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The map label for this gene is gcp [H]

Identifier: 188585041

GI number: 188585041

Start: 417978

End: 419012

Strand: Direct

Name: gcp [H]

Synonym: Nther_0402

Alternate gene names: 188585041

Gene position: 417978-419012 (Clockwise)

Preceding gene: 188585040

Following gene: 188585042

Centisome position: 13.2

GC content: 40.19

Gene sequence:

>1035_bases
ATGGAAACTCAAAGAGAAACTGTATATATTCTAGGAATCGAAACTTCATGTGACGAAACAGCAGTTTCTGTAGTCTCAAA
TGGTCAGAAGGTTTTAAGTAATGTAGTTAGCTCTCAAACCGATGTTCATTCCTTATATGGAGGGGTGGTTCCAGAAATAG
CTTCAAGGGAACATTCAAAATTGCTTCCTCCACTGGTGAGTAAGGCCGTTGACGAAGCAGGGTTAAATATGAATGATATC
AATGCCATAGCTGTTACTCAAGGTCCTGGACTGGTTGGCCCACTATTAGTTGGTGTATCGTTTGCTAAATCTTTAGCATA
TTCTCTAAAGATACCTCTAATTCCCGTTAACCATATTAAAGCACATCTATATGCCAATTTTATACTTGCTGACGACGATA
AAGATTCAAACTTACCTAGTTTCCCTTTAATTGCTTTAATAGTTTCAGGAGGCCATACTAATCTTTACTATTTGTATGAT
CACGATAATTGGAAGCTTCTGGGGCGCAGTAGAGACGATGCTTCCGGTGAGTCCTTTGACAAAATTGCTAGAGCTTTAGA
CCTGGGATATCCGGGTGGACCAGCTGTTGAAAAGGAAGCTCAAAAGGGCCAACCTAATGTTGATTTTCCGAAACCTAAGC
TAGAAAACGAATACGATTTTAGTTTCAGTGGTTTGAAAAGTGCTGTATTGAATTATTTGAACCGGAAAAAAATGAAAGGT
GAACAATACAGTAGCTCTGATATATGCGCAAGTTTTCAACAGGTGGTTGTTGACTCACTTGTGGAGAAAACAATCTCTGC
GGCTCGGGATAATCAGGTTGATACTATAGTTCTAGCGGGAGGAGTTTCTGCTAATGGACAGTTAAGAGCGAATTTTAAGG
AAACAACTGCTGGAGAGGGAATAAATTTATTTCTTCCTAGACTGGAGTACTGTACTGATAATGCAGCCATGATAGCTGCA
CTGGGTTATCATAACTATCGTCGTGGCTGGATTGCTTCCCTGGATCTGAATGCGGTCCCCAATTTGAGTCCATAA

Upstream 100 bases:

>100_bases
CAGCCCAAAATAATGGATGTGAAAAAAGTTCAACTATCAACATTCAACTTTAATACAGCCAAATACAAATTGAGATTTAT
TGAGAAGAAAGGTGATTTAT

Downstream 100 bases:

>100_bases
TTAAAGGGTTGTCCACCTTATTAAACAGCTAGATTATAACGGCTAGTCATGTGGATATTTTAAGGTGGGTAACCCTTATT
TTATTTTTAAAAACTTAGTT

Product: O-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
METQRETVYILGIETSCDETAVSVVSNGQKVLSNVVSSQTDVHSLYGGVVPEIASREHSKLLPPLVSKAVDEAGLNMNDI
NAIAVTQGPGLVGPLLVGVSFAKSLAYSLKIPLIPVNHIKAHLYANFILADDDKDSNLPSFPLIALIVSGGHTNLYYLYD
HDNWKLLGRSRDDASGESFDKIARALDLGYPGGPAVEKEAQKGQPNVDFPKPKLENEYDFSFSGLKSAVLNYLNRKKMKG
EQYSSSDICASFQQVVVDSLVEKTISAARDNQVDTIVLAGGVSANGQLRANFKETTAGEGINLFLPRLEYCTDNAAMIAA
LGYHNYRRGWIASLDLNAVPNLSP

Sequences:

>Translated_344_residues
METQRETVYILGIETSCDETAVSVVSNGQKVLSNVVSSQTDVHSLYGGVVPEIASREHSKLLPPLVSKAVDEAGLNMNDI
NAIAVTQGPGLVGPLLVGVSFAKSLAYSLKIPLIPVNHIKAHLYANFILADDDKDSNLPSFPLIALIVSGGHTNLYYLYD
HDNWKLLGRSRDDASGESFDKIARALDLGYPGGPAVEKEAQKGQPNVDFPKPKLENEYDFSFSGLKSAVLNYLNRKKMKG
EQYSSSDICASFQQVVVDSLVEKTISAARDNQVDTIVLAGGVSANGQLRANFKETTAGEGINLFLPRLEYCTDNAAMIAA
LGYHNYRRGWIASLDLNAVPNLSP
>Mature_344_residues
METQRETVYILGIETSCDETAVSVVSNGQKVLSNVVSSQTDVHSLYGGVVPEIASREHSKLLPPLVSKAVDEAGLNMNDI
NAIAVTQGPGLVGPLLVGVSFAKSLAYSLKIPLIPVNHIKAHLYANFILADDDKDSNLPSFPLIALIVSGGHTNLYYLYD
HDNWKLLGRSRDDASGESFDKIARALDLGYPGGPAVEKEAQKGQPNVDFPKPKLENEYDFSFSGLKSAVLNYLNRKKMKG
EQYSSSDICASFQQVVVDSLVEKTISAARDNQVDTIVLAGGVSANGQLRANFKETTAGEGINLFLPRLEYCTDNAAMIAA
LGYHNYRRGWIASLDLNAVPNLSP

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family [H]

Homologues:

Organism=Homo sapiens, GI116812636, Length=345, Percent_Identity=34.7826086956522, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI8923380, Length=322, Percent_Identity=30.7453416149068, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=42.814371257485, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17557464, Length=331, Percent_Identity=33.8368580060423, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71995670, Length=322, Percent_Identity=29.8136645962733, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320099, Length=369, Percent_Identity=30.3523035230352, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322891, Length=305, Percent_Identity=27.8688524590164, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20129063, Length=346, Percent_Identity=33.8150289017341, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI21357207, Length=332, Percent_Identity=29.8192771084337, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861 [H]

Pfam domain/function: PF00814 Peptidase_M22 [H]

EC number: =3.4.24.57 [H]

Molecular weight: Translated: 37203; Mature: 37203

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METQRETVYILGIETSCDETAVSVVSNGQKVLSNVVSSQTDVHSLYGGVVPEIASREHSK
CCCCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHCCHHHHHHCCHHHH
LLPPLVSKAVDEAGLNMNDINAIAVTQGPGLVGPLLVGVSFAKSLAYSLKIPLIPVNHIK
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEECCEEEHHHHE
AHLYANFILADDDKDSNLPSFPLIALIVSGGHTNLYYLYDHDNWKLLGRSRDDASGESFD
EEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCEEEECCCCCCCCCCHHH
KIARALDLGYPGGPAVEKEAQKGQPNVDFPKPKLENEYDFSFSGLKSAVLNYLNRKKMKG
HHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
EQYSSSDICASFQQVVVDSLVEKTISAARDNQVDTIVLAGGVSANGQLRANFKETTAGEG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCCCCCCC
INLFLPRLEYCTDNAAMIAALGYHNYRRGWIASLDLNAVPNLSP
CEEEECHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
METQRETVYILGIETSCDETAVSVVSNGQKVLSNVVSSQTDVHSLYGGVVPEIASREHSK
CCCCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHCCHHHHHHCCHHHH
LLPPLVSKAVDEAGLNMNDINAIAVTQGPGLVGPLLVGVSFAKSLAYSLKIPLIPVNHIK
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEECCEEEHHHHE
AHLYANFILADDDKDSNLPSFPLIALIVSGGHTNLYYLYDHDNWKLLGRSRDDASGESFD
EEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCEEEECCCCCCCCCCHHH
KIARALDLGYPGGPAVEKEAQKGQPNVDFPKPKLENEYDFSFSGLKSAVLNYLNRKKMKG
HHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
EQYSSSDICASFQQVVVDSLVEKTISAARDNQVDTIVLAGGVSANGQLRANFKETTAGEG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCCCCCCC
INLFLPRLEYCTDNAAMIAALGYHNYRRGWIASLDLNAVPNLSP
CEEEECHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA