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The map label for this gene is guaA

Identifier: 188585091

GI number: 188585091

Start: 476296

End: 477828

Strand: Direct

Name: guaA

Synonym: Nther_0452

Alternate gene names: 188585091

Gene position: 476296-477828 (Clockwise)

Preceding gene: 188585090

Following gene: 188585092

Centisome position: 15.05

GC content: 37.31

Gene sequence:

>1533_bases
TTGTCAAGGGAACTTGTGATTGTTTTAGATTTTGGAGGACAATATAGTCGACTAATAGCTAGAAGGATCAGAGAACACAA
TGTTTATTGTGAAATTTATCCTTACAATATTTCTATTAATAAATTGAAGCAATTATCCCCTGCTGCCATAGTACTTTCAG
GTGGACCAAGTAGTGTTTATCAAGAGGGTTCGCCTGATTTAGATACAGAAATTTTTGAGATTGGAATTCCTGTGCTAGGT
ATTTGTTATGGAATGCAGTTAATGGCCAAGAAACTTGGTGGAACAGTTACTGGATCCACTAAAAGAGAGTACGGTAAAGC
TTTACTAGAAATAGAAAATCCGAATCTTCTTACAGAAGGTGTGTCTAGTGATTTACTAGTTTGGATGAGCCATGGAGATT
CAGTCGAACAAGTCCCTCCTGGCTTTAAAGTTATGGGAAAGACTGAAAACACTCCTATTGCAGGTCTCTTTAACCCGGAT
AAAAACCTTTACGGAGTTCAATTTCACCTGGAAGTTATGCATACACCAAAGGGTCGTGAAATGTTAAAAAATTTCTTATT
TAATATAGCAGATTTATCAGCCGATTGGACTATGGGATCTTATATAGAAGAAACTGTTGAACAAATCAAAACAGAAGCCC
AGGGTAGAAAAGCAGTCTGCGGTTTATCTGGTGGAATTGATTCTACAGTGGCTGCTCTACTTGTTCAAAAGGCTATCGGT
GATGATTTGACCTGTATTTTTGTCAATCATGGGTTATTGAGAAAAAATGAACAAGACCAAGTTAGGGAATTGTTTGAACA
AGAATTTGATATCAATTTGGTTTATGTTGATGCTAGTGATAGGTTTTTAAATAAGCTCCAGGGTGTTACTGATCCAGAGC
AAAAGAGAAAAATTATTGGGGAAGAATTTATTAGGGTTTTTGAAGAAGAAGCCCGTAAAATAGGCGATGTGGACTTTTTA
GTTCAAGGTACCTTATATACCGATGTGGTAGAAAGTGGGACTGAGACAGCTAGTGTGATTAAATCACATCATAATGTGGG
CGGTTTGCCTGAGAAAATGGATTTATCTTTAATCGAACCATTGAATTCCCTTTTCAAAGACGAAGTGCGTCAAGTTGCAA
GAGAACTGGGACTTCATCGTGAAATTGTGGAAAGACATCCATTTCCAGGACCAGGCCTGGCTATTAGGGTTTTAGGAGAG
ATTACTAAAGAAAAACTAGACATTTTACGAGAAGCAGATGCTGTTGTTTCTGATGAGTTGAAAAAAATTGGACTCTATCA
TGATATCTGGCAGCTATTTACCGTCTTACCAGATATAAAAACTGTTGGGGTAAAAGGTGACGAACGATCTTACGATTATC
CAATTATACTTCGGGCTGTAAATAGTGAAGATGGAATGACTGCAGATTGGTATCGTTTTTCAAATGATGTGTTAGAAAGA
CTTTCTAATAGAGTAGTTAACGAAGTGGATGGAGTCAATAGGTTTATTTACGATATTACATCAAAACCCCCGGCAACCAT
TGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
AAAAAAAGAAGATGAAGATGTAGATGAAAACAATGATGAAAAAGAGGATAATTAAAATTGGCCAGTCAATAAATAGTGGA
TTAATTAAGGAGGGAACAGC

Downstream 100 bases:

>100_bases
CTTTACAATTTTGACCGGAACTGTTATTATATTAATATACGAACTTAAACCGTAAACTCTCGTATATTTTCGGGAATAAG
GCCCGAAAGTTTCTACCTAA

Product: GMP synthase (glutamine-hydrolyzing)

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSRELVIVLDFGGQYSRLIARRIREHNVYCEIYPYNISINKLKQLSPAAIVLSGGPSSVYQEGSPDLDTEIFEIGIPVLG
ICYGMQLMAKKLGGTVTGSTKREYGKALLEIENPNLLTEGVSSDLLVWMSHGDSVEQVPPGFKVMGKTENTPIAGLFNPD
KNLYGVQFHLEVMHTPKGREMLKNFLFNIADLSADWTMGSYIEETVEQIKTEAQGRKAVCGLSGGIDSTVAALLVQKAIG
DDLTCIFVNHGLLRKNEQDQVRELFEQEFDINLVYVDASDRFLNKLQGVTDPEQKRKIIGEEFIRVFEEEARKIGDVDFL
VQGTLYTDVVESGTETASVIKSHHNVGGLPEKMDLSLIEPLNSLFKDEVRQVARELGLHREIVERHPFPGPGLAIRVLGE
ITKEKLDILREADAVVSDELKKIGLYHDIWQLFTVLPDIKTVGVKGDERSYDYPIILRAVNSEDGMTADWYRFSNDVLER
LSNRVVNEVDGVNRFIYDITSKPPATIEWE

Sequences:

>Translated_510_residues
MSRELVIVLDFGGQYSRLIARRIREHNVYCEIYPYNISINKLKQLSPAAIVLSGGPSSVYQEGSPDLDTEIFEIGIPVLG
ICYGMQLMAKKLGGTVTGSTKREYGKALLEIENPNLLTEGVSSDLLVWMSHGDSVEQVPPGFKVMGKTENTPIAGLFNPD
KNLYGVQFHLEVMHTPKGREMLKNFLFNIADLSADWTMGSYIEETVEQIKTEAQGRKAVCGLSGGIDSTVAALLVQKAIG
DDLTCIFVNHGLLRKNEQDQVRELFEQEFDINLVYVDASDRFLNKLQGVTDPEQKRKIIGEEFIRVFEEEARKIGDVDFL
VQGTLYTDVVESGTETASVIKSHHNVGGLPEKMDLSLIEPLNSLFKDEVRQVARELGLHREIVERHPFPGPGLAIRVLGE
ITKEKLDILREADAVVSDELKKIGLYHDIWQLFTVLPDIKTVGVKGDERSYDYPIILRAVNSEDGMTADWYRFSNDVLER
LSNRVVNEVDGVNRFIYDITSKPPATIEWE
>Mature_509_residues
SRELVIVLDFGGQYSRLIARRIREHNVYCEIYPYNISINKLKQLSPAAIVLSGGPSSVYQEGSPDLDTEIFEIGIPVLGI
CYGMQLMAKKLGGTVTGSTKREYGKALLEIENPNLLTEGVSSDLLVWMSHGDSVEQVPPGFKVMGKTENTPIAGLFNPDK
NLYGVQFHLEVMHTPKGREMLKNFLFNIADLSADWTMGSYIEETVEQIKTEAQGRKAVCGLSGGIDSTVAALLVQKAIGD
DLTCIFVNHGLLRKNEQDQVRELFEQEFDINLVYVDASDRFLNKLQGVTDPEQKRKIIGEEFIRVFEEEARKIGDVDFLV
QGTLYTDVVESGTETASVIKSHHNVGGLPEKMDLSLIEPLNSLFKDEVRQVARELGLHREIVERHPFPGPGLAIRVLGEI
TKEKLDILREADAVVSDELKKIGLYHDIWQLFTVLPDIKTVGVKGDERSYDYPIILRAVNSEDGMTADWYRFSNDVLERL
SNRVVNEVDGVNRFIYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=37.4545454545455, Blast_Score=310, Evalue=2e-84,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=49.5201535508637, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI1789760, Length=153, Percent_Identity=32.6797385620915, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI133901714, Length=573, Percent_Identity=34.2059336823735, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI71992717, Length=573, Percent_Identity=34.2059336823735, Blast_Score=291, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI71992710, Length=573, Percent_Identity=34.2059336823735, Blast_Score=291, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=50, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI281365319, Length=500, Percent_Identity=35.2, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_NATTJ (B2A5V5)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001916636.1
- ProteinModelPortal:   B2A5V5
- SMR:   B2A5V5
- GeneID:   6315277
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0452
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57210; Mature: 57079

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 82-82 ACT_SITE 169-169 ACT_SITE 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRELVIVLDFGGQYSRLIARRIREHNVYCEIYPYNISINKLKQLSPAAIVLSGGPSSVY
CCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCCEEEEEECCCCHHH
QEGSPDLDTEIFEIGIPVLGICYGMQLMAKKLGGTVTGSTKREYGKALLEIENPNLLTEG
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCEEEEECCCCHHHCC
VSSDLLVWMSHGDSVEQVPPGFKVMGKTENTPIAGLFNPDKNLYGVQFHLEVMHTPKGRE
CCCCEEEEEECCCCHHHCCCCCEEECCCCCCCEEEEECCCCCEEEEEEEEEEEECCCHHH
MLKNFLFNIADLSADWTMGSYIEETVEQIKTEAQGRKAVCGLSGGIDSTVAALLVQKAIG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHC
DDLTCIFVNHGLLRKNEQDQVRELFEQEFDINLVYVDASDRFLNKLQGVTDPEQKRKIIG
CCEEEEEEECCHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHH
EEFIRVFEEEARKIGDVDFLVQGTLYTDVVESGTETASVIKSHHNVGGLPEKMDLSLIEP
HHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
LNSLFKDEVRQVARELGLHREIVERHPFPGPGLAIRVLGEITKEKLDILREADAVVSDEL
HHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKIGLYHDIWQLFTVLPDIKTVGVKGDERSYDYPIILRAVNSEDGMTADWYRFSNDVLER
HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LSNRVVNEVDGVNRFIYDITSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECC
>Mature Secondary Structure 
SRELVIVLDFGGQYSRLIARRIREHNVYCEIYPYNISINKLKQLSPAAIVLSGGPSSVY
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCCEEEEEECCCCHHH
QEGSPDLDTEIFEIGIPVLGICYGMQLMAKKLGGTVTGSTKREYGKALLEIENPNLLTEG
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCEEEEECCCCHHHCC
VSSDLLVWMSHGDSVEQVPPGFKVMGKTENTPIAGLFNPDKNLYGVQFHLEVMHTPKGRE
CCCCEEEEEECCCCHHHCCCCCEEECCCCCCCEEEEECCCCCEEEEEEEEEEEECCCHHH
MLKNFLFNIADLSADWTMGSYIEETVEQIKTEAQGRKAVCGLSGGIDSTVAALLVQKAIG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHC
DDLTCIFVNHGLLRKNEQDQVRELFEQEFDINLVYVDASDRFLNKLQGVTDPEQKRKIIG
CCEEEEEEECCHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHH
EEFIRVFEEEARKIGDVDFLVQGTLYTDVVESGTETASVIKSHHNVGGLPEKMDLSLIEP
HHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
LNSLFKDEVRQVARELGLHREIVERHPFPGPGLAIRVLGEITKEKLDILREADAVVSDEL
HHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKIGLYHDIWQLFTVLPDIKTVGVKGDERSYDYPIILRAVNSEDGMTADWYRFSNDVLER
HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LSNRVVNEVDGVNRFIYDITSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA