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The map label for this gene is uppS [H]

Identifier: 188528008

GI number: 188528008

Start: 1246208

End: 1246912

Strand: Reverse

Name: uppS [H]

Synonym: HPSH_06315

Alternate gene names: 188528008

Gene position: 1246912-1246208 (Counterclockwise)

Preceding gene: 188528009

Following gene: 188528007

Centisome position: 77.52

GC content: 38.44

Gene sequence:

>705_bases
TTGGATAACACTCTCAAACATCTTGCCATTATTATGGATGGTAATGGCAGGTGGGCTAAATTAAAGAATAAAGCTAGGGC
TTATGGGCATAAAAAGGGCGTAAAAACCCTTAAAGACATCACGATCTGGTGCGCTAATCATAAGCTAGAATGCTTGACTT
TATACGCTTTTTCTACAGAAAATTGGAAACGCCCTAAAAGTGAAGTGGATTTTTTAATGAAAATGCTTAAAAAATACCTT
AAAGATGAGCGATCCACTTACTTGGATAATAACATACGCTTCAGGGCGATAGGGGATTTAGAGGGCTTTTCTAAAGAACT
GAGAGAGACGATCTTGCAGCTTGAAAACGATACTGGGCATTTTAAGGATTTTACGCAAGTTTTAGCCCTCAATTACGGAT
CTAAAAACGAGCTTTCAAGGGCATTTAAAAGCTTGCTAGAAAGCCCGCCTAGCAATATAAGCCTTTTAGAAAGCTTAGAA
AATGAAATTTCTAATCGTTTAGACACGTGCGATTTGCCGGAAGTGGATTTATTGTTACGAACGGGGGGGGAAATGCGCTT
GTCTAATTTTTTATTGTGGCAGTCCAGCTATGCGGAATTGTTTTTCACGCCGATTTTATGGCCTGATTTCACCCCTAAAG
ATTTAGAAAATATCATTAGCGATTTTTACAAAAGAGTGCGCAAATTCGGGGAATTAAAATGCTAG

Upstream 100 bases:

>100_bases
TGAAAAAACCCACTTTTCTTGGCAGCATATCGCTTATTTAGTGGATGCTTGCACGCTTTAAATGGTGTATAATAAAGAAT
TTCTTTAAAGGGCAAAGGCA

Downstream 100 bases:

>100_bases
TAGAAATAGAGAATTTGACTAAAACCTATGGGAGTTTAAAAGCGTTAGACAATATCAATTTGAAACTACCCAAACAGCAA
TTTATAGGGCTTTTAGGCCC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYL
KDERSTYLDNNIRFRAIGDLEGFSKELRETILQLENDTGHFKDFTQVLALNYGSKNELSRAFKSLLESPPSNISLLESLE
NEISNRLDTCDLPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC

Sequences:

>Translated_234_residues
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYL
KDERSTYLDNNIRFRAIGDLEGFSKELRETILQLENDTGHFKDFTQVLALNYGSKNELSRAFKSLLESPPSNISLLESLE
NEISNRLDTCDLPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
>Mature_234_residues
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYL
KDERSTYLDNNIRFRAIGDLEGFSKELRETILQLENDTGHFKDFTQVLALNYGSKNELSRAFKSLLESPPSNISLLESLE
NEISNRLDTCDLPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=226, Percent_Identity=37.6106194690265, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI45580742, Length=226, Percent_Identity=37.6106194690265, Blast_Score=137, Evalue=8e-33,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=43.6123348017621, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71993029, Length=213, Percent_Identity=35.6807511737089, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=236, Percent_Identity=30.9322033898305, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319474, Length=222, Percent_Identity=31.0810810810811, Blast_Score=96, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18857969, Length=208, Percent_Identity=31.25, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27287; Mature: 27287

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTE
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEEECCC
NWKRPKSEVDFLMKMLKKYLKDERSTYLDNNIRFRAIGDLEGFSKELRETILQLENDTGH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCH
FKDFTQVLALNYGSKNELSRAFKSLLESPPSNISLLESLENEISNRLDTCDLPEVDLLLR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTE
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEEECCC
NWKRPKSEVDFLMKMLKKYLKDERSTYLDNNIRFRAIGDLEGFSKELRETILQLENDTGH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCH
FKDFTQVLALNYGSKNELSRAFKSLLESPPSNISLLESLENEISNRLDTCDLPEVDLLLR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]