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The map label for this gene is hom [H]

Identifier: 188527332

GI number: 188527332

Start: 520604

End: 521869

Strand: Reverse

Name: hom [H]

Synonym: HPSH_02695

Alternate gene names: 188527332

Gene position: 521869-520604 (Counterclockwise)

Preceding gene: 188527333

Following gene: 188527331

Centisome position: 32.44

GC content: 39.89

Gene sequence:

>1266_bases
ATGAAGAAAAGATTGAATATAGGGCTTGTGGGTTTAGGGTGTGTGGGGAGCGCGGTCGCTAAAATCTTACAAGAAAATCA
AGAAATCATTAAAGACAGAGCCGGCGTGGAAATCATGATTAAAAAAGCGGTGGTGCGAGATGTGAAAAAGCGCAAAGGCT
ATCCTTTTGAAATCAGTAATGATTTAGAAAGCCTGATAGGAGATGAAGAGATTGATATTGTCGTGGAGCTTATGGGTGGG
GTGGAAGTGCCTTATCTTTTAGCTAAAAAAACTTTAGCCAAACAAAAAGCCTTCGTTACAGCCAATAAAGCCATGTTAGC
GTATCACCGCTATGAATTAGAACAAATCGCTAAAAACACTCCCATAGGCTTTGAAGCGAGCGTGTGCGGGGGTATCCCTA
TTATCAAGGCTTTAAAAGACGGCTTGAGTGCTAATCACATCCTTTCTTTTAAAGGGATTTTAAACGGCACCAGCAATTAC
ATTTTAAGCCAGATGTTTAAAAATCAAGCGAGCTTTAAGGACGCTTTGAAAGACGCCCAACATTTAGGCTATGCGGAATT
AAACCCTGAATTTGACATTAAAGGCATTGATGCGGCGCACAAATTATTGATTTTAGCGTCTTTAGCCTATGGCATTGATG
CGAAATTAGAAGAAATTTTAATTGAAGGCATTGAAAAAATAGAGCCAGACGACATGGAGTTTGCTAAAGAATTTGGTTAT
AGCATTAAACTTTTAGGCATCGCTAAAAAACACCAAGATTGCATTGAATTAAGGGTGCATCCAAGCATGATTAAAAATGA
ATGCATGCTCTCTAAAGTGGATGGGGTGATGAACGCTATAAGCGTTATAGGGGATAAGGTGGGCGAGACTTTGTATTATG
GGGCTGGGGCTGGGGGAGAGCCTACCGCAAGCGCGGTCATTAGCGATATTATAGAAATCGCAAGGAAAAAAAGCTCTTTA
ATGCTAGGCTTTGAAACCCCTCAAAAACTCCCCCTAAAACCCAAAGAAGAAATCCAATGCGCTTATTATGCACGTTTGTT
AGTGAGCGATGAAAAAGGAGTTTTTTCTCAAATTAGTGCGATTTTAGCCCAAAATGATATTTCTCTCAACAATGTTTTAC
AAAAAGAAATCCCGCATTCCAACAAGGCTAAAATCTTATTTTCCACGCACACCACCAACGAAAAGTCTATGTTAAACGCC
CTTAAAGAGCTTGAAAATCTAAAAAGCGTGCTAGACACCCCTAAAATGATCCGTTTGGAACATTGA

Upstream 100 bases:

>100_bases
AAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAACGCTGTTTTAAAAAA
ACGAATTTAAAGGAAAAAAT

Downstream 100 bases:

>100_bases
ATGCGCTTTTTGAACAACAAGCATAGGGCAAAGGGCTTAAAGGCTGAAGAAGAAGCTTGCGAATTTTTAAAAACGCTGGG
TTTTGAAATGGTGGAGAGGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIMIKKAVVRDVKKRKGYPFEISNDLESLIGDEEIDIVVELMGG
VEVPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHQDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNA
LKELENLKSVLDTPKMIRLEH

Sequences:

>Translated_421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIMIKKAVVRDVKKRKGYPFEISNDLESLIGDEEIDIVVELMGG
VEVPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHQDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNA
LKELENLKSVLDTPKMIRLEH
>Mature_421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIMIKKAVVRDVKKRKGYPFEISNDLESLIGDEEIDIVVELMGG
VEVPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHQDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNA
LKELENLKSVLDTPKMIRLEH

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=134, Percent_Identity=35.0746268656716, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=232, Percent_Identity=25, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46340; Mature: 46340

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIMIKKAVVRDVKKRKGYPFEISN
CCCCCEECEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEECH
DLESLIGDEEIDIVVELMGGVEVPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNT
HHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQMFKNQASFKDALKDAQ
CCCCCCHHHCCHHHHHHHHCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
SIKLLGIAKKHQDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGE
EEEEEEEHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCC
PTASAVISDIIEIARKKSSLMLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISA
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
ILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNALKELENLKSVLDTPKMIRLE
HHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEC
H
C
>Mature Secondary Structure
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVEIMIKKAVVRDVKKRKGYPFEISN
CCCCCEECEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEECH
DLESLIGDEEIDIVVELMGGVEVPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQIAKNT
HHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQMFKNQASFKDALKDAQ
CCCCCCHHHCCHHHHHHHHCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
SIKLLGIAKKHQDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGE
EEEEEEEHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCC
PTASAVISDIIEIARKKSSLMLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISA
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
ILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNALKELENLKSVLDTPKMIRLE
HHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]