Click here to switch to the map view.

The map label for this gene is trpC [H]

Identifier: 188528068

GI number: 188528068

Start: 1303798

End: 1305156

Strand: Reverse

Name: trpC [H]

Synonym: HPSH_06625

Alternate gene names: 188528068

Gene position: 1305156-1303798 (Counterclockwise)

Preceding gene: 188528069

Following gene: 188528067

Centisome position: 81.14

GC content: 37.01

Gene sequence:

>1359_bases
ATGCCTAGCGTGTTAGAAAACATCCTTAAAGACAAGCTCCTAGAAGTTTCTGTGCTTAAAAAAAATCACGCTTTACCGAC
AAACATAAACCCAAGCGATAGGGATTTTAAAAAGGCGTTACTAGAAAAAAAGACCAGCTTTATTTTAGAATGCAAAAAAG
CATCGCCCTCTAAAGGTTTAATCAGAAAAGATTTTGATCTGTTGGAAATAGCCAAGACTTATGAAAAATTCGCCTCTTGC
ATTTCGGTTTTAGCCGATTCTAAATATTTTTTAGGCTCTTATGAAAACATTAAGATTGTTTCGCAACATTCCATTAAGCC
CATTTTATGCAAAGATTTTATCATTGATGCTTTTCAAATCAAACTCGCTAGAATGATGGGGGCTAATGCGGTGCTTTTAA
TGCTAAGCGTATTAGACGATAAGAATTATTTAGAGCTTTTCAATCTCGCTAAATCCTTAAACATGAGCGTACTGACTGAA
GTTTCCAACCAGCAAGAAATCAAGCGCTTGCTCAAACTCCAATACGACATTATCGGCATCAATAACAGGGATTTACACAC
CTTAAAAACCGACATTAACAACACGCTCAAATTACGCCCCCTTTTGCCTAAAGACGCGCTCGTGGTGAGTGAGTCCGGTA
TTTATTCGCATGCGCAAATCAAAGCCCTAGCCCCTTATGTGAATGGCTTTTTAGTGGGCAGCTCTTTAATGAAAGAAAAG
GATTTGAAAAAAGCGTGTATTAAATTGATTTTAGGCGAAAATAAAGTGTGCGGGCTTACAAGAATTAAAGACGCTAAAGC
CGTTTATAAAAACCATTTTATTTATGGAGGTTTGATTTTTGAAAAATCTTCGCCCAGATACATCAAGCCTAAAGAAGCCC
TAAAAATCACAAAAGCGGTTAAAAAATTGGATTTTGTGGGCGTGTTTGTGAAAGATAAGATTAAAAAAATTCAAAAAATC
GCTAAAAAGCTTGATTTAAAAGCGGTGCAGCTTTATGGCTATTCGCAACAAGAAATCGCTCAATTAAAAAAATCGCTCCC
TAAAACTTGCGCGATTTGGCAAGTAGGGAGTGTGATGAACGCTAACGATTTAGCGCCTAAAGTTAAAGAAGCTTCTCTAA
TCCTATACGACACTAAGGGGGATAAAATGGGAGGCAATGGCGTGAGTTTTGATTGGGGTATTTTAGAAAATGTCAAAACG
CCTTTCATGTTAGCTGGCGGGCTTAATTTGGATAATATTCAAAAAGCCTTGAAAGTTAAAGCGTTGGGTTTGGATTTCAA
TTCGGGTTTGGAAACAAGCCCCGGGATTAAAAATAAGGATAAAATCAAGCAATTAGCCCGAATTTTAAGAGAGTATTAA

Upstream 100 bases:

>100_bases
CATAAGGCTAAAGATTTAAAAGAGGGCGTGGGCATGACTTTAGAGCATTTAAAAACCAAAGTGCCTTATACGCATTTGCA
AAAAATCATAAGATTAAGCC

Downstream 100 bases:

>100_bases
AATGAATAAAAAAGCGTATTTTGGGGAGTTTGGAGGGAGTTTTGTTTCAGAATTGTTAGTGCCTGCATTAAGAGAGTTAG
AACAGGCGTTTGATGCGTGT

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPSVLENILKDKLLEVSVLKKNHALPTNINPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLEIAKTYEKFASC
ISVLADSKYFLGSYENIKIVSQHSIKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTE
VSNQQEIKRLLKLQYDIIGINNRDLHTLKTDINNTLKLRPLLPKDALVVSESGIYSHAQIKALAPYVNGFLVGSSLMKEK
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKDKIKKIQKI
AKKLDLKAVQLYGYSQQEIAQLKKSLPKTCAIWQVGSVMNANDLAPKVKEASLILYDTKGDKMGGNGVSFDWGILENVKT
PFMLAGGLNLDNIQKALKVKALGLDFNSGLETSPGIKNKDKIKQLARILREY

Sequences:

>Translated_452_residues
MPSVLENILKDKLLEVSVLKKNHALPTNINPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLEIAKTYEKFASC
ISVLADSKYFLGSYENIKIVSQHSIKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTE
VSNQQEIKRLLKLQYDIIGINNRDLHTLKTDINNTLKLRPLLPKDALVVSESGIYSHAQIKALAPYVNGFLVGSSLMKEK
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKDKIKKIQKI
AKKLDLKAVQLYGYSQQEIAQLKKSLPKTCAIWQVGSVMNANDLAPKVKEASLILYDTKGDKMGGNGVSFDWGILENVKT
PFMLAGGLNLDNIQKALKVKALGLDFNSGLETSPGIKNKDKIKQLARILREY
>Mature_451_residues
PSVLENILKDKLLEVSVLKKNHALPTNINPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLEIAKTYEKFASCI
SVLADSKYFLGSYENIKIVSQHSIKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEV
SNQQEIKRLLKLQYDIIGINNRDLHTLKTDINNTLKLRPLLPKDALVVSESGIYSHAQIKALAPYVNGFLVGSSLMKEKD
LKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKDKIKKIQKIA
KKLDLKAVQLYGYSQQEIAQLKKSLPKTCAIWQVGSVMNANDLAPKVKEASLILYDTKGDKMGGNGVSFDWGILENVKTP
FMLAGGLNLDNIQKALKVKALGLDFNSGLETSPGIKNKDKIKQLARILREY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=460, Percent_Identity=46.304347826087, Blast_Score=384, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322638, Length=238, Percent_Identity=37.3949579831933, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 50624; Mature: 50492

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSVLENILKDKLLEVSVLKKNHALPTNINPSDRDFKKALLEKKTSFILECKKASPSKGL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCC
IRKDFDLLEIAKTYEKFASCISVLADSKYFLGSYENIKIVSQHSIKPILCKDFIIDAFQI
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
KLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEVSNQQEIKRLLKLQYDIIGI
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHEEEC
NNRDLHTLKTDINNTLKLRPLLPKDALVVSESGIYSHAQIKALAPYVNGFLVGSSLMKEK
CCCCCHHHHHCCCCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAV
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHH
KKLDFVGVFVKDKIKKIQKIAKKLDLKAVQLYGYSQQEIAQLKKSLPKTCAIWQVGSVMN
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCEEHEECCCCCC
ANDLAPKVKEASLILYDTKGDKMGGNGVSFDWGILENVKTPFMLAGGLNLDNIQKALKVK
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHH
ALGLDFNSGLETSPGIKNKDKIKQLARILREY
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSVLENILKDKLLEVSVLKKNHALPTNINPSDRDFKKALLEKKTSFILECKKASPSKGL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCC
IRKDFDLLEIAKTYEKFASCISVLADSKYFLGSYENIKIVSQHSIKPILCKDFIIDAFQI
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
KLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEVSNQQEIKRLLKLQYDIIGI
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHEEEC
NNRDLHTLKTDINNTLKLRPLLPKDALVVSESGIYSHAQIKALAPYVNGFLVGSSLMKEK
CCCCCHHHHHCCCCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAV
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHH
KKLDFVGVFVKDKIKKIQKIAKKLDLKAVQLYGYSQQEIAQLKKSLPKTCAIWQVGSVMN
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCEEHEECCCCCC
ANDLAPKVKEASLILYDTKGDKMGGNGVSFDWGILENVKTPFMLAGGLNLDNIQKALKVK
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHH
ALGLDFNSGLETSPGIKNKDKIKQLARILREY
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]