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The map label for this gene is pgi

Identifier: 188527949

GI number: 188527949

Start: 1182809

End: 1184446

Strand: Direct

Name: pgi

Synonym: HPSH_06020

Alternate gene names: 188527949

Gene position: 1182809-1184446 (Clockwise)

Preceding gene: 188527948

Following gene: 188527951

Centisome position: 73.53

GC content: 40.35

Gene sequence:

>1638_bases
ATGCTAACCCAATTAAAAACTTATCCAAAATTACTCAAACATTATGAAGAAATCAAAGAAGTGCATATGCGCGATTGGTT
TTCTAAAGACAAAGAGCGAGCGAGCCGCTATTTTTTGCAATTTGAAAGCTTGAGCTTGGATTATTCCAAAAACCGCTTGA
ACGATACCACTTTAAAGCTTCTTTTTGAATTAGCGAATGACTGCTCTTTAAAAGAAAAAATTGAAGCGATGTTTAAAGGC
GAAAAGATCAACACCACCGAAAAAAGGGCCGTTTTACACACCGCTTTAAGAAGCTTGAACGACACTGAAATTTTACTAGA
CAACATGGAAGTGTTAAAAAGTATTAGAAGCGTTTTAAAACGCATGCGAGCCTTTAGCGATAGCGTGAGGAGCGGTAAAA
GATTAGGCTATACCAATCAAGTGATCACCGATATTGTCAATATCGGCATTGGGGGGTCAGATTTGGGCGCTTTAATGGTT
TGCACCGCGTTAAAACGCTACGCCCACCCGAGATTAAAAATGCATTTTGTGTCTAATGTGGATGGCACACAGATTTTAGA
TGTTTTAGAAAAACTCAATCCAGCCAGCACGCTTTTTATCGTGGCTTCTAAGACTTTTTCCACTCAAGAAACCTTAACCA
ACGCCCTAACCGCTAGAAAATGGTTTGTAGAAAGAAGCGGCGATGAAAAGCATATCGCTAAACACTTTGTAGCGGTATCC
ACTAATAAAGAAGCCGTGCAACAATTTGGCATTGACGAGCACAACATGTTTGAATTTTGGGATTTCGTAGGGGGGCGCTA
TAGTTTGTGGTCGGCTATTGGCTTATCCATCATGATCTATTTAGGGAAGAAAAATTTTAACGCTCTTTTGAAAGGAGCGT
ATTTGATGGATGAGCATTTTAGAAACGCCCCTTTTGAAAGCAATTTACCCGTTTTAATGGGGCTAATTGGCGTGTGGTAT
ATCAATTTTTTCCAGTCCAAAAGCCATTTAATCGCTCCTTACGATCAGTATTTAAGGCATTTCCCTAAGTTCATTCAGCA
ATTAGATATGGAAAGTAATGGCAAACGCATCAGCAAAAAAGGCGAAATCATCCCCTATGACACCTGCCCTGTTGTTTGGG
GCGATATGGGCATTAACGCTCAGCATGCCTTTTTCCAGCTCTTGCATCAAGGCACGCATTTAATACCCATTGATTTTATC
GCTTCCTTAGATAAAAAGCCTAACGCTAAAGGCCACCATGAGATTTTATTTAGCAATGTTTTAGCGCAAGCGCAAGCTTT
CATGAAAGGCAAGAGTTATGAAGAAGCGCTTGGGGAATTGCTCTTTAAAGGATTAGACAAAGATGAAGCCAAAGATTTAG
CCCACCACAGGGTGTTTTTTGGCAACCGCCCCTCTAATATCCTTTTATTAGAAAAGATTTCACCAAGCAATATTGGGGCG
CTAGTGGCTCTTTATGAGCATAAAGTCTTTGTGCAAGGGGTTATTTGGGATATTAACAGCTTTGATCAATGGGGCGTGGA
GCTTGGGAAAGAACTGGCCGTGCCGATTTTACAAGAATTAGAAGGGCATAAAAGCAACGCTTATTTTGACAGCTCCACTA
AGCGCTTGATAGAATTGTATAAGAATTACAACCAATAG

Upstream 100 bases:

>100_bases
CCTATAGTAAGCTAGAATGTTTTTTCTTAAAGTTTCCATTTGAAAATTGTAATTAAAACTAGCTTATAATACAGCGTTAT
ATCTTTTAAAAGGGGTATTG

Downstream 100 bases:

>100_bases
GCTTTGTTTGATAACAAGATAAAACCTAAAAAAACAATAAAGCAAAGCTTAATCCCCGTTCTCAAGCGATCCATTCAAAA
TAATCCGTTAATCATAACGG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MLTQLKTYPKLLKHYEEIKEVHMRDWFSKDKERASRYFLQFESLSLDYSKNRLNDTTLKLLFELANDCSLKEKIEAMFKG
EKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSIRSVLKRMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMV
CTALKRYAHPRLKMHFVSNVDGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFRNAPFESNLPVLMGLIGVWY
INFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKGEIIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFI
ASLDKKPNAKGHHEILFSNVLAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKRLIELYKNYNQ

Sequences:

>Translated_545_residues
MLTQLKTYPKLLKHYEEIKEVHMRDWFSKDKERASRYFLQFESLSLDYSKNRLNDTTLKLLFELANDCSLKEKIEAMFKG
EKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSIRSVLKRMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMV
CTALKRYAHPRLKMHFVSNVDGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFRNAPFESNLPVLMGLIGVWY
INFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKGEIIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFI
ASLDKKPNAKGHHEILFSNVLAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKRLIELYKNYNQ
>Mature_545_residues
MLTQLKTYPKLLKHYEEIKEVHMRDWFSKDKERASRYFLQFESLSLDYSKNRLNDTTLKLLFELANDCSLKEKIEAMFKG
EKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSIRSVLKRMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMV
CTALKRYAHPRLKMHFVSNVDGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFRNAPFESNLPVLMGLIGVWY
INFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKGEIIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFI
ASLDKKPNAKGHHEILFSNVLAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKRLIELYKNYNQ

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=547, Percent_Identity=51.5539305301645, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI296080693, Length=547, Percent_Identity=48.0804387568556, Blast_Score=519, Evalue=1e-147,
Organism=Escherichia coli, GI1790457, Length=542, Percent_Identity=53.1365313653137, Blast_Score=589, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI71996703, Length=548, Percent_Identity=49.4525547445255, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71996708, Length=548, Percent_Identity=49.4525547445255, Blast_Score=547, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6319673, Length=552, Percent_Identity=49.0942028985507, Blast_Score=525, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24651916, Length=548, Percent_Identity=53.6496350364963, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24651914, Length=548, Percent_Identity=53.6496350364963, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI17737445, Length=548, Percent_Identity=53.6496350364963, Blast_Score=582, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 62447; Mature: 62447

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQLKTYPKLLKHYEEIKEVHMRDWFSKDKERASRYFLQFESLSLDYSKNRLNDTTLKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LFELANDCSLKEKIEAMFKGEKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSIRSVLK
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMVCTALKRYAHPRLKMHFVSNV
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCC
DGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
CHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHF
CCHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHH
RNAPFESNLPVLMGLIGVWYINFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHCCCCCCCEECCC
GEIIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFIASLDKKPNAKGHHEILFSNV
CCEECCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHH
LAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
HHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCEEEEEECCCCCHHH
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKRLIELY
HHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHH
KNYNQ
HCCCC
>Mature Secondary Structure
MLTQLKTYPKLLKHYEEIKEVHMRDWFSKDKERASRYFLQFESLSLDYSKNRLNDTTLKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LFELANDCSLKEKIEAMFKGEKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSIRSVLK
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMVCTALKRYAHPRLKMHFVSNV
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCC
DGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
CHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHF
CCHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHH
RNAPFESNLPVLMGLIGVWYINFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHCCCCCCCEECCC
GEIIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFIASLDKKPNAKGHHEILFSNV
CCEECCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHH
LAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
HHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCEEEEEECCCCCHHH
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKRLIELY
HHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHH
KNYNQ
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA