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The map label for this gene is disA [H]

Identifier: 188584801

GI number: 188584801

Start: 183533

End: 184624

Strand: Direct

Name: disA [H]

Synonym: Nther_0159

Alternate gene names: 188584801

Gene position: 183533-184624 (Clockwise)

Preceding gene: 188584800

Following gene: 188584802

Centisome position: 5.8

GC content: 36.26

Gene sequence:

>1092_bases
TTGCGCTTGACATATTTATCAAAATTACATGATAATAAGGAGTTTTTAGATACTCTGGCTATGCTAGCTCCCGGGACGGG
GCTTCGAGCAGGACTTGAAAATGTTTTAAGGGCAAAAACTGGGGGATTGATTGTATTAGGTGACAATGAAGAGGTGCGTG
AGCTCATTACAGGGGGCTTTAAAATTGATGCCACCTTTTCTCCCAGTAATATGTATGAGTTAGCCAAAATGGATGGGGCT
TTAGTTTTGAGTAGTGATGCAAGAAAGATCGTTTACGCCAATGTTCATCTAAACCCTGATTCCAATATTTCTTCCAGTGA
GACTGGAATTCGACATAGAACAGCTGAAAGGGTGGCTAAACAAACTCAAAAGACTGTAGTTGCAATATCCCAAAGGAGAA
ATATTATTACTATTTACCATAATAACTGGAAATATGCTATGAGTGATATTGGTGTGATTTTAACAAAGGCAAATCAAGCA
GTGCAAACTCTGGATAAATACCGATCTGTACTGGATCAAGATTTGACTAATCTTTCGGCATTAGAATTTGAAGAATCAGT
GACTTTAGCTGATGTGGTGAAAGTGATTCAAAGATCTGAAATGGTTATGAGGATAGTAAAGGAAATAGAAAAATACATTA
CCGAATTGGGGACTGAGGGACGTTTGGTGAAGATGCAGCTAGATGAGCTAATTGTGAATGTTGAAGATGACAGTTATCTG
TTGATTAAGGATTATTATAATTCAGAGGGGCATTATTCGCCTGCGGAAATATCAAATAAAATTTCGGAGATCGAATCAGA
TGAATTATTAGAGCCTGAAAAAATATTAGAAGCTTTAGGATATCCAAAGAAAGCTAGTTATTTAGATCAAAAGGTCATGT
CCCGTGGTTTTAGAATTTTGAATAAAATTCCTCGTTTACCTATAAATATTGTGGAAAATGTGGTTGAAAGATTTGGCGAT
TTGAGAGGAATATTAAATGCTTCAATAGAAGAATTAGATGACGTAGAAGGTATAGGGGAAATTAGAGCGCGAGTGATAAA
GGATGGTTTACGAAGGATTAGAGAGCAAGCTTTAATAGATAGATATGTATAA

Upstream 100 bases:

>100_bases
TTACCCGAAGCTTGCCGTTTAAATCATCATCAAGGAAACATTGAGATTTATCCGGTATCCTATTTGAAAGATGTTTTAGA
AATATTATCAGGGTAGGTGA

Downstream 100 bases:

>100_bases
GTTGTAGGAGGAGGTTAATTCTTGGATATTAAAAAAATACTACCAAATATATTGACTATAGCCAATTTGACAGTGGGTTT
TGCCGCCATCCTATTGATTT

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MRLTYLSKLHDNKEFLDTLAMLAPGTGLRAGLENVLRAKTGGLIVLGDNEEVRELITGGFKIDATFSPSNMYELAKMDGA
LVLSSDARKIVYANVHLNPDSNISSSETGIRHRTAERVAKQTQKTVVAISQRRNIITIYHNNWKYAMSDIGVILTKANQA
VQTLDKYRSVLDQDLTNLSALEFEESVTLADVVKVIQRSEMVMRIVKEIEKYITELGTEGRLVKMQLDELIVNVEDDSYL
LIKDYYNSEGHYSPAEISNKISEIESDELLEPEKILEALGYPKKASYLDQKVMSRGFRILNKIPRLPINIVENVVERFGD
LRGILNASIEELDDVEGIGEIRARVIKDGLRRIREQALIDRYV

Sequences:

>Translated_363_residues
MRLTYLSKLHDNKEFLDTLAMLAPGTGLRAGLENVLRAKTGGLIVLGDNEEVRELITGGFKIDATFSPSNMYELAKMDGA
LVLSSDARKIVYANVHLNPDSNISSSETGIRHRTAERVAKQTQKTVVAISQRRNIITIYHNNWKYAMSDIGVILTKANQA
VQTLDKYRSVLDQDLTNLSALEFEESVTLADVVKVIQRSEMVMRIVKEIEKYITELGTEGRLVKMQLDELIVNVEDDSYL
LIKDYYNSEGHYSPAEISNKISEIESDELLEPEKILEALGYPKKASYLDQKVMSRGFRILNKIPRLPINIVENVVERFGD
LRGILNASIEELDDVEGIGEIRARVIKDGLRRIREQALIDRYV
>Mature_363_residues
MRLTYLSKLHDNKEFLDTLAMLAPGTGLRAGLENVLRAKTGGLIVLGDNEEVRELITGGFKIDATFSPSNMYELAKMDGA
LVLSSDARKIVYANVHLNPDSNISSSETGIRHRTAERVAKQTQKTVVAISQRRNIITIYHNNWKYAMSDIGVILTKANQA
VQTLDKYRSVLDQDLTNLSALEFEESVTLADVVKVIQRSEMVMRIVKEIEKYITELGTEGRLVKMQLDELIVNVEDDSYL
LIKDYYNSEGHYSPAEISNKISEIESDELLEPEKILEALGYPKKASYLDQKVMSRGFRILNKIPRLPINIVENVVERFGD
LRGILNASIEELDDVEGIGEIRARVIKDGLRRIREQALIDRYV

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; PF00633 HHH [H]

EC number: NA

Molecular weight: Translated: 41017; Mature: 41017

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTYLSKLHDNKEFLDTLAMLAPGTGLRAGLENVLRAKTGGLIVLGDNEEVRELITGGF
CCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCE
KIDATFSPSNMYELAKMDGALVLSSDARKIVYANVHLNPDSNISSSETGIRHRTAERVAK
EEEEEECCHHHHHHHHCCCCEEEECCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
QTQKTVVAISQRRNIITIYHNNWKYAMSDIGVILTKANQAVQTLDKYRSVLDQDLTNLSA
HHHHHHHHHHCCCCEEEEEECCCEEHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHH
LEFEESVTLADVVKVIQRSEMVMRIVKEIEKYITELGTEGRLVKMQLDELIVNVEDDSYL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHEEEECCCCEE
LIKDYYNSEGHYSPAEISNKISEIESDELLEPEKILEALGYPKKASYLDQKVMSRGFRIL
EEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
NKIPRLPINIVENVVERFGDLRGILNASIEELDDVEGIGEIRARVIKDGLRRIREQALID
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RYV
HCC
>Mature Secondary Structure
MRLTYLSKLHDNKEFLDTLAMLAPGTGLRAGLENVLRAKTGGLIVLGDNEEVRELITGGF
CCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCE
KIDATFSPSNMYELAKMDGALVLSSDARKIVYANVHLNPDSNISSSETGIRHRTAERVAK
EEEEEECCHHHHHHHHCCCCEEEECCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
QTQKTVVAISQRRNIITIYHNNWKYAMSDIGVILTKANQAVQTLDKYRSVLDQDLTNLSA
HHHHHHHHHHCCCCEEEEEECCCEEHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHH
LEFEESVTLADVVKVIQRSEMVMRIVKEIEKYITELGTEGRLVKMQLDELIVNVEDDSYL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHEEEECCCCEE
LIKDYYNSEGHYSPAEISNKISEIESDELLEPEKILEALGYPKKASYLDQKVMSRGFRIL
EEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
NKIPRLPINIVENVVERFGDLRGILNASIEELDDVEGIGEIRARVIKDGLRRIREQALID
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RYV
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA