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The map label for this gene is sdcS [H]

Identifier: 188527018

GI number: 188527018

Start: 207173

End: 208831

Strand: Direct

Name: sdcS [H]

Synonym: HPSH_01105

Alternate gene names: 188527018

Gene position: 207173-208831 (Clockwise)

Preceding gene: 188527014

Following gene: 188527019

Centisome position: 12.88

GC content: 42.62

Gene sequence:

>1659_bases
ATGGAAAATCATTCGCATGCCAATACGCATACAGATACGCGCGCCGATGATAAAAGCACTAAGATCGTGCGCTTGTTGGG
GTTAATAGGAGGGGTGTTAATCGCGCTTATTATCTATTACGCTTTAAACGCTCAACTGCCTCATATTGTAGAAGAAATCC
CCAAGCTCAATTCTTTAAATTATAAGGCGATGCCTGTTGTGGCTGGGGTGGCTGTTTTAATGGGGATATGGTGGATGACT
GAAGCCATTGACCTGCCCGCAACCGCGCTTTTACCTTTAGTGCTTTTTAGCGTCTTTAGCGTGGATCAATTCGCTAGCGT
TAGCTCTTCTTACGCATCGCCGATTATCTTTCTTTTTATGGGAGGGTTTATTTTAGCTTTAAGCATGCAAAAATGGAATT
TGCACACACGCATCGCTTTAAGCATTATTTTATTAGTAGGCACAAGCCCTAGGAGGTTGATTTTAGGTTTCATGATAGCT
ACAGGCTTTCTGTCTATGTGGGTGAGCAATACCGCAACGGCGGTGATGATGCTCCCTATTGGCATGAGCGTTTTGCAATT
AGTCGCTAAACTTGTGGGCAAAGAAAACGCCTCTAATTCATGGCATCAAAAAGAAGAAATCACCAAAGCGCATGGGGGTA
TTATGGGCAATATCGTGCATAAGGGCAAAGATATTTCTCAAGTCATTCAAGAAAAGACCATCATTTATCGCACGAATTTC
AGTATTTGCTTGATGCTTGGTATCGCTTATGCGGCTTCTATTGGTTCTTTAGGCACTCTTATTGGCACGCCGCCTAACGC
TTTATTAGCCGGCTATATGAAAACCGCTTTCAATATTGAAATTGATTTCGCTCAGTGGATGGTGTTTGGGACGCCGTTAG
CCTTCATCATGCTCATTTTATCGTGGCTCTTGCTCACTTATGTGATTTTCCCTTTAAAGATTAAAGAAATCCCAGGGGGT
AAGGAAGTCATTAAGGTAGAGTTAAAAAAATTAGGCCGCTTGAGTTGGGCGGAAATCTCTGTGGGCGTTATTTTTATTTT
GGCGTCTTTAGGGTGGATTTTTTTAGATACGATTTTAAAATCTTGGGGCATTAAGATAGATAAAATTGATTCAGTGATTG
CGATGGGGGTTTCTGCGCTTTTATTCATTTTGCCCGCTAACCATCATGGCGATAGGCTCATTGATTGGGGTGTTGCTAAA
AAACTCCCTTGGGATGTGTTGCTTTTATTTGGCGGCGGGTTAGCCTTGAGCGCGCAATTTTCTAAAACCGGGTTGAGTTT
GTGGATCGGGCATTTAGTTTCTGGCTTTTCGCATTTACCGATTTTATTCATTATTTTCATGGTCACTTTAATGGTCATTT
TCTTAACCGAAATCACTTCTAACACCGCCACCGCTGCGGCGTTTTTACCGGTGATTGGAGGGGTTGCGATGGGCATGGGT
TATGAAAATCATCAAAGCTTGTTATTGACCATTCCTGTAGCCTTGAGCGCGACTTGCGCGTTCATGCTCCCTGTAGCCAC
CCCACCCAATGCGATAGCTTATGGCTCTGGGTATGTTAAAATAACGGATATGATTAAAGCCGGTTTGTGGCTTAATTTAG
TGGGAGTTGTTTTGATTAGCGCGTTTAGCTATTTTTTAGTTTCGCTGGTATTTAATTGA

Upstream 100 bases:

>100_bases
ACCACTTCTTTTCCTGTTTTGATATGATTTTTCTAAAATCTTAGTTTTGAAAAAGTTTTATTGTAGCATGGAGGTTAGTA
ATTTTAAAGGGTAAAATAAA

Downstream 100 bases:

>100_bases
TCAAGGAAAAAAGTGAAAGAAGAGTTATTTAAAGAAAAATCTCGCTACATTACAGGGTTTGTTTTAATCATTGTGGCAGG
CTTGATTTTGTATGCGGACA

Product: sodium-dependent transporter

Products: tartrate [Cytoplasm]; succinate [Periplasm] [C]

Alternate protein names: Na(+)/dicarboxylate symporter [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MENHSHANTHTDTRADDKSTKIVRLLGLIGGVLIALIIYYALNAQLPHIVEEIPKLNSLNYKAMPVVAGVAVLMGIWWMT
EAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMLPIGMSVLQLVAKLVGKENASNSWHQKEEITKAHGGIMGNIVHKGKDISQVIQEKTIIYRTNF
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILSWLLLTYVIFPLKIKEIPGG
KEVIKVELKKLGRLSWAEISVGVIFILASLGWIFLDTILKSWGIKIDKIDSVIAMGVSALLFILPANHHGDRLIDWGVAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILFIIFMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYFLVSLVFN

Sequences:

>Translated_552_residues
MENHSHANTHTDTRADDKSTKIVRLLGLIGGVLIALIIYYALNAQLPHIVEEIPKLNSLNYKAMPVVAGVAVLMGIWWMT
EAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMLPIGMSVLQLVAKLVGKENASNSWHQKEEITKAHGGIMGNIVHKGKDISQVIQEKTIIYRTNF
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILSWLLLTYVIFPLKIKEIPGG
KEVIKVELKKLGRLSWAEISVGVIFILASLGWIFLDTILKSWGIKIDKIDSVIAMGVSALLFILPANHHGDRLIDWGVAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILFIIFMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYFLVSLVFN
>Mature_552_residues
MENHSHANTHTDTRADDKSTKIVRLLGLIGGVLIALIIYYALNAQLPHIVEEIPKLNSLNYKAMPVVAGVAVLMGIWWMT
EAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMLPIGMSVLQLVAKLVGKENASNSWHQKEEITKAHGGIMGNIVHKGKDISQVIQEKTIIYRTNF
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILSWLLLTYVIFPLKIKEIPGG
KEVIKVELKKLGRLSWAEISVGVIFILASLGWIFLDTILKSWGIKIDKIDSVIAMGVSALLFILPANHHGDRLIDWGVAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILFIIFMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYFLVSLVFN

Specific function: Mediates the transport of dicarboxylates across the cytoplasmic membrane via a Na(+)-electrochemical gradient [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily [H]

Homologues:

Organism=Homo sapiens, GI29171306, Length=513, Percent_Identity=35.4775828460039, Blast_Score=275, Evalue=9e-74,
Organism=Homo sapiens, GI31377715, Length=525, Percent_Identity=33.7142857142857, Blast_Score=272, Evalue=6e-73,
Organism=Homo sapiens, GI58761541, Length=521, Percent_Identity=33.5892514395393, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI19923838, Length=526, Percent_Identity=34.4106463878327, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI301069349, Length=507, Percent_Identity=33.1360946745562, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI4506979, Length=517, Percent_Identity=33.4622823984526, Blast_Score=252, Evalue=8e-67,
Organism=Homo sapiens, GI301069353, Length=470, Percent_Identity=32.7659574468085, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI31795546, Length=567, Percent_Identity=29.6296296296296, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI225637549, Length=566, Percent_Identity=31.4487632508834, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI301069346, Length=506, Percent_Identity=32.4110671936759, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI225637552, Length=484, Percent_Identity=32.8512396694215, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI219802232, Length=449, Percent_Identity=34.5211581291759, Blast_Score=220, Evalue=3e-57,
Organism=Escherichia coli, GI1789444, Length=446, Percent_Identity=23.9910313901345, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71989118, Length=526, Percent_Identity=32.6996197718631, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71988385, Length=484, Percent_Identity=33.8842975206612, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32565804, Length=472, Percent_Identity=34.1101694915254, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17551790, Length=510, Percent_Identity=28.2352941176471, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32564681, Length=513, Percent_Identity=29.4346978557505, Blast_Score=196, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324340, Length=500, Percent_Identity=22.8, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322263, Length=508, Percent_Identity=22.8346456692913, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366409, Length=496, Percent_Identity=32.258064516129, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI17737623, Length=496, Percent_Identity=32.258064516129, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24666468, Length=496, Percent_Identity=32.258064516129, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI45551633, Length=496, Percent_Identity=32.258064516129, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI281362116, Length=522, Percent_Identity=31.0344827586207, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281362114, Length=522, Percent_Identity=30.8429118773946, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281362112, Length=522, Percent_Identity=30.8429118773946, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI78706796, Length=502, Percent_Identity=28.8844621513944, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI78706798, Length=502, Percent_Identity=28.8844621513944, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 59963; Mature: 59963

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENHSHANTHTDTRADDKSTKIVRLLGLIGGVLIALIIYYALNAQLPHIVEEIPKLNSLN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCC
YKAMPVVAGVAVLMGIWWMTEAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFM
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIATGFLSMWVSNTATAVMMLPI
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEHHHHC
GMSVLQLVAKLVGKENASNSWHQKEEITKAHGGIMGNIVHKGKDISQVIQEKTIIYRTNF
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEHHHHCCCHHHHHHHHCCEEEECCH
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLIL
HHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHEEEEEHHHHHHHHHCHHHHHHHHH
SWLLLTYVIFPLKIKEIPGGKEVIKVELKKLGRLSWAEISVGVIFILASLGWIFLDTILK
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SWGIKIDKIDSVIAMGVSALLFILPANHHGDRLIDWGVAKKLPWDVLLLFGGGLALSAQF
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHCCCHHHHHEECCCEEEEEHH
SKTGLSLWIGHLVSGFSHLPILFIIFMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLIS
CCCCCEEEEEECHHHHHHHHHEEECCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHH
AFSYFLVSLVFN
HHHHHHHHHHCC
>Mature Secondary Structure
MENHSHANTHTDTRADDKSTKIVRLLGLIGGVLIALIIYYALNAQLPHIVEEIPKLNSLN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCC
YKAMPVVAGVAVLMGIWWMTEAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFM
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIATGFLSMWVSNTATAVMMLPI
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEHHHHC
GMSVLQLVAKLVGKENASNSWHQKEEITKAHGGIMGNIVHKGKDISQVIQEKTIIYRTNF
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEHHHHCCCHHHHHHHHCCEEEECCH
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLIL
HHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHEEEEEHHHHHHHHHCHHHHHHHHH
SWLLLTYVIFPLKIKEIPGGKEVIKVELKKLGRLSWAEISVGVIFILASLGWIFLDTILK
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SWGIKIDKIDSVIAMGVSALLFILPANHHGDRLIDWGVAKKLPWDVLLLFGGGLALSAQF
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHCCCHHHHHEECCCEEEEEHH
SKTGLSLWIGHLVSGFSHLPILFIIFMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLIS
CCCCCEEEEEECHHHHHHHHHEEECCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHH
AFSYFLVSLVFN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: tartrate [Periplasm]; succinate [Cytoplasm] [C]

Specific reaction: tartrate [Periplasm] + succinate [Cytoplasm] = tartrate [Cytoplasm] + succinate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA