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The map label for this gene is tdh [H]

Identifier: 188584934

GI number: 188584934

Start: 305667

End: 306710

Strand: Reverse

Name: tdh [H]

Synonym: Nther_0293

Alternate gene names: 188584934

Gene position: 306710-305667 (Counterclockwise)

Preceding gene: 188584939

Following gene: 188584933

Centisome position: 9.69

GC content: 40.52

Gene sequence:

>1044_bases
TTGACTGGTAAAATGAAAGCCTTAATGAAACAGGACAGGAGCAGTGGAGCTGTTTTGGAACAGGTTGACATTCCCAAGCC
GAAAAGTAACGAGGTGTTAATCAAGGTAGAGTCAGCTGCAATATGCGGAACAGACCTGCACATCTATAATTGGGATCAAT
GGGCAGACAGTCGAATTAACCCCCCTCTAATTTTTGGACATGAATTCAGTGGTGAAGTTGTCGAATTAGGAGCAGATGTC
AAAGATATTGAAACCGGAACCAGGGTAACAGCAGAAGGACATTTCGTTTGTGGAAAATGTTTTTTCTGTAAAACAGGCCA
AGCTCATATCTGTGAAAATGTTGAAATCATCGGGGTAGATACCACAGGATGTTTTGCCGAATATGTAGTTGTACCCCGAG
ACAATGTATGGATTCTCGATAAATCCATTCCACCAGAAATAGGTGCTATTCACGATCCAATAGGTAATGCCATCCACTCA
GCTCTCATAGATGAAATAACTGCCAAGGATGTCCTTGTGACTGGATGTGGCCCCATCGGTTTAGCCTCTATTGCTATTGC
CCGCAAAGCAGGAGCTTCCAAAATCTTTGCAACCGAAGTCAATTCCTATCGTATAGAATTAGCAAAAAAAATGGGAGCAG
ATGAAATCATAAATCCCATGGAACAAGACACAGTAGAATTAGTGAAAAGCAAAACAAACGGCGCTGGAGTAGACGTATTA
TTAGAAATGGCAGGTAAAGATACAGCTATAAATGAAGGACTGGCTGCTTTAAAAGGCGGAGGTTGGGTTTCATTCCTAGG
ATTGCCTCCAGGTAAAACTCAAATAGACCTGTCTAATGGATTAATATTTAAAGGCGCAAAAGCCTACGGTATTAACGGAA
GAATAATGTACGAAACTTGGTTTAAGATGCATAATCTGCTAAAATCGAGATTAGCTGATGATTTAATGCCTATGGTAACT
CACAAATTTTCCTTTGAACAATTTGAAGAAGCTTTTCAGCTTGCACAAGAGGGGAATACTGGTAAAATAATTTTGCACCC
CTAA

Upstream 100 bases:

>100_bases
ATACTATTTATTTATGATAATAAAAAAGGATTTTTCAAATAATTGTCAAAATATACAAGTGATAAGAAATTGAGAACCTT
AATCGCCAAGGAGTGATTTT

Downstream 100 bases:

>100_bases
TACGTAAAGATGTAAAAAATATTCTAAATTTAAGGAGTGATTAATTTGAGCTCACAAGAAAAACTAAACTTTATTCAAAC
AGAGCTAGAAGAATTAAAAG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTGKMKALMKQDRSSGAVLEQVDIPKPKSNEVLIKVESAAICGTDLHIYNWDQWADSRINPPLIFGHEFSGEVVELGADV
KDIETGTRVTAEGHFVCGKCFFCKTGQAHICENVEIIGVDTTGCFAEYVVVPRDNVWILDKSIPPEIGAIHDPIGNAIHS
ALIDEITAKDVLVTGCGPIGLASIAIARKAGASKIFATEVNSYRIELAKKMGADEIINPMEQDTVELVKSKTNGAGVDVL
LEMAGKDTAINEGLAALKGGGWVSFLGLPPGKTQIDLSNGLIFKGAKAYGINGRIMYETWFKMHNLLKSRLADDLMPMVT
HKFSFEQFEEAFQLAQEGNTGKIILHP

Sequences:

>Translated_347_residues
MTGKMKALMKQDRSSGAVLEQVDIPKPKSNEVLIKVESAAICGTDLHIYNWDQWADSRINPPLIFGHEFSGEVVELGADV
KDIETGTRVTAEGHFVCGKCFFCKTGQAHICENVEIIGVDTTGCFAEYVVVPRDNVWILDKSIPPEIGAIHDPIGNAIHS
ALIDEITAKDVLVTGCGPIGLASIAIARKAGASKIFATEVNSYRIELAKKMGADEIINPMEQDTVELVKSKTNGAGVDVL
LEMAGKDTAINEGLAALKGGGWVSFLGLPPGKTQIDLSNGLIFKGAKAYGINGRIMYETWFKMHNLLKSRLADDLMPMVT
HKFSFEQFEEAFQLAQEGNTGKIILHP
>Mature_346_residues
TGKMKALMKQDRSSGAVLEQVDIPKPKSNEVLIKVESAAICGTDLHIYNWDQWADSRINPPLIFGHEFSGEVVELGADVK
DIETGTRVTAEGHFVCGKCFFCKTGQAHICENVEIIGVDTTGCFAEYVVVPRDNVWILDKSIPPEIGAIHDPIGNAIHSA
LIDEITAKDVLVTGCGPIGLASIAIARKAGASKIFATEVNSYRIELAKKMGADEIINPMEQDTVELVKSKTNGAGVDVLL
EMAGKDTAINEGLAALKGGGWVSFLGLPPGKTQIDLSNGLIFKGAKAYGINGRIMYETWFKMHNLLKSRLADDLMPMVTH
KFSFEQFEEAFQLAQEGNTGKIILHP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=332, Percent_Identity=28.6144578313253, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=27.6139410187668, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI34577061, Length=373, Percent_Identity=26.8096514745308, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=26.8096514745308, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=24.5810055865922, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=24.4318181818182, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=25.8064516129032, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI262073058, Length=372, Percent_Identity=25.8064516129032, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71565152, Length=388, Percent_Identity=25.5154639175258, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI71565154, Length=378, Percent_Identity=26.4550264550265, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=42.8152492668622, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1788073, Length=321, Percent_Identity=27.4143302180685, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=30.3867403314917, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI226510992, Length=318, Percent_Identity=30.5031446540881, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI87082125, Length=338, Percent_Identity=28.698224852071, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786825, Length=386, Percent_Identity=28.7564766839378, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=26.4788732394366, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788407, Length=362, Percent_Identity=28.4530386740331, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1790718, Length=345, Percent_Identity=24.6376811594203, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786552, Length=383, Percent_Identity=28.7206266318538, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87081918, Length=324, Percent_Identity=27.4691358024691, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=351, Percent_Identity=30.1994301994302, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17562878, Length=351, Percent_Identity=28.7749287749288, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=26.4705882352941, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=284, Percent_Identity=28.5211267605634, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=290, Percent_Identity=27.2413793103448, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=275, Percent_Identity=25.0909090909091, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=324, Percent_Identity=26.5432098765432, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=329, Percent_Identity=27.6595744680851, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320033, Length=382, Percent_Identity=28.0104712041885, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=356, Percent_Identity=26.9662921348315, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319955, Length=356, Percent_Identity=26.9662921348315, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=266, Percent_Identity=30.4511278195489, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=262, Percent_Identity=28.6259541984733, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=275, Percent_Identity=28.3636363636364, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=278, Percent_Identity=28.4172661870504, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=257, Percent_Identity=25.6809338521401, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=260, Percent_Identity=26.5384615384615, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=281, Percent_Identity=25.2669039145907, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17137530, Length=335, Percent_Identity=28.6567164179104, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17737897, Length=335, Percent_Identity=27.7611940298507, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=26.2599469496021, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI221457811, Length=175, Percent_Identity=30.2857142857143, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551930, Length=175, Percent_Identity=30.2857142857143, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550770, Length=175, Percent_Identity=30.2857142857143, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37615; Mature: 37484

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKMKALMKQDRSSGAVLEQVDIPKPKSNEVLIKVESAAICGTDLHIYNWDQWADSRIN
CCCHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCEEECCEEEEEECCCCCCCCCC
PPLIFGHEFSGEVVELGADVKDIETGTRVTAEGHFVCGKCFFCKTGQAHICENVEIIGVD
CCEEECCCCCCCEEEECCCHHHCCCCCEEEECCCEEEEEEEEEECCCCEECCCEEEEEEC
TTGCFAEYVVVPRDNVWILDKSIPPEIGAIHDPIGNAIHSALIDEITAKDVLVTGCGPIG
CCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCHH
LASIAIARKAGASKIFATEVNSYRIELAKKMGADEIINPMEQDTVELVKSKTNGAGVDVL
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCCEEE
LEMAGKDTAINEGLAALKGGGWVSFLGLPPGKTQIDLSNGLIFKGAKAYGINGRIMYETW
EEECCCCCHHHCCHHHHCCCCEEEEEECCCCCCEEEECCCEEEECCEEECCCCEEEHHHH
FKMHNLLKSRLADDLMPMVTHKFSFEQFEEAFQLAQEGNTGKIILHP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure 
TGKMKALMKQDRSSGAVLEQVDIPKPKSNEVLIKVESAAICGTDLHIYNWDQWADSRIN
CCHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCEEECCEEEEEECCCCCCCCCC
PPLIFGHEFSGEVVELGADVKDIETGTRVTAEGHFVCGKCFFCKTGQAHICENVEIIGVD
CCEEECCCCCCCEEEECCCHHHCCCCCEEEECCCEEEEEEEEEECCCCEECCCEEEEEEC
TTGCFAEYVVVPRDNVWILDKSIPPEIGAIHDPIGNAIHSALIDEITAKDVLVTGCGPIG
CCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCHH
LASIAIARKAGASKIFATEVNSYRIELAKKMGADEIINPMEQDTVELVKSKTNGAGVDVL
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCCEEE
LEMAGKDTAINEGLAALKGGGWVSFLGLPPGKTQIDLSNGLIFKGAKAYGINGRIMYETW
EEECCCCCHHHCCHHHHCCCCEEEEEECCCCCCEEEECCCEEEECCEEECCCCEEEHHHH
FKMHNLLKSRLADDLMPMVTHKFSFEQFEEAFQLAQEGNTGKIILHP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]