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The map label for this gene is cysM [H]

Identifier: 188526912

GI number: 188526912

Start: 101586

End: 102503

Strand: Reverse

Name: cysM [H]

Synonym: HPSH_00535

Alternate gene names: 188526912

Gene position: 102503-101586 (Counterclockwise)

Preceding gene: 188526913

Following gene: 188526911

Centisome position: 6.37

GC content: 46.41

Gene sequence:

>918_bases
ATGATTATCACCACAATGCAAGACGCCATAGGTCGCACTCCCGTTTTTAAATTCACCAGCAAGGATTATCCGATTCCCAT
AAATTCCGCCATTTACGCCAAACTAGAGCATTTAAACCCAGGAGGGAGCGTTAAAGATCGCTTAGGCCAATACCTTATAG
AAGAAGGGTTTAGAACGGGTAAAATCACTTCTAAAACAACCATCATTGAGCCTACCGCAGGCAATACCGGCATCGCTCTA
GCTTTAGTAGCGCTCAAGCACCACCTAAAAACCATCTTTGTTGTCCCGGAAAAATTCAGCGCAGAAAAACAGCAAATCAT
GAGGGCTTTGGGGGCTAAAGTGATCAACACGCCTACTAGCGAGGGGATTTCTGGTGCCATTAAAAAAAGTAAAGAGTTAG
CCGAAAGCATCCCTAATAGCTATTTGCCCTTGCAATTTGAAAACCCTAATAATCCCGCCGCTTACTACCACACCCTAGCC
CCTGAGATTGTCCAAGAATTAGGCGCAGGGCTTACGAGCTTTGTAGCCGGGATAGGGAGTGGTGGCACTTTTGCGGGCAC
AGCTAGGTATTTGAAAGAACGCATCCCTACGATTCGCTTGATTGGGGTGGAGCCGGAGGGTTCTATTTTGAATGGGGGAG
AGCCTGGGCCTCATGAGATTGAGGGCATTGGCGTGGAGTTTATCCCTCCCTTTTTTGCAAACTTGGATATTGATGGCTTT
GAAACGATTTCAGATGAAGAGGGTTTTAGCTACACTAGGAAGTTAGCCAAACAAAACGGCTTATTAGTGGGGAGCTCTAG
CGGGGCAGCTTTTGTAGCAGCATTGAAAGAAGCGCAACGCCTCCCAGAAGGCAGCCAGGTTTTAACCATTTTCCCGGATG
TTGCCGATCGTTATCTCTCAAAAGGTATTTATTTATAA

Upstream 100 bases:

>100_bases
CTTTAATCCATCTTAATAAGCTAACATTTTATCTTAAATTTATTCCATTTAACGAGTTTAGTCATAATCGCAAAATTGAG
TTATTGTTATAGGAGGAATG

Downstream 100 bases:

>100_bases
ATTCATAAAAAGGAAAAATCATGCGCATGCAAACAAAATTAATCCATGGGGGCATTAGTGAGGATGCGGCAACGGGGGCG
GTGAGTGTGCCTATTTATCA

Product: cysteine synthetase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIITTMQDAIGRTPVFKFTSKDYPIPINSAIYAKLEHLNPGGSVKDRLGQYLIEEGFRTGKITSKTTIIEPTAGNTGIAL
ALVALKHHLKTIFVVPEKFSAEKQQIMRALGAKVINTPTSEGISGAIKKSKELAESIPNSYLPLQFENPNNPAAYYHTLA
PEIVQELGAGLTSFVAGIGSGGTFAGTARYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGF
ETISDEEGFSYTRKLAKQNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYLSKGIYL

Sequences:

>Translated_305_residues
MIITTMQDAIGRTPVFKFTSKDYPIPINSAIYAKLEHLNPGGSVKDRLGQYLIEEGFRTGKITSKTTIIEPTAGNTGIAL
ALVALKHHLKTIFVVPEKFSAEKQQIMRALGAKVINTPTSEGISGAIKKSKELAESIPNSYLPLQFENPNNPAAYYHTLA
PEIVQELGAGLTSFVAGIGSGGTFAGTARYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGF
ETISDEEGFSYTRKLAKQNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYLSKGIYL
>Mature_305_residues
MIITTMQDAIGRTPVFKFTSKDYPIPINSAIYAKLEHLNPGGSVKDRLGQYLIEEGFRTGKITSKTTIIEPTAGNTGIAL
ALVALKHHLKTIFVVPEKFSAEKQQIMRALGAKVINTPTSEGISGAIKKSKELAESIPNSYLPLQFENPNNPAAYYHTLA
PEIVQELGAGLTSFVAGIGSGGTFAGTARYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGF
ETISDEEGFSYTRKLAKQNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYLSKGIYL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=41.1003236245955, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=41.1003236245955, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=41.1003236245955, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=35.5263157894737, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=39.4822006472492, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=313, Percent_Identity=37.3801916932907, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17562970, Length=311, Percent_Identity=37.620578778135, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI32566674, Length=306, Percent_Identity=38.2352941176471, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=39.4648829431438, Blast_Score=190, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=36.8253968253968, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=36.1022364217252, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=37.828947368421, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=216, Percent_Identity=38.8888888888889, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321594, Length=312, Percent_Identity=38.7820512820513, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=32.0121951219512, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=38.8349514563107, Blast_Score=200, Evalue=8e-52,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=38.8349514563107, Blast_Score=200, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32752; Mature: 32752

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITTMQDAIGRTPVFKFTSKDYPIPINSAIYAKLEHLNPGGSVKDRLGQYLIEEGFRTG
CEEECCHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
KITSKTTIIEPTAGNTGIALALVALKHHLKTIFVVPEKFSAEKQQIMRALGAKVINTPTS
CCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHCHHHCCCCCC
EGISGAIKKSKELAESIPNSYLPLQFENPNNPAAYYHTLAPEIVQELGAGLTSFVAGIGS
CCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHCCC
GGTFAGTARYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGF
CCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCC
ETISDEEGFSYTRKLAKQNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYLS
CCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHH
KGIYL
CCCCC
>Mature Secondary Structure
MIITTMQDAIGRTPVFKFTSKDYPIPINSAIYAKLEHLNPGGSVKDRLGQYLIEEGFRTG
CEEECCHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
KITSKTTIIEPTAGNTGIALALVALKHHLKTIFVVPEKFSAEKQQIMRALGAKVINTPTS
CCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHCHHHCCCCCC
EGISGAIKKSKELAESIPNSYLPLQFENPNNPAAYYHTLAPEIVQELGAGLTSFVAGIGS
CCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHCCC
GGTFAGTARYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGF
CCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCC
ETISDEEGFSYTRKLAKQNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYLS
CCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHH
KGIYL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]