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The map label for this gene is nuoM [H]

Identifier: 188528061

GI number: 188528061

Start: 1294398

End: 1295936

Strand: Direct

Name: nuoM [H]

Synonym: HPSH_06590

Alternate gene names: 188528061

Gene position: 1294398-1295936 (Clockwise)

Preceding gene: 188528060

Following gene: 188528062

Centisome position: 80.47

GC content: 41.59

Gene sequence:

>1539_bases
ATGCAGTTTTTACATGCGCATCTTTTAAGCGTGGTGATCTTTTTCCCCATGCTGAGCGCGCTATTAGCGTTCTTTATGAG
CGATCAAGCGAGTAGGGCGTATGCGATTGTCATCGCTTTGATTGAATTGTTATTGGTCTTGTTGTTGTGGCATGGGTTTG
ATGTTCAAACAGCGGGCATGCAGTTTGAAGAAATGAAGGAATTGATCTATCAAATTGGCGTGAATTACCATGTGGGCGTT
GATGGCATCGCGCTCTTTTTGTTGCTCTTAAACGCTATTGTGGTGTTATTGTGCGTGATTTATGTCAAAGAGCATCGTAA
AGACTTTGCGATCTGTCTTTTATTGTTAGAGGGGATTTTGATGGGCGTGTTTTCTTCTCTTAATATGATCTTTTTCTACG
CTTTTTGGGAAATCTCGCTCTTGCCGGTTTTATACCTCATCGGTCGTTTTGGCCGTAACCATAAAATCTATTCTGGCATG
AAGTTTTTCCTCTACACCTTTTTAGCCTCATTATGCATGCTCTTAGGCATTTTATACATTGGGCATGACTATGCGAATGA
TTACGGCATGATGAGTTTTGATATTTTAGACTGGTATCAATTGAACTTTTCTAGTGGGGTTAAAACCTGGCTCTTTGTGG
CTTTCTTAATAGGGATTGCGGTTAAAATCCCGCTCTTTCCCTTGCACACATGGCTGCCTTATGCGTATTCTAACGCTCCT
ACTTTAGGCTCTGTCATGCTTTCAGCCTTGCTTTCTAAAATGGGGACTTACGCCTTATTACGCTTCTTGCTCCCGCTTTT
TCCTGAGCTTTCAGAAATCTATTTAACCCCCATAGCCATTGTGGCACTATGCATGATCATTTATGGAGGTTTTCTAGCTT
ACGCTCAAAAAGATTTAAAAACCCTCATCGCTTATAGCTCGTTCTCGCACATGGGAGTCGTGGTGCTTGGGGTTTTTTCT
TTCAATGTTGAGGGGATTTCAGGGGCGGTGTTTATGATGTTTGCGCATGGCGTTATCGTCATGGGATTATTTTTGCTCGC
TGGTATCCTAGAAGAGCGCGCCAGCAGTTTAGAAATCGCTCGCTTTGGATCAATCGCTAAAAGCGCTCCCATTCTTGCAG
CCTTTTTTATGATCGTTTTGATGGCGAATGTGGGCATGCCCTTAAGCATTGGCTTTGTGGGAGAGTTTTTAAGCTTATTA
GGGTTTTTTGCCACCTACCCTCTTTTAGCTATCATTGCCGGAACAAGCATCATTCTCTCAGCGATTTACATGCTCACTTC
ATATAAAGATGTCTTCTTTGGCAATTTGAAAACCGGGAACAATCAAATAAGCGTGTTTGAAGATTTGAACGCTCGTGAGG
TAGGGGTTTTAAGCGTGATTTTAGCTTTGATTTTAATTTTAGGGATTTATCCTAAAGTGCTTTTAAAACCGATTGAGCAA
GGCTCTAGGCAGCTTTTAGAGGTGATAGAAATCCGCTCGCTCCCTTTTTTAGGTTCATTGGATACTAAGATAAAAGAGGT
TTCTTATGTTAATAGATAG

Upstream 100 bases:

>100_bases
TAGGATCAGTCAAGACGGGAATTTAACTTCCATGCTGCGCTTCATGGTGGCTGGGGTTTTAATCTTATTAGCGTTTGTAG
CTTTTTTTGGGAGATAAGAA

Downstream 100 bases:

>100_bases
TCTCCACATCTCTTTTGACAGCTTTAATTTTGAGAGCATTTTACCCATGCTGGTGTTGGTGTGTGGGGGGATTTCCACGC
TCTTAATCAACGCTTTCACT

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLVLLLWHGFDVQTAGMQFEEMKELIYQIGVNYHVGV
DGIALFLLLLNAIVVLLCVIYVKEHRKDFAICLLLLEGILMGVFSSLNMIFFYAFWEISLLPVLYLIGRFGRNHKIYSGM
KFFLYTFLASLCMLLGILYIGHDYANDYGMMSFDILDWYQLNFSSGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIVALCMIIYGGFLAYAQKDLKTLIAYSSFSHMGVVVLGVFS
FNVEGISGAVFMMFAHGVIVMGLFLLAGILEERASSLEIARFGSIAKSAPILAAFFMIVLMANVGMPLSIGFVGEFLSLL
GFFATYPLLAIIAGTSIILSAIYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKVLLKPIEQ
GSRQLLEVIEIRSLPFLGSLDTKIKEVSYVNR

Sequences:

>Translated_512_residues
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLVLLLWHGFDVQTAGMQFEEMKELIYQIGVNYHVGV
DGIALFLLLLNAIVVLLCVIYVKEHRKDFAICLLLLEGILMGVFSSLNMIFFYAFWEISLLPVLYLIGRFGRNHKIYSGM
KFFLYTFLASLCMLLGILYIGHDYANDYGMMSFDILDWYQLNFSSGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIVALCMIIYGGFLAYAQKDLKTLIAYSSFSHMGVVVLGVFS
FNVEGISGAVFMMFAHGVIVMGLFLLAGILEERASSLEIARFGSIAKSAPILAAFFMIVLMANVGMPLSIGFVGEFLSLL
GFFATYPLLAIIAGTSIILSAIYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKVLLKPIEQ
GSRQLLEVIEIRSLPFLGSLDTKIKEVSYVNR
>Mature_512_residues
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLVLLLWHGFDVQTAGMQFEEMKELIYQIGVNYHVGV
DGIALFLLLLNAIVVLLCVIYVKEHRKDFAICLLLLEGILMGVFSSLNMIFFYAFWEISLLPVLYLIGRFGRNHKIYSGM
KFFLYTFLASLCMLLGILYIGHDYANDYGMMSFDILDWYQLNFSSGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIVALCMIIYGGFLAYAQKDLKTLIAYSSFSHMGVVVLGVFS
FNVEGISGAVFMMFAHGVIVMGLFLLAGILEERASSLEIARFGSIAKSAPILAAFFMIVLMANVGMPLSIGFVGEFLSLL
GFFATYPLLAIIAGTSIILSAIYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKVLLKPIEQ
GSRQLLEVIEIRSLPFLGSLDTKIKEVSYVNR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=372, Percent_Identity=30.1075268817204, Blast_Score=146, Evalue=5e-35,
Organism=Escherichia coli, GI1788613, Length=490, Percent_Identity=33.6734693877551, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1788827, Length=347, Percent_Identity=25.3602305475504, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788831, Length=396, Percent_Identity=26.7676767676768, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI145693160, Length=399, Percent_Identity=26.5664160401003, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788614, Length=501, Percent_Identity=24.5508982035928, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI2367154, Length=412, Percent_Identity=24.0291262135922, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 57014; Mature: 57014

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLVLLLWHGFDVQTAGM
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
QFEEMKELIYQIGVNYHVGVDGIALFLLLLNAIVVLLCVIYVKEHRKDFAICLLLLEGIL
CHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGVFSSLNMIFFYAFWEISLLPVLYLIGRFGRNHKIYSGMKFFLYTFLASLCMLLGILYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GHDYANDYGMMSFDILDWYQLNFSSGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
CCHHCCCCCCEEEHHHHHHHCCHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHCCCCC
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIVALCMIIYGGFLAYAQKDLK
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIAYSSFSHMGVVVLGVFSFNVEGISGAVFMMFAHGVIVMGLFLLAGILEERASSLEIA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGSIAKSAPILAAFFMIVLMANVGMPLSIGFVGEFLSLLGFFATYPLLAIIAGTSIILS
HHHHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKVLLKPIEQ
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSRQLLEVIEIRSLPFLGSLDTKIKEVSYVNR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLVLLLWHGFDVQTAGM
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
QFEEMKELIYQIGVNYHVGVDGIALFLLLLNAIVVLLCVIYVKEHRKDFAICLLLLEGIL
CHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGVFSSLNMIFFYAFWEISLLPVLYLIGRFGRNHKIYSGMKFFLYTFLASLCMLLGILYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GHDYANDYGMMSFDILDWYQLNFSSGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
CCHHCCCCCCEEEHHHHHHHCCHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHCCCCC
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIVALCMIIYGGFLAYAQKDLK
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIAYSSFSHMGVVVLGVFSFNVEGISGAVFMMFAHGVIVMGLFLLAGILEERASSLEIA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGSIAKSAPILAAFFMIVLMANVGMPLSIGFVGEFLSLLGFFATYPLLAIIAGTSIILS
HHHHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKVLLKPIEQ
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSRQLLEVIEIRSLPFLGSLDTKIKEVSYVNR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA