Click here to switch to the map view.

The map label for this gene is htpG [H]

Identifier: 188527014

GI number: 188527014

Start: 200943

End: 202808

Strand: Direct

Name: htpG [H]

Synonym: HPSH_01085

Alternate gene names: 188527014

Gene position: 200943-202808 (Clockwise)

Preceding gene: 188527013

Following gene: 188527018

Centisome position: 12.49

GC content: 37.62

Gene sequence:

>1866_bases
ATGTCTAATCAAGAATACACCTTCCAAACTGAAATCAACCAGCTTTTGGATTTGATGATCCACTCTTTGTATTCTAATAA
AGAGATTTTTTTAAGAGAGTTGATTTCTAACGCGAGCGACGCTTTGGACAAGCTGAATTATTTAATGCTGACTGATGAAA
AATTAAAAGGGCTGAATATCACGCCTGGCATTCATTTGAGTTTTGATAGCCAGAAAAAAACCTTAACGATTAAAGATAAT
GGTATAGGCATGGATAAAAACGAACTCATTGAGCATCTAGGCACGATCGCTAAATCAGGCACGAAGAGTTTTTTAAGCGC
TTTGAGCGGGGATAAGAAAAAAGATAGCGCACTGATTGGCCAATTTGGCGTGGGCTTTTATTCGGCGTTTATGGTAGCGA
GTAAGATTGTCGTTCAAACCAAAAAGGTAAATAGCGATCAAGCTTATGCATGGGTGAGCGATGGTAAGGGCAAGTTTGAA
ATCAGCGAGTGCGTCAAAGAGGAGCAAGGCACAGAAATCACCCTCTTTTTAAAAGATGAAGATTCTCATTTTGCGAGCCG
TTGGGAGATTGATAGCGTTGTTAAAAAGTATTCTGAGCATATCCCTTTCCCTATTTTTTTAACTTACACCGATACGAAAT
ACGAGGGCGAAGGAGATAATCAAAAAGAAATTAAAGAAGAAAAATGCGATCAGATCAATCAAGCGAGCGCTCTATGGAAA
ATGAATAAGAGCGAGTTGAAAGACAAAGATTACAAAGAGTTTTACCAATCGTTTGCGCATGATAACAGCGAACCTTTGAG
CTATATCCATAATAAAGTGGAAGGCTCTTTAGAATACACAACGCTTTTTTACATCCCTAGCAAAGCGCCCTTTGACATGT
TTAGGGTGGATTATAAAAGCGGAGTCAAACTTTATGTTAAAAGGGTGTTTATCACTGATGATGACAAAGAATTGTTGCCG
TCTTATTTGAGGTTTGTTAAAGGCGTGATTGACAGCGAAGATTTACCCTTGAATGTGAGCCGTGAAATCTTGCAGCAAAA
CAAGATTTTAGCCAATATCCGTTCGGCTTCAGTGAAAAAGATTTTAAGCGAGATTGAACGCTTGAGCAAGGATGAAAAAA
ATTACCATAAATTCTATGAGCCTTTTGGGAAAGTGTTAAAAGAAGGCTTGTATGGGGATTTTGAAAACAAAGAAAAACTT
TTAGAATTGTTAAGATTCTATTCTAAAGACAAAGAAAAGTTGGTTTCTTTAAAAGAATACAAAGAAAATTTAAAAGAAAA
TCAAAAAAGCATTTACTACCTTTTAGGCGAAAATTTAGACTTACTAAAGGCGTCCCCGCTTTTAGAAAAATACGCTCAAA
AAGGCTATGATGTTTTGTTATTGAGCGATGAAATTGATGCGTTTGTGATGCCAGGCGTGAATGAATACGATAAAACGCCC
TTTAAAGACGCTAGCCATAGCGAGAGCCTAAAAGAGCTTGGTTTAGAAGAAATCAACGATGAGGTAAAAGAGCGGTTTAA
AGATTTAATGAAAGCGTTTGAAGAAAATCTTAAAGATGAGATTAAAAGCGTAGAGCTTTCTAACCATCTCACTTCAGCGG
TGGCTTTAATAGGCGATGAACAAAATGCGATGATGGCTAATTGGATGCGTCAAATGGGCCAAAGCGTGCCTGAAAACAAG
AAAACGCTAGAATTAAACCCTAACCATGCGATTTTGCAAAAACTCTTAAAATGCGAAGATAAAGAGCAGTTGAGCGCTTT
TATCTGGTTGCTTTATGATGGGGCGAAGCTTTTAGAAAAAGGGGCTTTAAAAGACGCTAAAAGCTTTAACGAACGCCTAA
ATAGCGTGCTATTGAAAGCGTTGTAG

Upstream 100 bases:

>100_bases
AATTAAACATTCTTTCATGTTACTTTTTAAGCCATGGCATACCCCTTTTAAGCGCGCTTTTATTGTATAATCTTAAAAAT
TTTATTAAAGGAAAAGATCA

Downstream 100 bases:

>100_bases
GGGATAAAACCCTTTAAGGGTTTGAATAAACGCTTTATAAACCCTTCAAGTGCTAATCTAAAAACGGCAATGAATGGGCA
CGATAAAAGCCTTATTATGA

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MSNQEYTFQTEINQLLDLMIHSLYSNKEIFLRELISNASDALDKLNYLMLTDEKLKGLNITPGIHLSFDSQKKTLTIKDN
GIGMDKNELIEHLGTIAKSGTKSFLSALSGDKKKDSALIGQFGVGFYSAFMVASKIVVQTKKVNSDQAYAWVSDGKGKFE
ISECVKEEQGTEITLFLKDEDSHFASRWEIDSVVKKYSEHIPFPIFLTYTDTKYEGEGDNQKEIKEEKCDQINQASALWK
MNKSELKDKDYKEFYQSFAHDNSEPLSYIHNKVEGSLEYTTLFYIPSKAPFDMFRVDYKSGVKLYVKRVFITDDDKELLP
SYLRFVKGVIDSEDLPLNVSREILQQNKILANIRSASVKKILSEIERLSKDEKNYHKFYEPFGKVLKEGLYGDFENKEKL
LELLRFYSKDKEKLVSLKEYKENLKENQKSIYYLLGENLDLLKASPLLEKYAQKGYDVLLLSDEIDAFVMPGVNEYDKTP
FKDASHSESLKELGLEEINDEVKERFKDLMKAFEENLKDEIKSVELSNHLTSAVALIGDEQNAMMANWMRQMGQSVPENK
KTLELNPNHAILQKLLKCEDKEQLSAFIWLLYDGAKLLEKGALKDAKSFNERLNSVLLKAL

Sequences:

>Translated_621_residues
MSNQEYTFQTEINQLLDLMIHSLYSNKEIFLRELISNASDALDKLNYLMLTDEKLKGLNITPGIHLSFDSQKKTLTIKDN
GIGMDKNELIEHLGTIAKSGTKSFLSALSGDKKKDSALIGQFGVGFYSAFMVASKIVVQTKKVNSDQAYAWVSDGKGKFE
ISECVKEEQGTEITLFLKDEDSHFASRWEIDSVVKKYSEHIPFPIFLTYTDTKYEGEGDNQKEIKEEKCDQINQASALWK
MNKSELKDKDYKEFYQSFAHDNSEPLSYIHNKVEGSLEYTTLFYIPSKAPFDMFRVDYKSGVKLYVKRVFITDDDKELLP
SYLRFVKGVIDSEDLPLNVSREILQQNKILANIRSASVKKILSEIERLSKDEKNYHKFYEPFGKVLKEGLYGDFENKEKL
LELLRFYSKDKEKLVSLKEYKENLKENQKSIYYLLGENLDLLKASPLLEKYAQKGYDVLLLSDEIDAFVMPGVNEYDKTP
FKDASHSESLKELGLEEINDEVKERFKDLMKAFEENLKDEIKSVELSNHLTSAVALIGDEQNAMMANWMRQMGQSVPENK
KTLELNPNHAILQKLLKCEDKEQLSAFIWLLYDGAKLLEKGALKDAKSFNERLNSVLLKAL
>Mature_620_residues
SNQEYTFQTEINQLLDLMIHSLYSNKEIFLRELISNASDALDKLNYLMLTDEKLKGLNITPGIHLSFDSQKKTLTIKDNG
IGMDKNELIEHLGTIAKSGTKSFLSALSGDKKKDSALIGQFGVGFYSAFMVASKIVVQTKKVNSDQAYAWVSDGKGKFEI
SECVKEEQGTEITLFLKDEDSHFASRWEIDSVVKKYSEHIPFPIFLTYTDTKYEGEGDNQKEIKEEKCDQINQASALWKM
NKSELKDKDYKEFYQSFAHDNSEPLSYIHNKVEGSLEYTTLFYIPSKAPFDMFRVDYKSGVKLYVKRVFITDDDKELLPS
YLRFVKGVIDSEDLPLNVSREILQQNKILANIRSASVKKILSEIERLSKDEKNYHKFYEPFGKVLKEGLYGDFENKEKLL
ELLRFYSKDKEKLVSLKEYKENLKENQKSIYYLLGENLDLLKASPLLEKYAQKGYDVLLLSDEIDAFVMPGVNEYDKTPF
KDASHSESLKELGLEEINDEVKERFKDLMKAFEENLKDEIKSVELSNHLTSAVALIGDEQNAMMANWMRQMGQSVPENKK
TLELNPNHAILQKLLKCEDKEQLSAFIWLLYDGAKLLEKGALKDAKSFNERLNSVLLKAL

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI20149594, Length=674, Percent_Identity=37.9821958456973, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI155722983, Length=655, Percent_Identity=33.2824427480916, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI154146191, Length=401, Percent_Identity=35.9102244389027, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI153792590, Length=401, Percent_Identity=35.9102244389027, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI4507677, Length=210, Percent_Identity=47.1428571428571, Blast_Score=178, Evalue=2e-44,
Organism=Escherichia coli, GI1786679, Length=635, Percent_Identity=46.7716535433071, Blast_Score=552, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17559162, Length=656, Percent_Identity=37.8048780487805, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17542208, Length=669, Percent_Identity=36.0239162929746, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI115535205, Length=647, Percent_Identity=32.7666151468315, Blast_Score=293, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI115535167, Length=438, Percent_Identity=36.3013698630137, Blast_Score=254, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323840, Length=689, Percent_Identity=37.155297532656, Blast_Score=405, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6325016, Length=682, Percent_Identity=37.5366568914956, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17647529, Length=643, Percent_Identity=37.1695178849145, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI21357739, Length=632, Percent_Identity=37.1835443037975, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24586016, Length=648, Percent_Identity=33.179012345679, Blast_Score=316, Evalue=4e-86,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 71400; Mature: 71269

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQEYTFQTEINQLLDLMIHSLYSNKEIFLRELISNASDALDKLNYLMLTDEKLKGLNI
CCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
TPGIHLSFDSQKKTLTIKDNGIGMDKNELIEHLGTIAKSGTKSFLSALSGDKKKDSALIG
CCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHH
QFGVGFYSAFMVASKIVVQTKKVNSDQAYAWVSDGKGKFEISECVKEEQGTEITLFLKDE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEECC
DSHFASRWEIDSVVKKYSEHIPFPIFLTYTDTKYEGEGDNQKEIKEEKCDQINQASALWK
CCHHHHHCCHHHHHHHHHHCCCCEEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHH
MNKSELKDKDYKEFYQSFAHDNSEPLSYIHNKVEGSLEYTTLFYIPSKAPFDMFRVDYKS
CCHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHC
GVKLYVKRVFITDDDKELLPSYLRFVKGVIDSEDLPLNVSREILQQNKILANIRSASVKK
CCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ILSEIERLSKDEKNYHKFYEPFGKVLKEGLYGDFENKEKLLELLRFYSKDKEKLVSLKEY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
KENLKENQKSIYYLLGENLDLLKASPLLEKYAQKGYDVLLLSDEIDAFVMPGVNEYDKTP
HHHHHHCCCEEEEEECCCCCHHHCCHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCC
FKDASHSESLKELGLEEINDEVKERFKDLMKAFEENLKDEIKSVELSNHLTSAVALIGDE
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QNAMMANWMRQMGQSVPENKKTLELNPNHAILQKLLKCEDKEQLSAFIWLLYDGAKLLEK
CHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHH
GALKDAKSFNERLNSVLLKAL
HCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNQEYTFQTEINQLLDLMIHSLYSNKEIFLRELISNASDALDKLNYLMLTDEKLKGLNI
CCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
TPGIHLSFDSQKKTLTIKDNGIGMDKNELIEHLGTIAKSGTKSFLSALSGDKKKDSALIG
CCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHH
QFGVGFYSAFMVASKIVVQTKKVNSDQAYAWVSDGKGKFEISECVKEEQGTEITLFLKDE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEECC
DSHFASRWEIDSVVKKYSEHIPFPIFLTYTDTKYEGEGDNQKEIKEEKCDQINQASALWK
CCHHHHHCCHHHHHHHHHHCCCCEEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHH
MNKSELKDKDYKEFYQSFAHDNSEPLSYIHNKVEGSLEYTTLFYIPSKAPFDMFRVDYKS
CCHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHC
GVKLYVKRVFITDDDKELLPSYLRFVKGVIDSEDLPLNVSREILQQNKILANIRSASVKK
CCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ILSEIERLSKDEKNYHKFYEPFGKVLKEGLYGDFENKEKLLELLRFYSKDKEKLVSLKEY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
KENLKENQKSIYYLLGENLDLLKASPLLEKYAQKGYDVLLLSDEIDAFVMPGVNEYDKTP
HHHHHHCCCEEEEEECCCCCHHHCCHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCC
FKDASHSESLKELGLEEINDEVKERFKDLMKAFEENLKDEIKSVELSNHLTSAVALIGDE
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QNAMMANWMRQMGQSVPENKKTLELNPNHAILQKLLKCEDKEQLSAFIWLLYDGAKLLEK
CHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHH
GALKDAKSFNERLNSVLLKAL
HCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA