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The map label for this gene is addA [H]

Identifier: 188528332

GI number: 188528332

Start: 1560501

End: 1563350

Strand: Direct

Name: addA [H]

Synonym: HPSH_08020

Alternate gene names: 188528332

Gene position: 1560501-1563350 (Clockwise)

Preceding gene: 188528331

Following gene: 188528333

Centisome position: 97.01

GC content: 38.63

Gene sequence:

>2850_bases
ATGGATACAAAAAGACAATGCATGGCTTTAAAGGCTTCAGCAGGAAGTGGGAAGACTTTCGCTTTGAGCGTGCGGTTTTT
GGCCCTGTTGTTTAAGGGGGCTAATCCTAGCGAGATTTTGACGCTCACTTTCACTAAAAAAGCCACCGCCGAAATGAAAG
AGCGTATTTTAGACTATTTAAAAATCTTGCAAAAAGAAAACCTTGAAAGCGAAAAAGAAAAAGAAAAATCCCAAAATATC
CTAAAAGAATTAGAAGAAAAATACCGCTTAAACCCTAGTTTGGTGCAAAATAGCGCTCAAAAAATCTACCAACGCTTTTT
AAACGCCGAAATGAGAATCAGCACCATTGATGCGTTTTTCCAAAGCATTTTAAGGAAATTTTGCTGGTTTGTGGGGTTGA
GCGCGAATTTTGAAGTCAATGAAGACACAAAAGTGCACCAACAACAGCTCAATGCGAGTTTTTTGAGCGCTTTAAATAAT
GAACAGCTTGAGGAATTGAGCGTTTTTATCACTCAATGCTTAAGCCATGATAATTACACAAGCGATTCTATTTTAGAGCG
GTTGCGTTTTTTAAAAAACAAGCTCTATTTATTTGATCCTAACAAGAAAGAGCCTGCATTTGATGAAGAGAGTTTTTTAG
AAAAACTAAGAAGCTTAAACCAACAAATTCAAAGCGTAGAAACAGCGTCAGATACGGCTAAAACAGCCATTAAATGCGAT
GATTTTAGAGGGTTTTTAAACAGCTCTTTAACCTGGCTTGAAAAAAAGAGCGAATACCGCTCTTTCAAAAAACTCAAAGA
TGAAATCCCCACTTTAGAGAGCGAATGCGAAGAGATTGAAAACGATCTAAAACGCTATTATGAAGCCAAAGAAAGCGCAT
TGTTTAAAAAATTCCCTAAATTCATCCAGCTTTATGATAAAGCCACTTCTAAAATCCAAGCCCTGGATTTTGATGCGATT
AAAGATAAAGTCCATGCCTTATTGAATGGCTATGAAGAAATGCCGGCGGAGTTTTTTTATTTCAGATTGGACAGCAGGAT
CGCACACATTTTGATTGATGAATTTCAAGACACGAGCTTGAACGATTATAAGATTTTAGCCCCTTTTATTGATGAGATTA
AAGCCGGGATAGGGCAAGCTAAATGGCACAGGAGCGTGTTTTTTGTGGGCGATGTCAAGCAGAGCATTTATGGCTTTAGG
GGGAGTTTTAGCTCCTTGTTTGAAAGCGTTTCTAAGGAATTTTACCACGATAATTTACAATTCAACCACCGTAGTTCGCC
TTTGATCATTAATTATGTGAATACCATTTTTAAAAAGGCTTATCAAAATTCCCCCACCGCTTATTTGGAGCAAAAATACC
CTAAAGCTTCCAGCAATAAACATGCTAGAGACGGCTATGTTAAAGTCTCTTTAGTGGCTGATGGAAGAGAATTGTTATTA
GAACAAATCTTGCAAGAAGCTAAAAACCTTTTAGAGCACCGCATTGATCCTAAAGACATTACCCTTTTATGCGCCACTAA
TGACGACGCTTTAGAAATCAAAAATTATTTGCAAGAGAATTTGAGCGCGATTCGCCCAAGCACGGAATCTAGCGCTAAAT
TGTCTCAATTTGTGGAATCTAAAATCATTAAGAACGCTTTAGAATACGCTCTAGCTGAAGAACCTTACAAGCCCTTTTAT
AAGCACAGCGTTTTAAAACTCGCTGGATACTTGCATGATGATGCCATCGCTTTAGCTGGTTTTAACCCTAAAAAAGAGAG
CGTGGCAGGCTTTGTGTGGAAGGTGATGGAACTGTTTGAGCTTTATGGAGAGTGCGCGCAAATCTGCTTGGAGTTGGCGG
TTGGGTGCGAAGATGCGAATGAATTTTTAGAAAAATTAGAGGCTAAAGAGATCGCTTCTTTCAATGCAAAAGGCGCACAG
ATTATGACCATCCATAAATCTAAAGGCATGCAATTCCCTTATGTGATCGTGTGCGAACGCTTGGGCAAGCCTAAATCAAA
TAGCTCCAATCAATTCCTTGAAGAATATAGCGGCACAGAGCTTCTTCACCTTTATTACAGAATGAAAAATCGTGAGGTGG
TGGATAAAGATTACGCTAGGGCTTTAGATAAAGAAGAAGCGGCTAAAGATCATGAAGAAACCAACGTGTATTATGTCGCA
TTCACTAGGGCTGAGTTAGGGCTGATTGTCGTGGCTAAAGACAAAGACCAAAAGAAAGACAAAAAAGAAAGCAAAAGCAA
AGGAATGCGCGAAAAATTGGATCTTTTGCCTTTAGAAGAGGGAGAAATCGCGCCGGTTATTTCTTCTCAAAAAGAGCCTT
TAATTGCAAGCGTTGTAATCAAACCCCATGCCTATGGCGAGCAAGTCCAAGAGATAGAAGAAGAGCCTAGCGATTATGAA
AAGAATAACGACCAGGAAGCGATCAATTTTGGTATCGCCTTGCACAAGGGATTAGAATACCAATACGCTTATAATATTCC
TAAAAAAAGCGTTTTAGAATATTTAAACTACCATCATGGTTTTTATGGTTTGGATTACCAAGCGTTAGAAGAAAGTTTAG
AGCTTTTTGAAAACGATGCCAAGATACAAGCTCTTTTTAAAAATTTGGCCCTAAGGGGCGAAGTGGCTTTTTTATTTGAA
GGGGTTGTGTCTAGGATTGACGTTTTATTGTGGGATAAGGGGCAAAATTTGTATGTTTTAGATTATAAAAGCTCTCAAAA
TTACCAGCAAAGCCATAAGGCGCAAGTTTCTCATTACGCTGCGTTTTTGCAAACTCAAGCCCCCCATTTTAAGATACAAG
CGGGCATTATTTACGCTCATAAAAGACTGCTTGAAAAATTATGGGTTTGA

Upstream 100 bases:

>100_bases
AAAACCCTATGATTATAGCAAAAGATTAGGGTTTTTTAGCTTAAGCAAAAAAGGCTTTTAGGTTATAATAAAGGCAAAAT
AGAATTTTAGGATAGATCTA

Downstream 100 bases:

>100_bases
AATTAAAAATTTTAAGGTTGTCTATGAATATCAAAAAAACAGAAAACGCGCTCAGTGTAACGCTTAAAAACTTTATTAAA
AGCGAGTCTTTTGGAGGGAT

Product: putative recombination protein RecB

Products: NA

Alternate protein names: ATP-dependent helicase/nuclease AddA [H]

Number of amino acids: Translated: 949; Mature: 949

Protein sequence:

>949_residues
MDTKRQCMALKASAGSGKTFALSVRFLALLFKGANPSEILTLTFTKKATAEMKERILDYLKILQKENLESEKEKEKSQNI
LKELEEKYRLNPSLVQNSAQKIYQRFLNAEMRISTIDAFFQSILRKFCWFVGLSANFEVNEDTKVHQQQLNASFLSALNN
EQLEELSVFITQCLSHDNYTSDSILERLRFLKNKLYLFDPNKKEPAFDEESFLEKLRSLNQQIQSVETASDTAKTAIKCD
DFRGFLNSSLTWLEKKSEYRSFKKLKDEIPTLESECEEIENDLKRYYEAKESALFKKFPKFIQLYDKATSKIQALDFDAI
KDKVHALLNGYEEMPAEFFYFRLDSRIAHILIDEFQDTSLNDYKILAPFIDEIKAGIGQAKWHRSVFFVGDVKQSIYGFR
GSFSSLFESVSKEFYHDNLQFNHRSSPLIINYVNTIFKKAYQNSPTAYLEQKYPKASSNKHARDGYVKVSLVADGRELLL
EQILQEAKNLLEHRIDPKDITLLCATNDDALEIKNYLQENLSAIRPSTESSAKLSQFVESKIIKNALEYALAEEPYKPFY
KHSVLKLAGYLHDDAIALAGFNPKKESVAGFVWKVMELFELYGECAQICLELAVGCEDANEFLEKLEAKEIASFNAKGAQ
IMTIHKSKGMQFPYVIVCERLGKPKSNSSNQFLEEYSGTELLHLYYRMKNREVVDKDYARALDKEEAAKDHEETNVYYVA
FTRAELGLIVVAKDKDQKKDKKESKSKGMREKLDLLPLEEGEIAPVISSQKEPLIASVVIKPHAYGEQVQEIEEEPSDYE
KNNDQEAINFGIALHKGLEYQYAYNIPKKSVLEYLNYHHGFYGLDYQALEESLELFENDAKIQALFKNLALRGEVAFLFE
GVVSRIDVLLWDKGQNLYVLDYKSSQNYQQSHKAQVSHYAAFLQTQAPHFKIQAGIIYAHKRLLEKLWV

Sequences:

>Translated_949_residues
MDTKRQCMALKASAGSGKTFALSVRFLALLFKGANPSEILTLTFTKKATAEMKERILDYLKILQKENLESEKEKEKSQNI
LKELEEKYRLNPSLVQNSAQKIYQRFLNAEMRISTIDAFFQSILRKFCWFVGLSANFEVNEDTKVHQQQLNASFLSALNN
EQLEELSVFITQCLSHDNYTSDSILERLRFLKNKLYLFDPNKKEPAFDEESFLEKLRSLNQQIQSVETASDTAKTAIKCD
DFRGFLNSSLTWLEKKSEYRSFKKLKDEIPTLESECEEIENDLKRYYEAKESALFKKFPKFIQLYDKATSKIQALDFDAI
KDKVHALLNGYEEMPAEFFYFRLDSRIAHILIDEFQDTSLNDYKILAPFIDEIKAGIGQAKWHRSVFFVGDVKQSIYGFR
GSFSSLFESVSKEFYHDNLQFNHRSSPLIINYVNTIFKKAYQNSPTAYLEQKYPKASSNKHARDGYVKVSLVADGRELLL
EQILQEAKNLLEHRIDPKDITLLCATNDDALEIKNYLQENLSAIRPSTESSAKLSQFVESKIIKNALEYALAEEPYKPFY
KHSVLKLAGYLHDDAIALAGFNPKKESVAGFVWKVMELFELYGECAQICLELAVGCEDANEFLEKLEAKEIASFNAKGAQ
IMTIHKSKGMQFPYVIVCERLGKPKSNSSNQFLEEYSGTELLHLYYRMKNREVVDKDYARALDKEEAAKDHEETNVYYVA
FTRAELGLIVVAKDKDQKKDKKESKSKGMREKLDLLPLEEGEIAPVISSQKEPLIASVVIKPHAYGEQVQEIEEEPSDYE
KNNDQEAINFGIALHKGLEYQYAYNIPKKSVLEYLNYHHGFYGLDYQALEESLELFENDAKIQALFKNLALRGEVAFLFE
GVVSRIDVLLWDKGQNLYVLDYKSSQNYQQSHKAQVSHYAAFLQTQAPHFKIQAGIIYAHKRLLEKLWV
>Mature_949_residues
MDTKRQCMALKASAGSGKTFALSVRFLALLFKGANPSEILTLTFTKKATAEMKERILDYLKILQKENLESEKEKEKSQNI
LKELEEKYRLNPSLVQNSAQKIYQRFLNAEMRISTIDAFFQSILRKFCWFVGLSANFEVNEDTKVHQQQLNASFLSALNN
EQLEELSVFITQCLSHDNYTSDSILERLRFLKNKLYLFDPNKKEPAFDEESFLEKLRSLNQQIQSVETASDTAKTAIKCD
DFRGFLNSSLTWLEKKSEYRSFKKLKDEIPTLESECEEIENDLKRYYEAKESALFKKFPKFIQLYDKATSKIQALDFDAI
KDKVHALLNGYEEMPAEFFYFRLDSRIAHILIDEFQDTSLNDYKILAPFIDEIKAGIGQAKWHRSVFFVGDVKQSIYGFR
GSFSSLFESVSKEFYHDNLQFNHRSSPLIINYVNTIFKKAYQNSPTAYLEQKYPKASSNKHARDGYVKVSLVADGRELLL
EQILQEAKNLLEHRIDPKDITLLCATNDDALEIKNYLQENLSAIRPSTESSAKLSQFVESKIIKNALEYALAEEPYKPFY
KHSVLKLAGYLHDDAIALAGFNPKKESVAGFVWKVMELFELYGECAQICLELAVGCEDANEFLEKLEAKEIASFNAKGAQ
IMTIHKSKGMQFPYVIVCERLGKPKSNSSNQFLEEYSGTELLHLYYRMKNREVVDKDYARALDKEEAAKDHEETNVYYVA
FTRAELGLIVVAKDKDQKKDKKESKSKGMREKLDLLPLEEGEIAPVISSQKEPLIASVVIKPHAYGEQVQEIEEEPSDYE
KNNDQEAINFGIALHKGLEYQYAYNIPKKSVLEYLNYHHGFYGLDYQALEESLELFENDAKIQALFKNLALRGEVAFLFE
GVVSRIDVLLWDKGQNLYVLDYKSSQNYQQSHKAQVSHYAAFLQTQAPHFKIQAGIIYAHKRLLEKLWV

Specific function: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domai

COG id: COG1074

COG function: function code L; ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014152
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR011604
- InterPro:   IPR014016
- InterPro:   IPR011335 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 109359; Mature: 109359

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKRQCMALKASAGSGKTFALSVRFLALLFKGANPSEILTLTFTKKATAEMKERILDYL
CCCHHHHHEEECCCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHH
KILQKENLESEKEKEKSQNILKELEEKYRLNPSLVQNSAQKIYQRFLNAEMRISTIDAFF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QSILRKFCWFVGLSANFEVNEDTKVHQQQLNASFLSALNNEQLEELSVFITQCLSHDNYT
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCC
SDSILERLRFLKNKLYLFDPNKKEPAFDEESFLEKLRSLNQQIQSVETASDTAKTAIKCD
HHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFRGFLNSSLTWLEKKSEYRSFKKLKDEIPTLESECEEIENDLKRYYEAKESALFKKFPK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIQLYDKATSKIQALDFDAIKDKVHALLNGYEEMPAEFFYFRLDSRIAHILIDEFQDTSL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
NDYKILAPFIDEIKAGIGQAKWHRSVFFVGDVKQSIYGFRGSFSSLFESVSKEFYHDNLQ
CCCCHHHHHHHHHHHCCCHHHHHCCEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
FNHRSSPLIINYVNTIFKKAYQNSPTAYLEQKYPKASSNKHARDGYVKVSLVADGRELLL
CCCCCCCEEHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHHHH
EQILQEAKNLLEHRIDPKDITLLCATNDDALEIKNYLQENLSAIRPSTESSAKLSQFVES
HHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
KIIKNALEYALAEEPYKPFYKHSVLKLAGYLHDDAIALAGFNPKKESVAGFVWKVMELFE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
LYGECAQICLELAVGCEDANEFLEKLEAKEIASFNAKGAQIMTIHKSKGMQFPYVIVCER
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHH
LGKPKSNSSNQFLEEYSGTELLHLYYRMKNREVVDKDYARALDKEEAAKDHEETNVYYVA
HCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCHHHHHCCCCCCCEEEEE
FTRAELGLIVVAKDKDQKKDKKESKSKGMREKLDLLPLEEGEIAPVISSQKEPLIASVVI
EEECCCCEEEEECCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE
KPHAYGEQVQEIEEEPSDYEKNNDQEAINFGIALHKGLEYQYAYNIPKKSVLEYLNYHHG
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCC
FYGLDYQALEESLELFENDAKIQALFKNLALRGEVAFLFEGVVSRIDVLLWDKGQNLYVL
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCEEEEE
DYKSSQNYQQSHKAQVSHYAAFLQTQAPHFKIQAGIIYAHKRLLEKLWV
EECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTKRQCMALKASAGSGKTFALSVRFLALLFKGANPSEILTLTFTKKATAEMKERILDYL
CCCHHHHHEEECCCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHH
KILQKENLESEKEKEKSQNILKELEEKYRLNPSLVQNSAQKIYQRFLNAEMRISTIDAFF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QSILRKFCWFVGLSANFEVNEDTKVHQQQLNASFLSALNNEQLEELSVFITQCLSHDNYT
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCC
SDSILERLRFLKNKLYLFDPNKKEPAFDEESFLEKLRSLNQQIQSVETASDTAKTAIKCD
HHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFRGFLNSSLTWLEKKSEYRSFKKLKDEIPTLESECEEIENDLKRYYEAKESALFKKFPK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIQLYDKATSKIQALDFDAIKDKVHALLNGYEEMPAEFFYFRLDSRIAHILIDEFQDTSL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
NDYKILAPFIDEIKAGIGQAKWHRSVFFVGDVKQSIYGFRGSFSSLFESVSKEFYHDNLQ
CCCCHHHHHHHHHHHCCCHHHHHCCEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
FNHRSSPLIINYVNTIFKKAYQNSPTAYLEQKYPKASSNKHARDGYVKVSLVADGRELLL
CCCCCCCEEHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHHHH
EQILQEAKNLLEHRIDPKDITLLCATNDDALEIKNYLQENLSAIRPSTESSAKLSQFVES
HHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
KIIKNALEYALAEEPYKPFYKHSVLKLAGYLHDDAIALAGFNPKKESVAGFVWKVMELFE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
LYGECAQICLELAVGCEDANEFLEKLEAKEIASFNAKGAQIMTIHKSKGMQFPYVIVCER
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHH
LGKPKSNSSNQFLEEYSGTELLHLYYRMKNREVVDKDYARALDKEEAAKDHEETNVYYVA
HCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCHHHHHCCCCCCCEEEEE
FTRAELGLIVVAKDKDQKKDKKESKSKGMREKLDLLPLEEGEIAPVISSQKEPLIASVVI
EEECCCCEEEEECCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE
KPHAYGEQVQEIEEEPSDYEKNNDQEAINFGIALHKGLEYQYAYNIPKKSVLEYLNYHHG
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCC
FYGLDYQALEESLELFENDAKIQALFKNLALRGEVAFLFEGVVSRIDVLLWDKGQNLYVL
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCEEEEE
DYKSSQNYQQSHKAQVSHYAAFLQTQAPHFKIQAGIIYAHKRLLEKLWV
EECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA