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The map label for this gene is hldE [H]

Identifier: 188527297

GI number: 188527297

Start: 485453

End: 486844

Strand: Direct

Name: hldE [H]

Synonym: HPSH_02520

Alternate gene names: 188527297

Gene position: 485453-486844 (Clockwise)

Preceding gene: 188527296

Following gene: 188527298

Centisome position: 30.18

GC content: 42.31

Gene sequence:

>1392_bases
ATGAAACAAATCTTAGTCGTGGGGGATCTGATCGCTGATTATTACCTGTGGGGGAGAAGCGAACGCCTTTCGCCTGAAGC
CCCTGTGCCTGTTTTAGAAGTCCAAAGGGAGAGCAAGAATTTAGGCGGAGCGGCTAATGTGGCGAACAACCTCATCTCTT
TAAAGGCTAAAGTTTTTTTATGTGGGGTCGTGGGCGATGATTTAGAGGGCGAGCATTTTATTAACGCTCTCAAAGCCAGG
AATATTGACACTTCATGCATTTTAACAGATAAAACCCGTTGCACCACGCTCAAAACGCGCATCATCGCGCAAAACCAGCA
AATCGTGCGCGTGGATAAGGAAATCAAAGACCCCTTAAACGCTGATTTAAGAAAAAAACTTTTAGATTTTTTCACAGAAA
AAATCCAAGAAATAGATGGCGTTATCCTTTCAGATTACAATAAGGGCGTGTTGGATTTTGAACTCACTCAAAAAATGATC
GCTCTAGCCAACAAACACCACAAGCTCATTTTATGCGACCCTAAAGGGAAGGATTATAGCAAATACGCTCATGCGAGTTT
GATCACGCCTAATCGCATTGAATTAGAGCATGCGCTCCATTTGAAGTTAGACAGCCATGCGAATTTATCAAAAGCGCTCC
AAATCTTAAAAGAAACTTATCATATCGCCATGCCTTTAGTAACTTTGAGCGAACAAGGCATCGCTTTTTTAGAAAAAGGC
GAGCTAGTCAATTGCCCCACTATCGCTAAAGAGGTTTATGATGTAACCGGGGCAGGCGATACGGTGATAGCGTCTTTAAC
GCTCTCTTTATTAGAATCGATGAGCCTAAAAGAAGCTTGCGAGTTTGCCAATGCGGCTGCGGCTGTGGTGGTGGGTAAAA
TGGGGAGCGCGTTAGCGAGTTTAGAAGAAATCGCTTTGATTTTAAACCAAACGCACCCTAAAATCCTCCCTTTAGAAAAG
CTGTTAGAAACTCTAGAACACCATCAGCAAAAAATCGTTTTCACCAATGGCTGTTTTGACATTCTCCATAAAGGGCATGC
GAGTTATTTGCAAAAGGCTAAAGCTTTAGGGGATATTCTCATTGTAGGGTTAAATAGCGACGCTTCCGTTAAAAGGCTTA
AGGGGGATAAACGCCCCATAGTGAGCGAAAAAGACAGAGCGTTTCTTTTAGCGAGTTTGTCTTGCGTGGATTATGTTGTG
GTGTTTGAAGAAGACACGCCAATCAAATTAATTCAAGCCCTAAAGCCTGATATTTTAGTCAAGGGAGCGGACTATCTCAA
TAAAGAAATCATAGGGAGCGAGTTTGCTAAAGAAACCCGTTTGATGGAGTTTGAAGAAGGTTATTCCACAAGCGCTATCA
TAGAAAGAATTAAAAGGACATGCAATGATTGA

Upstream 100 bases:

>100_bases
CCACTATTTTGGATTTGGATTACACCCCTTTATACGATTTAGAAAGCGGCATTAAAGATTATTTGCCCCATATCCGTGCG
ATTTTTAAAGAACATTGCGC

Downstream 100 bases:

>100_bases
TGGTTTGATTAAAAAAGAATTTTTAGCCCATAAGGAAGCGTTAGAAAAAAGTTTAGAAAGTTTGCAAGAAGCGTTAAAAC
AAAGCGTTCATCTTTTGATA

Product: ADP-heptose synthase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKQILVVGDLIADYYLWGRSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGEHFINALKAR
NIDTSCILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMI
ALANKHHKLILCDPKGKDYSKYAHASLITPNRIELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKEACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILPLEK
LLETLEHHQQKIVFTNGCFDILHKGHASYLQKAKALGDILIVGLNSDASVKRLKGDKRPIVSEKDRAFLLASLSCVDYVV
VFEEDTPIKLIQALKPDILVKGADYLNKEIIGSEFAKETRLMEFEEGYSTSAIIERIKRTCND

Sequences:

>Translated_463_residues
MKQILVVGDLIADYYLWGRSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGEHFINALKAR
NIDTSCILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMI
ALANKHHKLILCDPKGKDYSKYAHASLITPNRIELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKEACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILPLEK
LLETLEHHQQKIVFTNGCFDILHKGHASYLQKAKALGDILIVGLNSDASVKRLKGDKRPIVSEKDRAFLLASLSCVDYVV
VFEEDTPIKLIQALKPDILVKGADYLNKEIIGSEFAKETRLMEFEEGYSTSAIIERIKRTCND
>Mature_463_residues
MKQILVVGDLIADYYLWGRSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGEHFINALKAR
NIDTSCILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMI
ALANKHHKLILCDPKGKDYSKYAHASLITPNRIELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKEACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILPLEK
LLETLEHHQQKIVFTNGCFDILHKGHASYLQKAKALGDILIVGLNSDASVKRLKGDKRPIVSEKDRAFLLASLSCVDYVV
VFEEDTPIKLIQALKPDILVKGADYLNKEIIGSEFAKETRLMEFEEGYSTSAIIERIKRTCND

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=472, Percent_Identity=41.7372881355932, Blast_Score=330, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 51278; Mature: 51278

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQILVVGDLIADYYLWGRSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFL
CCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHEEEEEEE
CGVVGDDLEGEHFINALKARNIDTSCILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLN
EEECCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHEECCHHHCCCCC
ADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMIALANKHHKLILCDPKGKDYS
HHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEHHHHHHHHHHHCCCCEEEEECCCCCCHH
KYAHASLITPNRIELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
HHHHHCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEECC
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKEACEFANAAAAVVVGKMGSALAS
CEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEEIALILNQTHPKILPLEKLLETLEHHQQKIVFTNGCFDILHKGHASYLQKAKALGDIL
HHHHHHHHHCCCCCEECHHHHHHHHHHCCCEEEEECCHHHHHHCCHHHHHHHHHHCCCEE
IVGLNSDASVKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVFEEDTPIKLIQALKPDILV
EEEECCCCHHHHHCCCCCCCCCCCCCEEEEEEHHHEEEEEEEECCCCHHHHHHCCCCEEE
KGADYLNKEIIGSEFAKETRLMEFEEGYSTSAIIERIKRTCND
ECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQILVVGDLIADYYLWGRSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFL
CCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHEEEEEEE
CGVVGDDLEGEHFINALKARNIDTSCILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLN
EEECCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHEECCHHHCCCCC
ADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMIALANKHHKLILCDPKGKDYS
HHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEHHHHHHHHHHHCCCCEEEEECCCCCCHH
KYAHASLITPNRIELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
HHHHHCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEECC
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKEACEFANAAAAVVVGKMGSALAS
CEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEEIALILNQTHPKILPLEKLLETLEHHQQKIVFTNGCFDILHKGHASYLQKAKALGDIL
HHHHHHHHHCCCCCEECHHHHHHHHHHCCCEEEEECCHHHHHHCCHHHHHHHHHHCCCEE
IVGLNSDASVKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVFEEDTPIKLIQALKPDILV
EEEECCCCHHHHHCCCCCCCCCCCCCEEEEEEHHHEEEEEEEECCCCHHHHHHCCCCEEE
KGADYLNKEIIGSEFAKETRLMEFEEGYSTSAIIERIKRTCND
ECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA