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The map label for this gene is glyA

Identifier: 188526989

GI number: 188526989

Start: 175043

End: 176293

Strand: Direct

Name: glyA

Synonym: HPSH_00930

Alternate gene names: 188526989

Gene position: 175043-176293 (Clockwise)

Preceding gene: 188526988

Following gene: 188526990

Centisome position: 10.88

GC content: 41.57

Gene sequence:

>1251_bases
ATGGCGTATTTTTTAGAACAAACGGATAGTGAAATTTTTGAGCTTATCTTTGAAGAATACAAGCGGCAAAACGAGCATTT
AGAAATGATAGCGAGCGAGAATTACACTTTTGCAAGCGTTATGGAGGCTATGGGGAGTGTTTTAACGAATAAATACGCTG
AAGGCTATCCTAACAAGCGCTACTATGGAGGCTGTGAAGTGGTGGATAAAATAGAAAGCTTGGCCATAGAAAGGGCTAAA
AAACTTTTTAATTGCCAGTTCGCTAATGTGCAAGCGCACTCAGGCTCACAAGCCAATAACGCTGTCTATCACGCTCTTTT
AAAGCCTTATGACAAGATTTTGGGCATGGATTTAAGCTGTGGAGGGCATTTAACGCATGGCGCTAAAGTGAGTTTAACCG
GTAAGCATTATCAGAGCTTTTCTTATGGCGTGAATTTAGATGGCTATATTGATTATGAAGAAGCGCTAAAAATCGCTCAA
AGCGTTAAGCCAGAAATCATTGTGTGCGGGTTTTCAGCCTATCCAAGGGAGATTGATTTTAAGAAATTTAGAGAAATCGC
TGATGAAGTGGGGGCGTTATTATTAGGCGATATAGCTCATGTGGCAGGGCTTGTGGTAGCCGGTGAGCATGCCCATCCTT
TCCCGCATTGCCATGTGGTTTCAAGCACCACTCATAAGACCTTAAGAGGGCCTAGAGGGGGGCTTATTTTAACCAATGAT
GAAGAGATAGCGGCCAAGATTGATAAAGCGATTTTTCCAGGAACTCAAGGCGGGCCTTTGATGCATGCAATTGCTGCTAA
AGCGGTGGGGTTTAAAGAGAATCTAAAACCAGAATTTAAGGCTTATGCGCAATTAGTGAAATCTAACATGCAAGTTTTGG
CTAAAGCGTTACAAGAAAAAAACCATAAGTTAGTGAGTGGTGGCACTTCTAACCATTTGCTTTTAATGGATTTCTTAGAC
AAGCCTTATAGCGGGAAAGACGCTGATATTGCATTAGGGAATGCCGGAATCACCGTGAATAAAAACACCATTCCTGGCGA
AACGCGTAGCCCTTTTGTAACGAGCGGGATAAGGATTGGCTCAGCGGCATTGAGCGCAAGGGGCATGGGAGCTAAGGAAT
TTGAAATCATAGGGAATAAAATATCAGATATTTTGAATGATATTAATAATGTTAGTTTGCAATTGCATGTGAAAGAAGAA
TTGAAAGCCATGGCCAGTCAATTCCCTGTGTACCAACAACCTATTTTTTAA

Upstream 100 bases:

>100_bases
TAGTGATGCTACTCACTGGGGCTAAAAGCATTAAAGATGTGATTTTATTCCCAGCGATGCGTCCTGTTAAAAACGATTTT
AATGTGGAGAGTGAAGAATA

Downstream 100 bases:

>100_bases
GGGAGTCAAGATGACAGAAATGGAATTAAAGCTCATTAAGATAGACACAAGCCATTATTTTGAAAAAAAACCAGGCTTGG
GGGAGAGGGTGGATTATGCG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAYFLEQTDSEIFELIFEEYKRQNEHLEMIASENYTFASVMEAMGSVLTNKYAEGYPNKRYYGGCEVVDKIESLAIERAK
KLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSCGGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQ
SVKPEIIVCGFSAYPREIDFKKFREIADEVGALLLGDIAHVAGLVVAGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTND
EEIAAKIDKAIFPGTQGGPLMHAIAAKAVGFKENLKPEFKAYAQLVKSNMQVLAKALQEKNHKLVSGGTSNHLLLMDFLD
KPYSGKDADIALGNAGITVNKNTIPGETRSPFVTSGIRIGSAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEE
LKAMASQFPVYQQPIF

Sequences:

>Translated_416_residues
MAYFLEQTDSEIFELIFEEYKRQNEHLEMIASENYTFASVMEAMGSVLTNKYAEGYPNKRYYGGCEVVDKIESLAIERAK
KLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSCGGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQ
SVKPEIIVCGFSAYPREIDFKKFREIADEVGALLLGDIAHVAGLVVAGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTND
EEIAAKIDKAIFPGTQGGPLMHAIAAKAVGFKENLKPEFKAYAQLVKSNMQVLAKALQEKNHKLVSGGTSNHLLLMDFLD
KPYSGKDADIALGNAGITVNKNTIPGETRSPFVTSGIRIGSAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEE
LKAMASQFPVYQQPIF
>Mature_415_residues
AYFLEQTDSEIFELIFEEYKRQNEHLEMIASENYTFASVMEAMGSVLTNKYAEGYPNKRYYGGCEVVDKIESLAIERAKK
LFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSCGGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQS
VKPEIIVCGFSAYPREIDFKKFREIADEVGALLLGDIAHVAGLVVAGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTNDE
EIAAKIDKAIFPGTQGGPLMHAIAAKAVGFKENLKPEFKAYAQLVKSNMQVLAKALQEKNHKLVSGGTSNHLLLMDFLDK
PYSGKDADIALGNAGITVNKNTIPGETRSPFVTSGIRIGSAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEEL
KAMASQFPVYQQPIF

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=418, Percent_Identity=44.0191387559809, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI261862352, Length=418, Percent_Identity=44.0191387559809, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI261862350, Length=418, Percent_Identity=44.0191387559809, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI261862348, Length=418, Percent_Identity=44.0191387559809, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI261862346, Length=417, Percent_Identity=43.8848920863309, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI22547186, Length=432, Percent_Identity=42.3611111111111, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI22547189, Length=418, Percent_Identity=40.4306220095694, Blast_Score=285, Evalue=6e-77,
Organism=Escherichia coli, GI1788902, Length=405, Percent_Identity=54.0740740740741, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=43.25, Blast_Score=311, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=43.25, Blast_Score=311, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6319739, Length=429, Percent_Identity=39.3939393939394, Blast_Score=312, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6323087, Length=397, Percent_Identity=41.5617128463476, Blast_Score=303, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=44.6969696969697, Blast_Score=337, Evalue=7e-93,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=44.6969696969697, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45589; Mature: 45457

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYFLEQTDSEIFELIFEEYKRQNEHLEMIASENYTFASVMEAMGSVLTNKYAEGYPNKR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
YYGGCEVVDKIESLAIERAKKLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSC
CCCCHHHHHHHHHHHHHHHHHHHCCEECEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQSVKPEIIVCGFSAYPREIDF
CCCCCCCCEEEEECCHHCCEECCCCCCCEECHHHHHHHHHHCCCCEEEECCCCCCCCCCH
KKFREIADEVGALLLGDIAHVAGLVVAGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTND
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEECCCCHHHHCCCCCCEEEECC
EEIAAKIDKAIFPGTQGGPLMHAIAAKAVGFKENLKPEFKAYAQLVKSNMQVLAKALQEK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
NHKLVSGGTSNHLLLMDFLDKPYSGKDADIALGNAGITVNKNTIPGETRSPFVTSGIRIG
CCEEEECCCCCCEEEEEHHCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCCEEC
SAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEELKAMASQFPVYQQPIF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AYFLEQTDSEIFELIFEEYKRQNEHLEMIASENYTFASVMEAMGSVLTNKYAEGYPNKR
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
YYGGCEVVDKIESLAIERAKKLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSC
CCCCHHHHHHHHHHHHHHHHHHHCCEECEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQSVKPEIIVCGFSAYPREIDF
CCCCCCCCEEEEECCHHCCEECCCCCCCEECHHHHHHHHHHCCCCEEEECCCCCCCCCCH
KKFREIADEVGALLLGDIAHVAGLVVAGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTND
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEECCCCHHHHCCCCCCEEEECC
EEIAAKIDKAIFPGTQGGPLMHAIAAKAVGFKENLKPEFKAYAQLVKSNMQVLAKALQEK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
NHKLVSGGTSNHLLLMDFLDKPYSGKDADIALGNAGITVNKNTIPGETRSPFVTSGIRIG
CCEEEECCCCCCEEEEEHHCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCCEEC
SAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEELKAMASQFPVYQQPIF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA