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The map label for this gene is lepB [H]

Identifier: 188527577

GI number: 188527577

Start: 781241

End: 782113

Strand: Direct

Name: lepB [H]

Synonym: HPSH_03995

Alternate gene names: 188527577

Gene position: 781241-782113 (Clockwise)

Preceding gene: 188527576

Following gene: 188527578

Centisome position: 48.57

GC content: 39.98

Gene sequence:

>873_bases
ATGAAATTTTTACGCTCTGTTTATGCGTTTTGCTCCAGTTGGGTAGGGACGATCATTATTGTGCTGTTGGTTATCTTTTT
TGTCGCACAAGCCTTTATCATTCCTTCTCGCTCTATGGTAGGCACGCTCTATGAGGGCGATATGCTCTTTGTCAAAAAGT
TTTCTTACGGCATACCCATTCCTAAAATCCCATGGATTGAGCTTCCTGTTATGCCTGATTTTAAAAATAACGGGCATTTG
ATAGAGGGGGATCGCCCTAAGCGTGGCGAAGTGGTGGTGTTTATCCCGCCCCATGAAAAAAAATCTTACTATGTCAAAAG
GAATTTTGCTATTGGAGGCGATGAGGTGTTATTCACTAATGAGGGGCTTTATTTGCACCCTTTTGAGAGCGACACAGACA
AAAATTACATCGCTAAACATTACCCTAACGCCATGACTAAAGAATTTATGGGTAAAATTTTTGTTTTAAACCCTTATAAA
AGTGAGCATCCGGGTATCCATTACCAAAAAGACAATGAAACCTTCCACTTAATGGAGCAGTTAGCCACTCAAGGCGCAGA
AGCTAATATCAGCATGCAACTCATTCAAATGGAGGGCGAAAAGGTGTTTTACAAGAAAATCAATAACGATGAATTTTTCA
TGATCGGCGATAACAGAGATAATTCTAGCGACTCGCGCTTTTGGGGGAGTGTGGCTTATAAAAACATCGTGGGTTCGCCA
TGGATTGTTTATTTCAGTTTGAGTTTAAAAAATAGCCTGGAAATGGATGCAGAAAATAACCCCAAAAAACGCTATTTGGT
GCGTTGGGAGCGCATGTTTAAAAGCGTTGAAGGCTTAGAAAAAATCATTAAAAAAGAAAAAGCAACGCCTTAA

Upstream 100 bases:

>100_bases
TATCACGCCTGTGCCTAAAGGCGTGGGGCCTATGACGATCGTTTCGCTTTTAGAAAACACTCTCATCGCTTTTGAAAAAC
AACAAAGGAAGGGATTTTAA

Downstream 100 bases:

>100_bases
GGTTTTTTGTGCAATTTTTTGATTCCTCTTTAGAAAGTTTTATCACCACCTTAATGAAGATTCTAGCCCTTTTAATCGCT
ATCATAGGGCATGAGATCAT

Product: signal peptidase I (lepB)

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKFLRSVYAFCSSWVGTIIIVLLVIFFVAQAFIIPSRSMVGTLYEGDMLFVKKFSYGIPIPKIPWIELPVMPDFKNNGHL
IEGDRPKRGEVVVFIPPHEKKSYYVKRNFAIGGDEVLFTNEGLYLHPFESDTDKNYIAKHYPNAMTKEFMGKIFVLNPYK
SEHPGIHYQKDNETFHLMEQLATQGAEANISMQLIQMEGEKVFYKKINNDEFFMIGDNRDNSSDSRFWGSVAYKNIVGSP
WIVYFSLSLKNSLEMDAENNPKKRYLVRWERMFKSVEGLEKIIKKEKATP

Sequences:

>Translated_290_residues
MKFLRSVYAFCSSWVGTIIIVLLVIFFVAQAFIIPSRSMVGTLYEGDMLFVKKFSYGIPIPKIPWIELPVMPDFKNNGHL
IEGDRPKRGEVVVFIPPHEKKSYYVKRNFAIGGDEVLFTNEGLYLHPFESDTDKNYIAKHYPNAMTKEFMGKIFVLNPYK
SEHPGIHYQKDNETFHLMEQLATQGAEANISMQLIQMEGEKVFYKKINNDEFFMIGDNRDNSSDSRFWGSVAYKNIVGSP
WIVYFSLSLKNSLEMDAENNPKKRYLVRWERMFKSVEGLEKIIKKEKATP
>Mature_290_residues
MKFLRSVYAFCSSWVGTIIIVLLVIFFVAQAFIIPSRSMVGTLYEGDMLFVKKFSYGIPIPKIPWIELPVMPDFKNNGHL
IEGDRPKRGEVVVFIPPHEKKSYYVKRNFAIGGDEVLFTNEGLYLHPFESDTDKNYIAKHYPNAMTKEFMGKIFVLNPYK
SEHPGIHYQKDNETFHLMEQLATQGAEANISMQLIQMEGEKVFYKKINNDEFFMIGDNRDNSSDSRFWGSVAYKNIVGSP
WIVYFSLSLKNSLEMDAENNPKKRYLVRWERMFKSVEGLEKIIKKEKATP

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=248, Percent_Identity=30.6451612903226, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 33660; Mature: 33660

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLRSVYAFCSSWVGTIIIVLLVIFFVAQAFIIPSRSMVGTLYEGDMLFVKKFSYGIPI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCEEEEEEECCCCCC
PKIPWIELPVMPDFKNNGHLIEGDRPKRGEVVVFIPPHEKKSYYVKRNFAIGGDEVLFTN
CCCCEEEECCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEEEEECCCCEEEEEC
EGLYLHPFESDTDKNYIAKHYPNAMTKEFMGKIFVLNPYKSEHPGIHYQKDNETFHLMEQ
CCEEEECCCCCCCCCHHHHHCCCHHHHHHCCEEEEECCCCCCCCCCEEECCCCHHHHHHH
LATQGAEANISMQLIQMEGEKVFYKKINNDEFFMIGDNRDNSSDSRFWGSVAYKNIVGSP
HHHCCCCCCEEEEEEEECCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCC
WIVYFSLSLKNSLEMDAENNPKKRYLVRWERMFKSVEGLEKIIKKEKATP
EEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKFLRSVYAFCSSWVGTIIIVLLVIFFVAQAFIIPSRSMVGTLYEGDMLFVKKFSYGIPI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCEEEEEEECCCCCC
PKIPWIELPVMPDFKNNGHLIEGDRPKRGEVVVFIPPHEKKSYYVKRNFAIGGDEVLFTN
CCCCEEEECCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEEEEECCCCEEEEEC
EGLYLHPFESDTDKNYIAKHYPNAMTKEFMGKIFVLNPYKSEHPGIHYQKDNETFHLMEQ
CCEEEECCCCCCCCCHHHHHCCCHHHHHHCCEEEEECCCCCCCCCCEEECCCCHHHHHHH
LATQGAEANISMQLIQMEGEKVFYKKINNDEFFMIGDNRDNSSDSRFWGSVAYKNIVGSP
HHHCCCCCCEEEEEEEECCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCC
WIVYFSLSLKNSLEMDAENNPKKRYLVRWERMFKSVEGLEKIIKKEKATP
EEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]