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The map label for this gene is glmS [H]

Identifier: 188528302

GI number: 188528302

Start: 1529588

End: 1531381

Strand: Direct

Name: glmS [H]

Synonym: HPSH_07870

Alternate gene names: 188528302

Gene position: 1529588-1531381 (Clockwise)

Preceding gene: 188528301

Following gene: 188528303

Centisome position: 95.09

GC content: 40.86

Gene sequence:

>1794_bases
ATGTGCGGGATTGTAGGTTATATAGGGGATAGCGAGAAAAAATCCATTCTTTTAGAGGGTTTAAAGGAATTAGAATACAG
AGGCTATGACAGCGCTGGTTTAGCCGTATTGAGCGCTGATCGTTTGGAAGTGTTTAAAACTCAAGGGAAATTAGAAAACC
TTACGCTAGAGCTTAAAAATAAAGAGTTTTTGGATTTTGGCGTGAGTATCGCTCACACCAGATGGGCCACGCATGGCAAG
CCAAGCAGCGCCAACGCCCACCCGCATTTTACAGAAAATCTAGCCTTAGTGCATAATGGCATCATTGAAAATTACGCCGT
TTTGAAAAAGGAACTAGAAGAAAAGGGGCATGCGTTTTTAAGCCAAACGGACACGGAAGTGATTGCGCATTTATTAGAAG
AAACGCTTAAAAGCGAGAGCGATTTATTGAAAGCTTTTGAAAAAAGCATCAGCCTTTTAAAAGGGAGTTATGCGGTTTTA
ATGCTCCATAAAAGGGCTAAAGAGAGTCTCTTTTACGCTAAATCTTCTTCGCCTTTAATCGTGGGTAAGGGCAAAGAAGG
GGTGTTTTTTGCGTCAAGTTTGAGCGTGTTAGCCCCTAAAGTGGATCAATTTGTCATTTTAGAAGAAAACAGCGTGGGGC
AGATTTCTTTAGAAAATTTTAAAGATTTAAAAAATATTGAAAACATGAAAGATTACGCTTTTGAGAATAAAGATTATTCT
AAAGGGGATTTTAGGAATTATTTAGAAAAAGAGATTTATGAGCAGCATAGCAGTTTGTTAGAGTGTTTGGAGGGGCGCTT
GGAAGCCTTGAATGTGTATTGCGAGATCGATCCTAAATTTTTAGAAAATGTGAGCGAGATCACGCTGTGTTCTTGCGGGA
GCAGTTACCATGCGAGTTTGGCGAGCGTGTATTTGTTTGAAAGGTTAGCCAAAATAAGAGCGAGGGCCATTTTAGCGAGC
GAATACCGCTACGCCAATTTTAAAAGCAACCCTAACGAGCTTTTTATAGCGATTTCTCAAAGCGGCGAAACCGCTGACAC
TTTAGAGGCGTTAAAATTAGCCAAAGCCCAAGGGCTTAAAACCATTAGTTTGTGTAACGCCCCTTTTAGCATGATGAGCC
GCATTAGCGATCACACGCTTTTGATTAGAGCGGGGGTAGAGCGGAGCGTGGCATCCACTAAGGCGTTTTCTTCGCAAGTG
ATGCTTTTATGGCTTTTGAGCGTGTATATAGGCAAACAGCTAGGGACAATTTCTAAAGAAGAAGAAAAAATCCAGGCTAA
AAACATGCTAAATAGCGTGAATGCGATGAAAGTAGAGTCTAAATTGCATGAAAAGATCAAGCGCTTATCCAAACGCTACT
TGCATGGGCATGGCTTTTTTTATATCGGGCGCGATGTGTTTTACCCGCTCGCTTTAGAAGGAGCGTTAAAACTTAAAGAA
ATCAGCTACTTGCATGCTGAGGGGTATGCGAGCGCGGAGATGAAGCATGGGCCTATTGCGTTAGTGGATTCCAACCTTTT
TACCATTGCTTTATTGTCTAAACATCTGCTATTTGATAAAACCAAAAGCAATATTGAAGAATTGAGCGCTAGGGATTCTA
CGATTTGCGTGTTAAGCTCTGAAATTTTAGAGATCGCTGATGATTTTATCCAATTAGAAGAGAGCGAAAGCTACATGGAA
GAATTTTTCCGCATGAATTTAGCGATGCAACTTTTAGCCTTAGAAATCGCTATGCGTTTAAATCATGATGTGGATCACCC
AAGAAACTTGGCTAAAAGCGTTACCGTGGAATAA

Upstream 100 bases:

>100_bases
GAATGAAGCGTTTTTTACGCAACTAAGCGAAGAAGTGGAGCGATTGAAGGAGCTTATTAACGCTTTAAATAAGATCAAAA
AAGGGTTATTGGTGTTTTAA

Downstream 100 bases:

>100_bases
AAGCGATTAGGAGTAAGATAATGGAAGTGATTTGTAAGCATTACACCCCTTTAGACATTGCAAGCCAAGCGATCCGCACT
TGCTGGCAGAGCTTTGAATA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MCGIVGYIGDSEKKSILLEGLKELEYRGYDSAGLAVLSADRLEVFKTQGKLENLTLELKNKEFLDFGVSIAHTRWATHGK
PSSANAHPHFTENLALVHNGIIENYAVLKKELEEKGHAFLSQTDTEVIAHLLEETLKSESDLLKAFEKSISLLKGSYAVL
MLHKRAKESLFYAKSSSPLIVGKGKEGVFFASSLSVLAPKVDQFVILEENSVGQISLENFKDLKNIENMKDYAFENKDYS
KGDFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASLASVYLFERLAKIRARAILAS
EYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLKTISLCNAPFSMMSRISDHTLLIRAGVERSVASTKAFSSQV
MLLWLLSVYIGKQLGTISKEEEKIQAKNMLNSVNAMKVESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSSEILEIADDFIQLEESESYME
EFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE

Sequences:

>Translated_597_residues
MCGIVGYIGDSEKKSILLEGLKELEYRGYDSAGLAVLSADRLEVFKTQGKLENLTLELKNKEFLDFGVSIAHTRWATHGK
PSSANAHPHFTENLALVHNGIIENYAVLKKELEEKGHAFLSQTDTEVIAHLLEETLKSESDLLKAFEKSISLLKGSYAVL
MLHKRAKESLFYAKSSSPLIVGKGKEGVFFASSLSVLAPKVDQFVILEENSVGQISLENFKDLKNIENMKDYAFENKDYS
KGDFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASLASVYLFERLAKIRARAILAS
EYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLKTISLCNAPFSMMSRISDHTLLIRAGVERSVASTKAFSSQV
MLLWLLSVYIGKQLGTISKEEEKIQAKNMLNSVNAMKVESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSSEILEIADDFIQLEESESYME
EFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE
>Mature_597_residues
MCGIVGYIGDSEKKSILLEGLKELEYRGYDSAGLAVLSADRLEVFKTQGKLENLTLELKNKEFLDFGVSIAHTRWATHGK
PSSANAHPHFTENLALVHNGIIENYAVLKKELEEKGHAFLSQTDTEVIAHLLEETLKSESDLLKAFEKSISLLKGSYAVL
MLHKRAKESLFYAKSSSPLIVGKGKEGVFFASSLSVLAPKVDQFVILEENSVGQISLENFKDLKNIENMKDYAFENKDYS
KGDFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASLASVYLFERLAKIRARAILAS
EYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLKTISLCNAPFSMMSRISDHTLLIRAGVERSVASTKAFSSQV
MLLWLLSVYIGKQLGTISKEEEKIQAKNMLNSVNAMKVESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSSEILEIADDFIQLEESESYME
EFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=31.0595065312046, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=30.2189781021898, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI29570798, Length=199, Percent_Identity=28.643216080402, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=41.3008130081301, Blast_Score=437, Evalue=1e-123,
Organism=Escherichia coli, GI1788651, Length=195, Percent_Identity=27.1794871794872, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532897, Length=428, Percent_Identity=29.9065420560748, Blast_Score=182, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17532899, Length=428, Percent_Identity=29.9065420560748, Blast_Score=182, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17539970, Length=375, Percent_Identity=30.6666666666667, Blast_Score=176, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322745, Length=376, Percent_Identity=33.5106382978723, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6323731, Length=437, Percent_Identity=27.0022883295195, Blast_Score=133, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6323730, Length=210, Percent_Identity=36.6666666666667, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=29.5487627365357, Blast_Score=281, Evalue=9e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67027; Mature: 67027

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGDSEKKSILLEGLKELEYRGYDSAGLAVLSADRLEVFKTQGKLENLTLELKN
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCCEEEEEEECC
KEFLDFGVSIAHTRWATHGKPSSANAHPHFTENLALVHNGIIENYAVLKKELEEKGHAFL
CHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQTDTEVIAHLLEETLKSESDLLKAFEKSISLLKGSYAVLMLHKRAKESLFYAKSSSPLI
HCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHEEEECCCCCEE
VGKGKEGVFFASSLSVLAPKVDQFVILEENSVGQISLENFKDLKNIENMKDYAFENKDYS
EECCCCCEEEECCHHHHCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCC
KGDFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHCCHHHEEEECCCCHHHHHH
ASVYLFERLAKIRARAILASEYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLK
HHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCC
TISLCNAPFSMMSRISDHTLLIRAGVERSVASTKAFSSQVMLLWLLSVYIGKQLGTISKE
EEEECCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EEKIQAKNMLNSVNAMKVESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCHHHHH
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSS
HHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
EILEIADDFIQLEESESYMEEFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGDSEKKSILLEGLKELEYRGYDSAGLAVLSADRLEVFKTQGKLENLTLELKN
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCCEEEEEEECC
KEFLDFGVSIAHTRWATHGKPSSANAHPHFTENLALVHNGIIENYAVLKKELEEKGHAFL
CHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQTDTEVIAHLLEETLKSESDLLKAFEKSISLLKGSYAVLMLHKRAKESLFYAKSSSPLI
HCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHEEEECCCCCEE
VGKGKEGVFFASSLSVLAPKVDQFVILEENSVGQISLENFKDLKNIENMKDYAFENKDYS
EECCCCCEEEECCHHHHCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCC
KGDFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHCCHHHEEEECCCCHHHHHH
ASVYLFERLAKIRARAILASEYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLK
HHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCC
TISLCNAPFSMMSRISDHTLLIRAGVERSVASTKAFSSQVMLLWLLSVYIGKQLGTISKE
EEEECCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EEKIQAKNMLNSVNAMKVESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCHHHHH
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSS
HHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
EILEIADDFIQLEESESYMEEFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]