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The map label for this gene is bioA [H]

Identifier: 188527795

GI number: 188527795

Start: 1019119

End: 1020429

Strand: Reverse

Name: bioA [H]

Synonym: HPSH_05155

Alternate gene names: 188527795

Gene position: 1020429-1019119 (Counterclockwise)

Preceding gene: 188527799

Following gene: 188527791

Centisome position: 63.44

GC content: 40.27

Gene sequence:

>1311_bases
ATGAATTTTCAAGAAAATTTAGCCGCTTTGGATTTGGAGTATCTCTGGCACCCTTGCTCGCAAATGCAAGAGCATCAAAA
TTTCCCCATTATCCCCATTAAAAAGGCTCAAGGGATTTACCTCTATGATTTTAATGGTAACGCTTACATGGATTTAATCA
GCTCATGGTGGGTGAATCTTTTTGGGCATAATAACGCCTACATCAGCCAGCAGCTTAAAAATCAAATTGATAATCTAGAG
CATGTCCTCTTGGCTTCTTTCAGCCATAAGCCCATCATCACGCTCTCTCAAAGGCTTTGCCAGCTCACTCATATGGACAA
ATGCTTTTATGCGGATAACGGCTCATCTTGTATTGAAATCGCTTTGAAAATGAGCTATCACGCCCATTTTTTAAAGAATC
AAACGAGCCGCAAAAAGCTTTTTTTATCGCTCTCTAATTCCTATCATGGCGAGACTTTGGGAGCGTTAAGCGCGGGCGAT
GTGAAACTTTATAAAGACACTTACACCCCTTTATTGCTCAAAAATCTCACCACACCCGTGCCTAAAAACGACAATGAAAT
AGAAAATAGTTTGAACGCTTTGAAGCGTTTGTTAGACAAGCATCATGAAGAAATTTGCGCCTTCATTGCAGAGCCTCTTT
TGCAATGCGCAGGGAATATGCATATTTATAGCGCAAAATATTTAAAACAAGCCGTTTTATTGTGCAAGCAAAAAAACATC
CACATTATTTTTGATGAAATCGCTACCGGGTTTGGGCGCACAGGGAGCATGTTCGCTTTTGAACAATGCGAAATTGAGCC
GGATTTCTTATGCTTGTCTAAAGGGATTAGTGGGGGGTATTTGCCTTTAAGCGCGCTATTAACCCGCAATGAAATCTATA
GCCAATTTTACGCTCCCTATGAAGAAAATAAAGCGTTTTTGCATTCGCACAGCTACACAGGAAATGCCCTAGCATGCGCA
TGCGCAAACGCTACGCTGGATATTTTTGAAAAAGAAAATGTTATTGAAAAGAACAAGGCTTTAAGCGAATTTATTTTTAA
CGCGCTCCAAAACGCATTAAAACCCTTGATAGAGCAACAAGTGGTGTCCAATTTAAGGCATTTGGGCATGGTCTTTGCCT
TTGAAGTCTTTATTCAAACCAAAGAGCGTCTGAGTTTGGCGGTTTTTAAAAAAGCTCTAACCAAAGGCTTGTTATTGCGC
CCTTTAAACAACACCATTTACCTCATGCCCCCTTATATTATCACGCATGAAGAAATCAAAAAGGCGATTGCGGGGTTAGT
GGAAATTCTTGATGGGTTAAAAAAAGGCTGA

Upstream 100 bases:

>100_bases
AAATGTGAAATTCAGGTTTAAACAACCTTATAGTAAAATCAAATAACCCTATTTTAACCAAAGGTTATTAAAATTATCCT
TATTATAGAGAGTTTTTAAC

Downstream 100 bases:

>100_bases
AAGCGTTTTTTTCTGTCTGTTTGATTTCAAAAATCAAGTTTTTAACTTGATATGAAACCTATTCAATGAAACCTATTCAA
TGATTTTAGGCACAACGAAG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNGNAYMDLISSWWVNLFGHNNAYISQQLKNQIDNLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEIALKMSYHAHFLKNQTSRKKLFLSLSNSYHGETLGALSAGD
VKLYKDTYTPLLLKNLTTPVPKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAFEQCEIEPDFLCLSKGISGGYLPLSALLTRNEIYSQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSEFIFNALQNALKPLIEQQVVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALTKGLLLR
PLNNTIYLMPPYIITHEEIKKAIAGLVEILDGLKKG

Sequences:

>Translated_436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNGNAYMDLISSWWVNLFGHNNAYISQQLKNQIDNLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEIALKMSYHAHFLKNQTSRKKLFLSLSNSYHGETLGALSAGD
VKLYKDTYTPLLLKNLTTPVPKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAFEQCEIEPDFLCLSKGISGGYLPLSALLTRNEIYSQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSEFIFNALQNALKPLIEQQVVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALTKGLLLR
PLNNTIYLMPPYIITHEEIKKAIAGLVEILDGLKKG
>Mature_436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNGNAYMDLISSWWVNLFGHNNAYISQQLKNQIDNLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEIALKMSYHAHFLKNQTSRKKLFLSLSNSYHGETLGALSAGD
VKLYKDTYTPLLLKNLTTPVPKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAFEQCEIEPDFLCLSKGISGGYLPLSALLTRNEIYSQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSEFIFNALQNALKPLIEQQVVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALTKGLLLR
PLNNTIYLMPPYIITHEEIKKAIAGLVEILDGLKKG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=402, Percent_Identity=27.8606965174129, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI284507298, Length=311, Percent_Identity=28.9389067524116, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI13994255, Length=378, Percent_Identity=25.9259259259259, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI24119277, Length=442, Percent_Identity=22.8506787330317, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI37574042, Length=427, Percent_Identity=24.824355971897, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI226442705, Length=425, Percent_Identity=24.2352941176471, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI226442709, Length=373, Percent_Identity=24.1286863270777, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786991, Length=429, Percent_Identity=34.7319347319347, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=28.1012658227848, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI145693181, Length=402, Percent_Identity=27.8606965174129, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=25.3588516746411, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788044, Length=402, Percent_Identity=25.8706467661692, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1787560, Length=405, Percent_Identity=26.6666666666667, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786349, Length=366, Percent_Identity=25.9562841530055, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=400, Percent_Identity=24.5, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=26.3279445727483, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=297, Percent_Identity=26.2626262626263, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=23.394495412844, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=464, Percent_Identity=32.5431034482759, Blast_Score=252, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6323470, Length=430, Percent_Identity=25.1162790697674, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=403, Percent_Identity=24.5657568238213, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=25.7281553398058, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=24.8837209302326, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=25.0580046403712, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI161085790, Length=436, Percent_Identity=24.7706422018349, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49497; Mature: 49497

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNGNAYMDLISSWWVNL
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHH
FGHNNAYISQQLKNQIDNLEHVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHH
ALKMSYHAHFLKNQTSRKKLFLSLSNSYHGETLGALSAGDVKLYKDTYTPLLLKNLTTPV
HHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHCCCCC
PKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
HIIFDEIATGFGRTGSMFAFEQCEIEPDFLCLSKGISGGYLPLSALLTRNEIYSQFYAPY
EEEHHHHHCCCCCCCCEEEEHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCH
EENKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKALSEFIFNALQNALKPLIEQQ
HCCCEEEEECCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALTKGLLLRPLNNTIYLMPPYIITHEEIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEECCEEECHHHHH
KAIAGLVEILDGLKKG
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNGNAYMDLISSWWVNL
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHH
FGHNNAYISQQLKNQIDNLEHVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHH
ALKMSYHAHFLKNQTSRKKLFLSLSNSYHGETLGALSAGDVKLYKDTYTPLLLKNLTTPV
HHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHCCCCC
PKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
HIIFDEIATGFGRTGSMFAFEQCEIEPDFLCLSKGISGGYLPLSALLTRNEIYSQFYAPY
EEEHHHHHCCCCCCCCEEEEHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCH
EENKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKALSEFIFNALQNALKPLIEQQ
HCCCEEEEECCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALTKGLLLRPLNNTIYLMPPYIITHEEIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEECCEEECHHHHH
KAIAGLVEILDGLKKG
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]