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The map label for this gene is glmS [H]

Identifier: 188584886

GI number: 188584886

Start: 253996

End: 255819

Strand: Direct

Name: glmS [H]

Synonym: Nther_0244

Alternate gene names: 188584886

Gene position: 253996-255819 (Clockwise)

Preceding gene: 188584884

Following gene: 188584887

Centisome position: 8.02

GC content: 38.6

Gene sequence:

>1824_bases
ATGTGTGGTATTGTTGGATATATTGGTGATAAACTTGCAATAGATGAACTTATCAAAGGGTTAAAGAAACTTGAATATAG
AGGTTATGATTCCGCTGGTGTGGCAATTGTGGAAAAAGATGACCTCAAGACCATTAAAACTAAAGGTCGTCTAACGGACC
TTGAAGAACGAATAGATACTCAATTTACATCTACTGAAGGGATTGGTCACACACGGTGGGCTACTCATGGAAAACCATCA
GAAGACAATTCCCATCCCCACAGTGATTGTTTTGGAAATATAGCAGTTGTTCACAATGGGATAATTGAGAACTTTCAACA
TTTGAAGGCAGAGCTACAAAATAAGGGACACAAGTTCACATCCCAGACAGATACAGAAGTGATTGCCCACCTACTGGAAG
AATATTATCAGGATGATCTGCTTGAATGTGTCTTTAAGGTGATCGAGAGATTGGAAGGTTCTTATGCTCTAGCTATTATG
CACAAAAATGAACCTGGTAAAATTATCTGTGCTAGAAAGGATAGCCCTTTGATCGTGGGGCAAGGTGAGGGAGAAAATGT
AGTAGCTTCTGATATACCAGCAATTTTGGACTATACAAGGGAAGCTCTAATCTTAGATGATGGAGAAGTAGCCCTGGTAG
AAAAAGATAATATAACTCTATACAATAGTGATAAAAAAGAAATTGAAAAAGAACCTTTACAGATAAATTGGGATGCAGAA
GAAGCCGAAAAAGGTGGTTATGACCACTTTATGTTGAAAGAAATTCATGAACAACCCAAAGCTGTCAGAGAAACTATCAG
GGGCCGTATCAAAGATGGTCAAGTTAATTTTGAAGAACTTAAATACTTAAATTACGATAAGATCAGTCAGCTAAATAGTG
TTAAAATAGTAGCTTGTGGCACAGCCTATCATGCTGGCTTGGTAGGTAAAACTATGATAGAAAGCCTGGCAAATATACCT
GTAGAGGTGGATATAGCCTCGGAGTTTAGATACCGTGATCCTTTAATTAAAAATGACGATTTAGTAATTGTTATCAGTCA
ATCGGGAGAAACTGCCGATACCCTGGCGGCTCTAAGGGAGTCTCAGAAACGAGGAGCCAAAGTATTAGCCATTACTAATG
TAGTGGGAAGCTCAGTCTCTAGAGAAGCTGACGAAGTAATTTATACTTGGGCCGGTCCTGAAATTGCTGTGGCTTCAACA
AAAGCTTATGTAACTCAGCTAGTGGTCTTTTCTTTATTAAGTATTTATTTTGCCCAGGCCAAAGCAACCATAGAAGAAGA
ACGCCAGAAAAAACTTGTTCAAGCTCTATCTAACTTATCCCAGTATATAGAAGCGATCTTCAAAGAGGAACAGCAGATTG
AAGAAACTGCAAGGAGCATTTCTAAACAAGAAAATGTCTTTTTCATTGGAAGAGCACTGGACTGGGCAGTGGCAGAAGAA
GGTGCCCTTAAACTAAAAGAAATTTCTTATATTCATGCTGAAGCATATGCTGCAGGGGAATTAAAGCACGGAACTCTTGC
TTTAATTGTGGATGATGTTCCAGTAATATCTTTAGTTACCCAGCCTCACGTTTATGATAAAATGCTATCCAATCTTCAGG
AAGTCAAAGCTCGAGGAGGAAATTGCATTGCCGTAGCTTTTGAAAATGACCGTGAAATTGAAAATGAAGTGAATCATGTT
TTAAGAATACCGGAAATCGATCCTCTATTTAGCCCAATTATTAGCGTTGTACCATTGCAGTTGTTGTCTTATTATGCTGC
AGTTGCTCGAGGTACAGATGTAGATAAACCAAGAAACCTGGCTAAAAGTGTGACAGTAGAATAA

Upstream 100 bases:

>100_bases
ATAAAACCGGGAAGCGATTCCCGGGACAAAAAGTGCCGGGTGATGAAAACTTAATAATTGAATATAGCTTATTAACGGTA
GAAATGGAGGGAACAGATAT

Downstream 100 bases:

>100_bases
AACTAAGTAGTAGTGTTGGCGTTGTTGTTGCATTAAAACTAAGTTTGAACATTTAAAAGAAAGTCTGAACACCAAAAAGA
AAATTAGAACATTTTAAAAG

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIVGYIGDKLAIDELIKGLKKLEYRGYDSAGVAIVEKDDLKTIKTKGRLTDLEERIDTQFTSTEGIGHTRWATHGKPS
EDNSHPHSDCFGNIAVVHNGIIENFQHLKAELQNKGHKFTSQTDTEVIAHLLEEYYQDDLLECVFKVIERLEGSYALAIM
HKNEPGKIICARKDSPLIVGQGEGENVVASDIPAILDYTREALILDDGEVALVEKDNITLYNSDKKEIEKEPLQINWDAE
EAEKGGYDHFMLKEIHEQPKAVRETIRGRIKDGQVNFEELKYLNYDKISQLNSVKIVACGTAYHAGLVGKTMIESLANIP
VEVDIASEFRYRDPLIKNDDLVIVISQSGETADTLAALRESQKRGAKVLAITNVVGSSVSREADEVIYTWAGPEIAVAST
KAYVTQLVVFSLLSIYFAQAKATIEEERQKKLVQALSNLSQYIEAIFKEEQQIEETARSISKQENVFFIGRALDWAVAEE
GALKLKEISYIHAEAYAAGELKHGTLALIVDDVPVISLVTQPHVYDKMLSNLQEVKARGGNCIAVAFENDREIENEVNHV
LRIPEIDPLFSPIISVVPLQLLSYYAAVARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIVGYIGDKLAIDELIKGLKKLEYRGYDSAGVAIVEKDDLKTIKTKGRLTDLEERIDTQFTSTEGIGHTRWATHGKPS
EDNSHPHSDCFGNIAVVHNGIIENFQHLKAELQNKGHKFTSQTDTEVIAHLLEEYYQDDLLECVFKVIERLEGSYALAIM
HKNEPGKIICARKDSPLIVGQGEGENVVASDIPAILDYTREALILDDGEVALVEKDNITLYNSDKKEIEKEPLQINWDAE
EAEKGGYDHFMLKEIHEQPKAVRETIRGRIKDGQVNFEELKYLNYDKISQLNSVKIVACGTAYHAGLVGKTMIESLANIP
VEVDIASEFRYRDPLIKNDDLVIVISQSGETADTLAALRESQKRGAKVLAITNVVGSSVSREADEVIYTWAGPEIAVAST
KAYVTQLVVFSLLSIYFAQAKATIEEERQKKLVQALSNLSQYIEAIFKEEQQIEETARSISKQENVFFIGRALDWAVAEE
GALKLKEISYIHAEAYAAGELKHGTLALIVDDVPVISLVTQPHVYDKMLSNLQEVKARGGNCIAVAFENDREIENEVNHV
LRIPEIDPLFSPIISVVPLQLLSYYAAVARGTDVDKPRNLAKSVTVE
>Mature_607_residues
MCGIVGYIGDKLAIDELIKGLKKLEYRGYDSAGVAIVEKDDLKTIKTKGRLTDLEERIDTQFTSTEGIGHTRWATHGKPS
EDNSHPHSDCFGNIAVVHNGIIENFQHLKAELQNKGHKFTSQTDTEVIAHLLEEYYQDDLLECVFKVIERLEGSYALAIM
HKNEPGKIICARKDSPLIVGQGEGENVVASDIPAILDYTREALILDDGEVALVEKDNITLYNSDKKEIEKEPLQINWDAE
EAEKGGYDHFMLKEIHEQPKAVRETIRGRIKDGQVNFEELKYLNYDKISQLNSVKIVACGTAYHAGLVGKTMIESLANIP
VEVDIASEFRYRDPLIKNDDLVIVISQSGETADTLAALRESQKRGAKVLAITNVVGSSVSREADEVIYTWAGPEIAVAST
KAYVTQLVVFSLLSIYFAQAKATIEEERQKKLVQALSNLSQYIEAIFKEEQQIEETARSISKQENVFFIGRALDWAVAEE
GALKLKEISYIHAEAYAAGELKHGTLALIVDDVPVISLVTQPHVYDKMLSNLQEVKARGGNCIAVAFENDREIENEVNHV
LRIPEIDPLFSPIISVVPLQLLSYYAAVARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=36.9883040935673, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=36.4296081277213, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI29570798, Length=203, Percent_Identity=30.0492610837438, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=45.2032520325203, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=41.6666666666667, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=40.0462962962963, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=40.0462962962963, Blast_Score=308, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6322745, Length=433, Percent_Identity=36.7205542725173, Blast_Score=286, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=30.7339449541284, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=41.4634146341463, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=37.2463768115942, Blast_Score=440, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67552; Mature: 67552

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGDKLAIDELIKGLKKLEYRGYDSAGVAIVEKDDLKTIKTKGRLTDLEERIDT
CCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCHHHHHHHCC
QFTSTEGIGHTRWATHGKPSEDNSHPHSDCFGNIAVVHNGIIENFQHLKAELQNKGHKFT
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
SQTDTEVIAHLLEEYYQDDLLECVFKVIERLEGSYALAIMHKNEPGKIICARKDSPLIVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCEEEE
QGEGENVVASDIPAILDYTREALILDDGEVALVEKDNITLYNSDKKEIEKEPLQINWDAE
CCCCCCEEHHHHHHHHHHCCCEEEEECCCEEEEEECCEEEECCCHHHHCCCCEEEECCHH
EAEKGGYDHFMLKEIHEQPKAVRETIRGRIKDGQVNFEELKYLNYDKISQLNSVKIVACG
HHHCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHCCCCEEEEEEC
TAYHAGLVGKTMIESLANIPVEVDIASEFRYRDPLIKNDDLVIVISQSGETADTLAALRE
CHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHH
SQKRGAKVLAITNVVGSSVSREADEVIYTWAGPEIAVASTKAYVTQLVVFSLLSIYFAQA
HHHCCCEEEEEHHHHCCHHCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
KATIEEERQKKLVQALSNLSQYIEAIFKEEQQIEETARSISKQENVFFIGRALDWAVAEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHCC
GALKLKEISYIHAEAYAAGELKHGTLALIVDDVPVISLVTQPHVYDKMLSNLQEVKARGG
CCEEHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCC
NCIAVAFENDREIENEVNHVLRIPEIDPLFSPIISVVPLQLLSYYAAVARGTDVDKPRNL
CEEEEEECCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIVGYIGDKLAIDELIKGLKKLEYRGYDSAGVAIVEKDDLKTIKTKGRLTDLEERIDT
CCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCHHHHHHHCC
QFTSTEGIGHTRWATHGKPSEDNSHPHSDCFGNIAVVHNGIIENFQHLKAELQNKGHKFT
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
SQTDTEVIAHLLEEYYQDDLLECVFKVIERLEGSYALAIMHKNEPGKIICARKDSPLIVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCEEEE
QGEGENVVASDIPAILDYTREALILDDGEVALVEKDNITLYNSDKKEIEKEPLQINWDAE
CCCCCCEEHHHHHHHHHHCCCEEEEECCCEEEEEECCEEEECCCHHHHCCCCEEEECCHH
EAEKGGYDHFMLKEIHEQPKAVRETIRGRIKDGQVNFEELKYLNYDKISQLNSVKIVACG
HHHCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHCCCCEEEEEEC
TAYHAGLVGKTMIESLANIPVEVDIASEFRYRDPLIKNDDLVIVISQSGETADTLAALRE
CHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHH
SQKRGAKVLAITNVVGSSVSREADEVIYTWAGPEIAVASTKAYVTQLVVFSLLSIYFAQA
HHHCCCEEEEEHHHHCCHHCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
KATIEEERQKKLVQALSNLSQYIEAIFKEEQQIEETARSISKQENVFFIGRALDWAVAEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHCC
GALKLKEISYIHAEAYAAGELKHGTLALIVDDVPVISLVTQPHVYDKMLSNLQEVKARGG
CCEEHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCC
NCIAVAFENDREIENEVNHVLRIPEIDPLFSPIISVVPLQLLSYYAAVARGTDVDKPRNL
CEEEEEECCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]