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The map label for this gene is kbl [C]

Identifier: 188584933

GI number: 188584933

Start: 304440

End: 305621

Strand: Reverse

Name: kbl [C]

Synonym: Nther_0292

Alternate gene names: 188584933

Gene position: 305621-304440 (Counterclockwise)

Preceding gene: 188584934

Following gene: 188584931

Centisome position: 9.65

GC content: 38.49

Gene sequence:

>1182_bases
TTGAGCTCACAAGAAAAACTAAACTTTATTCAAACAGAGCTAGAAGAATTAAAAGAAAAAGGACTTTACAAAGATATCAA
AACTTTAGAGGGGCCACAAGGTGCCTGGGTACAAATTAAAGGTAAAAAGATGTTAAACTTCTGTTCGAATAACTATCTAG
GCTTTGCTAACCATTCTCAAATAGTTGAGGCTGCCAAAAAAGCCATCGACGAGTACGGAGTAGGTCCTGGAGCTGTACGA
ACTATTGCAGGGACTATGGATATTCACCATCAGCTAGAACGGAAGTTGGCCGAATTTAAAGGAGTAGAAGCTGCTCTTTC
AGTTCAATCAGGATTTAAAGCAAATTTATCAGCTATTCCTGCACTAGTAGGAAAAGGGGATACTATTATCAGCGATGAAT
TAAACCACGCAAGTATTATTGATGGCTCAAGATTGTCCAGAGCAGATATCAAAGTTTATTCACATAATGATGTAGATAGC
TTAGAATCAGTGCTAAAAGAGAACCCGCCTGGAAAAAAATTGATTATCACTGATGGTGTATTCAGCATGGATGGAGACAT
TGCTCCATTACCAGAAATTGTAGAAGTAGCTAAAAAATACGATGCCATGACTATGGTGGACGATGCTCATGGTGAGGGAG
TTTTAGGAAGAAGTGGCCGAGGCATAGTTGACCACTTTAACTTGCATGGAGAAGTAGATATCGAAATTGGTACCTTCTCA
AAAGCCCTAGGTGTTATGGGTGGCTGTATAGCAGGTAGTGCACAGCTAATAGAATATATCAGACAAAAATCTCGTCCTTT
TACATTTAGTTCTGCCCTTACAGTACCGGATACTGCTGCAACACTAGAAGCCATTAAAATACTATCAGATAGTGACGAAT
TAGTAACCAAATTATGGGACAATGCCGATTACTTTAAAAAAGGAATTAAAGAATTAGGATTTGACACTGGCGAATCTGAA
ACTCCAATAACTCCAGTGATGATCGGTGATGCTAAAGCAGCCAGCGAATTTAGTGAAAAATTATTTGAAGAAAACATTTT
TGCACAAGCTATTGGGTTCCCATTAGTTCCACATGGCAAAGCAAGAATTCGGGCAATGATTTCAGCTGCCCACAGTAAAG
AGGATCTAGATTTTGCTCTTGAAAAGTTCTCAAAAGTAGGAAAAGAACTTAACCTGATTTAA

Upstream 100 bases:

>100_bases
AGCTTTTCAGCTTGCACAAGAGGGGAATACTGGTAAAATAATTTTGCACCCCTAATACGTAAAGATGTAAAAAATATTCT
AAATTTAAGGAGTGATTAAT

Downstream 100 bases:

>100_bases
CATAAGTTTTCGAATTAACATTTGCATACACAATTATTCGTACATTTTGATAGCAAGGATTTCTTCCAGGCTTTCGCCTG
GAGCTCCAAAGTAATAGGTG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSSQEKLNFIQTELEELKEKGLYKDIKTLEGPQGAWVQIKGKKMLNFCSNNYLGFANHSQIVEAAKKAIDEYGVGPGAVR
TIAGTMDIHHQLERKLAEFKGVEAALSVQSGFKANLSAIPALVGKGDTIISDELNHASIIDGSRLSRADIKVYSHNDVDS
LESVLKENPPGKKLIITDGVFSMDGDIAPLPEIVEVAKKYDAMTMVDDAHGEGVLGRSGRGIVDHFNLHGEVDIEIGTFS
KALGVMGGCIAGSAQLIEYIRQKSRPFTFSSALTVPDTAATLEAIKILSDSDELVTKLWDNADYFKKGIKELGFDTGESE
TPITPVMIGDAKAASEFSEKLFEENIFAQAIGFPLVPHGKARIRAMISAAHSKEDLDFALEKFSKVGKELNLI

Sequences:

>Translated_393_residues
MSSQEKLNFIQTELEELKEKGLYKDIKTLEGPQGAWVQIKGKKMLNFCSNNYLGFANHSQIVEAAKKAIDEYGVGPGAVR
TIAGTMDIHHQLERKLAEFKGVEAALSVQSGFKANLSAIPALVGKGDTIISDELNHASIIDGSRLSRADIKVYSHNDVDS
LESVLKENPPGKKLIITDGVFSMDGDIAPLPEIVEVAKKYDAMTMVDDAHGEGVLGRSGRGIVDHFNLHGEVDIEIGTFS
KALGVMGGCIAGSAQLIEYIRQKSRPFTFSSALTVPDTAATLEAIKILSDSDELVTKLWDNADYFKKGIKELGFDTGESE
TPITPVMIGDAKAASEFSEKLFEENIFAQAIGFPLVPHGKARIRAMISAAHSKEDLDFALEKFSKVGKELNLI
>Mature_392_residues
SSQEKLNFIQTELEELKEKGLYKDIKTLEGPQGAWVQIKGKKMLNFCSNNYLGFANHSQIVEAAKKAIDEYGVGPGAVRT
IAGTMDIHHQLERKLAEFKGVEAALSVQSGFKANLSAIPALVGKGDTIISDELNHASIIDGSRLSRADIKVYSHNDVDSL
ESVLKENPPGKKLIITDGVFSMDGDIAPLPEIVEVAKKYDAMTMVDDAHGEGVLGRSGRGIVDHFNLHGEVDIEIGTFSK
ALGVMGGCIAGSAQLIEYIRQKSRPFTFSSALTVPDTAATLEAIKILSDSDELVTKLWDNADYFKKGIKELGFDTGESET
PITPVMIGDAKAASEFSEKLFEENIFAQAIGFPLVPHGKARIRAMISAAHSKEDLDFALEKFSKVGKELNLI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=384, Percent_Identity=39.0625, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI284448556, Length=409, Percent_Identity=36.6748166259169, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=40.5405405405405, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=36.2162162162162, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI83977442, Length=390, Percent_Identity=32.0512820512821, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI83977440, Length=390, Percent_Identity=32.0512820512821, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI83977444, Length=390, Percent_Identity=32.0512820512821, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4502025, Length=399, Percent_Identity=32.0802005012531, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI40316939, Length=399, Percent_Identity=32.0802005012531, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI5454084, Length=330, Percent_Identity=30.6060606060606, Blast_Score=158, Evalue=7e-39,
Organism=Escherichia coli, GI1790046, Length=389, Percent_Identity=42.9305912596401, Blast_Score=321, Evalue=6e-89,
Organism=Escherichia coli, GI1786993, Length=358, Percent_Identity=36.3128491620112, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71994529, Length=390, Percent_Identity=42.5641025641026, Blast_Score=318, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI32566772, Length=366, Percent_Identity=35.792349726776, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17560914, Length=363, Percent_Identity=35.8126721763085, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17560912, Length=363, Percent_Identity=35.8126721763085, Blast_Score=217, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI71982617, Length=278, Percent_Identity=33.8129496402878, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71982625, Length=278, Percent_Identity=33.8129496402878, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=33.7874659400545, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6320438, Length=382, Percent_Identity=32.7225130890052, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6323954, Length=274, Percent_Identity=31.7518248175182, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24662918, Length=385, Percent_Identity=44.4155844155844, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=35.6756756756757, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI17137420, Length=357, Percent_Identity=34.453781512605, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24653280, Length=271, Percent_Identity=33.9483394833948, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24653276, Length=271, Percent_Identity=33.9483394833948, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24653278, Length=271, Percent_Identity=33.9483394833948, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42643; Mature: 42512

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQEKLNFIQTELEELKEKGLYKDIKTLEGPQGAWVQIKGKKMLNFCSNNYLGFANHSQ
CCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEECHHHHHHHCCCCCCCCCHHH
IVEAAKKAIDEYGVGPGAVRTIAGTMDIHHQLERKLAEFKGVEAALSVQSGFKANLSAIP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHH
ALVGKGDTIISDELNHASIIDGSRLSRADIKVYSHNDVDSLESVLKENPPGKKLIITDGV
HHHCCCCEEECCCCCCCEECCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEECCE
FSMDGDIAPLPEIVEVAKKYDAMTMVDDAHGEGVLGRSGRGIVDHFNLHGEVDIEIGTFS
EECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCCCEEEEEECCHH
KALGVMGGCIAGSAQLIEYIRQKSRPFTFSSALTVPDTAATLEAIKILSDSDELVTKLWD
HHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHC
NADYFKKGIKELGFDTGESETPITPVMIGDAKAASEFSEKLFEENIFAQAIGFPLVPHGK
CHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ARIRAMISAAHSKEDLDFALEKFSKVGKELNLI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSQEKLNFIQTELEELKEKGLYKDIKTLEGPQGAWVQIKGKKMLNFCSNNYLGFANHSQ
CCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEECHHHHHHHCCCCCCCCCHHH
IVEAAKKAIDEYGVGPGAVRTIAGTMDIHHQLERKLAEFKGVEAALSVQSGFKANLSAIP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHH
ALVGKGDTIISDELNHASIIDGSRLSRADIKVYSHNDVDSLESVLKENPPGKKLIITDGV
HHHCCCCEEECCCCCCCEECCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEECCE
FSMDGDIAPLPEIVEVAKKYDAMTMVDDAHGEGVLGRSGRGIVDHFNLHGEVDIEIGTFS
EECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCCCEEEEEECCHH
KALGVMGGCIAGSAQLIEYIRQKSRPFTFSSALTVPDTAATLEAIKILSDSDELVTKLWD
HHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHC
NADYFKKGIKELGFDTGESETPITPVMIGDAKAASEFSEKLFEENIFAQAIGFPLVPHGK
CHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ARIRAMISAAHSKEDLDFALEKFSKVGKELNLI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA