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The map label for this gene is carA [H]

Identifier: 188528025

GI number: 188528025

Start: 1260618

End: 1261745

Strand: Direct

Name: carA [H]

Synonym: HPSH_06400

Alternate gene names: 188528025

Gene position: 1260618-1261745 (Clockwise)

Preceding gene: 188528024

Following gene: 188528026

Centisome position: 78.37

GC content: 42.82

Gene sequence:

>1128_bases
ATGATCTCTCTCTATTTAGAAAACGGGCTTTTTTTGCAAGCGCAAAGTTTTGGGGCTAGCGGCACGCAAGCAGGCGAGCT
TGTTTTTAACACTTCTATGAGCGGCTATCAAGAAGTCATTAGCGACCCTAGCTATAAGGGGCAATTTGTGGTTTTTAGCA
TGCCTGAAATTGGGGTTGTGGGCGCTAATTTTAAAGATGATGAATCCTTTTTTTCATGCGCAGGGATTTTAGCGCGCCAT
TACAACGAATTTTTTTCTAATTCAAGGGCGGATTTTAGCCTGAGCGCTTATTTGAAAGAGCGTGGCGTTTTAGGGATTTG
CGGCGTTGATACCAGAAGTTTGATCAAAACCTTACGCCATCATGGGTGCTTGATGATGGTCGCTTCCACGATAGAGCATG
ACAAAAACAAGCTTGAAGAAATTTTAAAAAACGCCCCCAGAATTTCTCACTCCCCCCTAGTGTCTAGCGTTTCTACGCAA
AAAATCACCACGCACCAGCACGCGACTTTTGATTTCAAAACCCTAGATTACAAGCCTTTTGATGAAAAAACCTCTCATAA
AATTATCGCAGTGCTAGACTTTGGGGCTAAAGGTAATATTTTAAACGAGCTTCAAAATGTGGGGTTAAAAGCCCTTATTT
ACCCGCACCACACTAAAGCGAACGAGCTGATTAAGGCCTATGAAAAAAAAGAAATTAGCGGGATTTTCCTCTCTAACGGG
CCAGGTGATCCTTTAAGCTTGCAGCAAGAAATTGCAGAAATCAAACAGCTCATTAACGCTAAAATCCCCATGTTTGGCAT
TTGCTTAGGGCATCAATTGCTCTCTATCGCACAAGGTTATCCTACTTACAAGCTCAAATTTGGCCATCATGGGAGCAACC
ACCCCGTTAAAAACCTAAAAACAAACGCCGTTGAAATCACCGCGCAAAACCACAACTATTGCGTCCCTGAAGAAATTGAA
GAAATCGCTATTATCACGCACCGCAATCTTTTTGACAACACCATTGAGGGCGTGCGTTATAAAAACGCTCCCATTATTTC
TGTCCAGCACCACCCAGAAAGCAGCCCCGGCCCCAAAGAGAGCCACTATATTTTTAAGGAATTTGTGGAATTGTTAAAGG
GTTTTTAG

Upstream 100 bases:

>100_bases
TCAAGCATTACAAACGCAAACTGCCCGTAGGGAGCGATGAATACGAGCTTGTGTTTGAAAGGCTCTATGAAGAAGAATTA
AGGCGTAAAGGCTTTTTATA

Downstream 100 bases:

>100_bases
GGGTTTTTTAAAACAGCGCCTATAGAGGTTGAAAAAGCACTTTAAAAATAGATTTAAATCTTTTTATCAAAAAATCTCGC
ATTTACTCTAAATTAGTTCT

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MISLYLENGLFLQAQSFGASGTQAGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVVGANFKDDESFFSCAGILARH
YNEFFSNSRADFSLSAYLKERGVLGICGVDTRSLIKTLRHHGCLMMVASTIEHDKNKLEEILKNAPRISHSPLVSSVSTQ
KITTHQHATFDFKTLDYKPFDEKTSHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
PGDPLSLQQEIAEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLKTNAVEITAQNHNYCVPEEIE
EIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKESHYIFKEFVELLKGF

Sequences:

>Translated_375_residues
MISLYLENGLFLQAQSFGASGTQAGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVVGANFKDDESFFSCAGILARH
YNEFFSNSRADFSLSAYLKERGVLGICGVDTRSLIKTLRHHGCLMMVASTIEHDKNKLEEILKNAPRISHSPLVSSVSTQ
KITTHQHATFDFKTLDYKPFDEKTSHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
PGDPLSLQQEIAEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLKTNAVEITAQNHNYCVPEEIE
EIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKESHYIFKEFVELLKGF
>Mature_375_residues
MISLYLENGLFLQAQSFGASGTQAGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVVGANFKDDESFFSCAGILARH
YNEFFSNSRADFSLSAYLKERGVLGICGVDTRSLIKTLRHHGCLMMVASTIEHDKNKLEEILKNAPRISHSPLVSSVSTQ
KITTHQHATFDFKTLDYKPFDEKTSHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
PGDPLSLQQEIAEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLKTNAVEITAQNHNYCVPEEIE
EIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKESHYIFKEFVELLKGF

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=388, Percent_Identity=32.4742268041237, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI21361331, Length=383, Percent_Identity=31.331592689295, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI169790915, Length=383, Percent_Identity=31.331592689295, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1786215, Length=380, Percent_Identity=39.2105263157895, Blast_Score=266, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI193204318, Length=388, Percent_Identity=30.4123711340206, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324878, Length=387, Percent_Identity=34.1085271317829, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6322331, Length=409, Percent_Identity=31.7848410757946, Blast_Score=192, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24642586, Length=398, Percent_Identity=30.4020100502513, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45555749, Length=398, Percent_Identity=30.4020100502513, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase [H]

EC number: =6.3.5.5 [H]

Molecular weight: Translated: 41809; Mature: 41809

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLYLENGLFLQAQSFGASGTQAGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVV
CEEEEEECCEEEEEECCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCEE
GANFKDDESFFSCAGILARHYNEFFSNSRADFSLSAYLKERGVLGICGVDTRSLIKTLRH
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCEEEECCCHHHHHHHHHH
HGCLMMVASTIEHDKNKLEEILKNAPRISHSPLVSSVSTQKITTHQHATFDFKTLDYKPF
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHEEECCCCCEEEEEECCCCCC
DEKTSHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
CCCCCCEEEEEEECCCCCCHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECC
PGDPLSLQQEIAEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLK
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
TNAVEITAQNHNYCVPEEIEEIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKE
CCEEEEEECCCCCCCHHHHHHEEEEEECCHHHHHHCCCEECCCCEEEEECCCCCCCCCCH
SHYIFKEFVELLKGF
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MISLYLENGLFLQAQSFGASGTQAGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVV
CEEEEEECCEEEEEECCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCEE
GANFKDDESFFSCAGILARHYNEFFSNSRADFSLSAYLKERGVLGICGVDTRSLIKTLRH
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCEEEECCCHHHHHHHHHH
HGCLMMVASTIEHDKNKLEEILKNAPRISHSPLVSSVSTQKITTHQHATFDFKTLDYKPF
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHEEECCCCCEEEEEECCCCCC
DEKTSHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
CCCCCCEEEEEEECCCCCCHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECC
PGDPLSLQQEIAEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLK
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
TNAVEITAQNHNYCVPEEIEEIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKE
CCEEEEEECCCCCCCHHHHHHEEEEEECCHHHHHHCCCEECCCCEEEEECCCCCCCCCCH
SHYIFKEFVELLKGF
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA