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The map label for this gene is guaC [H]

Identifier: 188527299

GI number: 188527299

Start: 487592

End: 488569

Strand: Reverse

Name: guaC [H]

Synonym: HPSH_02530

Alternate gene names: 188527299

Gene position: 488569-487592 (Counterclockwise)

Preceding gene: 188527302

Following gene: 188527283

Centisome position: 30.37

GC content: 40.39

Gene sequence:

>978_bases
TTGAAAATATTTGATTACGAAAACATCCAGCTCATCCCTAATAAATGTATCGTGAATAGCCGTTCAGAGTGTGATACGAC
CGTTACCTTAGGTAGGCACACATTTAAAATGCCAATAGTCCCAGCAAACATGCAAACAATCATCAACGACTCGATCGCAG
AATTTCTAGCGGAAAATGGCTATTTCTACATCATGCACCGTTTTGATGGAGCGGCAAGAATCCCGTTTGTCAAAAAAATG
AAGGAACGCCAATGGATCAGCTCCATCAGTGTTGGGGTGAAAAAGGAAGAATATCTTTTTATAGAAGAGTTGGCCAAACA
AAAATTAGCGTCAGATTATATCACGATTGATATTGCGCATGGCCATTCAAATTCTGTCATTGAAATGATCCAACACATCA
AAACGCATTTGCCAGAAACTTTTGTGATTGCCGGGAATGTTGGCACACCAGAAGCAGTCCGTGAATTAGAGAACGCCGGT
GCTGACGCTACAAAAGTTGGCATTGGACCTGGGAAAGCGTGTATCACCAAAATCAAAACAGGCTTTGGTACGGGTGGTTG
GCAACTGGCAGCTCTTAGATGGTGCGCTAAAGCAGCAAGAAAACCGATTATTGCAGATGGTGGTATTCGCACGCATGGCG
ATATTGCAAAATCAATACGCTTTGGCGCGACAATGGTAATGATTGGCTCGCTTTTTGCAGGGCATGAAGAATCATCTGGG
GAAACAAAAATAGAAAATGGTATCGCATATAAAGAATATTTCGGTTCAGCATCAGAGTTCCAAAAAGGTGAAAAGAAAAA
TATTGAAGGTAAGAAAATTTGGATCCAACATAAAGGATCATTAAAAGATACGCTGATTGAAATGCATCAAGATCTACAAT
CTTCAATCTCCTATGCAGGTGGGAGAGATCTTGAAGCGATTCGAAAAGTTGATTATGTCATTGTGAAAAATTCAATTTTC
AATGGAGACGCAATCTAA

Upstream 100 bases:

>100_bases
ATTCAAATTAAGATAGATTACAAAAGGTTCTTAAAAATAATGCTTAAAATCAAATAATGTTCGTGTTTTGCTCTATACGA
ACATCAAAAGGATCGTGTCA

Downstream 100 bases:

>100_bases
AAAAGATTGATGAAACGAAAGCAAAAGACAGAAAAAATGGTCTCCAACTTGTTTTTCAAGCGGTTTGCTTTGACTTAGAT
TTTTGTTGTTTTTAATCCTT

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKIFDYENIQLIPNKCIVNSRSECDTTVTLGRHTFKMPIVPANMQTIINDSIAEFLAENGYFYIMHRFDGAARIPFVKKM
KERQWISSISVGVKKEEYLFIEELAKQKLASDYITIDIAHGHSNSVIEMIQHIKTHLPETFVIAGNVGTPEAVRELENAG
ADATKVGIGPGKACITKIKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
ETKIENGIAYKEYFGSASEFQKGEKKNIEGKKIWIQHKGSLKDTLIEMHQDLQSSISYAGGRDLEAIRKVDYVIVKNSIF
NGDAI

Sequences:

>Translated_325_residues
MKIFDYENIQLIPNKCIVNSRSECDTTVTLGRHTFKMPIVPANMQTIINDSIAEFLAENGYFYIMHRFDGAARIPFVKKM
KERQWISSISVGVKKEEYLFIEELAKQKLASDYITIDIAHGHSNSVIEMIQHIKTHLPETFVIAGNVGTPEAVRELENAG
ADATKVGIGPGKACITKIKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
ETKIENGIAYKEYFGSASEFQKGEKKNIEGKKIWIQHKGSLKDTLIEMHQDLQSSISYAGGRDLEAIRKVDYVIVKNSIF
NGDAI
>Mature_325_residues
MKIFDYENIQLIPNKCIVNSRSECDTTVTLGRHTFKMPIVPANMQTIINDSIAEFLAENGYFYIMHRFDGAARIPFVKKM
KERQWISSISVGVKKEEYLFIEELAKQKLASDYITIDIAHGHSNSVIEMIQHIKTHLPETFVIAGNVGTPEAVRELENAG
ADATKVGIGPGKACITKIKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
ETKIENGIAYKEYFGSASEFQKGEKKNIEGKKIWIQHKGSLKDTLIEMHQDLQSSISYAGGRDLEAIRKVDYVIVKNSIF
NGDAI

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=338, Percent_Identity=31.6568047337278, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541954, Length=338, Percent_Identity=31.6568047337278, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541952, Length=338, Percent_Identity=31.6568047337278, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541948, Length=338, Percent_Identity=31.6568047337278, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI156104880, Length=338, Percent_Identity=29.8816568047337, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI217035146, Length=255, Percent_Identity=32.5490196078431, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI217035148, Length=255, Percent_Identity=32.156862745098, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI217035150, Length=255, Percent_Identity=32.5490196078431, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI34328930, Length=255, Percent_Identity=32.5490196078431, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI156616279, Length=255, Percent_Identity=32.5490196078431, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI217035152, Length=255, Percent_Identity=32.5490196078431, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI34328928, Length=255, Percent_Identity=32.5490196078431, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI66933016, Length=255, Percent_Identity=31.7647058823529, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786293, Length=348, Percent_Identity=30.7471264367816, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788855, Length=220, Percent_Identity=38.1818181818182, Blast_Score=111, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17560440, Length=334, Percent_Identity=30.2395209580838, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=262, Percent_Identity=30.1526717557252, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994389, Length=188, Percent_Identity=33.5106382978723, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322012, Length=252, Percent_Identity=29.7619047619048, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323585, Length=253, Percent_Identity=28.8537549407115, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323464, Length=253, Percent_Identity=28.8537549407115, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24641071, Length=263, Percent_Identity=31.1787072243346, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24641073, Length=263, Percent_Identity=31.1787072243346, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28571163, Length=263, Percent_Identity=31.1787072243346, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 35973; Mature: 35973

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFDYENIQLIPNKCIVNSRSECDTTVTLGRHTFKMPIVPANMQTIINDSIAEFLAENG
CCCCCCCCEEECCCHHCCCCCCCCCCEEEECCEEEECCEECCCHHHHHHHHHHHHHHCCC
YFYIMHRFDGAARIPFVKKMKERQWISSISVGVKKEEYLFIEELAKQKLASDYITIDIAH
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEC
GHSNSVIEMIQHIKTHLPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKACITKIKT
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
GFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ETKIENGIAYKEYFGSASEFQKGEKKNIEGKKIWIQHKGSLKDTLIEMHQDLQSSISYAG
CCHHHCCCCHHHHCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
GRDLEAIRKVDYVIVKNSIFNGDAI
CCCHHHHHHHCEEEEECCCCCCCCC
>Mature Secondary Structure
MKIFDYENIQLIPNKCIVNSRSECDTTVTLGRHTFKMPIVPANMQTIINDSIAEFLAENG
CCCCCCCCEEECCCHHCCCCCCCCCCEEEECCEEEECCEECCCHHHHHHHHHHHHHHCCC
YFYIMHRFDGAARIPFVKKMKERQWISSISVGVKKEEYLFIEELAKQKLASDYITIDIAH
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEC
GHSNSVIEMIQHIKTHLPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKACITKIKT
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
GFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ETKIENGIAYKEYFGSASEFQKGEKKNIEGKKIWIQHKGSLKDTLIEMHQDLQSSISYAG
CCHHHCCCCHHHHCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
GRDLEAIRKVDYVIVKNSIFNGDAI
CCCHHHHHHHCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]