Click here to switch to the map view.

The map label for this gene is ribB [H]

Identifier: 188527352

GI number: 188527352

Start: 535451

End: 536485

Strand: Direct

Name: ribB [H]

Synonym: HPSH_02795

Alternate gene names: 188527352

Gene position: 535451-536485 (Clockwise)

Preceding gene: 188527351

Following gene: 188527353

Centisome position: 33.29

GC content: 39.9

Gene sequence:

>1035_bases
ATGATCTTAAAACGAGTTACTGAAGCTTTAGAAGCGTATAAAAATGGCGAAATGCTTATTGTTATGGATGATGAAGACAG
AGAAAATGAGGGGGATTTGGTTTTAGCTGGGATTTTTTCCACCCCTGAGAAAATCAATTTCATGGCCACGCATGCTAGGG
GGTTGATTTGCGTGTCTTTGACCAAAGATTTAGCGAATAAATTTGAATTACCCCCTATGGTTAGCGTGAATGATTCTAAT
CATGAGACCGCTTTCACGGTTTCCATTGACGCTAAAGAAGCCAAAACCGGGATTTCTGCTTTTGAAAGGCATTTAACGAT
TGAATTATTGTGTAAAGACACCACCAAGCCTAGCGATTTTGTGCGCCCGGGGCATATTTTCCCTTTAATCGCCAAAGATG
GAGGCGTGTTAGCGCGCACGGGCCATACTGAAGCGAGCGTGGATTTATGCAAATTGGCTGGATTAAAGCCTGTGAGCGTG
ATTTGTGAAATCATGAAAGAAGACGGCTCTATGGCGAGAAGGGGGGATAAATTTTTGAGCGATTTTGCCCTAAAGCACAA
TCTCAAAACTCTCTATGTTTCTGATTTGATTAGCTATCGTTTAGAAAATGAAAGTTTGCTGAAAATGTTTTGCCAAGAAG
AAAGGGAATTTTTAAAACACCAAACGCAATGCTACACTTTTTTAGACCACCAGCAAAAAAACCATTACGCTTTTAAGTTT
AAAGGCGCAAAAACCAATGATTTAGCCCCTTTAGTGCGTTTCCACCCTATCAAAGAGGATTTTGATTTTTTAACGACTGG
CGCGTTTGAAGTGTTTTTTAAGGCTTTAGAATATTTAAAGCGCGAAGGGGGTTATTTGATCTTTATGAACACGCATTCTA
AAGAAAACAATATCGTTAAAGATTTTGGGATCGGGGCGTTAGTGTTAAAAAATTTGGGGATAAAGGATTTCAGGCTTTTA
AGCTCTTCTGAAGACAGGCAGTATAAGGCTTTGAGCGGGTTTGGGCTTAAGCTTGTAGAAACGATTAGCCTTTGA

Upstream 100 bases:

>100_bases
TTTTTTCCCCATCAATGATCAAGTAATAATCGTTATTAAACATGCTATATTTGTTGTTTTTATAACACTTAATATTATTG
AATAAAACGAGGGAGTTAGA

Downstream 100 bases:

>100_bases
GGCTTGTTGGGTTTCATTGAATGTGTTGTAATGTTTTTAAGGTATAATAAACTCTTTTTAAGTCAAGCAATAAAGTTTGC
AACCTGATGAGAGTAATAAT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLANKFELPPMVSVNDSN
HETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTNDLAPLVRFHPIKEDFDFLTTGAFEVFFKALEYLKREGGYLIFMNTHSKENNIVKDFGIGALVLKNLGIKDFRLL
SSSEDRQYKALSGFGLKLVETISL

Sequences:

>Translated_344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLANKFELPPMVSVNDSN
HETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTNDLAPLVRFHPIKEDFDFLTTGAFEVFFKALEYLKREGGYLIFMNTHSKENNIVKDFGIGALVLKNLGIKDFRLL
SSSEDRQYKALSGFGLKLVETISL
>Mature_344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLANKFELPPMVSVNDSN
HETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTNDLAPLVRFHPIKEDFDFLTTGAFEVFFKALEYLKREGGYLIFMNTHSKENNIVKDFGIGALVLKNLGIKDFRLL
SSSEDRQYKALSGFGLKLVETISL

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=45.049504950495, Blast_Score=185, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320695, Length=203, Percent_Identity=41.871921182266, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 38866; Mature: 38866

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSL
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEE
TKDLANKFELPPMVSVNDSNHETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDF
HHHHHHHCCCCCEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHEEEEEEECCCCCCHHC
VRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSVICEIMKEDGSMARRGDKFLS
CCCCCEEEEEECCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
DFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KGAKTNDLAPLVRFHPIKEDFDFLTTGAFEVFFKALEYLKREGGYLIFMNTHSKENNIVK
CCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHH
DFGIGALVLKNLGIKDFRLLSSSEDRQYKALSGFGLKLVETISL
HHCHHHHHHHHCCCCCEEECCCCCCCHHHHHHCCCCEEHHEECC
>Mature Secondary Structure
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSL
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEE
TKDLANKFELPPMVSVNDSNHETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDF
HHHHHHHCCCCCEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHEEEEEEECCCCCCHHC
VRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSVICEIMKEDGSMARRGDKFLS
CCCCCEEEEEECCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
DFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KGAKTNDLAPLVRFHPIKEDFDFLTTGAFEVFFKALEYLKREGGYLIFMNTHSKENNIVK
CCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHH
DFGIGALVLKNLGIKDFRLLSSSEDRQYKALSGFGLKLVETISL
HHCHHHHHHHHCCCCCEEECCCCCCCHHHHHHCCCCEEHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]