BacMap

Definition	Helicobacter pylori Shi470, complete genome.
Accession	NC_010698
Length	1,608,548

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The map label for this gene is ppiA [H]

Identifier: 188528211

GI number: 188528211

Start: 1433891

End: 1434379

Strand: Direct

Name: ppiA [H]

Synonym: HPSH_07375

Alternate gene names: 188528211

Gene position: 1433891-1434379 (Clockwise)

Preceding gene: 188528208

Following gene: 188528212

Centisome position: 89.14

GC content: 44.38

Gene sequence:

>489_bases
ATGGATCCAATTAAAACTTATGAAATTAAAGAAGAAGAGCTTGCAAAAACCGCTTACGCCACGATCAAAACCAATAAAGG
CAATATCGCTTTAGAGCTTTTTTATAAAGATGCGCCCCAAGCGGTGAGTAACTTTGTAGCTCTGGCTAAAGAGGGTTTTT
ATAATGGGCTTAGCTTCCATCGTGTGATCGCAGGCTTTGTGGCTCAAGGAGGTTGCCCTTATGGCACAGGCACAGGCGGG
CCAGGACACCGCATTAAATGCGAAGTGGTCCATAACCCCAACAAGCACAAAAGAGGCTCGCTCTCTATGGCGCATGCTGG
AAGAGATACAGGGGGGAGTCAATTTTTCTTGTGTTTTGCGGATTTGCCCCATTTAGATGGCGAGCACACCGTATTTGGCA
AAATCAAAAACGCAGAAGGCCTTAATGTCTTGGATAAAATCAAACAAGGCGATATTATAGAGAGCGTTGTGTTTAGCTCT
TCTCTATAA

Upstream 100 bases:

>100_bases
CAAAAGTATCCTGCCACACTATCGGCCAAAATACCATTTGTTTTAATTTATTGCTATAATAGATCATTTGAATGACAAAA
GCTTATCGCAAAGGTTTATG

Downstream 100 bases:

>100_bases
GGAACAAGAAACTAGACATGCTCATACTCAGCCGCAAAGTTAATGAAGGGATTGTCATTGATGATAACATCCACATTAAA
GTCATTTCCATAGATAGAGG

Product: peptidyl-prolyl cis-trans isomerase B, cyclosporin-type rotamase (ppi)

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVALAKEGFYNGLSFHRVIAGFVAQGGCPYGTGTGG
PGHRIKCEVVHNPNKHKRGSLSMAHAGRDTGGSQFFLCFADLPHLDGEHTVFGKIKNAEGLNVLDKIKQGDIIESVVFSS
SL

Sequences:

>Translated_162_residues
MDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVALAKEGFYNGLSFHRVIAGFVAQGGCPYGTGTGG
PGHRIKCEVVHNPNKHKRGSLSMAHAGRDTGGSQFFLCFADLPHLDGEHTVFGKIKNAEGLNVLDKIKQGDIIESVVFSS
SL
>Mature_162_residues
MDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVALAKEGFYNGLSFHRVIAGFVAQGGCPYGTGTGG
PGHRIKCEVVHNPNKHKRGSLSMAHAGRDTGGSQFFLCFADLPHLDGEHTVFGKIKNAEGLNVLDKIKQGDIIESVVFSS
SL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=129, Percent_Identity=42.6356589147287, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI24308049, Length=132, Percent_Identity=43.1818181818182, Blast_Score=103, Evalue=5e-23,
Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=41.3533834586466, Blast_Score=103, Evalue=5e-23,
Organism=Homo sapiens, GI64276486, Length=134, Percent_Identity=40.2985074626866, Blast_Score=101, Evalue=2e-22,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=43.0769230769231, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI4758950, Length=130, Percent_Identity=43.8461538461538, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI310127646, Length=143, Percent_Identity=39.8601398601399, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310114371, Length=143, Percent_Identity=39.8601398601399, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310119221, Length=143, Percent_Identity=39.8601398601399, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4826932, Length=124, Percent_Identity=41.9354838709677, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI256017253, Length=129, Percent_Identity=43.4108527131783, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI221139811, Length=129, Percent_Identity=43.4108527131783, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI256017251, Length=129, Percent_Identity=43.4108527131783, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI310129267, Length=130, Percent_Identity=41.5384615384615, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI310120620, Length=130, Percent_Identity=41.5384615384615, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI4505991, Length=129, Percent_Identity=44.9612403100775, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI20911035, Length=139, Percent_Identity=33.8129496402878, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI310110104, Length=130, Percent_Identity=41.5384615384615, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI22547212, Length=134, Percent_Identity=42.5373134328358, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI7657473, Length=134, Percent_Identity=42.5373134328358, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI22547215, Length=134, Percent_Identity=42.5373134328358, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI178057341, Length=133, Percent_Identity=41.3533834586466, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI169164185, Length=130, Percent_Identity=39.2307692307692, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI169163623, Length=130, Percent_Identity=39.2307692307692, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI169163387, Length=130, Percent_Identity=39.2307692307692, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI209417936, Length=130, Percent_Identity=40, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI30102944, Length=130, Percent_Identity=40, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI219842199, Length=130, Percent_Identity=40, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI5031987, Length=130, Percent_Identity=41.5384615384615, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI6631100, Length=137, Percent_Identity=36.4963503649635, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI45439316, Length=174, Percent_Identity=37.3563218390805, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310127745, Length=126, Percent_Identity=38.8888888888889, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310119290, Length=126, Percent_Identity=38.8888888888889, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310132444, Length=131, Percent_Identity=39.6946564885496, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310113152, Length=131, Percent_Identity=39.6946564885496, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310114540, Length=126, Percent_Identity=38.8888888888889, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI150418007, Length=131, Percent_Identity=39.6946564885496, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI5174637, Length=162, Percent_Identity=38.2716049382716, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI303305009, Length=162, Percent_Identity=38.2716049382716, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI42560244, Length=124, Percent_Identity=37.0967741935484, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI169214050, Length=128, Percent_Identity=39.0625, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI239751853, Length=128, Percent_Identity=39.0625, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI113428306, Length=128, Percent_Identity=39.0625, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI5454154, Length=138, Percent_Identity=36.9565217391304, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1789763, Length=135, Percent_Identity=42.2222222222222, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1786736, Length=139, Percent_Identity=37.410071942446, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=139, Percent_Identity=43.8848920863309, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71997782, Length=133, Percent_Identity=42.8571428571429, Blast_Score=112, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17532641, Length=130, Percent_Identity=40, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71980594, Length=132, Percent_Identity=40.1515151515151, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71980590, Length=132, Percent_Identity=40.1515151515151, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17506307, Length=132, Percent_Identity=49.2424242424242, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17506311, Length=139, Percent_Identity=39.568345323741, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17552780, Length=149, Percent_Identity=42.9530201342282, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32563659, Length=139, Percent_Identity=33.8129496402878, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551284, Length=140, Percent_Identity=39.2857142857143, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17551282, Length=140, Percent_Identity=39.2857142857143, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17566266, Length=136, Percent_Identity=37.5, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=138, Percent_Identity=39.8550724637681, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559074, Length=137, Percent_Identity=37.2262773722628, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=130, Percent_Identity=37.6923076923077, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552782, Length=137, Percent_Identity=36.4963503649635, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552784, Length=142, Percent_Identity=34.5070422535211, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=135, Percent_Identity=37.037037037037, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321848, Length=132, Percent_Identity=40.1515151515151, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320359, Length=132, Percent_Identity=40.1515151515151, Blast_Score=74, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320510, Length=134, Percent_Identity=39.5522388059701, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=132, Percent_Identity=39.3939393939394, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323246, Length=127, Percent_Identity=37.007874015748, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922376, Length=162, Percent_Identity=39.5061728395062, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17986117, Length=132, Percent_Identity=41.6666666666667, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357249, Length=142, Percent_Identity=40.1408450704225, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922912, Length=119, Percent_Identity=47.0588235294118, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=35.3383458646617, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130249, Length=130, Percent_Identity=44.6153846153846, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355677, Length=145, Percent_Identity=36.551724137931, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45549139, Length=129, Percent_Identity=41.8604651162791, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24664125, Length=129, Percent_Identity=39.5348837209302, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357783, Length=129, Percent_Identity=39.5348837209302, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650807, Length=130, Percent_Identity=37.6923076923077, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136360, Length=147, Percent_Identity=37.4149659863946, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17647301, Length=132, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586038, Length=137, Percent_Identity=35.7664233576642, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17514; Mature: 17514

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVALAKEGFYNGLSFH
CCCCCCCCCCHHHHHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHH
RVIAGFVAQGGCPYGTGTGGPGHRIKCEVVHNPNKHKRGSLSMAHAGRDTGGSQFFLCFA
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCEEEEEEE
DLPHLDGEHTVFGKIKNAEGLNVLDKIKQGDIIESVVFSSSL
CCCCCCCCEEEEEEECCCCCCCHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVALAKEGFYNGLSFH
CCCCCCCCCCHHHHHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHH
RVIAGFVAQGGCPYGTGTGGPGHRIKCEVVHNPNKHKRGSLSMAHAGRDTGGSQFFLCFA
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCEEEEEEE
DLPHLDGEHTVFGKIKNAEGLNVLDKIKQGDIIESVVFSSSL
CCCCCCCCEEEEEEECCCCCCCHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]