVKTDGVFIFVG
TIPKTEFIEGQVELTEQGYVKVNDQMETSVPGVYSAGDVNDKFLRQVVTACADGAIAATACERFLEERQDIEEKIEEPSQ
EKSVIVVFWSPTVKESMEAISQLEEVVGNDNQVKIVNIDTYKSTGIADNYQINEIPSIIAVRNKKVVASLTGKEVNKEKL
ADFYQDLV

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI65787454, Length=290, Percent_Identity=26.551724137931, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI21389617, Length=290, Percent_Identity=26.551724137931, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI226437568, Length=290, Percent_Identity=26.551724137931, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1787114, Length=316, Percent_Identity=39.873417721519, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI87081763, Length=322, Percent_Identity=31.9875776397516, Blast_Score=151, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6320560, Length=312, Percent_Identity=37.5, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321898, Length=316, Percent_Identity=36.7088607594937, Blast_Score=202, Evalue=9e-53,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 44967; Mature: 44836

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVFDVLIIGGGPAGLTAGIYASRSKLKTAILEKKRKPGGQMSTTWELENYPGFKEATG
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
PDIAKSLSEHAEKFGCEFLKGEVKEIDLHSNPKVVTSKKGEEYHAKSVIMATGAEPRTLG
HHHHHHHHHHHHHHCHHHHCCCCEEEEECCCCCEEECCCCCCHHHCEEEEECCCCCCEEC
LPGEHEFRGLGVGYCATCDADFYTDQEVIVIGSGDAAVEEAIYLTRFAKKVTIVVVHEEG
CCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCEEEEEEEECCC
KMDATKVIQERAFENPKIDYIWNSVVEEIKGDELVDRVVVKNIKTGETSEVKTDGVFIFV
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEECCEEEEE
GTIPKTEFIEGQVELTEQGYVKVNDQMETSVPGVYSAGDVNDKFLRQVVTACADGAIAAT
ECCCCCHHCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
ACERFLEERQDIEEKIEEPSQEKSVIVVFWSPTVKESMEAISQLEEVVGNDNQVKIVNID
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEE
TYKSTGIADNYQINEIPSIIAVRNKKVVASLTGKEVNKEKLADFYQDLV
CCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SDVFDVLIIGGGPAGLTAGIYASRSKLKTAILEKKRKPGGQMSTTWELENYPGFKEATG
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
PDIAKSLSEHAEKFGCEFLKGEVKEIDLHSNPKVVTSKKGEEYHAKSVIMATGAEPRTLG
HHHHHHHHHHHHHHCHHHHCCCCEEEEECCCCCEEECCCCCCHHHCEEEEECCCCCCEEC
LPGEHEFRGLGVGYCATCDADFYTDQEVIVIGSGDAAVEEAIYLTRFAKKVTIVVVHEEG
CCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCEEEEEEEECCC
KMDATKVIQERAFENPKIDYIWNSVVEEIKGDELVDRVVVKNIKTGETSEVKTDGVFIFV
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEECCEEEEE
GTIPKTEFIEGQVELTEQGYVKVNDQMETSVPGVYSAGDVNDKFLRQVVTACADGAIAAT
ECCCCCHHCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
ACERFLEERQDIEEKIEEPSQEKSVIVVFWSPTVKESMEAISQLEEVVGNDNQVKIVNID
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEE
TYKSTGIADNYQINEIPSIIAVRNKKVVASLTGKEVNKEKLADFYQDLV
CCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223622; 2537814 [H]