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The map label for this gene is murC [H]

Identifier: 188585042

GI number: 188585042

Start: 419445

End: 420842

Strand: Direct

Name: murC [H]

Synonym: Nther_0403

Alternate gene names: 188585042

Gene position: 419445-420842 (Clockwise)

Preceding gene: 188585041

Following gene: 188585043

Centisome position: 13.25

GC content: 36.91

Gene sequence:

>1398_bases
ATGCTAAAGGGCTTTAAAAAGATACATTTTATAGGAATTGGTGGATACGGAATGAGTGCTTTGGCCCAGGTGCTTATCGA
AGAAGGTTATCAAGTATCGGGTTCTGATATATCAAGTTCTTCCAGAATTGATTTTTTGAAAGAACTGGGAGTTGAAATTT
ATCTATCCCATAAAGCTGAAAACATAAATAGTGTAGATCTTGTCATATATTCTACGGCAATTCCTGGGGATAATCCTGAA
TTGTTGGCGGCTAAACAACGGGGTATTTCTTTGTGGCACAGATCGGAGTTATTGGCAGAATTAATAAATTCCAGATATGG
GATTGCCATTACTGGTGCCCATGGAAAAACTACTACCACTTCAATGTTATCACTGATTCTCGAAGAAGCTTCTGCTGATC
CCACCTGTATAATTGGAGGAGAACTACCAAACTTTGGAAGCAATGCGAGAGTGGGTGATAGTGAGTATGTAGTAGCAGAA
GCCTGTGAAAGTGACCATTCTTTCTTAAGGTATAGTCCTCAAATAGCAGTTATCACAAACATTGAAGCAGACCATTTAGA
ACACTATAATGGCAGTTTTGATCAACTTTTAAAATCCTATAGACAATTCATAGAAAATATCGACGATTCTGGGAAGGTAT
TTATCTATTCTGAATGTGAATACCATGATTACTTATTAGAAGGAATGTCTAAGAACTGTAAAACATTTGGCTTTTCCCAG
GATGCTGATTTTAGGGCTACGGATCTTAAGTTAAACAAAGGTACGACAGAGTTTACTATTGAAAGTGACCTTGCTGATAG
CTTTAAAGTAGAATTAATGGTTCCAGGAGAGCACAATATTTTAAATGCACTTGCAGCTGCTTCTGTAGCTTTGGATTTAA
AGATTTCTCCCACTGCAATAAAAAGAGCATTACAAAAATTTACCGGTGCCAAGCGTAGATTCATGGAAATTGGTCAACTT
CAAGGTGCTACTATAGTGGATGATTATGCACATCATCCCACAGAAATAAAAGCAACCTTAAAAACTGCTCAAGAACAAAG
CGATAATAAAGTGATTGCAATTTTTCAACCCCATCGCTTTACTAGGACTCAATATTTTATGGATGATTTTGCAAGTTCCT
TTGAAGAAGCTGATACTGTCATTCTTCATAAAGTTTTTGCTGCCGGTGAAGACGAAATTCCAGGTGCGAATTCGAAAAAC
CTTAAGGATAAGATTAAAGAAAATGTACCTGGTTTAGAAGTTTACGTGACTGATGACATGGAAGATATAGCCGAAATTGT
GTCTAATATTGTAGATAAAGGTGACTATGTAATAACTATGGGTGCTGGTGATATTTGGAAAGTTGCCCATTGGCTGGTTG
ACGAAGATTATCAAAAGCAACTTAACAGTGAAGGTTAA

Upstream 100 bases:

>100_bases
AATACTATTCTAAAAATATGCTTTTATTTGTGGTATAATGTAGAGCGGTGTTTAATTTTAATGAAAAAAATTGTAGTCTA
GAGAGAAGAGAGGGATTTTC

Downstream 100 bases:

>100_bases
TAAAATGTGTTATCAGAGCCCTATGGATCAGTTTTATAATGAAATAATTACAACAATTTCACAAAATAATATTTTACCTT
TGGGAAGCGGTTGTAATTTG

Product: UDP-N-acetylmuramate--alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MLKGFKKIHFIGIGGYGMSALAQVLIEEGYQVSGSDISSSSRIDFLKELGVEIYLSHKAENINSVDLVIYSTAIPGDNPE
LLAAKQRGISLWHRSELLAELINSRYGIAITGAHGKTTTTSMLSLILEEASADPTCIIGGELPNFGSNARVGDSEYVVAE
ACESDHSFLRYSPQIAVITNIEADHLEHYNGSFDQLLKSYRQFIENIDDSGKVFIYSECEYHDYLLEGMSKNCKTFGFSQ
DADFRATDLKLNKGTTEFTIESDLADSFKVELMVPGEHNILNALAAASVALDLKISPTAIKRALQKFTGAKRRFMEIGQL
QGATIVDDYAHHPTEIKATLKTAQEQSDNKVIAIFQPHRFTRTQYFMDDFASSFEEADTVILHKVFAAGEDEIPGANSKN
LKDKIKENVPGLEVYVTDDMEDIAEIVSNIVDKGDYVITMGAGDIWKVAHWLVDEDYQKQLNSEG

Sequences:

>Translated_465_residues
MLKGFKKIHFIGIGGYGMSALAQVLIEEGYQVSGSDISSSSRIDFLKELGVEIYLSHKAENINSVDLVIYSTAIPGDNPE
LLAAKQRGISLWHRSELLAELINSRYGIAITGAHGKTTTTSMLSLILEEASADPTCIIGGELPNFGSNARVGDSEYVVAE
ACESDHSFLRYSPQIAVITNIEADHLEHYNGSFDQLLKSYRQFIENIDDSGKVFIYSECEYHDYLLEGMSKNCKTFGFSQ
DADFRATDLKLNKGTTEFTIESDLADSFKVELMVPGEHNILNALAAASVALDLKISPTAIKRALQKFTGAKRRFMEIGQL
QGATIVDDYAHHPTEIKATLKTAQEQSDNKVIAIFQPHRFTRTQYFMDDFASSFEEADTVILHKVFAAGEDEIPGANSKN
LKDKIKENVPGLEVYVTDDMEDIAEIVSNIVDKGDYVITMGAGDIWKVAHWLVDEDYQKQLNSEG
>Mature_465_residues
MLKGFKKIHFIGIGGYGMSALAQVLIEEGYQVSGSDISSSSRIDFLKELGVEIYLSHKAENINSVDLVIYSTAIPGDNPE
LLAAKQRGISLWHRSELLAELINSRYGIAITGAHGKTTTTSMLSLILEEASADPTCIIGGELPNFGSNARVGDSEYVVAE
ACESDHSFLRYSPQIAVITNIEADHLEHYNGSFDQLLKSYRQFIENIDDSGKVFIYSECEYHDYLLEGMSKNCKTFGFSQ
DADFRATDLKLNKGTTEFTIESDLADSFKVELMVPGEHNILNALAAASVALDLKISPTAIKRALQKFTGAKRRFMEIGQL
QGATIVDDYAHHPTEIKATLKTAQEQSDNKVIAIFQPHRFTRTQYFMDDFASSFEEADTVILHKVFAAGEDEIPGANSKN
LKDKIKENVPGLEVYVTDDMEDIAEIVSNIVDKGDYVITMGAGDIWKVAHWLVDEDYQKQLNSEG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=473, Percent_Identity=40.169133192389, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI1790680, Length=463, Percent_Identity=26.9978401727862, Blast_Score=167, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51471; Mature: 51471

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGFKKIHFIGIGGYGMSALAQVLIEEGYQVSGSDISSSSRIDFLKELGVEIYLSHKAE
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCEEEEEECCCC
NINSVDLVIYSTAIPGDNPELLAAKQRGISLWHRSELLAELINSRYGIAITGAHGKTTTT
CCCCEEEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHH
SMLSLILEEASADPTCIIGGELPNFGSNARVGDSEYVVAEACESDHSFLRYSPQIAVITN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHCCCCCCEEECCCEEEEEC
IEADHLEHYNGSFDQLLKSYRQFIENIDDSGKVFIYSECEYHDYLLEGMSKNCKTFGFSQ
CCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCC
DADFRATDLKLNKGTTEFTIESDLADSFKVELMVPGEHNILNALAAASVALDLKISPTAI
CCCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHEEEEEEECHHHH
KRALQKFTGAKRRFMEIGQLQGATIVDDYAHHPTEIKATLKTAQEQSDNKVIAIFQPHRF
HHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
TRTQYFMDDFASSFEEADTVILHKVFAAGEDEIPGANSKNLKDKIKENVPGLEVYVTDDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCH
EDIAEIVSNIVDKGDYVITMGAGDIWKVAHWLVDEDYQKQLNSEG
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCHHHHHCCCCC
>Mature Secondary Structure
MLKGFKKIHFIGIGGYGMSALAQVLIEEGYQVSGSDISSSSRIDFLKELGVEIYLSHKAE
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCEEEEEECCCC
NINSVDLVIYSTAIPGDNPELLAAKQRGISLWHRSELLAELINSRYGIAITGAHGKTTTT
CCCCEEEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHH
SMLSLILEEASADPTCIIGGELPNFGSNARVGDSEYVVAEACESDHSFLRYSPQIAVITN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHCCCCCCEEECCCEEEEEC
IEADHLEHYNGSFDQLLKSYRQFIENIDDSGKVFIYSECEYHDYLLEGMSKNCKTFGFSQ
CCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCC
DADFRATDLKLNKGTTEFTIESDLADSFKVELMVPGEHNILNALAAASVALDLKISPTAI
CCCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHEEEEEEECHHHH
KRALQKFTGAKRRFMEIGQLQGATIVDDYAHHPTEIKATLKTAQEQSDNKVIAIFQPHRF
HHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
TRTQYFMDDFASSFEEADTVILHKVFAAGEDEIPGANSKNLKDKIKENVPGLEVYVTDDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCH
EDIAEIVSNIVDKGDYVITMGAGDIWKVAHWLVDEDYQKQLNSEG
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA