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The map label for this gene is trpE [H]

Identifier: 188528071

GI number: 188528071

Start: 1306734

End: 1308371

Strand: Reverse

Name: trpE [H]

Synonym: HPSH_06640

Alternate gene names: 188528071

Gene position: 1308371-1306734 (Counterclockwise)

Preceding gene: 188528072

Following gene: 188528070

Centisome position: 81.34

GC content: 39.5

Gene sequence:

>1638_bases
TTGAATTTATCGCACCAAATCTTTCTTGCCACACACAAGAAAGATAACGGCAACAAGCACCACACAAATAACCTTTTATT
GCCCATTTATCTATTTCTTGTAGAATGCAAGTTTATTTTTAGCGTGAAGAAATTGATGATCAGTCTAGTAGAAAAAGCCC
CTTACATTCCCTATCCCCTAGCTCTTTATGAAAAATTAGAGCAACAGCACACCTTGCTTTTTGAAAGCGCTGAGATTGAG
AGTAAAGCGCACACCAAATCCCTTTTAATGGCTAAAGCCTGTTTGAAGCTGATTTGCAACCACAATATCGTAACTATCAC
TAGTCTAACGCCTAATGGCGGGGCGTTTTTGCAAAAATTGAGTGCGTTTTTTAAAACGCCTATACAAGACAATGCCCTAA
TTTTAACCTACACCAAAAATAAAAAAACGCAAGATGAGTTTTTAAAGCTCTTTGAGCCTAGCCCTTTTGACGCTTTAAGG
GGGATTTTTAAAAGCGTTAAAACAAAACCCAAACACCCCTTTACGCTTTTAAGCGCGGGCGTTTTTTCTTTTGAAATGCT
CAATTTTTTTGAAGACTTGCCTCACTTAAAAGCGCAAGACAACACAGCGCATGACTTTATTTTTTTTGTTGCACAAAATT
TGATCATCATAGACCATAAAGAAAAAAGCGCTGAAATCTTGGGGGCGTGTTTTGATGAGCGTTTTAAAACAGAGATAGCC
CAAGAATTACAGGATTTAAAAGAGTTGGCTAAAAACATCAAAAGCGATTTTATCCCTAAAAAATCCAAGCAAAGTAAAGA
AGTTAGCACTAATTGCAGCGATAGCGAGTTTGAAAAAAAGGCGCTATCCTTACAAGAAGAAATCAAAAAAGGCGAGATTT
TTCAAGCGGTGTTGTCGCGTAGCTTTTATATGGAGTGCTTGGAGGGTTTGAGCGCGTATTACCATTTAAAGCTGACTAAT
CCTAGCCCCTATATGTTCTATATCAAAGACGGCGATTTTGTTCTTTTTGGGGCAAGCCCTGAGAGCGCTTTAAAATACAA
CGCTTTAACCAATACGGCTGAAATTTATCCCATTGCTGGCACTCGTTTAAGGGGTAAGGACAAACAAGGGAATATTGATT
ACGATTTAGACAGTAAAATGGAATTTGATTTGCAACACGATTATAAAGAAAGGGCTGAACACATCATGCTAGTGGATTTA
GCCAGAAACGACATGGCCAGAGTTTCAAAAAAACGCTATTGCGATAAGCTTTTAAAAGTGGATAAGTATTCCAATGTCAT
GCATTTAGTCTCAAGGGTTGTTGGGGAATTGAAAAAAGGGTGCGATAGTTTGCATGCTTACAGGAGCTTTATGAACGCCG
GCACGCTTAGTGGGGCGCCTAAAATTTCTGCGATCAGGCTCATTTACCAATTGGAAAACCAAAGGAGAGGCTCTTATGGG
GGGAGTGTGGGGTATTTAAATAGCGAGGGTTCTATGGATTCTTGCATCACTATCCGTTCATGTTTTGTCAAAAACAATAG
GGCCGTGATCCAAGCAGGAGCTGGTATTGTGCTAGACAGCGTGCCACAAAACGAAGCGAATGAAACAAGAGCCAAAGCAC
AAGCCCTTATTGATGCGATCAGGAAAACAATTTTATGA

Upstream 100 bases:

>100_bases
AGATGGCGGCCTTTCAATGAGCGTTTTTTAGGCATCACCCCGCCTAATGGCTCAAACGATATGGGTTTGATTGACATTGA
AAAAGAGGGTGAAACCATCC

Downstream 100 bases:

>100_bases
AAATCTTTTTTATAGATAATTTTGATTCTTTCTCTTATAACTTGGTGTATGAATTAGAGTGTTTGGGTTATGAAGTGGCT
GTTTATCAAAACGATATTGA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MNLSHQIFLATHKKDNGNKHHTNNLLLPIYLFLVECKFIFSVKKLMISLVEKAPYIPYPLALYEKLEQQHTLLFESAEIE
SKAHTKSLLMAKACLKLICNHNIVTITSLTPNGGAFLQKLSAFFKTPIQDNALILTYTKNKKTQDEFLKLFEPSPFDALR
GIFKSVKTKPKHPFTLLSAGVFSFEMLNFFEDLPHLKAQDNTAHDFIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIA
QELQDLKELAKNIKSDFIPKKSKQSKEVSTNCSDSEFEKKALSLQEEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTN
PSPYMFYIKDGDFVLFGASPESALKYNALTNTAEIYPIAGTRLRGKDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDL
ARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAIRLIYQLENQRRGSYG
GSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNEANETRAKAQALIDAIRKTIL

Sequences:

>Translated_545_residues
MNLSHQIFLATHKKDNGNKHHTNNLLLPIYLFLVECKFIFSVKKLMISLVEKAPYIPYPLALYEKLEQQHTLLFESAEIE
SKAHTKSLLMAKACLKLICNHNIVTITSLTPNGGAFLQKLSAFFKTPIQDNALILTYTKNKKTQDEFLKLFEPSPFDALR
GIFKSVKTKPKHPFTLLSAGVFSFEMLNFFEDLPHLKAQDNTAHDFIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIA
QELQDLKELAKNIKSDFIPKKSKQSKEVSTNCSDSEFEKKALSLQEEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTN
PSPYMFYIKDGDFVLFGASPESALKYNALTNTAEIYPIAGTRLRGKDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDL
ARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAIRLIYQLENQRRGSYG
GSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNEANETRAKAQALIDAIRKTIL
>Mature_545_residues
MNLSHQIFLATHKKDNGNKHHTNNLLLPIYLFLVECKFIFSVKKLMISLVEKAPYIPYPLALYEKLEQQHTLLFESAEIE
SKAHTKSLLMAKACLKLICNHNIVTITSLTPNGGAFLQKLSAFFKTPIQDNALILTYTKNKKTQDEFLKLFEPSPFDALR
GIFKSVKTKPKHPFTLLSAGVFSFEMLNFFEDLPHLKAQDNTAHDFIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIA
QELQDLKELAKNIKSDFIPKKSKQSKEVSTNCSDSEFEKKALSLQEEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTN
PSPYMFYIKDGDFVLFGASPESALKYNALTNTAEIYPIAGTRLRGKDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDL
ARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAIRLIYQLENQRRGSYG
GSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNEANETRAKAQALIDAIRKTIL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=502, Percent_Identity=45.8167330677291, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1788114, Length=397, Percent_Identity=28.2115869017632, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1786809, Length=220, Percent_Identity=28.1818181818182, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=281, Percent_Identity=42.3487544483986, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324361, Length=374, Percent_Identity=23.2620320855615, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 61748; Mature: 61748

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSHQIFLATHKKDNGNKHHTNNLLLPIYLFLVECKFIFSVKKLMISLVEKAPYIPYPL
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
ALYEKLEQQHTLLFESAEIESKAHTKSLLMAKACLKLICNHNIVTITSLTPNGGAFLQKL
HHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHH
SAFFKTPIQDNALILTYTKNKKTQDEFLKLFEPSPFDALRGIFKSVKTKPKHPFTLLSAG
HHHHCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
VFSFEMLNFFEDLPHLKAQDNTAHDFIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHH
QELQDLKELAKNIKSDFIPKKSKQSKEVSTNCSDSEFEKKALSLQEEIKKGEIFQAVLSR
HHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SFYMECLEGLSAYYHLKLTNPSPYMFYIKDGDFVLFGASPESALKYNALTNTAEIYPIAG
HHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCHHHEECCCCCCCEEEECCC
TRLRGKDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDLARNDMARVSKKRYCDKLLKV
CEECCCCCCCCCCCCCCCCEECCHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
DKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAIRLIYQLENQRRGSYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
GSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNEANETRAKAQALIDAI
CCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHH
RKTIL
HHHCC
>Mature Secondary Structure
MNLSHQIFLATHKKDNGNKHHTNNLLLPIYLFLVECKFIFSVKKLMISLVEKAPYIPYPL
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
ALYEKLEQQHTLLFESAEIESKAHTKSLLMAKACLKLICNHNIVTITSLTPNGGAFLQKL
HHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHH
SAFFKTPIQDNALILTYTKNKKTQDEFLKLFEPSPFDALRGIFKSVKTKPKHPFTLLSAG
HHHHCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
VFSFEMLNFFEDLPHLKAQDNTAHDFIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHH
QELQDLKELAKNIKSDFIPKKSKQSKEVSTNCSDSEFEKKALSLQEEIKKGEIFQAVLSR
HHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SFYMECLEGLSAYYHLKLTNPSPYMFYIKDGDFVLFGASPESALKYNALTNTAEIYPIAG
HHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCHHHEECCCCCCCEEEECCC
TRLRGKDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDLARNDMARVSKKRYCDKLLKV
CEECCCCCCCCCCCCCCCCEECCHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
DKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAIRLIYQLENQRRGSYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
GSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNEANETRAKAQALIDAI
CCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHH
RKTIL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]