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The map label for this gene is lptD [H]

Identifier: 188528003

GI number: 188528003

Start: 1241156

End: 1243417

Strand: Reverse

Name: lptD [H]

Synonym: HPSH_06290

Alternate gene names: 188528003

Gene position: 1243417-1241156 (Counterclockwise)

Preceding gene: 188528004

Following gene: 188528002

Centisome position: 77.3

GC content: 37.05

Gene sequence:

>2262_bases
ATGATTTATTGGTTGTATTTGGCGGTCTTTTTTTTGTTGAGCGCATTAGACGCTAAAGAAATCGCTATGCAACGATTTGA
CAAACAAAACCATAAGATTTTTGAAATCCTTGCAGATAAAGTGAGCGCTAAAGACAATGTGATAACCGCATCAGGGAATG
CGATCTTATTGAATTATGATGTGTATATTTTAGCGGACAAGGTGCGTTATGATACCAAGACTAAAGAAGCGTTATTAGAA
GGGAATATCAAGGTTTATAAGGGCGAGGGCTTACTCATTAAAACCGATTATGTGAAATTGAGTTTGAATGAAAAATATGA
AATCATTTTCCCCTTTTATGTCCAAGACAGCGTGAGCGGGATTTGGGTGAGCGCGGATATTGCTAGCGGGAAGAATCAAA
AATATAAGATTAAAAACATGAGCGCTTCAGGGTGCAGCATTGATAATCCCATTTGGCATGTCAATGCGACTTCAGGCTCA
TTCAACATGCAAAAATCGCATTTGTCTATGTGGAATCCTAAGATCTATGTCGGCGATATTCCTATATTGTATTTGCCCTA
TATTTTCATGTCCACGAGCAATAAAAGAACTACCGGGTTTTTATACCCTGAATTTGGCACTTCCAATTTAGACGGCTTTA
TTTATTTGCAACCCTTTTATTTAGCCCCCAAAAACTCATGGGATATGACCTTTACCCCACAAATCCGTTATAAAAGGGGT
TTTGGCTTGAATTTTGAAGCGCGCTACATCAACTCTAAAGACGACAGGTTTTTATTCAATGCGCGCTATTTTAGGAATTA
CACTCAATATGTCAAACGCTATGATTTGAGGAATCAAAATATCTACGGGTTTGAATTTTTAAGCTCTAGCAGGGACACTC
TACAAAAATACTTTCATCTTAAGTCTAATATTGACAACGGGCATTACATTGACTTTTTATACATGAACGATTTGGACTAT
GTGCGTTTTGAAAAGGTTAATAAGCGTATCACGGACGCCACGCACATGTCTAGGGCGAATTACTATTTGCAAACAGAAAA
TCATTATTACGGCTTGAATATCAAGTATTTTTTAAACCTGAATAAAATCAACAATAACCGCACTTTCCAATCTGTCCCTA
ATTTGCAATACCATAAATATTTAAATTCTTTGTATTTTAAAAATTTGTTGTATTCGGTAGATTATCAGTTTAGAAACACC
GCAAGAGAGATCGGTTATGGCTATGTGCAAAACGCTTTGAATGTGCCGGTGGGCTTGCAATTTTCTTTGTTTAAAAAGTA
TTTGTCTATAGGGCTTTGGAATGATCTCCAATTATCTAATGTGGCTTTAATGCAATCTAAAAATTCCTTCGTGCCCACGA
TCCCTAATGAATCAAGGGAATTTGGGAACTTTGTGTCTTCAAATTTTTCCATGTATGTCAATACGGATTTAGCCAGAGAA
TACAACAAGCTTTTTCATACGATCCAATTGGAAGCGATTTTCAACATCCCTTATTACACCTTTAAAAACGGCTTATTTTC
TCAAAACATGTATGCTTTAAGCGCGCAAGCCTTAAACAGCTACACTTCGCCTTTATTGAGGGATTATGATTATCAAGGGC
GTTTGTATAACTCTGTGTGGAATCCTAACAGCATTTTACCTAGCAATGCGAGCAATAAGACGGTGAATTTAACCCTAACG
CAATACCTTTATGGCTTAGGGGGGCAAGAGTTATTGTATTTTAAAATATCACAACTCATCAATCTTGACGATAAGGTTTC
GCCCTTCAGGATGCCATTAGAGAGCAAGATCGGGTTTTCACCCTTAACAGGATTGAATATCTTTGGGAATGTCTTTTATT
CGTTTTATCAAAACCGCCTAGAAGAAATCTCTGTGAACGCCAATTACCAACGCAAGTTTTTAAGCTTTAACCTCTCTTAT
TTTCTAAAAAACAATTTTAGCAGTGGGATTAATAGCATTGTAGAAAATCCTGCGGATTATTTAAAGGCGGGTTTTAGCAA
CGACTTTGGCTATTTTTCCATGAGCGCGGATGTGGGTTATGATATTAGAAATAATGTGGTTTTAAATTGGAATGTGGGGA
TTTATAAAAAAATCCGTTGTTTTGGGATTGGCTTTCAATTCGTCAACCAACGGCGCCCTATCCTCACCGGCGATCCCAAC
CAGCCTATAAGAGTGTTTGAAAATAACTATGTTAAGCTAGAATTAGACTTTTCACCGATCACTAAAACCAATGTAACTTA
CCGCTCTTTACAGCGTAAGTAA

Upstream 100 bases:

>100_bases
TTTTTCTATGCCCCTTTTTATGGTTTGTAGTGTTTAAAAACCCCTATCATAGGGCGTGGCATGAAGAAAAAAGCAAAAGT
CTTTTGGTGTTAGTTTAATC

Downstream 100 bases:

>100_bases
AAAAAGGAATGCATTTGAATACTGACTTTAGCCATATCACCGATATAGAGGGCATGCGTTTTATCAATGAAGAAGACGCT
TTGAACAAATTGATTAATGA

Product: organic solvent tolerance protein

Products: NA

Alternate protein names: Organic solvent tolerance protein [H]

Number of amino acids: Translated: 753; Mature: 753

Protein sequence:

>753_residues
MIYWLYLAVFFLLSALDAKEIAMQRFDKQNHKIFEILADKVSAKDNVITASGNAILLNYDVYILADKVRYDTKTKEALLE
GNIKVYKGEGLLIKTDYVKLSLNEKYEIIFPFYVQDSVSGIWVSADIASGKNQKYKIKNMSASGCSIDNPIWHVNATSGS
FNMQKSHLSMWNPKIYVGDIPILYLPYIFMSTSNKRTTGFLYPEFGTSNLDGFIYLQPFYLAPKNSWDMTFTPQIRYKRG
FGLNFEARYINSKDDRFLFNARYFRNYTQYVKRYDLRNQNIYGFEFLSSSRDTLQKYFHLKSNIDNGHYIDFLYMNDLDY
VRFEKVNKRITDATHMSRANYYLQTENHYYGLNIKYFLNLNKINNNRTFQSVPNLQYHKYLNSLYFKNLLYSVDYQFRNT
AREIGYGYVQNALNVPVGLQFSLFKKYLSIGLWNDLQLSNVALMQSKNSFVPTIPNESREFGNFVSSNFSMYVNTDLARE
YNKLFHTIQLEAIFNIPYYTFKNGLFSQNMYALSAQALNSYTSPLLRDYDYQGRLYNSVWNPNSILPSNASNKTVNLTLT
QYLYGLGGQELLYFKISQLINLDDKVSPFRMPLESKIGFSPLTGLNIFGNVFYSFYQNRLEEISVNANYQRKFLSFNLSY
FLKNNFSSGINSIVENPADYLKAGFSNDFGYFSMSADVGYDIRNNVVLNWNVGIYKKIRCFGIGFQFVNQRRPILTGDPN
QPIRVFENNYVKLELDFSPITKTNVTYRSLQRK

Sequences:

>Translated_753_residues
MIYWLYLAVFFLLSALDAKEIAMQRFDKQNHKIFEILADKVSAKDNVITASGNAILLNYDVYILADKVRYDTKTKEALLE
GNIKVYKGEGLLIKTDYVKLSLNEKYEIIFPFYVQDSVSGIWVSADIASGKNQKYKIKNMSASGCSIDNPIWHVNATSGS
FNMQKSHLSMWNPKIYVGDIPILYLPYIFMSTSNKRTTGFLYPEFGTSNLDGFIYLQPFYLAPKNSWDMTFTPQIRYKRG
FGLNFEARYINSKDDRFLFNARYFRNYTQYVKRYDLRNQNIYGFEFLSSSRDTLQKYFHLKSNIDNGHYIDFLYMNDLDY
VRFEKVNKRITDATHMSRANYYLQTENHYYGLNIKYFLNLNKINNNRTFQSVPNLQYHKYLNSLYFKNLLYSVDYQFRNT
AREIGYGYVQNALNVPVGLQFSLFKKYLSIGLWNDLQLSNVALMQSKNSFVPTIPNESREFGNFVSSNFSMYVNTDLARE
YNKLFHTIQLEAIFNIPYYTFKNGLFSQNMYALSAQALNSYTSPLLRDYDYQGRLYNSVWNPNSILPSNASNKTVNLTLT
QYLYGLGGQELLYFKISQLINLDDKVSPFRMPLESKIGFSPLTGLNIFGNVFYSFYQNRLEEISVNANYQRKFLSFNLSY
FLKNNFSSGINSIVENPADYLKAGFSNDFGYFSMSADVGYDIRNNVVLNWNVGIYKKIRCFGIGFQFVNQRRPILTGDPN
QPIRVFENNYVKLELDFSPITKTNVTYRSLQRK
>Mature_753_residues
MIYWLYLAVFFLLSALDAKEIAMQRFDKQNHKIFEILADKVSAKDNVITASGNAILLNYDVYILADKVRYDTKTKEALLE
GNIKVYKGEGLLIKTDYVKLSLNEKYEIIFPFYVQDSVSGIWVSADIASGKNQKYKIKNMSASGCSIDNPIWHVNATSGS
FNMQKSHLSMWNPKIYVGDIPILYLPYIFMSTSNKRTTGFLYPEFGTSNLDGFIYLQPFYLAPKNSWDMTFTPQIRYKRG
FGLNFEARYINSKDDRFLFNARYFRNYTQYVKRYDLRNQNIYGFEFLSSSRDTLQKYFHLKSNIDNGHYIDFLYMNDLDY
VRFEKVNKRITDATHMSRANYYLQTENHYYGLNIKYFLNLNKINNNRTFQSVPNLQYHKYLNSLYFKNLLYSVDYQFRNT
AREIGYGYVQNALNVPVGLQFSLFKKYLSIGLWNDLQLSNVALMQSKNSFVPTIPNESREFGNFVSSNFSMYVNTDLARE
YNKLFHTIQLEAIFNIPYYTFKNGLFSQNMYALSAQALNSYTSPLLRDYDYQGRLYNSVWNPNSILPSNASNKTVNLTLT
QYLYGLGGQELLYFKISQLINLDDKVSPFRMPLESKIGFSPLTGLNIFGNVFYSFYQNRLEEISVNANYQRKFLSFNLSY
FLKNNFSSGINSIVENPADYLKAGFSNDFGYFSMSADVGYDIRNNVVLNWNVGIYKKIRCFGIGFQFVNQRRPILTGDPN
QPIRVFENNYVKLELDFSPITKTNVTYRSLQRK

Specific function: Involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis [H]

COG id: COG1452

COG function: function code M; Organic solvent tolerance protein OstA

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lptD family [H]

Homologues:

None

Paralogues:

None

Copy number: 60 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020889
- InterPro:   IPR005653
- InterPro:   IPR007543 [H]

Pfam domain/function: PF03968 OstA; PF04453 OstA_C [H]

EC number: NA

Molecular weight: Translated: 87958; Mature: 87958

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYWLYLAVFFLLSALDAKEIAMQRFDKQNHKIFEILADKVSAKDNVITASGNAILLNYD
CEEHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCEEEEEEE
VYILADKVRYDTKTKEALLEGNIKVYKGEGLLIKTDYVKLSLNEKYEIIFPFYVQDSVSG
EEEEEECEECCCHHHHHHHCCCEEEEECCEEEEEEEEEEEEECCCEEEEEEEEEECCCCE
IWVSADIASGKNQKYKIKNMSASGCSIDNPIWHVNATSGSFNMQKSHLSMWNPKIYVGDI
EEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCEEEHHHHHHCCCEEEECCC
PILYLPYIFMSTSNKRTTGFLYPEFGTSNLDGFIYLQPFYLAPKNSWDMTFTPQIRYKRG
CHHHHCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCEEECCCEEEECC
FGLNFEARYINSKDDRFLFNARYFRNYTQYVKRYDLRNQNIYGFEFLSSSRDTLQKYFHL
CCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
KSNIDNGHYIDFLYMNDLDYVRFEKVNKRITDATHMSRANYYLQTENHYYGLNIKYFLNL
HCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEEEEEEEE
NKINNNRTFQSVPNLQYHKYLNSLYFKNLLYSVDYQFRNTAREIGYGYVQNALNVPVGLQ
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHCCCCCCCC
FSLFKKYLSIGLWNDLQLSNVALMQSKNSFVPTIPNESREFGNFVSSNFSMYVNTDLARE
HHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCEEEEECHHHHH
YNKLFHTIQLEAIFNIPYYTFKNGLFSQNMYALSAQALNSYTSPLLRDYDYQGRLYNSVW
HHHHHHEEEEEEEEECCCCEECCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCEEEECCC
NPNSILPSNASNKTVNLTLTQYLYGLGGQELLYFKISQLINLDDKVSPFRMPLESKIGFS
CCCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCCCHHHCCCCC
PLTGLNIFGNVFYSFYQNRLEEISVNANYQRKFLSFNLSYFLKNNFSSGINSIVENPADY
CCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEEEEEEEEECCHHHHHHHHHHCCHHH
LKAGFSNDFGYFSMSADVGYDIRNNVVLNWNVGIYKKIRCFGIGFQFVNQRRPILTGDPN
HHCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCEEEEEEEEECHHHHCCCCCEEECCCC
QPIRVFENNYVKLELDFSPITKTNVTYRSLQRK
CCEEEEECCEEEEEEECCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MIYWLYLAVFFLLSALDAKEIAMQRFDKQNHKIFEILADKVSAKDNVITASGNAILLNYD
CEEHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCEEEEEEE
VYILADKVRYDTKTKEALLEGNIKVYKGEGLLIKTDYVKLSLNEKYEIIFPFYVQDSVSG
EEEEEECEECCCHHHHHHHCCCEEEEECCEEEEEEEEEEEEECCCEEEEEEEEEECCCCE
IWVSADIASGKNQKYKIKNMSASGCSIDNPIWHVNATSGSFNMQKSHLSMWNPKIYVGDI
EEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCEEEHHHHHHCCCEEEECCC
PILYLPYIFMSTSNKRTTGFLYPEFGTSNLDGFIYLQPFYLAPKNSWDMTFTPQIRYKRG
CHHHHCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCEEECCCEEEECC
FGLNFEARYINSKDDRFLFNARYFRNYTQYVKRYDLRNQNIYGFEFLSSSRDTLQKYFHL
CCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
KSNIDNGHYIDFLYMNDLDYVRFEKVNKRITDATHMSRANYYLQTENHYYGLNIKYFLNL
HCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEEEEEEEE
NKINNNRTFQSVPNLQYHKYLNSLYFKNLLYSVDYQFRNTAREIGYGYVQNALNVPVGLQ
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHCCCCCCCC
FSLFKKYLSIGLWNDLQLSNVALMQSKNSFVPTIPNESREFGNFVSSNFSMYVNTDLARE
HHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCEEEEECHHHHH
YNKLFHTIQLEAIFNIPYYTFKNGLFSQNMYALSAQALNSYTSPLLRDYDYQGRLYNSVW
HHHHHHEEEEEEEEECCCCEECCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCEEEECCC
NPNSILPSNASNKTVNLTLTQYLYGLGGQELLYFKISQLINLDDKVSPFRMPLESKIGFS
CCCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCCCHHHCCCCC
PLTGLNIFGNVFYSFYQNRLEEISVNANYQRKFLSFNLSYFLKNNFSSGINSIVENPADY
CCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEEEEEEEEECCHHHHHHHHHHCCHHH
LKAGFSNDFGYFSMSADVGYDIRNNVVLNWNVGIYKKIRCFGIGFQFVNQRRPILTGDPN
HHCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCEEEEEEEEECHHHHCCCCCEEECCCC
QPIRVFENNYVKLELDFSPITKTNVTYRSLQRK
CCEEEEECCEEEEEEECCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]