Click here to switch to the map view.

The map label for this gene is ttcA [H]

Identifier: 188527970

GI number: 188527970

Start: 1202745

End: 1203506

Strand: Direct

Name: ttcA [H]

Synonym: HPSH_06125

Alternate gene names: 188527970

Gene position: 1202745-1203506 (Clockwise)

Preceding gene: 188527969

Following gene: 188527974

Centisome position: 74.77

GC content: 41.99

Gene sequence:

>762_bases
ATGGCCTATGAAATTTCTAAAAAAGTCTTACACATTGTGGGTAAGACCAACGCCACTTACAAACTCATAGAAGAAGGCGA
TAAAGTCTTATTAGGATTGAGTGGGGGCAAGGATTCTATCATGCTCGCTTGCATCTTAGCCAGGATGCAAAAACATGCCC
CTTTCAAATTTGATTTTAAAGCGGTTACCGTGCATTATGGTTTGGGCGAAGATTTGAAGTGGTTGAGCGATTTGTGCCAA
GAGCAAGGCATTGAACATGAGATCATTTACACCCAAATCGCTGCCACCATCAACGAAAAACGCCGTGAAAAAAGCTCGTT
TTGTTCGTTTTGTTCTCGTTTGAGGAGAGGGACTTTGTATTCTAAAGCTTTAGAAGAAGGCTATAATAAAGTCGCTATCG
CACACCATTTAGATGACGCCGTAGAGAGCTTTTTTATGAATTTCACTTATAACGGGAGTTTAAGGAGCATGCCCCCCATT
TATAGGGCTGAAAACGGCTTATTGGTGATCCGCCCTTTGATTAAGGTTCGAGAAGCCAGCAGTATTCATTTTGTTACTTC
TCAAAATATCCCCGTCGCCCCTGATTGCAATTGCCCAGCCAAACAGCCCACCTCTGATAAGCCCCCTATCGCGCGATTAG
CCACTAAAAATTTCTTAAAAGAAATGCAAAACTTGCACCCTCATTTCTTTGACAGCTTAGAAAACGCATTCAACAATGTT
CAAGCGAACAGCTTTAGCGACTCTAAGTATTTAGACGCTTAA

Upstream 100 bases:

>100_bases
AAGAAATCATTATTGTGAAATATAATTCCGATCACATTAGCGAAGAAGAAATCATTCGCTTAGCGCAAAACTTTAGAAAA
TAAATAATCAAGGATCAAAA

Downstream 100 bases:

>100_bases
GCTTTCATTCAAGCTTTTTTGTTGAGTATTTTGATCGCAATCGTGAATAATACCCCTTCAAAAATAGCCGCCATGAGCAA
TGCGTAGTAGGTGTTTTGTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MAYEISKKVLHIVGKTNATYKLIEEGDKVLLGLSGGKDSIMLACILARMQKHAPFKFDFKAVTVHYGLGEDLKWLSDLCQ
EQGIEHEIIYTQIAATINEKRREKSSFCSFCSRLRRGTLYSKALEEGYNKVAIAHHLDDAVESFFMNFTYNGSLRSMPPI
YRAENGLLVIRPLIKVREASSIHFVTSQNIPVAPDCNCPAKQPTSDKPPIARLATKNFLKEMQNLHPHFFDSLENAFNNV
QANSFSDSKYLDA

Sequences:

>Translated_253_residues
MAYEISKKVLHIVGKTNATYKLIEEGDKVLLGLSGGKDSIMLACILARMQKHAPFKFDFKAVTVHYGLGEDLKWLSDLCQ
EQGIEHEIIYTQIAATINEKRREKSSFCSFCSRLRRGTLYSKALEEGYNKVAIAHHLDDAVESFFMNFTYNGSLRSMPPI
YRAENGLLVIRPLIKVREASSIHFVTSQNIPVAPDCNCPAKQPTSDKPPIARLATKNFLKEMQNLHPHFFDSLENAFNNV
QANSFSDSKYLDA
>Mature_252_residues
AYEISKKVLHIVGKTNATYKLIEEGDKVLLGLSGGKDSIMLACILARMQKHAPFKFDFKAVTVHYGLGEDLKWLSDLCQE
QGIEHEIIYTQIAATINEKRREKSSFCSFCSRLRRGTLYSKALEEGYNKVAIAHHLDDAVESFFMNFTYNGSLRSMPPIY
RAENGLLVIRPLIKVREASSIHFVTSQNIPVAPDCNCPAKQPTSDKPPIARLATKNFLKEMQNLHPHFFDSLENAFNNVQ
ANSFSDSKYLDA

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=253, Percent_Identity=33.201581027668, Blast_Score=150, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI193211090, Length=246, Percent_Identity=35.7723577235772, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 28552; Mature: 28421

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYEISKKVLHIVGKTNATYKLIEEGDKVLLGLSGGKDSIMLACILARMQKHAPFKFDFK
CCCHHHHHHHHHHCCCCCEEHEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEE
AVTVHYGLGEDLKWLSDLCQEQGIEHEIIYTQIAATINEKRREKSSFCSFCSRLRRGTLY
EEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
SKALEEGYNKVAIAHHLDDAVESFFMNFTYNGSLRSMPPIYRAENGLLVIRPLIKVREAS
HHHHHCCCCEEEHHHHHHHHHHHHHHHCEECCCCCCCCCCEECCCCEEEEEHHHHHHCCC
SIHFVTSQNIPVAPDCNCPAKQPTSDKPPIARLATKNFLKEMQNLHPHFFDSLENAFNNV
CEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
QANSFSDSKYLDA
CCCCCCCCCCCCC
>Mature Secondary Structure 
AYEISKKVLHIVGKTNATYKLIEEGDKVLLGLSGGKDSIMLACILARMQKHAPFKFDFK
CCHHHHHHHHHHCCCCCEEHEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEE
AVTVHYGLGEDLKWLSDLCQEQGIEHEIIYTQIAATINEKRREKSSFCSFCSRLRRGTLY
EEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
SKALEEGYNKVAIAHHLDDAVESFFMNFTYNGSLRSMPPIYRAENGLLVIRPLIKVREAS
HHHHHCCCCEEEHHHHHHHHHHHHHHHCEECCCCCCCCCCEECCCCEEEEEHHHHHHCCC
SIHFVTSQNIPVAPDCNCPAKQPTSDKPPIARLATKNFLKEMQNLHPHFFDSLENAFNNV
CEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
QANSFSDSKYLDA
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA