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The map label for this gene is hemA

Identifier: 188527046

GI number: 188527046

Start: 234048

End: 235397

Strand: Reverse

Name: hemA

Synonym: HPSH_01245

Alternate gene names: 188527046

Gene position: 235397-234048 (Counterclockwise)

Preceding gene: 188527047

Following gene: 188527045

Centisome position: 14.63

GC content: 38.22

Gene sequence:

>1350_bases
ATGGAGTTAGAAACTCATTTGTCAAAATATTTCACCCTAGCCTTTACGCATAAAAGCATGGGCTTAGAAATGCGAGAAAA
ACTCGCTATCAATTCGAGCGCAACGCTTAAAGAATTTTTACAAACCATTAAAAACCATTGCCCTAACATCAAAGAGTGCA
TGGTGTTATCCACATGCAATCGCTTTGAAATTTATGCGAGCCTAAAGCATGGCGCTCACGCTAATGAACAAAAAAGTGCG
TTATTAAAAATTTTGGCTCAAAATAAAAAAATGAGCGTGTCTGATTTAGAAAAATGCGTTTTAATGAGCGTTGATGAAAG
CGCAGTCCATCATGTCTTTAGCGTGTGCAGCAGTTTGGATAGCCTAGTAGTGGGGGAAACTCAAATCACAGGGCAGATGA
AAAACGCCTATAAATTCGCTTTTGAAGAGAAATTTTGCTCCAAAGATTTAACCCGATTGCTCCATTTTGCTTTCAAATGC
GCCGCTAAAGTGCGCAATTTAACCGGCATTTCTAAGCAAGGGGTCTCCATCTCTTCAGTGGCGGTCAAAGAAGCGCTTAA
TATTTTTGAAAAAGAAAGGATTAAGGATAAAAAAGCCCTTGTGATAGGGCTTGGCGAGATGGCTCAATTAGTCATCAAGC
ACCTTTTAAACAAGCAATTTGAAGCGCTTATTTTAGGGCGTAATGAGGCTAAATTTGAAGATTTCATCAAAGAATTAGAA
GAGCCTAAAAAAGTGAGCTTTCAAAATATAGAAAATTTAAACGCTTATATCAATGAATACCAACTGCTTTTTTGCGCCAC
TTCTTCGCCGCATTTTATCGTGCAAAATGACATGTTAAAAGAAACGATTTTCAGGCGTTTTTGGTTTGATTTAGCCGTGC
CACGGAATATTGAAAAGCCGGTATTGGATAATATTTTCTTATACAGCGTGGATGATTTAGAGCCTATGGTTAGAGAAAAT
GTGGAAAACCGGCAAGAGAGCAGAACGAAAGCTTATGAGATTGTAGGGCTTGCCACAATGGAGTTTTACCAATGGATCCA
AAGTTTAGAAGTAGAGCCTTTGATTAAGGATTTAAGGGAATTAGCTAGGATTTCAGCCCAGAAGGAATTGCAAAAAGCGC
TTAAAAAACGCTATGTGCCTAAAGAATACGAAAGCAACATTGAAAAGATCTTACACAACGCTTTCAATACCTTTTTGCAC
CACCCTACCATCGCCTTAAAAAAGAACGCTCAAAAAGAAGAATCCGATGTGCTTGTGGGCGCGATTAAAAACCTGTTTAA
TTTAGACAAATCTAGCGCTAATCATGCCCAGAATTTGAATCTCTATAAATGCGAATATTACGAGGAATAA

Upstream 100 bases:

>100_bases
CCGCTCAAGTTTATTCTAAAAAGGCCCTTGAAGCCATTAAAAAGGAAAACAATTTGATTTTAGAAAAACTAGCGCAAGAT
GTCATTTACAGGACTTTTTA

Downstream 100 bases:

>100_bases
TGCATGCTATTTTCAAAACTCTTTGCCCCCACTCTCAAAGAACCCCCTAAAGATGCCGTGTTAAAAAGCCATAAACACTT
AGCTCAAGCAGGATACATTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MELETHLSKYFTLAFTHKSMGLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLKHGAHANEQKSA
LLKILAQNKKMSVSDLEKCVLMSVDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNEAKFEDFIKELE
EPKKVSFQNIENLNAYINEYQLLFCATSSPHFIVQNDMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVREN
VENRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRELARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLH
HPTIALKKNAQKEESDVLVGAIKNLFNLDKSSANHAQNLNLYKCEYYEE

Sequences:

>Translated_449_residues
MELETHLSKYFTLAFTHKSMGLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLKHGAHANEQKSA
LLKILAQNKKMSVSDLEKCVLMSVDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNEAKFEDFIKELE
EPKKVSFQNIENLNAYINEYQLLFCATSSPHFIVQNDMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVREN
VENRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRELARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLH
HPTIALKKNAQKEESDVLVGAIKNLFNLDKSSANHAQNLNLYKCEYYEE
>Mature_449_residues
MELETHLSKYFTLAFTHKSMGLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLKHGAHANEQKSA
LLKILAQNKKMSVSDLEKCVLMSVDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNEAKFEDFIKELE
EPKKVSFQNIENLNAYINEYQLLFCATSSPHFIVQNDMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVREN
VENRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRELARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLH
HPTIALKKNAQKEESDVLVGAIKNLFNLDKSSANHAQNLNLYKCEYYEE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=415, Percent_Identity=27.710843373494, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 51723; Mature: 51723

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELETHLSKYFTLAFTHKSMGLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCN
CCHHHHHHHHHHHEEEHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
RFEIYASLKHGAHANEQKSALLKILAQNKKMSVSDLEKCVLMSVDESAVHHVFSVCSSLD
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKCAAKVRNLTGISKQGVSISSV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNEAKFEDFIKELE
HHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHC
EPKKVSFQNIENLNAYINEYQLLFCATSSPHFIVQNDMLKETIFRRFWFDLAVPRNIEKP
CCHHCCHHHHHHHHHHHCCEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCCH
VLDNIFLYSVDDLEPMVRENVENRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRE
HHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLHHPTIALKKNAQKEESDVLVG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHH
AIKNLFNLDKSSANHAQNLNLYKCEYYEE
HHHHHHHCCCCCCCHHCCCCEEEECCCCC
>Mature Secondary Structure
MELETHLSKYFTLAFTHKSMGLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCN
CCHHHHHHHHHHHEEEHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
RFEIYASLKHGAHANEQKSALLKILAQNKKMSVSDLEKCVLMSVDESAVHHVFSVCSSLD
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKCAAKVRNLTGISKQGVSISSV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNEAKFEDFIKELE
HHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHC
EPKKVSFQNIENLNAYINEYQLLFCATSSPHFIVQNDMLKETIFRRFWFDLAVPRNIEKP
CCHHCCHHHHHHHHHHHCCEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCCH
VLDNIFLYSVDDLEPMVRENVENRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRE
HHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLHHPTIALKKNAQKEESDVLVG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHH
AIKNLFNLDKSSANHAQNLNLYKCEYYEE
HHHHHHHCCCCCCCHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA