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The map label for this gene is lon [H]

Identifier: 188528169

GI number: 188528169

Start: 1387124

End: 1389592

Strand: Direct

Name: lon [H]

Synonym: HPSH_07140

Alternate gene names: 188528169

Gene position: 1387124-1389592 (Clockwise)

Preceding gene: 188528168

Following gene: 188528170

Centisome position: 86.23

GC content: 41.19

Gene sequence:

>2469_bases
ATGACTGAAGATTTTCCTAAAATTCTGCCTTTATTGGTGGAAGAAGACACCTTTTTATACCCCTTTATGATAGCCCCTAT
TTTTTTGCAAAATAATGCGAGCATTAAGGCGTTAGCTTACGCTAAAACCAATAAATCATTAGTCTTTATTGCATGCCAAA
AAGACAAATTGAATGACAATGAAGCCCCTTATTATGATGTGGGGGTGATTGGATCTGTTATGCGTGAAGCCAACATGCCT
AATGGGCGCGTGAAATTGCTCTTTAATGGCATCGCTAAGGGGCGTATTTTAGAGCCTGTCAAAGAAAACGAGCAAGGCTT
TTTAGAAGCTCAAATAATCCCTATTGAATATTTAGAATACGATAAAGAAAACATTCAAGCTATCATAGAAGTGTTAAAAG
AAAAAGTGATCACTCTAGCCAATGTCAGCTCACTCTTTCCTCCGGATTTGATCAAGGCTTTAGAAGACAATGACGATCCT
AACCGCATCGCTGATTTAATCGCAGCGGCCTTGCGTTTGAAAAAAGATCAGGCGTATTCTCTTTTTGCCAGCGACAACAC
CGAGCAGCGCTTGTTGGATTTGATTGATATTGTGATAGAAGAGACTAAAACCCAAAAACTCCAAAAAGAAATCAAATCCA
AAGTCCATCAAAAAATGGAGCAAACCAATAAGGAATTTTTCTTAAAAGAGCAGCTCAAACAGATCCAAAAAGAGCTTGGC
ACAGACAAACAGCGAGATGAAGATTTAAACCAATACTACCAAAAACTAGAGAGCGTCAAGCCTTTTTTAAAAGAAGAAGC
GTTTAAGGAGATTAAAAAGCAAATTGACCGGCTAAGCCGAACCCATGCGGACAGCTCTGATAGTGCGACTTTACAAAATT
ATATTGAAACCATGTTAGATGTGCCTTTTGGGCAATACGGGAAAAAAGCGCTTGACATTAAGCATGTGAAAGAGCAACTA
GACAAGGATCATTATTCCTTAAAAAGGCCTAAAGAGCGTATTGTAGAATACTTTGCGACCATGCAACTTTTAGAAATGCG
CCACAAGAAAAAGCAAGAAAAAAAAGACAAAGCTAAAGGCACGATTTTATGCTTTTATGGGCCTCCTGGCGTGGGTAAAA
CGAGTTTGGCTAATTCCATTGCTAAAGCGATAGAGCGCCCTTTAGTTCGGATCGCTTTGGGGGGATTAGAAGATGTGAAT
GAATTGAGAGGGCACAGACGCACTTATATAGGCTCAATGCCCGGGCGCATTGTCCAAGGGCTTATTGAAGCCAAAAAGAT
GAATCCGGTCATGGTTTTAGATGAAATTGATAAGGTGGATAGGAGCGTTAGGGGTGATCCAGCGAGCGCTTTATTAGAGA
TCTTAGACCCTGAGCAAAATATCGCTTTTAGGGATCATTATGCGAATTTTAGCATTGATTTATCGCAAGTGATTTTTATC
GCTACCGCTAATAATATTGACAGAATCCCGGCTCCTTTAAGAGACAGAATGGAATTTATCAGCGTGTCCAGCTATACGCC
TAATGAAAAAGAAGAAATCGCTAAAAACTACCTCATCCCCCAAGAATTAGAAAAGCACGCCTTAAAGCCTAGCGAAGTTG
AAATTAGCCATGAGTGTTTGAAACTCATTATTGAAAAATACACCAGAGAAGCGGGCGTTAGGGATTTACGAAGACAAATC
GCAACGATTATGCGTAAAGTGGCTTTAAAATACCTAGAAGATAGCCAACACAAAAAAGGGCGAACCAAAAAAGGCGAAGA
TAGAAAAAGCGAAAATGAAGATTTCTGCGTCTCTGTCACGCCTAGCAACCTTAAAGAGTATTTAGAACGCATGGTGTTTG
AAATTGACCCCATAGATGAAGAAAATAAAATCGGTATCGTCAATGGTTTGGCATGGACTCCAGTAGGCGGCGATGTGCTT
AAAATTGAAGCGCTTAAGATTAGAGGCAAGGGGGAATTGAAGCTCACCGGGAGCTTAGGCGATGTGATGAAAGAATCCGC
CATTATCGCCTTTTCTGTTGTCAAAGCCTTATTGGATAACGAAACCTTAAAAGCGCCTAAAATCCCTAGCGAAACCCCTA
AAGACGCAGAGGGCAAGAAAAAGAAAAAAGCGCTGAAAGTTTATAACGCTTATGATTTGCATTTGCATGTCCCTGAGGGG
GCTACGCCTAAAGACGGCCCGAGCGCTGGGATCGCTATGGCGAGCGTGATGGCGAGCATTTTGTGCGATAGGGCTACAAG
AAGCGAAGTGGCAATGACGGGCGAATTGACTTTGAGCGGGGAAGTTTTACCCATAGGGGGGTTGAAAGAAAAATTGATCG
CTGCTTTTAAAGCCGGCATTAAAACCGCTCTCATTCCTGTCAAAAATTACGAAAGGGATTTAGATGAAATCCCTGCTGAA
GTGCGAGAGAATTTAAACATCGTTGCGGTGAAAAACATCGCTGAAGTGCTAGAAAAAACTTTGCTTTAA

Upstream 100 bases:

>100_bases
AAAGAGACTAAACCCAAACCATCGCACATGCCTTGGTATGTGTTAATCTTTGATTGGTAGGATATTTCAAACCATGCAAA
TTATAACAGAGAGATGAAAA

Downstream 100 bases:

>100_bases
AATTTGGCATGAAAGCAGGCATTATTGGTTTAGGGCTTATGGGGGGGAGTTTGGGGCTGGCCTTGCAAGAATGGGGGCGT
TTTAAAAGCGTTACAGGCTA

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 822; Mature: 821

Protein sequence:

>822_residues
MTEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKALAYAKTNKSLVFIACQKDKLNDNEAPYYDVGVIGSVMREANMP
NGRVKLLFNGIAKGRILEPVKENEQGFLEAQIIPIEYLEYDKENIQAIIEVLKEKVITLANVSSLFPPDLIKALEDNDDP
NRIADLIAAALRLKKDQAYSLFASDNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEFFLKEQLKQIQKELG
TDKQRDEDLNQYYQKLESVKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLDVPFGQYGKKALDIKHVKEQL
DKDHYSLKRPKERIVEYFATMQLLEMRHKKKQEKKDKAKGTILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVN
ELRGHRRTYIGSMPGRIVQGLIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNIAFRDHYANFSIDLSQVIFI
ATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECLKLIIEKYTREAGVRDLRRQI
ATIMRKVALKYLEDSQHKKGRTKKGEDRKSENEDFCVSVTPSNLKEYLERMVFEIDPIDEENKIGIVNGLAWTPVGGDVL
KIEALKIRGKGELKLTGSLGDVMKESAIIAFSVVKALLDNETLKAPKIPSETPKDAEGKKKKKALKVYNAYDLHLHVPEG
ATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALIPVKNYERDLDEIPAE
VRENLNIVAVKNIAEVLEKTLL

Sequences:

>Translated_822_residues
MTEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKALAYAKTNKSLVFIACQKDKLNDNEAPYYDVGVIGSVMREANMP
NGRVKLLFNGIAKGRILEPVKENEQGFLEAQIIPIEYLEYDKENIQAIIEVLKEKVITLANVSSLFPPDLIKALEDNDDP
NRIADLIAAALRLKKDQAYSLFASDNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEFFLKEQLKQIQKELG
TDKQRDEDLNQYYQKLESVKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLDVPFGQYGKKALDIKHVKEQL
DKDHYSLKRPKERIVEYFATMQLLEMRHKKKQEKKDKAKGTILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVN
ELRGHRRTYIGSMPGRIVQGLIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNIAFRDHYANFSIDLSQVIFI
ATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECLKLIIEKYTREAGVRDLRRQI
ATIMRKVALKYLEDSQHKKGRTKKGEDRKSENEDFCVSVTPSNLKEYLERMVFEIDPIDEENKIGIVNGLAWTPVGGDVL
KIEALKIRGKGELKLTGSLGDVMKESAIIAFSVVKALLDNETLKAPKIPSETPKDAEGKKKKKALKVYNAYDLHLHVPEG
ATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALIPVKNYERDLDEIPAE
VRENLNIVAVKNIAEVLEKTLL
>Mature_821_residues
TEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKALAYAKTNKSLVFIACQKDKLNDNEAPYYDVGVIGSVMREANMPN
GRVKLLFNGIAKGRILEPVKENEQGFLEAQIIPIEYLEYDKENIQAIIEVLKEKVITLANVSSLFPPDLIKALEDNDDPN
RIADLIAAALRLKKDQAYSLFASDNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEFFLKEQLKQIQKELGT
DKQRDEDLNQYYQKLESVKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLDVPFGQYGKKALDIKHVKEQLD
KDHYSLKRPKERIVEYFATMQLLEMRHKKKQEKKDKAKGTILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVNE
LRGHRRTYIGSMPGRIVQGLIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNIAFRDHYANFSIDLSQVIFIA
TANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECLKLIIEKYTREAGVRDLRRQIA
TIMRKVALKYLEDSQHKKGRTKKGEDRKSENEDFCVSVTPSNLKEYLERMVFEIDPIDEENKIGIVNGLAWTPVGGDVLK
IEALKIRGKGELKLTGSLGDVMKESAIIAFSVVKALLDNETLKAPKIPSETPKDAEGKKKKKALKVYNAYDLHLHVPEGA
TPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALIPVKNYERDLDEIPAEV
RENLNIVAVKNIAEVLEKTLL

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=742, Percent_Identity=35.9838274932615, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI31377667, Length=792, Percent_Identity=36.489898989899, Blast_Score=466, Evalue=1e-131,
Organism=Escherichia coli, GI1786643, Length=819, Percent_Identity=40.7814407814408, Blast_Score=576, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17505831, Length=699, Percent_Identity=37.4821173104435, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17556486, Length=678, Percent_Identity=32.7433628318584, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319449, Length=704, Percent_Identity=37.0738636363636, Blast_Score=460, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24666867, Length=702, Percent_Identity=37.1794871794872, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI221513036, Length=702, Percent_Identity=37.1794871794872, Blast_Score=451, Evalue=1e-127,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 92762; Mature: 92631

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKALAYAKTNKSLVFIACQKDKLNDN
CCCCHHHHHHHHCCCCCEEHHHHHHHHHEECCCCEEEEEEEECCCCEEEEEEECCCCCCC
EAPYYDVGVIGSVMREANMPNGRVKLLFNGIAKGRILEPVKENEQGFLEAQIIPIEYLEY
CCCEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHCCCCCCEEEEEEEHHHHHC
DKENIQAIIEVLKEKVITLANVSSLFPPDLIKALEDNDDPNRIADLIAAALRLKKDQAYS
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEE
LFASDNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEFFLKEQLKQIQKELG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDKQRDEDLNQYYQKLESVKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
VPFGQYGKKALDIKHVKEQLDKDHYSLKRPKERIVEYFATMQLLEMRHKKKQEKKDKAKG
CCCCCCCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVNELRGHRRTYIGSMPGRIVQG
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHH
LIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNIAFRDHYANFSIDLSQVIFI
HHHHHHCCCEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHCCCCCCEEEHHHEEEE
ATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECL
EECCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHH
KLIIEKYTREAGVRDLRRQIATIMRKVALKYLEDSQHKKGRTKKGEDRKSENEDFCVSVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
PSNLKEYLERMVFEIDPIDEENKIGIVNGLAWTPVGGDVLKIEALKIRGKGELKLTGSLG
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCEECCCCCCEEEEEEEEECCCCCEEEECCHH
DVMKESAIIAFSVVKALLDNETLKAPKIPSETPKDAEGKKKKKALKVYNAYDLHLHVPEG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCC
ATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEECCCHHHHHHHHHHHCH
KTALIPVKNYERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL
HHEEEECHHHHCCHHHCCHHHHCCCCEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
TEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKALAYAKTNKSLVFIACQKDKLNDN
CCCHHHHHHHHCCCCCEEHHHHHHHHHEECCCCEEEEEEEECCCCEEEEEEECCCCCCC
EAPYYDVGVIGSVMREANMPNGRVKLLFNGIAKGRILEPVKENEQGFLEAQIIPIEYLEY
CCCEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHCCCCCCEEEEEEEHHHHHC
DKENIQAIIEVLKEKVITLANVSSLFPPDLIKALEDNDDPNRIADLIAAALRLKKDQAYS
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEE
LFASDNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEFFLKEQLKQIQKELG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDKQRDEDLNQYYQKLESVKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
VPFGQYGKKALDIKHVKEQLDKDHYSLKRPKERIVEYFATMQLLEMRHKKKQEKKDKAKG
CCCCCCCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVNELRGHRRTYIGSMPGRIVQG
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHH
LIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNIAFRDHYANFSIDLSQVIFI
HHHHHHCCCEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHCCCCCCEEEHHHEEEE
ATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECL
EECCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHH
KLIIEKYTREAGVRDLRRQIATIMRKVALKYLEDSQHKKGRTKKGEDRKSENEDFCVSVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
PSNLKEYLERMVFEIDPIDEENKIGIVNGLAWTPVGGDVLKIEALKIRGKGELKLTGSLG
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCEECCCCCCEEEEEEEEECCCCCEEEECCHH
DVMKESAIIAFSVVKALLDNETLKAPKIPSETPKDAEGKKKKKALKVYNAYDLHLHVPEG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCC
ATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEECCCHHHHHHHHHHHCH
KTALIPVKNYERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL
HHEEEECHHHHCCHHHCCHHHHCCCCEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]