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The map label for this gene is thyX

Identifier: 188528303

GI number: 188528303

Start: 1531402

End: 1532028

Strand: Direct

Name: thyX

Synonym: HPSH_07875

Alternate gene names: 188528303

Gene position: 1531402-1532028 (Clockwise)

Preceding gene: 188528302

Following gene: 188528304

Centisome position: 95.2

GC content: 40.03

Gene sequence:

>627_bases
ATGGAAGTGATTTGTAAGCATTACACCCCTTTAGACATTGCAAGCCAAGCGATCCGCACTTGCTGGCAGAGCTTTGAATA
CAGCGATGATGGAGGCTCTAAAGATAAGGAATTGATCCACAGAGTGGGGAATATTTTTAGGCATTCTTCCACTTTAGAGC
ATCTTTATTACAATTTTGAAATCAAGGGTTTGAGCAGGGGAGCGTTGCAAGAATTGAGCCGGCACCGCATAGCGAGCTTG
AGCGTGAAATCAAGCCGCTACACTTTAAGGGAATTGAAAGAAGTGGAGAGCTTTTTACCCCTTAATGAAACGAATTTAGA
AAGAGCCAAAGAGTTTTTAGTGTTTGTGGGTAATGAAAAAGTGGATGCAATGAGCGTTTTAGCTTTGGAAAATCTCAGGG
TTTTATTGAGCGAGCATAACATTAAAAACGATTTAGCCAAATACGCCATGCCGGAGAGCTATAAAACGCATTTAGTGTAT
AGCATTAACGCTAGGAGTTTGCAAAATTTATTGACTTTAAGGAGCAGTAATAAAGCCTTAAAAGAAATGCAAGATTTAGC
CAAAGCCTTATTTGACGCTTTACCTTGCGAGCATCAATATTTGTTTGAAGATTGCTTGAAGCGCTAG

Upstream 100 bases:

>100_bases
TAGCCTTAGAAATCGCTATGCGTTTAAATCATGATGTGGATCACCCAAGAAACTTGGCTAAAAGCGTTACCGTGGAATAA
AAGCGATTAGGAGTAAGATA

Downstream 100 bases:

>100_bases
ATCTAAAAAATACCGCTTCAATAACGCTAATTCTTTAATGTTGTGAAGCACCCAACCGCTAAAGCGATTGGGCTTCCTAG
GCTGATGTTGGGGGAGAGTT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGSKDKELIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRIASL
SVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVGNEKVDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLVY
SINARSLQNLLTLRSSNKALKEMQDLAKALFDALPCEHQYLFEDCLKR

Sequences:

>Translated_208_residues
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGSKDKELIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRIASL
SVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVGNEKVDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLVY
SINARSLQNLLTLRSSNKALKEMQDLAKALFDALPCEHQYLFEDCLKR
>Mature_208_residues
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGSKDKELIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRIASL
SVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVGNEKVDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLVY
SINARSLQNLLTLRSSNKALKEMQDLAKALFDALPCEHQYLFEDCLKR

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 24044; Mature: 24044

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGSKDKELIHRVGNIFRHSSTLEHLYYNFE
CCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEE
IKGLSRGALQELSRHRIASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVGNEK
ECCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCCC
VDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLVYSINARSLQNLLTLRSSNKAL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHCCHHHH
KEMQDLAKALFDALPCEHQYLFEDCLKR
HHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGSKDKELIHRVGNIFRHSSTLEHLYYNFE
CCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEE
IKGLSRGALQELSRHRIASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVGNEK
ECCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCCC
VDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLVYSINARSLQNLLTLRSSNKAL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHCCHHHH
KEMQDLAKALFDALPCEHQYLFEDCLKR
HHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]