Click here to switch to the map view.

The map label for this gene is ureI [H]

Identifier: 188526876

GI number: 188526876

Start: 62543

End: 63130

Strand: Reverse

Name: ureI [H]

Synonym: HPSH_00340

Alternate gene names: 188526876

Gene position: 63130-62543 (Counterclockwise)

Preceding gene: 188526877

Following gene: 188526875

Centisome position: 3.92

GC content: 44.39

Gene sequence:

>588_bases
ATGCTAGGACTTGTATTGTTATATGTTGGGATTGTTTTAATCAGCAACGGGATTTGCGGATTAACCAAAGTCGATCCTAA
AAGCACTGCGGTGATGAACTTTTTTGTGGGCGGGCTTTCCATTGTTTGTAATGTGGTTGTCATCACTTATTCTGCGCTCA
ACCCTACAGCCCCTGTAGAAGGTGCAGAAGATATTGCTCAAGTATCGCACCATTTGACTAGCTTCTATGGGCCAGCGACT
GGGTTATTGTTCGGTTTTACCTACTTGTATGCGGCTATCAACCACACTTTTGGTTTGGATTGGAGGCCCTACTCTTGGTA
TAGCTTATTCGTAGCGATCAACACTGTTCCTGCTGCGATTTTATCCCACTATAGCGATATGCTTGATGACCACAAAGTGT
TAGGCATCACTGAAGGCGATTGGTGGGCGATCATTTGGTTGGCTTGGGGTGTTTTGTGGCTTACCGCTTTCATTGAAAAC
ATCTTGAAAATCCCTTTAGGGAAATTCACTCCATGGCTTGCTATCATTGAGGGTATTTTAACCGCTTGGATCCCTGCTTG
GTTACTCTTTATCCAACACTGGGTGTGA

Upstream 100 bases:

>100_bases
TTTTGTCAATTTACTATTTTTCTTTATGATTAGCTCAAGCAACAAAAGTTATTCGTAAGGTGCGTTTGTTGTAAAAATTT
TTGTTTGGAAGGAAAAGGCA

Downstream 100 bases:

>100_bases
GATGATCATAGAGCGTTTAATAGGCAATCTAAGGGATTTAAACCCCTTGGATTTCAGCGTGGATTATGTGGATTTGGAAT
GGTTTGAAACGAGGAAAAAA

Product: urea transporter

Products: NA

Alternate protein names: Urease accessory protein ureI [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIVCNVVVITYSALNPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTVPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLAIIEGILTAWIPAWLLFIQHWV

Sequences:

>Translated_195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIVCNVVVITYSALNPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTVPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLAIIEGILTAWIPAWLLFIQHWV
>Mature_195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIVCNVVVITYSALNPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTVPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLAIIEGILTAWIPAWLLFIQHWV

Specific function: Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AmiS/UreI family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003211 [H]

Pfam domain/function: PF02293 AmiS_UreI [H]

EC number: NA

Molecular weight: Translated: 21641; Mature: 21641

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIVCNVVVITYSALNPTAPVE
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GAEDIAQVSHHLTSFYGPATGLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTVPAAI
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIENILKIPLGKFTPWLAIIEGIL
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
TAWIPAWLLFIQHWV
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIVCNVVVITYSALNPTAPVE
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GAEDIAQVSHHLTSFYGPATGLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTVPAAI
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIENILKIPLGKFTPWLAIIEGIL
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
TAWIPAWLLFIQHWV
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]