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The map label for this gene is nadC [H]

Identifier: 188528144

GI number: 188528144

Start: 1361959

End: 1362780

Strand: Reverse

Name: nadC [H]

Synonym: HPSH_07015

Alternate gene names: 188528144

Gene position: 1362780-1361959 (Counterclockwise)

Preceding gene: 188528145

Following gene: 188528143

Centisome position: 84.72

GC content: 41.24

Gene sequence:

>822_bases
ATGGAAATTAAAACCTTTTTAGAATGCGCTTTAAAAGAAGATTTAGGGCATGGGGATTTGTTTGAAAGGGTGTTAGAAAA
AGACTTTAAAGCCACAGCCTTTGTTAGGGCTAAACAAGAGGGCGTGTTTTCAGGCGAAAAATACGCTTTAGAGTTGTTGG
AAATGACTGGCATTGAATGCGTTCAAACGATTAAGGATAAAGAGTGCTTCAAGCCTAAAGACACTTTAATGGAGATTAGG
GGGGATTTTAGCATGCTTTTAAAGGTTGAGCGCACCCTTTTAAACCTTTTGCAACACAGCAGCGGGATCGCTACTTTAAC
GAGTCGTTTTGTGAAAGCCTTAAACTCCCATGAAGTGCGTTTGTTGGACACACGAAAAACCAGACCCCTTTTAAGGATCT
TTGAAAAATATTCCGTGCTTAATGGGGGAGCGAGCAACCACCGCTTAGGGCTAGATGACGCTTTAATGCTTAAAGACACG
CATTTAAAGCATGTCAAAGATCTCAAAAGCTTTTTAACGCATGCCAGAAAAAACTTGCCTTTCACGGCTAAAATTGAAAT
TGAATGCGAGAGCTTTGAAGAGGCCAAAAACGCCATGAATGCGGGAGCGGATATTGTGATGTGCGATAATGTGAGCGTTT
TAGAGACTAAAGAAATTGCCGCTTATAGAGATATGCATTATCCCTTTGTTTTATTGGAAGCGAGCGGGAACATTTCACTA
GAGAGCATCAACGCTTACGCTAAAAGCGGTGTGGATGCCATTAGCGTAGGGGCTTTAATCCATCAAGCCACTTTTATTGA
CATGCACATGAAAATGGCTTAA

Upstream 100 bases:

>100_bases
AGGCTTATAAAAACCACAGGGCTTTTAACGCGATTGAATTAAAAGATGAGGTGGCGCGTTTGGCCAAACTCGCTTTAACT
AAAATGATGGAGTTGTCCTA

Downstream 100 bases:

>100_bases
AGACTTTAAAAAGGGTTATTAGCATGCTAAAAGAATATTTAGAAAGCATTAAAGATCTTACGCCTGAAAAGAATGAACTC
ACGCACCGCCCTTCTTTATA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MEIKTFLECALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTIKDKECFKPKDTLMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLKHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNVSVLETKEIAAYRDMHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA

Sequences:

>Translated_273_residues
MEIKTFLECALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTIKDKECFKPKDTLMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLKHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNVSVLETKEIAAYRDMHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
>Mature_273_residues
MEIKTFLECALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTIKDKECFKPKDTLMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLKHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNVSVLETKEIAAYRDMHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=274, Percent_Identity=30.2919708029197, Blast_Score=128, Evalue=5e-30,
Organism=Escherichia coli, GI1786299, Length=279, Percent_Identity=34.7670250896057, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6321162, Length=275, Percent_Identity=33.8181818181818, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30717; Mature: 30717

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKTFLECALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIEC
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VQTIKDKECFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVR
HHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLP
EEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTAKIEIECESFEEAKNAMNAGADIVMCDNVSVLETKEIAAYRDMHYPFVLLEASGNISL
EEEEEEEEEHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCEEH
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MEIKTFLECALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIEC
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VQTIKDKECFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVKALNSHEVR
HHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLP
EEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTAKIEIECESFEEAKNAMNAGADIVMCDNVSVLETKEIAAYRDMHYPFVLLEASGNISL
EEEEEEEEEHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCEEH
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]