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The map label for this gene is nuoL [H]

Identifier: 188528060

GI number: 188528060

Start: 1292556

End: 1294394

Strand: Direct

Name: nuoL [H]

Synonym: HPSH_06585

Alternate gene names: 188528060

Gene position: 1292556-1294394 (Clockwise)

Preceding gene: 188528059

Following gene: 188528061

Centisome position: 80.36

GC content: 43.39

Gene sequence:

>1839_bases
ATGCAATATTCTTCTTTGCTGTCAGTGGTGTTGTTTTTGCCTTTAATCGGTGCAATTTATGCGGGGCTGTTTGGGGCTAA
AGCTAAAGCGTTGCATGTGGGCGTTTTCAATTCTTTGTGCGTGCTGGTTTCTTTCATTGGCGCTGTGGTTCTTTTCATTC
AAGCATGGCACAATCAAAGCTATGAAAAATATTTATTTGACTGGATCGTGGTAGGGAATTTTAAAGTTGGCTTTTCTCTC
ATGCTGGATAATATCAATGCGGTCATGATTGTCGTGGTAACTTTAGTTTCTTTTTTAGTGCATGTGTATTCTATAGGCTA
TATGGAGCATGATAAAGGGTTTAACCGCTATTTCTCCTACCTCAGCGGCTTTGTGTTTTCCATGCTGGTGTTGGTGTTGA
GCGATAATTTTTTAGGGCTTTTCATTGGCTGGGAAGGGGTGGGGCTATGCTCTTACTTGCTCATTGGCTTTTGGTATCAT
AAGACAAGCGCGAATAACGCTTCTATTGAGGCCTTTGTGATGAATCGAATCACGGATTTAGGCATGCTCATGGGGATTAT
TTTGATCTTTTGGAATTTTGGCACCCTCCAGTATAAAGAAGTCTTTAGCATGCTCAATAACACCGATTATTCCATGCTCT
TTTACATTAGCGTGTTTCTTTTTATTGGCGCTATGGGGAAGAGCGCTCAATTCCCTATGCACACATGGTTAGCCAACGCT
ATGGAGGGGCCTACCCCCGTGTCCGCTCTCATCCATGCAGCGACGATGGTAACCGCTGGGGTGTATCTAGTCATCAGAGC
CAATCCTTTGTATAGCGCGGTGTTTGAAGTGGGTTATTTTATCGCATGTTTAGGGGCGTTTGTGGCTCTTTTTGGAGCGA
GCATGGCTTTAGTCAATAAGGATTTAAAGCGCATTGTGGCTTATTCCACGCTTTCTCAATTAGGCTATATGTTTGTAGCG
GCCGGTCTTGGGGCTTATGCGATCGCGCTTTTCCACCTCTTTACGCATGCGTTTTTCAAATCCCTCCTTTTCTTAGGATC
AGGGAATGTCATGCATGCGATGGAAGACAATCTGGATATTACTAAAATGGGCGCTTTATACAAGCCTATGAGGATCACCG
CTATCTTTATGATTATAGGTTCAGTGGCTTTGTGCGGGATTTACCCTTTCGCGGGATACTTTTCTAAAGACAAAATTTTA
GAAGCGGCTTTTGGGATGCACCACCATATTTTATGGTTTGCGCTTCTAATCGGGGCGATCTTTACCGCTTTTTATAGCTT
CAGGCTCATCATGCTTGTGTTTTTTGCGCCCAAACAGCACGCCATCAACCACCCCCATGAGGCTCAAAATTTCATGCTTT
TAAGCATGCTGCCGTTAGGGGTTTTAGCGGTCATTGCCGGGTTTTTTGAAGAGCCGTTTTTTCATTTCATCTCTCAAGTG
ATCCCTAGCGCTGAAGAGTATCCCGTCCCGCTCGCTCTTTTGATCAGTATCACCACCATAGTGGTGCTATTGAGCATCGC
CTATGCCATATTTAAATATAAAAATGGTATCACTTCCAAAAAAGAGGGGGGCTTTTTATACAAGCTCTTGCTCAACCAAT
ACTATATCCCCAAGCTCTATCAAGGGATTGCAAAAGTTTTTAACGCCATCGCTTCATTCTTGCACCAAGTCGTGGAATTA
AGGATCATTGATGCGGTAGTGGATACTATAGGAAAAAGCGTTTTTGTCATAGGGCGTGTGTTTAGGATCAGTCAAGACGG
GAATTTAACTTCCATGCTGCGCTTCATGGTGGCTGGGGTTTTAATCTTATTAGCGTTTGTAGCTTTTTTTGGGAGATAA

Upstream 100 bases:

>100_bases
CCGCTAGTGAGGTGGCTATTGGTTTGGGCTTGGTGATTTTGTGGTTTAAGAAATTCAAGAGCTTAGATATTGATTCTTTA
AACGCTATGAAAGGTTGAGC

Downstream 100 bases:

>100_bases
GAAATGCAGTTTTTACATGCGCATCTTTTAAGCGTGGTGATCTTTTTCCCCATGCTGAGCGCGCTATTAGCGTTCTTTAT
GAGCGATCAAGCGAGTAGGG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MQYSSLLSVVLFLPLIGAIYAGLFGAKAKALHVGVFNSLCVLVSFIGAVVLFIQAWHNQSYEKYLFDWIVVGNFKVGFSL
MLDNINAVMIVVVTLVSFLVHVYSIGYMEHDKGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KTSANNASIEAFVMNRITDLGMLMGIILIFWNFGTLQYKEVFSMLNNTDYSMLFYISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMRITAIFMIIGSVALCGIYPFAGYFSKDKIL
EAAFGMHHHILWFALLIGAIFTAFYSFRLIMLVFFAPKQHAINHPHEAQNFMLLSMLPLGVLAVIAGFFEEPFFHFISQV
IPSAEEYPVPLALLISITTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPKLYQGIAKVFNAIASFLHQVVEL
RIIDAVVDTIGKSVFVIGRVFRISQDGNLTSMLRFMVAGVLILLAFVAFFGR

Sequences:

>Translated_612_residues
MQYSSLLSVVLFLPLIGAIYAGLFGAKAKALHVGVFNSLCVLVSFIGAVVLFIQAWHNQSYEKYLFDWIVVGNFKVGFSL
MLDNINAVMIVVVTLVSFLVHVYSIGYMEHDKGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KTSANNASIEAFVMNRITDLGMLMGIILIFWNFGTLQYKEVFSMLNNTDYSMLFYISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMRITAIFMIIGSVALCGIYPFAGYFSKDKIL
EAAFGMHHHILWFALLIGAIFTAFYSFRLIMLVFFAPKQHAINHPHEAQNFMLLSMLPLGVLAVIAGFFEEPFFHFISQV
IPSAEEYPVPLALLISITTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPKLYQGIAKVFNAIASFLHQVVEL
RIIDAVVDTIGKSVFVIGRVFRISQDGNLTSMLRFMVAGVLILLAFVAFFGR
>Mature_612_residues
MQYSSLLSVVLFLPLIGAIYAGLFGAKAKALHVGVFNSLCVLVSFIGAVVLFIQAWHNQSYEKYLFDWIVVGNFKVGFSL
MLDNINAVMIVVVTLVSFLVHVYSIGYMEHDKGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KTSANNASIEAFVMNRITDLGMLMGIILIFWNFGTLQYKEVFSMLNNTDYSMLFYISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMRITAIFMIIGSVALCGIYPFAGYFSKDKIL
EAAFGMHHHILWFALLIGAIFTAFYSFRLIMLVFFAPKQHAINHPHEAQNFMLLSMLPLGVLAVIAGFFEEPFFHFISQV
IPSAEEYPVPLALLISITTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPKLYQGIAKVFNAIASFLHQVVEL
RIIDAVVDTIGKSVFVIGRVFRISQDGNLTSMLRFMVAGVLILLAFVAFFGR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=454, Percent_Identity=36.784140969163, Blast_Score=268, Evalue=9e-72,
Organism=Escherichia coli, GI1788614, Length=508, Percent_Identity=41.3385826771654, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI1788829, Length=418, Percent_Identity=30.8612440191388, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1788831, Length=358, Percent_Identity=27.9329608938547, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788827, Length=425, Percent_Identity=26.5882352941176, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788613, Length=361, Percent_Identity=25.4847645429363, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI2367154, Length=465, Percent_Identity=23.4408602150538, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=370, Percent_Identity=24.3243243243243, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68131; Mature: 68131

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]