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The map label for this gene is serS [H]

Identifier: 188528251

GI number: 188528251

Start: 1473685

End: 1474932

Strand: Reverse

Name: serS [H]

Synonym: HPSH_07585

Alternate gene names: 188528251

Gene position: 1474932-1473685 (Counterclockwise)

Preceding gene: 188528252

Following gene: 188528250

Centisome position: 91.69

GC content: 41.11

Gene sequence:

>1248_bases
ATGATTGATAAAAAACTTTTATTGCAAGATTTTGAGATGGTGGCTCTTTCTTTAAAAAAGCGTAATAATGCGATGGATGA
TGCATTGGAGCGCTTGCGCGAAGTCATCACGCATTATAAAAAGCAACTCATTGAATTAGAAGGCTTGCAAGCCTTTCAAA
ACAAGGTTTCTAAAGAATTTGGTATCAAAATGGCTCAAAAAGTGGATACAAGCGATCTCAAAAAAGAGCTAGAAAACAAT
AAAATCAAACTGAATGAGCTTTCCAAAAGCGTGGGCGAATTGGAACAACAAATAGATTTAAGGCTTTCAATAATCCCTAA
TCTGGTGGATGAAAAAACCCCTTTAGGCGCAAGCGAAGAAGACAACATAGAAATTAAAAAAATCTTAACCCCTAGAAATT
TCACTTTCAAACCCAAAGAGCATTTTGAACTCGCTCAACAAAATGGCTGGATTGATTTTGAAAGTGGCGTGAAACTCGCT
AAAAGCCGTTTTTCTGTCATTAGGGGTTTTGGGGCTAAAATTTATCGCGCGCTCATCCATTTAATGTTGGATTTTAATGA
AAAAAATGGCTTTGAAATCATCTACACGCCGGCGTTAGTGAATGAAAAAATGCTTTTTGGGACCGGGCAATTGCCCAAAT
TCAAAGAAGATGTTTTCAAAATAGAAAATGAAAATTTGTATCTGATCCCTACCGCTGAAGTAACGCTCACTAATCTATAC
AACGACACGATTGTTAGCGTTGAAAAACTCCCTATTAAAATGACCGCGCACACGCCTTGTTTTAGGAGTGAAGCAGGGAG
TGCGGGCAAGGACACAAGAGGGATGATAAGACAGCACCAGTTTGATAAAGTGGAGCTAGTGGCTATCACGCACCCTAAAG
AAAGCGATGCCATGCAAGAGCATATGCTAGAGAGCGCGAGCGAAATTTTAAAGGCTTTGGAATTACCGCACCGGTTTGTG
CAATTGTGCAGCGCGGATTTAGGCTTTAGCGCAAGCAACACCATAGATATTGAAGTGTGGCTGCCCGGGCAAAATTGCTA
CAGAGAAATCAGCTCGGTGTCTAACACGAGGGATTTTCAAGCCAGGCGCGCGAAAATCCGCTTCAAAGAGAATCAAAAAA
ACCAATTAGCGCACACCTTAAACGGCTCTTCTTTAGCGGTAGGCAGGACGATGGTCGCTTTAATGGAAAACCACCAGCAA
GCGGATGGGAGCATCCATATTCCTAAGGCGTTAGAAAAATACCTTTAA

Upstream 100 bases:

>100_bases
TTTAGAGGGTAAAATGGGGGCTTTGAGCGCTCAAATGGATAAAAACGATATAGATGAATGGGCTAAATTGTGGCATTTTA
GAACGATTAAAGAGGGTTGA

Downstream 100 bases:

>100_bases
GGCTAGTTTGTGCTGAATGAAGAGCAAAATTCTAAAGGATTAGAAGAAAAAGGGGGTGAAAACAGAAACGAAAAAGAAGC
CCCTTTAAAGGGCATTCATT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MIDKKLLLQDFEMVALSLKKRNNAMDDALERLREVITHYKKQLIELEGLQAFQNKVSKEFGIKMAQKVDTSDLKKELENN
KIKLNELSKSVGELEQQIDLRLSIIPNLVDEKTPLGASEEDNIEIKKILTPRNFTFKPKEHFELAQQNGWIDFESGVKLA
KSRFSVIRGFGAKIYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIVSVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDAMQEHMLESASEILKALELPHRFV
QLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQ
ADGSIHIPKALEKYL

Sequences:

>Translated_415_residues
MIDKKLLLQDFEMVALSLKKRNNAMDDALERLREVITHYKKQLIELEGLQAFQNKVSKEFGIKMAQKVDTSDLKKELENN
KIKLNELSKSVGELEQQIDLRLSIIPNLVDEKTPLGASEEDNIEIKKILTPRNFTFKPKEHFELAQQNGWIDFESGVKLA
KSRFSVIRGFGAKIYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIVSVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDAMQEHMLESASEILKALELPHRFV
QLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQ
ADGSIHIPKALEKYL
>Mature_415_residues
MIDKKLLLQDFEMVALSLKKRNNAMDDALERLREVITHYKKQLIELEGLQAFQNKVSKEFGIKMAQKVDTSDLKKELENN
KIKLNELSKSVGELEQQIDLRLSIIPNLVDEKTPLGASEEDNIEIKKILTPRNFTFKPKEHFELAQQNGWIDFESGVKLA
KSRFSVIRGFGAKIYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIVSVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDAMQEHMLESASEILKALELPHRFV
QLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQ
ADGSIHIPKALEKYL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=329, Percent_Identity=31.6109422492401, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI8923421, Length=330, Percent_Identity=31.8181818181818, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI225579074, Length=330, Percent_Identity=31.8181818181818, Blast_Score=178, Evalue=7e-45,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=46.5116279069767, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539260, Length=421, Percent_Identity=27.790973871734, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17542084, Length=317, Percent_Identity=26.4984227129338, Blast_Score=124, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320226, Length=431, Percent_Identity=32.2505800464037, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321799, Length=359, Percent_Identity=27.5766016713092, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24581334, Length=353, Percent_Identity=30.3116147308782, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI17737985, Length=294, Percent_Identity=30.6122448979592, Blast_Score=139, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47319; Mature: 47319

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKKLLLQDFEMVALSLKKRNNAMDDALERLREVITHYKKQLIELEGLQAFQNKVSKEF
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKMAQKVDTSDLKKELENNKIKLNELSKSVGELEQQIDLRLSIIPNLVDEKTPLGASEE
CCHHHHHCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCC
DNIEIKKILTPRNFTFKPKEHFELAQQNGWIDFESGVKLAKSRFSVIRGFGAKIYRALIH
CCEEEEEEECCCCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
HHHHCCCCCCCEEEEECHHHCCCEEECCCCCCHHHHHHHEECCCCEEEEECCCEEEEECC
NDTIVSVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDAMQE
CCCEEEEECCCEEEECCCCCHHCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHH
HMLESASEILKALELPHRFVQLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHH
ARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQADGSIHIPKALEKYL
HHHHHEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHCC
>Mature Secondary Structure
MIDKKLLLQDFEMVALSLKKRNNAMDDALERLREVITHYKKQLIELEGLQAFQNKVSKEF
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKMAQKVDTSDLKKELENNKIKLNELSKSVGELEQQIDLRLSIIPNLVDEKTPLGASEE
CCHHHHHCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCC
DNIEIKKILTPRNFTFKPKEHFELAQQNGWIDFESGVKLAKSRFSVIRGFGAKIYRALIH
CCEEEEEEECCCCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
HHHHCCCCCCCEEEEECHHHCCCEEECCCCCCHHHHHHHEECCCCEEEEECCCEEEEECC
NDTIVSVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDAMQE
CCCEEEEECCCEEEECCCCCHHCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHH
HMLESASEILKALELPHRFVQLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHH
ARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQADGSIHIPKALEKYL
HHHHHEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA