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The map label for this gene is moaA

Identifier: 188527386

GI number: 188527386

Start: 573189

End: 574070

Strand: Direct

Name: moaA

Synonym: HPSH_02975

Alternate gene names: 188527386

Gene position: 573189-574070 (Clockwise)

Preceding gene: 188527384

Following gene: 188527388

Centisome position: 35.63

GC content: 35.26

Gene sequence:

>882_bases
ATGCCTACTACGCCATTAAATTTTTTTGATGGTGAAGAATTATTGCCTTTGGATAATGTTTTAGAATTTCTTAAAATCGC
CATTGATGAAGGCGTTAAAAAAATTAGAATCACTGGTGGGGAGCCTCTATTACGCAAGGGTTTAGATGAATTTATCGCTA
AACTACACGCTTACAATAAAGAAGTGGCGTTAGTTTTAAGCACTAATGGTTTTTTACTCAAAAAAATGGCTAAGGATTTA
AAAAATGCCGGGTTATCCCGAGTGAATGTTTCATTGGATTCTTTAAAAAGCGATAGGGTTTTAAAAATCTCTCAAAAAGA
CGCTCTTAAAAATACGCTAGAAGGGATTGAAGAGTCCTTGGAAGTGGGTTTAAAACTCAAATTAAACATGGTTGTGATGA
AAAGCGTTAATGATGATGAAATCTTAGAGCTTTTAGAATACGCAAAAAATAGGCATATCCAAATCCGCTACATTGAATTT
ATGGAAAACACGCATGCTAAAAGTTTGGTTAAAGGCTTGAAAGAGCGAGAAATTTTAGATTTGATCGCTCAAAAATATCA
AATCATTGCGACAGAAAAACCTAAACAAGGGTCTTCTAAAATCTACACGCTAGAAAATGGCTATCAATTTGGCATTATCG
CTCCGCATAGCGATGATTTTTGCCAATCTTGCAATCGTATCCGTTTGGCTTCTGATGGTAAGATTTGCCCATGTTTATAC
TATCAAGACGCCATAGACGCTAAAGAGGCGATCATGAATAAGGATACAAAAAATATAAAAAGGCTTTTAAAGCAATCTAT
CATCAATAAACCAGAAAAAAACATGTGGAATGATAAAAACAGCGAAACTCCCACAAGGGCGTTTTACTATACAGGGGGGT
AG

Upstream 100 bases:

>100_bases
CATAAGGGAAAAGGGAGTGTTAGTAGATAATTTTAATAGGGTTATTGACTATATTAGGGTTTCTGTAACCAAACAATGTA
ATTTCAGGTGTCAGTATTGC

Downstream 100 bases:

>100_bases
GACACAGGAGGGTAGGGAAAATATTTATTATTTTAAACCTTTTTGTTAAGAATAAGGCGGTTTGTTTAGGATTTTGGTTA
TAGTGGCTAGGATTAAACAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPTTPLNFFDGEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFIAKLHAYNKEVALVLSTNGFLLKKMAKDL
KNAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLEVGLKLKLNMVVMKSVNDDEILELLEYAKNRHIQIRYIEF
MENTHAKSLVKGLKEREILDLIAQKYQIIATEKPKQGSSKIYTLENGYQFGIIAPHSDDFCQSCNRIRLASDGKICPCLY
YQDAIDAKEAIMNKDTKNIKRLLKQSIINKPEKNMWNDKNSETPTRAFYYTGG

Sequences:

>Translated_293_residues
MPTTPLNFFDGEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFIAKLHAYNKEVALVLSTNGFLLKKMAKDL
KNAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLEVGLKLKLNMVVMKSVNDDEILELLEYAKNRHIQIRYIEF
MENTHAKSLVKGLKEREILDLIAQKYQIIATEKPKQGSSKIYTLENGYQFGIIAPHSDDFCQSCNRIRLASDGKICPCLY
YQDAIDAKEAIMNKDTKNIKRLLKQSIINKPEKNMWNDKNSETPTRAFYYTGG
>Mature_292_residues
PTTPLNFFDGEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFIAKLHAYNKEVALVLSTNGFLLKKMAKDLK
NAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLEVGLKLKLNMVVMKSVNDDEILELLEYAKNRHIQIRYIEFM
ENTHAKSLVKGLKEREILDLIAQKYQIIATEKPKQGSSKIYTLENGYQFGIIAPHSDDFCQSCNRIRLASDGKICPCLYY
QDAIDAKEAIMNKDTKNIKRLLKQSIINKPEKNMWNDKNSETPTRAFYYTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=299, Percent_Identity=26.0869565217391, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI116734668, Length=299, Percent_Identity=26.0869565217391, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1786999, Length=284, Percent_Identity=25.7042253521127, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32566329, Length=301, Percent_Identity=29.2358803986711, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17561210, Length=301, Percent_Identity=29.9003322259136, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32566331, Length=296, Percent_Identity=29.0540540540541, Blast_Score=147, Evalue=6e-36,
Organism=Drosophila melanogaster, GI28574488, Length=258, Percent_Identity=31.7829457364341, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574490, Length=261, Percent_Identity=31.4176245210728, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 33286; Mature: 33155

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTPLNFFDGEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFIAKLHAYNK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
EVALVLSTNGFLLKKMAKDLKNAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESL
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
EVGLKLKLNMVVMKSVNDDEILELLEYAKNRHIQIRYIEFMENTHAKSLVKGLKEREILD
HCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHH
LIAQKYQIIATEKPKQGSSKIYTLENGYQFGIIAPHSDDFCQSCNRIRLASDGKICPCLY
HHHHHHEEEECCCCCCCCCEEEEEECCEEEEEECCCCCHHHHCCCCEEECCCCCEEEEEH
YQDAIDAKEAIMNKDTKNIKRLLKQSIINKPEKNMWNDKNSETPTRAFYYTGG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
PTTPLNFFDGEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFIAKLHAYNK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
EVALVLSTNGFLLKKMAKDLKNAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESL
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
EVGLKLKLNMVVMKSVNDDEILELLEYAKNRHIQIRYIEFMENTHAKSLVKGLKEREILD
HCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHH
LIAQKYQIIATEKPKQGSSKIYTLENGYQFGIIAPHSDDFCQSCNRIRLASDGKICPCLY
HHHHHHEEEECCCCCCCCCEEEEEECCEEEEEECCCCCHHHHCCCCEEECCCCCEEEEEH
YQDAIDAKEAIMNKDTKNIKRLLKQSIINKPEKNMWNDKNSETPTRAFYYTGG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA