Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 188527595

GI number: 188527595

Start: 794805

End: 796043

Strand: Direct

Name: fabF [H]

Synonym: HPSH_04085

Alternate gene names: 188527595

Gene position: 794805-796043 (Clockwise)

Preceding gene: 188527594

Following gene: 188527596

Centisome position: 49.41

GC content: 44.96

Gene sequence:

>1239_bases
GTGCGTCGGATTGTAGTAACTGGAATGGGAATGATCAATTCGCTAGGTTTAAATAAAGAAGATTCTTTTTTAGCGATCGC
TAAAGGGGAATGCGGTATCAAAAACATAGAAAGTTTTGATGCGAGCGTGTTTCCTGTGCGTATCGCTGGAGAAATCACTG
ACTTTGACCCTACAGAGGTGATGAATCCCAAAGATGTTAAAAAGGCGGGTCGTTTCATTCAATTAGCCTTGAAAGCCACA
AGAGAGGCGATGAAAGATAGTGGGATTTTAGACGCTCACAATAAATGTCCTGAAGAATTGGCAAACCGCATGGGCGTAAG
CTCTGGCTCTGGGATTGGCGGGTTAGGCAATATTGAAGCGAATTCCATTTTTTGTTTTGAAAAAGGCCCTAGAAAAGTCA
ATCCCTTTTTTATCACTTCTGCGTTAGTGAATATGATTGGTGGTTTCACTTCCATTGAGTTTGGCATTAAAGGGCCCAAC
CTCTCTAGCGTAACGGCTTGTGCAGCAGGCACTCATGCCATTATTGAAGCCGTTAAAACCATTTTGCTTAATGGGGCTGA
TAAAATGCTAGTCGTGGGAGCGGAATCCACCATTTGTCCCGTAGGGATTGGGGGGTTTGCGAGCATTAAAGCCCTTTCTA
CAAGGAATGATGATCCCAAAAAAGCTTCAAGACCTTTTGATAAGGATCGCAATGGCTTTGTGATGGGCGAAGGCGCTGGG
GCTTTGGTGCTTGAAGAATACGAGAGCGCGAAAAAAAGAGGGGCAAAAATTTATGCAGAATTTGCCGGGTATGGTGAGAG
CGGCGATGCTAACCATATCACAGCCCCGGCTCCTGAGGGTGAAGGGGCTTTTAGAGCCATGAAAATGGCTTTAGAAATGG
CGAAAGTGGAAATAGGCTATGTGAACGCTCATGGGACTAGCACGCATTATAACGATTGGTATGAGAGCATCGCTCTAAAA
AATGTGTTTGGCTCTAAAGAAAAAGTCCCTCCTGTCAGCTCCACTAAAGGGCAGATTGGGCATTGTTTGGGTGCTGCGGG
CGCGTTAGAAGCCGTTATTTCTATCATGGCCATGAATCAAGGGATCTTACCTCCTACCATCAATCAAGAAACGCCTGACC
CAGAATGCGATTTGGATTATATCCCTAATGCGGCTAGAGAAAAGCAAGTGGATGCGGTGATGAGTAACTCATTTGGTTTT
GGTGGCACTAATGGTGTTGTGATTTTCAAAAAAGCCTAG

Upstream 100 bases:

>100_bases
CTTTCGTGTTAGCATTCAATGGAATGCTTTAGTTAGGAAGCCCCTTGCTTTAGAAAGGGGCGGTTTCACTGAATTAAAAT
TTTGAAATGAGGAGCTATTG

Downstream 100 bases:

>100_bases
TTTTACGAAGTTAGGATTTTGAATGGCCATTTATTTAGATTTTGAAAATCATATTAAAGAGATTCAAAATGAAATTGAAT
TAGCCCTTATTAGAGGCGAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASVFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAT
REAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPN
LSSVTACAAGTHAIIEAVKTILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGF
GGTNGVVIFKKA

Sequences:

>Translated_412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASVFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAT
REAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPN
LSSVTACAAGTHAIIEAVKTILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGF
GGTNGVVIFKKA
>Mature_412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASVFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAT
REAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPN
LSSVTACAAGTHAIIEAVKTILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGF
GGTNGVVIFKKA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=42.3809523809524, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=50, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI41872631, Length=393, Percent_Identity=24.1730279898219, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=49.2753623188406, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=36.2768496420048, Blast_Score=236, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=36.0381861575179, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=42.0454545454545, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=430, Percent_Identity=26.7441860465116, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=412, Percent_Identity=26.4563106796117, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=35.2017937219731, Blast_Score=239, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=41.3461538461538, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI221330659, Length=398, Percent_Identity=27.3869346733668, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19920632, Length=398, Percent_Identity=27.3869346733668, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24581345, Length=399, Percent_Identity=27.0676691729323, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43528; Mature: 43528

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASVFPVRIAGEITDFDPTEV
CCEEEEECCCHHHHCCCCCCCCEEEEECCCCCCCCHHHCCCEEEEEEEECCCCCCCCHHC
MNPKDVKKAGRFIQLALKATREAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
NSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPNLSSVTACAAGTHAIIEAVKT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHHH
ILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
HHHCCCCCEEEEECCCCCCEECCCCHHHEEEECCCCCCCHHHCCCCCCCCCCEEEECCCC
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGY
EEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHEEEEE
VNAHGTSTHYNDWYESIALKNVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQ
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGFGGTNGVVIFKKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASVFPVRIAGEITDFDPTEV
CCEEEEECCCHHHHCCCCCCCCEEEEECCCCCCCCHHHCCCEEEEEEEECCCCCCCCHHC
MNPKDVKKAGRFIQLALKATREAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
NSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPNLSSVTACAAGTHAIIEAVKT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHHH
ILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
HHHCCCCCEEEEECCCCCCEECCCCHHHEEEECCCCCCCHHHCCCCCCCCCCEEEECCCC
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGY
EEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHEEEEE
VNAHGTSTHYNDWYESIALKNVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQ
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGFGGTNGVVIFKKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]