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The map label for this gene is ggt [H]

Identifier: 188527900

GI number: 188527900

Start: 1135096

End: 1136799

Strand: Reverse

Name: ggt [H]

Synonym: HPSH_05755

Alternate gene names: 188527900

Gene position: 1136799-1135096 (Counterclockwise)

Preceding gene: 188527901

Following gene: 188527899

Centisome position: 70.67

GC content: 43.19

Gene sequence:

>1704_bases
ATGAGACGGAGTTTTTTGAAAACGATTGGCTTGGGTGTGATAGCGCTCTCTTTGGGTTTGTTAAGCCCTTTGAGTGCAGC
GAGTTACCCCCCCATTAAAAACACTAAAGTAGGCTTAGCCCTTTCTAGCCACCCGCTAGCTAGTGAGATCGGGCAAAAGG
TTTTAGAAGATGGAGGTAATGCGATTGATGCGGCTGTAGCGATAGGTTTTGCTCTAGCGGTCGTCCATCCTGCAGCAGGC
AATATTGGTGGTGGGGGTTTTGCGGTTATCCATTTGGCTAATGGTGAAAATGTTGCCTTAGATTTTAGAGAAAAAGCCCC
CTTAAAAGCCACTAAGGACATGTTTTTAGACAAGCAAGGCAATGTAGTCCCTAAGCTCAGCGAAGATGGCTATTTGGCGG
CTGGGGTTCCTGGAACGGTGGCGGGCATGGAAGCGATGTTGAAGAAATACGGCACAAAAAAGCTATCGCAACTCATTGAT
CCTGCCATTAAATTGGCTGAAAATGGTTATGTGATTTCACAAAGACAAGCAGAAACCCTAAAAGAAGCAAGGGAGCGGTT
TTTAAAATACAGTTCTAGCAAAAAGTATTTTTTTAAAAAAGGGCATCTTGATTATCAAGAAGGGGATTTGTTTGTCCAAA
AAGATTTAGCCAAGACTTTGAATCAAATCAAAACGCTAGGCGCTAAAGGCTTTTATCAAGGGCAAGTCGCTGATTTGATT
GAGAAAGACATGAAAAAAAATGGAGGGATTATCACTAAAGAAGATTTAGCCAGTTACAATGTGAAATGGCGCAAACCCGT
GGTAGGGAGTTATCGTGGGTATAAGATCATTTCTATGTCGCCGCCAAGTTCAGGAGGCACGCATTTGATCCAGATTTTAA
ATGTCATGGAAAATGCGGATTTAAGTGCCCTTGGGTATGGGGCTTCTAAGAATATCCATATCGCTGCAGAAGCGATGCGT
CAAGCTTATGCGGACAGATCGGTTTATATGGGAGACGCTGATTTTGTTTCAGTGCCGGTGGATAAATTGATTAATAAGGC
GTATGCCAAAAAGATTTTTGACGCTATCCAGCCAGATACGGTTACGCCAAGCTCTCAAATCAAACCAGGAATGGGGCAGT
TGCATGAAGGGAGCAATACCACGCATTATTCTGTAGCGGACAGGTGGGGGAATGCAGTCAGCGTTACTTACACCATTAAC
GCTTCTTATGGAAGCGCTGCTAGTATTGATGGGGCAGGATTTTTATTGAACAATGAAATGGATGATTTTTCCATAAAGCC
TGGGAATCCTAATCTCTATGGTTTAGTAGGGGGCGATGCGAATGCGATTGAAGCCAATAAGCGCCCTTTAAGCTCCATGT
CGCCTACGATCGTGTTGAAAAACAATAAGGTTTTCATGGTGGTAGGAAGCCCTGGAGGGTCTAGGATTATCACTACAGTG
TTGCAAGTGATTTCCAATGTCATTGATTACAACATGAATATTTCTGAAGCGGTCTCAGCCCCTAGATTCCACATGCAATG
GTTGCCTGATGAATTAAGGATTGAAAAGTTTGGCATGCCTGCTGATGTGAAAAATAACCTCACTAAAATGGGCTATCAAA
TCGTTACTAAGCCAGTCATGGGTGATGTGAATGCGATCCAAGTTTTGCCTAAAACTAAAGGGAGCGTTTTCTATGGATCA
ACGGATCCAAGGAAAGAATTTTAA

Upstream 100 bases:

>100_bases
CAAACGATAATGGCTAATAGCATCATATAACTATAAGCGAGAGGGTGCTTTGTAAAGCTTATGCTATAATAACGATTATT
GTTGATTGAAAGGAAAACAG

Downstream 100 bases:

>100_bases
TTCTTTGTCATATGCGGGTTTTTAATCCTATTTAGCCTTATTTTTTGGGATGGAGGGGGGATTTTTTAGCGAGAAAATCT
TAAATTTAGTTTTAAATTCA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEDGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKDMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYVISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVADLI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFMVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKNNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF

Sequences:

>Translated_567_residues
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEDGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKDMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYVISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVADLI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFMVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKNNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF
>Mature_567_residues
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEDGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKDMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYVISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVADLI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFMVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKNNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=479, Percent_Identity=32.776617954071, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI73915090, Length=479, Percent_Identity=32.776617954071, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI73915096, Length=479, Percent_Identity=32.776617954071, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI73915094, Length=479, Percent_Identity=32.776617954071, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI113429324, Length=477, Percent_Identity=31.2368972746331, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI113429326, Length=481, Percent_Identity=30.7692307692308, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI109148539, Length=473, Percent_Identity=28.7526427061311, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=25.5434782608696, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI153266901, Length=553, Percent_Identity=25.8589511754069, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI153266907, Length=551, Percent_Identity=24.8638838475499, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI30581157, Length=176, Percent_Identity=38.6363636363636, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI30581155, Length=176, Percent_Identity=38.6363636363636, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI218505805, Length=174, Percent_Identity=34.4827586206897, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI310124095, Length=174, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789856, Length=537, Percent_Identity=52.3277467411546, Blast_Score=558, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI212646519, Length=511, Percent_Identity=35.4207436399217, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI72000294, Length=511, Percent_Identity=35.4207436399217, Blast_Score=252, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17506189, Length=609, Percent_Identity=30.8702791461412, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI193208247, Length=551, Percent_Identity=33.0308529945554, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI193208245, Length=558, Percent_Identity=33.1541218637993, Blast_Score=221, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17542894, Length=493, Percent_Identity=32.8600405679513, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI72001497, Length=227, Percent_Identity=31.7180616740088, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI72001495, Length=227, Percent_Identity=31.7180616740088, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17564448, Length=437, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323330, Length=523, Percent_Identity=31.3575525812619, Blast_Score=186, Evalue=8e-48,
Organism=Drosophila melanogaster, GI161077496, Length=529, Percent_Identity=33.2703213610586, Blast_Score=232, Evalue=7e-61,
Organism=Drosophila melanogaster, GI18859893, Length=555, Percent_Identity=31.7117117117117, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI45551474, Length=542, Percent_Identity=30.2583025830258, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI161077880, Length=542, Percent_Identity=30.2583025830258, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI161077878, Length=542, Percent_Identity=30.2583025830258, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24642670, Length=542, Percent_Identity=30.2583025830258, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24642666, Length=542, Percent_Identity=30.2583025830258, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI18859741, Length=531, Percent_Identity=28.060263653484, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61053; Mature: 61053

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEDGGN
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCC
AIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKDMFLDKQG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHCCCCC
NVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYVISQRQAETL
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEHHHHHHH
KEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVADLI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENAD
HHHHHHCCCEEEHHHHHCCCCEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
LSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDT
CCEECCCCCCCEEHHHHHHHHHHCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHCCCCC
VTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEM
CCCHHCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEECCCC
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFMVVGSPGGSRIITTV
CCCEECCCCCCEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEEEECCCCHHHHHHH
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKNNLTKMGYQIVTKPVM
HHHHHHHHHCCCCHHHHHCCCCCEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHEECCCC
GDVNAIQVLPKTKGSVFYGSTDPRKEF
CCCCEEEEEECCCCCEEECCCCCCCCC
>Mature Secondary Structure
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEDGGN
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCC
AIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKDMFLDKQG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHCCCCC
NVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYVISQRQAETL
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEHHHHHHH
KEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVADLI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENAD
HHHHHHCCCEEEHHHHHCCCCEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
LSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDT
CCEECCCCCCCEEHHHHHHHHHHCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHCCCCC
VTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEM
CCCHHCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEECCCC
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFMVVGSPGGSRIITTV
CCCEECCCCCCEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEEEECCCCHHHHHHH
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKNNLTKMGYQIVTKPVM
HHHHHHHHHCCCCHHHHHCCCCCEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHEECCCC
GDVNAIQVLPKTKGSVFYGSTDPRKEF
CCCCEEEEEECCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]